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Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis

Cellular & Molecular Immunology 2011年第6期8卷 469-478页

作者： Da P Chen Chun K Wong lai s tam Edmund K Li Christopher WK Lam Department of Chemical Pathology The Chinese University of Hong KongPrince of Wales HospitalShatinNTHong KongChina Department of Clinical Laboratory Children’s Hospital of Chongqing Medical UniversityChongqingChina Department of Medicine and Therapeutics The Chinese University of Hong KongPrince of Wales HospitalNgan Shing StreetShatinNTHong KongChina Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyAvenida Wai LongTaipaMacaoChina

Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune ***,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLs)in rheumatoid arthritis(RA)have not been ***,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLs from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these *** urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLs(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLs was observed following the combined treatment with monosodium urate crystals and TNF-a or *** experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase *** results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA.

关键词： cytokines fibroblast-like synoviocytes rheumatoid arthritis signal transduction uric acid

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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Peripheral corneal ulcer secondary to acquired eyelash trichomegaly following treatment with erlotinib in Asia:a case report

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 468-469页

作者： Kin-Man tam Iat-Fan lai Department of Ophthalmic Center Kiang Wu HospitalMacao 999078China

Dear Editor,Erlotinib is an epidermal growth factor receptor (EGFR)inhibitor used in the treatment of non-small cell lung *** side effects of erlotinib include rash and diarrhea,while eyelash trichomegaly and hair dis... 详细信息

关键词： diarrhea treatment ulcer

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian sanqiao Yao Feng lai Yangfan Liang Chuanchuan Liu Yujia Lu sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina school of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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New Optimization Method, the Algorithms of Changes, for Heat Exchanger Design

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Chinese Journal of Mechanical Engineering 2012年第1期25卷 55-62页

作者： tam Houkuan tam Lapmou tam sikchung CHIO Chouhei GHAJAR Afshin J Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of Macao Department of Mathematics Faculty of Science and TechnologyUniversity of Macao school of Mechanical and Aerospace Engineering Oklahoma State University

Heat exchangers are widely used in the process engineering such as the chemical industries, the petroleum industries, and the HVAC applications etc. An optimally designed heat exchanger cannot only help the optimization of the equipment size but also the reduction of the power consumption. In this paper, a new optimization approach called algorithms of changes (AOC) is proposed for design and optimization of the shell-tube heat exchanger. This new optimization technique is developed based on the concept of the book of changes (I Ching) which is one of the oldest Chinese classic texts. In AOC, the hexagram operations in I Ching are generalized to binary string case and an iterative process, which imitates the I Ching inference, is defined. Before applying the AOC to the heat exchanger design problem, the new optimization method is examined by the benchmark optimization problems such as the global optimization test functions and the travelling salesman problem (TsP). Based on the TsP results, the AOC is shown to be superior to the genetic algorithms (GA). The AOC is then used in the optimal design of heat exchanger. The shell inside diameter, tube outside diameter, and baffles spacing are treated as the design (or optimized) variables. The cost of the heat exchanger is arranged as the objective function. For the heat exchanger design problem, the results show that the AOC is comparable to the GA method. Both methods can find the optimal solution in a short period of time.

关键词： optimization genetic algorithms (GA) travelling salesman problem (TsP) heat exchanger design algorithms of changes (AOC)

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Characterizing the optimal operation of photocatalytic degradation of BDE-209 by nano-sized TiO_2

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Journal of Environmental sciences 2012年第9期24卷 1670-1678页

作者： Ka lai Chow Yu Bon Man Jin shu Zheng Yan Liang Nora Fung Yee tam Ming Hung Wong Croucher Institute for Environmental sciences and Department of Biology Hong Kong Baptist University Hong Kong SAR China Department of Biology and Chemistry City University of Hong Kong Hong Kong SAR China

Brominated flame retardants have been widely used in industry. There is a rapid growing public concern for their availabilities in the environment. Advanced oxidation process （AOP） is a promising and efficient technology which may be used to remove emerging chemicals such as brominated flame retardants. This study aims at investigating optimal operational conditions for the removal of BDE-209 using nano-scaled titanium（IV） oxide. The residual PBDE congeners after photocatalytical degradation of BDE-209 by TiO2 were analysed by gas chromatography-mass spectrometry （GC-Ms）. It was found that the degradability of BDE-209 by TiO2 was attributed to its photocatalytic activity but not the small size of the particles. The half-life of removing BDE-209 by TiO2 was 3.05 days under visible light. Tetra- and penta-BDEs were the major degraded products of BDE-209. Optimum conditions for photocatalytical degradation of BDE-209 was found to be at pH 12 （93% ± 1%）, 5, 10, 20 mg/L （93.0% ± 1.70%, 91.6% ± 3.21%, 91.9% ± 0.952%, respectively）, respectively of humic acid and in the form of anatase/rutile TiO2 （82% ± 3%）. Hence, the efficiency of removing BDE-209 can be maximized while being cost effective at the said operating conditions.

关键词： PBDEs TiO2 photocatalysis hydroxyl radicals

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Public Health Control Measures for the Co-circulation of Influenza and sARs-CoV-2 During Influenza seasons

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China CDC weekly 2022年第2期4卷 22-26页

作者： John s tam Yuelong shu Department of Applied Biology and Chemical Technology Hong Kong Polytechnic UniversityHong KongChina Asia Pacific Alliance for the Control of Influenza(APACI) South MelbourneVICAustralia school of Public Health(shenzhen) Sun Yat-sen UniversityGuangzhouGuangdongChina

sEAsONAL INFLUENZA IN THE MIDsT OF COVID-19 The World Health Organization(WHO)named the disease caused by severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)as coronavirus disease 2019(COVID-19)and declared the outbreak a Public Health Emergency of International Concern(PHEIC)on January 30,2020 and a pandemic on March 11,***,there have been 239,437,517 confirmed cases of COVID-19 reported to WHO,including 4,879,235(2.1%)deaths as of October 15,2021(1).The COVID-19 pandemic continues to cause an unparalleled impact on global public health security and economic well-being in the context of previous influenza pandemics as well as other emerging infectious diseases in history(2).As the epidemiology,clinical presentations,and control measures for sARs-CoV-2 and influenza share many features,there is a need to develop strategies to address additional challenges arising in the continued surveillance,prevention,and clinical management of influenza in conjunction with COVID-19 pandemic responses.

关键词： epidemiology prevention acute

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Modeling of Reversibleγ/αTransformations of Low Carbon steels in the Intercritical Temperature Range

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材料热处理学报 2004年第05B期25卷 702-705页

作者： tamás RTl Imre FELDE Hakan GR Budapest Polytechnic Budapest HungaryBay Zoltdn Institute for Materials Science and Technology Budapest HungaryMetallurgical and Materials Eng. Dept. Middle East Technical University Ankara Turkey

A phenomenological kinetic model has been developed for the prediction of non-isothermal reversible incomplete transformations in low-carbon hypoeutectoid steels. The theoretical basis of the proposed method has its origin in a possible extension of the traditional Austin-Rickett kinetic differential equation. To critically assess the applicability of the model, a number of experiments based on computer simulations have been performed to predict the austenite/ferrite proeutectoid transformation in the temperature range of Aei to Ae3 on plain carbon hypoeutectoid steels. A comparison with published experimental data has verified that the model developed is reasonable both quantitatively and with respect to well-established trends. Extension of the method of prediction appears promising when the non-isothermal reactions occurring during heat treatment (such as carbide precipitation and dissolution) can be assumed to proceed in a reversible manner.

关键词：奥氏体转变动力学低碳钢临界温度

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao school of Pharmaceutical science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China state Key Laboratory for Quality Ensurance and sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and s-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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