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Journal of Environmental Sciences 2019年第5期31卷 174-199页

作者： Kar Chiew lai Lai Yee Lee Billie Yan Zhang Hiew Suchithra Thangalazhy-Gopakumar Suyin Gan Department of Chemical and Environmental Engineering University of Nottingham Malaysia Campus

The remediation of wastewater requires treatment technologies which are robust, efficient,simple to operate and affordable such as adsorption. Lately, three-dimensional(3D)graphene based materials have attracted significant attention as effective adsorbents for wastewater treatment. The intrinsic properties of 3D graphene structure such as large surface area and interconnected porous structure can facilitate the transport of pollutants into the 3D network and provide abundant active sites for trapping the pollutants. For the synthesis of 3D graphene structure, ice-templating is commonly practiced due to its facile steps, cost effectiveness and high scalability potential. This review covers the icetemplating fabrication technique for 3D graphene based materials and their application as adsorbents in eliminating dyes and heavy metals from aqueous media. The assembly mechanisms of the ice-templating fsynthesis are comprehensively discussed. Further discussion on the fundamental principles, critical process parameters and characteristics of ice-templated 3D graphene structures is also included. A thorough review on the mechanisms for batch adsorption of dyes and heavy metals is presented based on the structures and properties of the 3D graphene materials. The review further evaluates the dynamic adsorption in packed columns and the regeneration of 3D graphene based materials.

关键词： Ice-templating 3D graphene based structure Adsorption mechanism Dyes Heavy metals

Synthesis of a highly recoverable 3D MnO2/rGO hybrid aerogel for efficient adsorptive separation of pharmaceutical residue

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Journal of Environmental Sciences 2022年第8期34卷 194-203页

作者： Billie Yan Zhang Hiew Wan Ting Tee Nicholas Yung Li Loh Kar Chiew lai Svenja Hanson Suyin Gan Suchithra Thangalazhy-Gopakumar Lai Yee Lee Department of Chemical and Environmental Engineering University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Chemical and Environmental Engineering University of Nottingham Ningbo ChinaNingbo 315100China

Water contamination by non-steroidal anti-inflammatory drugs,such as acetaminophen,is an emerging ecological concern.In this study,a newthree-dimensionalmanganese dioxideengrafted reduced graphene oxide(3D MnO_(2)/rGO)hybrid aerogel was developed for acetaminophen sequestration.The synthesis involved firstly the self-assembly of GO aerogel,followed by thermal reduction and in-situ MnO_(2) growth by redox-reaction.The aerogel demonstrated interlinked planes with smooth surfaces deposited with MnO_(2) nanospheres and pores of 138.4–235.3μm width.The influences of adsorbent dosage,initial pH,acetaminophen concentration,temperature and contact time were investigated.It was determined that the adsorption of acetaminophen occurred on uniform sorption sites in the aerogel,as suggested by the best fit of data to the Langmuir isotherm,yielding a maximum adsorption capacity of 252.87 mg/g.This highest adsorption performance of the 3D MnO_(2)/rGO aerogel was attained at a dosage of 0.6 g/L,initial pH of 6.2 and temperature of 40℃.The process kinetics were in-line with the pseudo-first-order and pseudo-second-order kinetics at 10 and 20–500 mg/L concentrations,respectively.Thermodynamic assay showed the spontaneity and endothermicity features of the 3D MnO_(2)/rGO-acetaminophen system.The acetaminophen adsorption mechanisms were mainly hydrogen bonding and pore entrapment.Moreover,the as-synthesised aerogel was effectively regenerated using acetone and re-utilised in four adsorption-desorption cycles.Overall,the results highly recommend the implementation of the 3D MnO_(2)/rGO hybrid aerogel for purification of wastewater polluted by acetaminophen residue.

关键词： Acetaminophen Adsorption Adsorption mechanism 3D reduced graphene oxide Manganese oxide nanoparticles Regeneration

Role and outcome of conventional surgery in the treatment of pyogenic liver abscess in the modern era of minimally invasive therapy

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World Journal of Gastroenterology 2008年第5期14卷 747-751页

作者： Simon Siu-Man Ng Janet Fung-yee lee Paul Bo-San lai Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China

AIM:To evaluate the role and outcome of conventional surgery in the treatment of pyogenic liver abscess in the modern era of minimally invasive therapy. METHODS:The medical records of thirteen patients with pyogenic liver abscess who underwent surgical treatment between January 1995 and December 2002 were retrospectively reviewed to determine the clinical presentation, indication and nature of surgery, and out-come of surgery. RESULTS:The patients were predominantly women (10/13) with a mean age of 65 ± 17 years. Their main presenting symptoms were abdominal pain (100%) and fever (77%). The aetiologies included biliary (n = 6), cryptogenic (n = 3), portal (n = 2), and trauma (n = 2). Seven patients underwent percutaneous drainage as the initial treatment. Of these, three patients developed peritonitis secondary to peritoneal spillage. Another four patients failed to respond because of multilocula-tion. Salvage surgery was required in these patients. Six patients proceeded to straight laparotomy:two had marked sepsis and multiloculated abscess that precluded percutaneous drainage, and four presented with perito-nitis of uncertain pathology. Surgical procedures included deroofment and drainage (n = 9), liver resection (n = 3), peritoneal lavage (n = 2), cholecystectomy (n = 4), and exploration of common bile duct (n = 2). One patient required reoperation because of bleeding. Three patients required further percutaneous drainage after surgery. The overall mortality was 46%. Four patients died of multiorgan failure and two patients died of pulmonary embolism. CONCLUSION:Surgical treatment of pyogenic liver ab-scess is occasionally needed when percutaneous drainage has failed due to various reasons. Mortality rate in this group of patients has remained high.

关键词：化脓性肝脏脓肿外科手术肝脏疾病经皮引流术

PNF技术对肘关节恐怖三联症术后功能恢复的影响

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泸州医学院学报 2014年第3期37卷 295-298页

作者：袁丽郭声敏 lee lai yee 泸州医学院附属医院康复医学科四川泸州646000 加拿大McMaster大学康复科学系

目的:观察本体感觉神经肌肉促进疗法(PNF)对恐怖三联症术后肘关节功能恢复的临床疗效。方法:选取恐怖三联症术后患者40例,随机分为对照组和PNF组各20例。2组均于术后第2 d、患者病情稳定后,进行常规肌肉牵伸、肌力训练、关节被动活动等... 详细信息

目的:观察本体感觉神经肌肉促进疗法(PNF)对恐怖三联症术后肘关节功能恢复的临床疗效。方法:选取恐怖三联症术后患者40例,随机分为对照组和PNF组各20例。2组均于术后第2 d、患者病情稳定后,进行常规肌肉牵伸、肌力训练、关节被动活动等康复治疗。PNF组增加等张训练、收缩-放松、动态反转和稳定性反转等PNF技术。4个月后,用关节活动度和Mayo评分对恐怖三联症术后肘关节功能恢复情况进行评估。结果:4个月后,PNF治疗组的关节活动度和Mayo评分均显著优于对照组,差异具有统计学意义(P<0.05)。结论:PNF技术对恐怖三联症术后功能恢复有明显疗效,值得临床推广应用。

关键词： PNF 恐怖三联症关节活动度 Mayo 术后康复

A simple and purification-free nucleic acid extraction method for rapid diagnosis of malaria

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Asian Pacific Journal of Tropical Medicine 2023年第9期16卷 428-430页

作者： lee Phone Youth Zen Meng yee lai Mohd Hafizi Abdul Hamid Jenarun Jelip Rose Nani Mudin Noor Hafizan Bt Mat Salleh Netty Darwina Dawam Nirzayanna Eyan Abdul Ajak Mohd Ashrin Afiq Bin Zainudin yee Ling Lau Department of Parasitology Faculty of MedicineUniversiti Malaya50603 Kuala LumpurMalaysia Vector Borne Disease Sector Ministry of HealthPutrajayaMalaysia Lipis District Health Office PahangMalaysia State Health Department Negeri SembilanMalaysia Microbiology Sector Hospital Kuala Kubu BharuSelangorMalaysia

In a point of care setting for the diagnosis of malaria,DNA extraction using conventional methods are time-consuming and complicated.Therefore,in this study we aim to utilize a simple nucleic acid extraction method to directly extract DNA from blood.This would in turn reduce the time,cost and equipment needed to perform DNA extraction.This method is then coupled with LAMP assay for rapid diagnosis of malaria.

关键词： diagnosis malaria utilize

Intercellular and inter-organ crosstalk in browning of white adipose tissue:molecular mechanism and therapeutic complications

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Journal of Molecular Cell Biology 2021年第7期13卷 466-479页

作者： lai yee Cheong Aimin Xu The State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina

Adipose tissue(AT)is highly plastic and heterogeneous in response to environmental and nutritional changes.The development of heat-dissipating beige adipocytes in white AT(WAT)through a process known as browning(or beiging)has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic complications.This is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic health.WAT consists of adipocytes,nerves,vascular endothelial cells,various types of immune cells,adipocyte progenitor cells,and fibroblasts.These cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning capacity.In addition,inter-organ crosstalk is also important for beige adipocyte biogenesis.Here,we summarize recent findings on fat depot-specific differences,secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes,as well as challenges in targeting beige adipocytes as a potential anti-obese therapy.

关键词： adipose tissue browning circulating factors energy homeostasis adipose biology obesity

Hepatic venous outflow obstruction after piggyback liver transplantation by an unusual mechanism:Report of a case

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World Journal of Gastroenterology 2006年第33期12卷 5416-5418页

作者： Simon Siu-Man Ng Simon Chun-Ho Yu Janet Fung-yee lee Paul Bo-San lai Wan-yee Lau Departments of Surgery and Diagnostic Radiology & Organ Imaging Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China

Hepatic venous outflow obstruction after piggyback liver transplantation is a very rare complication. An unusual mechanism aggravating it is reported. A 33-year-old man with end-stage hepatitis B liver cirrhosis underwent a piggyback orthotopic liver transplantation using a full-size cadaveric graft. Two months after transplantation, he developed gross ascites refractory to maximal diuretic therapy. Doppler ultrasound showed patent portal and hepatic veins. Serial computed tomography scans revealed a hypoperfused right posterior segment of the liver which subsequently underwent atrophy. Hepatic venography demonstrated a high-grade stenosis with an element of torsion of venous drainage at the anastomosis. The stenosis was successfully treated with repeated percutaneous balloon angioplasty. The patient remained asymptomatic six months afterwards with complete resolution of ascites and peripheral edema. We postulate that liver allograft segmental hypoperfusion and atrophy may aggravate or result in a hepatic venous outflow problem by the mechanism of torsion effect. Percutaneous balloon angioplasty is a safe and effective treatment modality for anastomotic stenosis.

关键词：肝静脉阻塞肝移植病理机制治疗

Modifications of ALPPS–from complex to more complex or from complex to less complex operations

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 346-352页

作者： Wan yee Lau Eric CH lai Faculty of Medicine The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina Department of Surgery Pamela Youde Nethersole Eastern HospitalHong Kong SARChina

BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has recently been developed to induce rapid liver hypertrophy to reduce the chance of post-hepatectomy liver failure in patients with borderline or insufficient future liver remnant. ALPPS is still in an early developmental stage and its techniques have not been standardized. This study aimed to review the technical modifications of the conventional ALPPS procedure. DATA SOURCES: Studies were identified by searching MEDLINE and PubMed for articles published from January 2007 to December 2016 using the keywords 'associating liver partition and portal vein ligation for staged hepatectomy' and 'ALPPS'. Additional articles were identified by a manual search of references from key articles. RESULTS: There have been a lot of modifications of the conventional ALPPS. These are classified as: (1) modifications aiming to improve surgical results; (2) modifications aiming to expand surgical indications; (3) salvage ALPPS; (4) ALPPS using the minimally invasive approach. Some of these modifications have made the conventional ALPPS procedure to become even more complex, although there have also been other attempts to make the procedure less complex. The results of most of these modifications have been reported in small case series or case reports. We need better well-designed studies to establish the true roles of these modifications. However, it is interesting to see how this conventional ALPPS procedure has evolved since its introduction. CONCLUSIONS: There is a trend for the use of minimally invasive procedure in the phase 1 or 2 of the conventional ALPPS procedure. Some of these modifications have expanded the use of ALPPS in patients who have been considered to have unresectable liver tumors. The long-term oncological outcomes of these modifications are still unknown.

关键词： associating liver partition and portal vein ligation for stage hepatectomy hepatocellular carcinoma hepatectomy liver metastasis portal vein embolization

澳大利亚数学课程中七大通用能力的探析及启示——基于数学核心素养的视角

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数学教育学报 2017年第4期26卷 44-49,102页

作者：童莉 Mun yee lai 重庆师范大学数学科学学院重庆401331 弗林德斯大学教育学院澳大利亚阿德莱德5042

学生核心素养的发展是落实＆quot;立德树人＆quot;教育根本任务的重要途径,数学核心素养的研制是广大数学教育研究者们肩负的重任.澳大利亚数学课程中的七大通用能力包括：读写能力、运算能力、信息通信技术能力、批判性与创造性思维、... 详细信息

学生核心素养的发展是落实＆quot;立德树人＆quot;教育根本任务的重要途径,数学核心素养的研制是广大数学教育研究者们肩负的重任.澳大利亚数学课程中的七大通用能力包括：读写能力、运算能力、信息通信技术能力、批判性与创造性思维、个人与社会能力、道德理解、跨文化理解等7个方面,其价值取向与中国新近颁布的学生发展核心素养类似.作为澳大利亚数学课程的一大亮点,它的目标、内容和评价有诸多特色,对中国数学核心素养的研制有着重要的启示作用.

关键词：通用能力澳大利亚数学课程核心素养数学核心素养

Obituary:Prof.Yun Zhang(1963-2023)-A scientist focused on toxins and their underlying mechanisms to decipher human diseases

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Zoological Research 2024年第1期45卷 230-232页

作者： Wenhui lee Ren lai the Key Laboratory of Bioactive Peptides of Yunnan Province Engineering Laboratory of Peptides of Chinese Academy of SciencesKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Centre for Non-Human PrimatesKunming Primate Research CentreNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Sino-African Joint Research CentreNew Cornerstone Science InstituteKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of human diseases.His educational journey was marked by frequent changes in schools due to his parents’occupational relocations.However,despite these challenges,he consistently displayed diligence and was admitted to the East China University of Science and Technology,Shanghai,after completing high school in 1980.He remained an active and loyal member of the School of Biotechnology at the university.

关键词： admitted harbor mechanisms