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Manifestations of COVID-19 infection in children with malignancy:A single-center experience in Jordan

World Journal of Virology 2022年第5期11卷 321-330页

作者： Mousa Ahmad Qatawneh Moath Altarawneh Ruba Alhazaimeh Mais Jazazi Omaiema Jarrah Alaa Shorman laila alsadah Maher Mustafa Department of Hematology and Medical Oncology and Stem Cell Transplantation Unit Queen Rania Children’s HospitalRoyal Medical ServicesAmman 11183Jordan Department of Neonatology Queen Rania Children’s HospitalRoyal Medical ServicesAmman 11183Jordan Department of General Pediatrics Queen Rania Children’s HospitalRoyal Medical ServicesAmman 11183Jordan

BACKGROUND The coronavirus disease 2019(COVID-19)has been the cause of a global health crisis since the end of *** countries are following the guidelines and recommendations released by the World Health Organization to decrease the spread of the *** account for only 3%-5%of COVID-19 *** data are available regarding the clinical course,disease severity,and mode of treatment in children with malignancy and *** To evaluate the treatment plan and outcome of children with malignancy who contracted *** A retrospective study of the medical files of patients with malignancy who contracted COVID-19 between July 2020 and June 2021 was *** following data were reviewed for all patients:primary disease,laboratory data,admission ward,clinical status upon admission,disease course,treatment plan,and *** patients were those with malignancy who tested positive for COVID-19 by reverse transcription polymerase chain *** A total of 40 patients who had malignancy contracted COVID-19 from July 1,2020 to June 1,*** primary diseases were as follows:34 patients(85%)had hematological malignancies(30 had acute lymphoblastic leukemia,2 had acute myeloblastic leukemia,and 2 had Hodgkin lymphoma),whereas 6 patients(15%)had solid tumors(2 had neuroblastoma,2 had rhabdomyosarcoma,and 2 had central nervous system tumors).Twelve patients(30%)did not need hospitalization and underwent home isolation only,whereas twenty-eight patients(70%)required hospitalization(26 patients were admitted in the COVID-19 ward and 2 were admitted in the pediatric intensive care unit).CONCLUSION COVID-19 with malignancy in the pediatric age group has a benign course and does not increase the risk of having severe infection compared to other children.

关键词： COVID-19 Malignancy Disease severity score Children Jordan

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Wave Reflection by Rectangular Breakwaters for Coastal Protection

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Fluid Dynamics & Materials Processing 2024年第3期20卷 579-593页

作者： Hasna Akarni Hamza Mabchour laila El Aarabi Soumia Mordane Laboratory of Polymer Physics Mechanical Sciences and MaterialsFaculty of Sciences Ben M’SikHassan II University of CasablancaCasablanca20670Morocco

In this study,we focus on the numerical modelling of the interaction between waves and submerged structures in the presence of a uniform flow *** the same and opposite senses of wave propagation are *** main objective is an understanding of the effect of the current and various geometrical parameters on the reflection *** wave used in the study is based on potential theory,and the submerged structures consist of two rectangular breakwaters positioned at a fixed distance from each other and attached to the bottom of a wave *** numerical modeling approach employed in this work relies on the Boundary Element Method(BEM).The results are compared with experimental data to validate the *** findings of the study demonstrate that the double rectangular breakwater configuration exhibits superior wave attenuation abilities if compared to a single rectangular breakwater,particularly at low ***,the study reveals that wave mitigation is more pronounced when the current and wave propagation are coplanar,whereas it is less effective in the case of opposing current.

关键词： Wave current breakwaters Boundary Element Method(BEM) reflection coefficient

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Threshold-Based Software-Defined Networking(SDN)Solution for Healthcare Systems against Intrusion Attacks

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1469-1483页

作者： laila M.Halman Mohammed J.F.Alenazi Department of Computer Engineering College of Computer ScienceKing Saud UniversityRiyadh11451Saudi Arabia

The healthcare sector holds valuable and sensitive *** amount of this data and the need to handle,exchange,and protect it,has been increasing at a fast *** to their nature,software-defined networks(SDNs)are widely used in healthcare systems,as they ensure effective resource utilization,safety,great network management,and *** this sector,due to the value of thedata,SDNs faceamajor challengeposed byawide range of attacks,such as distributed denial of service(DDoS)and probe *** attacks reduce network performance,causing the degradation of different key performance indicators(KPIs)or,in the worst cases,a network failure which can threaten human *** can be significant,especially with the current expansion of portable healthcare that supports mobile and wireless devices for what is called mobile health,or *** this study,we examine the effectiveness of using SDNs for defense against DDoS,as well as their effects on different network KPIs under various *** propose a threshold-based DDoS classifier(TBDC)technique to classify DDoS attacks in healthcare SDNs,aiming to block traffic considered a hazard in the form of a DDoS *** then evaluate the accuracy and performance of the proposed TBDC *** technique shows outstanding performance,increasing the mean throughput by 190.3%,reducing the mean delay by 95%,and reducing packet loss by 99.7%relative to normal,with DDoS attack traffic.

关键词： Network resilience network management attack prediction software defined networking(SDN) distributed denial of service(DDoS) healthcare

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Method Verification and Validation of Hydralazine Hydrochloride: Spectrophotometric Analysis in Pure and Pharmaceutical Formulations

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American Journal of Analytical Chemistry 2024年第7期15卷 219-228页

作者： laila Abdullah Alshatti The Public Authority for Applied Education and Training College of Nursing General Science Department Shwaikh B State of Kuwait

The new method proposed is based on the formation of hydralazine-Bromophenol blue ion pair simply and without further extraction or heating. The ion pair was prepared in the presence of pH 3 citrate buffer forming a yellow-colored chromogen. A new maximum UV-visible band formed at 416 nm. The color was stable for more than 10 hours and obeyed Beer’s Law over the concentration range of 10 - 50 µg/mL. The calculated molar absorptivity and Sandell’s sensitivity were 1.01 × 104 L∙mol−1∙cm−1 and 0.0514 µg/mL, respectively. The elements of method validation stipulated by The International Conference on Harmonization [Q2 (R1)] were applied for hydralazine hydrochloride assay in pure and pharmaceutical tablet formulation. The average recoveries of the pure solution and the pharmaceutical formulation were 98.94% and 99.50%, respectively. The results were statistically compared by F-test, which indicates that the method can be precise and repeatable for both pure and pharmaceutical solutions. The method was found to be accurate, reproducible, and cost-effective, and validated for the assay of hydralazine in terms of the routine quality control.

关键词： Spectrophotometry Validation Hydralazine Hydrochloride International Conference on Harmonization Q2 (R1)

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Serum Immunoglobulin Concentrations in Juvenile Idiopathic Arthritis Cases during Active and Inactive Disease States

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第2期14卷 49-59页

作者： Sajib Muhammad Rayhan Kamrul laila Shahana A. Rahman Consultant (Paediatrics) Kalkini Upazila Health Complex Dhaka Bangladesh Department of Paediatrics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Department of Paediatrics (on PRL) Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Both the humoral and cell mediated immunities are involved in the pathogenesis of JIA. It is reported that overall immunoglobulin levels in JIA patients are significantly higher than their control during the active state of disease. Methodology: This prospective observational study was conducted over a period of 18 months All the newly diagnosed oligo-articular and poly-articular JIA patients having active disease were included by purposive sampling. Data were collected by a semi-structured predesigned questionnaire. Result: Most of the study subjects (57.6%) belonged to age group > 3 - 9 years. Oligo JIA was diagnosed in 66.7% and poly JIA in 33.3% of JIA children. The difference in mean (±SD) ESR (33.52 ± 21.29 and 15.09 ± 7.71 mm in 1st hour) at active and inactive states was highly significant. Mean (±SD) difference of IgG, IgM and IgA in active and inactive states of disease were highly significant. Conclusion: Higher and abnormal levels of immunoglobulin (IgG, IgM, and IgA) were present among JIA patients in active disease state which became normal during inactive disease state after treatment.

关键词： JIA Oligoarticular JIA Polyarticular JIA Immunoglobulins Acitive Disease Inactive Disease

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Nitrogen-Doped Amorphous Carbon Homojunction from Palmyra Sugar as a Renewable Solar Cell

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Journal of Renewable Materials 2024年第1期12卷 57-69页

作者： Budhi Priyanto Imam Khambali Irma Septi Ardiani Khoirotun Nadhiyah Anna Zakiyatul laila M.Chasrun Hasani Bima Romadhon Retno Asih Yoyok Cahyono Triwikantoro Darminto Department of Electronic Engineering Faculty of EngineeringUniversitas Muhammadiyah MalangKota MalangIndonesia Advanced Materials Research Group Department of PhysicsFaculty of Science and Data AnalyticsInstitut Teknologi Sepuluh NopemberSurabayaIndonesia Department of Electronic Engineering Faculty of Industrials EngineeringInstitut Teknologi National MalangKota MalangIndonesia

An a-C/a-C:N junction,which used palmyra sugar as the carbon source and ammonium hydroxide(NH4OH)as the dopant source,was successfully deposited on the ITO glass substrate using the nano-spraying *** current-voltage relationship of the junction was found to be a Schottky-like contact,and therefore the junction shows the characteristic *** means the a-C and a-C:N are semiconductors with different types of ***,the samples showed an increase in current and voltage value when exposed to visible light(bright state)compared to the dark condition,thereby,indicating the creation of electron-hole pairs during the *** was also discovered that the relationship between current and voltage for the a-C/a-C:N junction sample formed a curve that satisfies the rule of the photovoltaic effect when exposed to visible light from a light *** exposure of this sample to direct sunlight at AM 1.5 conditions produced a curve that meets the rules for the emergence of the photovoltaic effect with higher characteristics for the current-voltage ***,the a-C/a-C:N junction sample is a solar cell successfully fabricated using a sample method and has a maximum efficiency of 0.0013%.

关键词： Solar cell amorphous carbon palmyra sugar

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The Role of AI in Cyber Security: Safeguarding Digital Identity

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Journal of Information Security 2024年第2期15卷 245-278页

作者： Mohammad Binhammad Shaikha Alqaydi Azzam Othman laila Hatim Abuljadayel Department of Computer Science British University Dubai Dubai The United Arab Emirates Department of Cybersecurity Dar Al Hekma University Jeddah Saudi Arabia

This article signals the use of Artificial Intelligence (AI) in information security where its merits, downsides as well as unanticipated negative outcomes are noted. It considers AI based models that can strengthen or undermine infrastructural functions and organize the networks. In addition, the essay delves into AI’s role in Cyber security software development and the need for AI-resilient strategies that could anticipate and thwart AI-created vulnerabilities. The document also touched on the socioeconomic ramifications of the emergence of AI in Cyber security as well. Looking into AI and security literature, the report outlines benefits including made threat detection precision, extended security ops efficiency, and preventive security tasks. At the same time, it emphasizes the positive side of AI, but it also shows potential limitations such as data bias, lack of interpretability, ethical concerns, and security flaws. The work similarly focuses on the characterized of misuse and sophisticated cyberattacks. The research suggests ways to diminish AI-generating maleficence which comprise ethical AI development, robust safety measures and constant audits and updates. With regard to the AI application in Cyber security, there are both pros and cons in terms of socio-economic issues, for example, job displacement, economic growth and the change in the required workforce skills.

关键词： Artificial Intelligence Cyber Attack Cyber Security Real-Time Mitigation Social Media Security AI-Driven Threat Intelligence

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Serum Zinc and Copper Level in Juvenile Idiopathic Arthritis (JIA) Patients and Its Correlation with Disease Duration-A Tertiary Hospital Study

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第2期14卷 60-68页

作者： Mohammad Imnul Islam Mujammel Haque Tanzida Sultana Mousumi Ahmed Mohammed Mahbubul Islam Kamrul laila Manik Kumar Talukder Department of Paediatrics Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh

Background: Juvenile Idiopathic Arthritis (JIA) is the most prevalent rheumatic disease in children. It is associated with abnormal levels of serum zinc (Zn) and copper (Cu) as during inflammation serum copper concentration increases and zinc decreases. Objective: To assess the serum Zn and Cu levels in different sub-types of JIA patients and their correlation with the disease duration. Methods: This cross-sectional study was conducted over twelve months at the Pediatric Rheumatology Division, Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University. Sixty-nine JIA cases that fulfilled the International League of Association for Rheumatology (ILAR) criteria were taken as cases and age and sex-matched healthy children were considered as controls. The serum Zn and Cu tests were done using the spectrophotometric method with INDIKO PLUS Drug Analyzer. Data were recorded in a pre-designed questionnaire. Data were checked, verified and analyzed manually where continuous variables were analyzed using unpaired t-test and categorical variables using the ANOVA test. Pearson’s correlation coefficient test was used to see the correlation of serum zinc and copper levels with disease duration. Results: Boys were predominant in both case and control groups, with the majority within the 10 to 16-year-age group. Enthesitis-related arthritis (ERA) was the most common subtype followed by sJIA, Oligo JIA, Poly JIA (RF-) and unclassified subtypes. Disease duration was found less than 12 months in 30.4% of JIA patients. Serum analysis revealed a statistically significant reduction in mean zinc levels and increased copper levels in JIA patients compared to controls. This study observed a negative correlation between serum zinc levels and disease duration, whereas serum copper levels exhibited a positive correlation with disease duration. Conclusion: In conclusion, this study revealed that JIA patients exhibit alterations in serum zinc and copper levels. Serum copper levels s

关键词： Copper Juvenile Idiopathic Arthritis Zinc

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Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus

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World Journal of Diabetes 2024年第3期15卷 331-347页

作者： Saleh Fahad Alqifari Omar Alkomi Abdullah Esmail Khadijeh Alkhawami Shahd Yousri Mohamad Ayham Muqresh Nawwarah Alharbi Abdullah A Khojah Ahmed Aljabri Abdulrahman Allahham Kousalya Prabahar Hanan Alshareef Mohammed Aldhaeefi Tariq Alrasheed Ali Alrabiah laila A AlBishi Department of Pharmacy Practice Faculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi University-College of MedicineAl Bukayriyah 52726Saudi Arabia Department of Family Medicine Dr.Soliman Fakeeh Hospital DSFHJeddah 21461Saudi Arabia Department of Pharmacy Practice Faculty of PharmacyKing Abdulaziz UniversityJeddah 22252Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Internal Medicine Faculty of MedicineUniversity of TabukTabuk 71491Saudi Arabia Department of Pharmacy Practice Raabe College of PharmacyOhio Northern UniversityOhioOH 45810United States Department of Pediatric Faculty of MedicineUniversity of TabukTabuk 71491Saudi Arabia

Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus common second-line choice after metformin for treating *** considerations can make selecting and switching between different GLP-1 RAs *** study aims to provide a comprehensive guide for the usage of GLP-1 RAs and dual GIP and GLP-1 RAs for the management of T2DM.

关键词： Glucagon-like peptide-1 receptor agonist Diabetes mellitus Metabolic syndrome Dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist Clinical practice Endocrinology

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Prognostic Factors in Cardiorenal Syndrome Type 1: Retrospective Observational and Analytical Study

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World Journal of Cardiovascular Diseases 2024年第7期14卷 435-445页

作者： Mariam El Galiou Amal Zniber Hajar Fitah Naima Ouzeddoun Tarik Bouattar Nawal Doghmi laila Lahlou Loubna Benamar Nephrology-Dialysis-Renal Transplantation Department Ibn Sina University Hospital Mohamed V University Rabat Morocco Department of Cardiology B Ibn Sina University Hospital Mohamed V University Rabat Morocco Laboratory of Biostatistics Clinical Research and Epidemiology Department of Public Health Mohamed V University Rabat Morocco

Introduction: Type 1 cardiorenal syndrome (CRS 1) is characterized by acute impairment of cardiac function leading to acute renal dysfunction. CRS1 is present in 25% of patients admitted for heart failure. The objective of our study is to analyze the epidemiological, clinical, therapeutic profile and the risk and prognostic factors of these patients. Materials and Methods: We identified 120 patients with cardiorenal syndrome (CRS) over a one-year period to determine the prevalence and risk factors for developing CRS 1. We analyzed the clinical, biological, and evolutionary profiles of patients with CRS 1 and determined the risk factors for the occurrence of acute kidney injury (AKI) as well as the mortality factors in these patients. Résultats: The average age of our patients with CRS1 is 58 ± 9 years, with a sex ratio of 1.4. The average eGFR of our patients is 35 ± 6.5 ml/min/1.73m2. Diabetes was found in 17% of our patients and hypertension in 14%. The etiology of cardiac impairment is predominantly acute coronary syndrome (ACS), followed by rhythm disorders. Renally, all our patients have acute kidney injury (AKI), with 86% having functional acute renal failure and 14% having acute tubular necrosis. Therapeutically, 50% of our patients are on diuretics, 42% receive beta-blocker treatment, and RAAS blockers are used in 29% of cases. Renal replacement therapy (RRT) sessions were required in 13.8% of cases. In univariate analysis, male gender, tachyarrhythmia, and hypertension are associated with the early onset of acute kidney injury (AKI). The use of diuretics, anemia, and low left ventricular ejection fraction (LVEF) are linked to a higher risk of developing CRS 1 (p = 0.021, p = 0.037, p = 0.010 respectively). In multivariate analysis, advanced age is significantly associated with increased mortality risk in CRS 1 patients (p = 0.030), while beta-blocker use is considered a protective factor (p = 0.014). Conclusion: Our study identifies several key factors asso

关键词： Acute Kidney Injury Type 1 Cardiorenal Syndrome Acute Heart Failure Diuretics

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