Manifestations of COVID-19 infection in children with malignancy:A single-center experience in Jordan

作     者：Mousa Ahmad Qatawneh Moath Altarawneh Ruba Alhazaimeh Mais Jazazi Omaiema Jarrah Alaa Shorman Laila Alsadah Maher Mustafa 

作者机构：Department of Hematology and Medical Oncology and Stem Cell Transplantation UnitQueen Rania Children’s HospitalRoyal Medical ServicesAmman 11183Jordan Department of NeonatologyQueen Rania Children’s HospitalRoyal Medical ServicesAmman 11183Jordan Department of General PediatricsQueen Rania Children’s HospitalRoyal Medical ServicesAmman 11183Jordan 

出 版 物：《World Journal of Virology》 (世界病毒学杂志)

年 卷 期：2022年第11卷第5期

页      面：321-330页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：COVID-19 Malignancy Disease severity score Children Jordan 

摘      要：BACKGROUND The coronavirus disease 2019(COVID-19)has been the cause of a global health crisis since the end of *** countries are following the guidelines and recommendations released by the World Health Organization to decrease the spread of the *** account for only 3%-5%of COVID-19 *** data are available regarding the clinical course,disease severity,and mode of treatment in children with malignancy and *** To evaluate the treatment plan and outcome of children with malignancy who contracted *** A retrospective study of the medical files of patients with malignancy who contracted COVID-19 between July 2020 and June 2021 was *** following data were reviewed for all patients:primary disease,laboratory data,admission ward,clinical status upon admission,disease course,treatment plan,and *** patients were those with malignancy who tested positive for COVID-19 by reverse transcription polymerase chain *** A total of 40 patients who had malignancy contracted COVID-19 from July 1,2020 to June 1,*** primary diseases were as follows:34 patients(85%)had hematological malignancies(30 had acute lymphoblastic leukemia,2 had acute myeloblastic leukemia,and 2 had Hodgkin lymphoma),whereas 6 patients(15%)had solid tumors(2 had neuroblastoma,2 had rhabdomyosarcoma,and 2 had central nervous system tumors).Twelve patients(30%)did not need hospitalization and underwent home isolation only,whereas twenty-eight patients(70%)required hospitalization(26 patients were admitted in the COVID-19 ward and 2 were admitted in the pediatric intensive care unit).CONCLUSION COVID-19 with malignancy in the pediatric age group has a benign course and does not increase the risk of having severe infection compared to other children.