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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric ho Yin Lau Carrie Yuen ting Ip ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METhoDS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

Pollution hazards of heavy metals in sewage sludge from four wastewater treatment plants in Nanchang, China

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Transactions of Nonferrous Metals Society of China 2017年第10期27卷 2249-2259页

作者： ting YANG Hua-jun HUANG Fa-ying lai School of Land Resources and Environment Jiangxi Agricultural University Nanchang 330045 China

The pollution hazards of heavy metals were investigated in sewage sludge collected from four wastewater treatment plantsin Nanchang City,China,including honggutan(HGT),Chaoyang(CY),Qingshanhu(QSH)and Xianghu(XH).Contamination/riskcharacteristics of heavy metals(Cu,Pb,Zn,Cd,Cr and Ni)were evaluated based on their leachable content,total content andchemical *** sewage sludge from QSH contained higher total contents of heavy metals(except Pb)than those from HGT,XH and *** total contents of Cd and Ni were mostly beyond ***,Cr and Pb were predominantly present in potentialeffect and stable *** and Ni showed higher *** presented roughly uniform distribution into four *** leaching contents of heavy metals almost exceeded the threshold values,especially for Zn and *** potential ecological riskindexes of heavy metals in sewage sludge were4263.34?7480.26,indicating very high *** contamination is the major concern.

关键词： sewage sludge heavy metal contamination degree environment risk

Diphtheria Toxin/Human B-Cell Activating Factor Fusion Protein Kills Human Acute Lymphoblastic Leukemia BALL-1 Cells: An Experimental Study

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Chinese Journal of Cancer Research 2012年第3期24卷 238-244页

作者： Xin-pu Gao Zheng-min Liu Yu-lian Jiao Bin Cui Yue-ting Zhu Jie Zhang lai-cheng Wang Yue-ran Zhao Central Laboratory Provincial Hospital Affiliated to Shandong UniversityJinan 250021China Laboratory Department of Jinan Blood Station Blood Center of Shandong ProvinceJinan 250001China

Objective： This study aimed to express a fusion protein of diphtheria toxin and human B cell-activating factor （DT388sBAFF） in Escherichia coli （E. coli） and investigate its activity in human B-lineage acute lymphoblastic leukemia 1 cells （BALL-1）. Methods： A fragment of DT388sBAFF fusion gene was separated from plasmid pUC57-DT388sBAFF digested with Nde I and Xho I, and inserted into the expression vector pcold II digested with the same enzymes. Recombinants were screened by the colony polymerase chain reaction （PCR） and restriction map. The recombinant expression vector was transformed into BL21 and its expression was induced by isopropyl β-D-1-thiogalactopyranoside （IPTG）. The recombinant protein was identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis （SDS-PAGE） and Western blot, and then purified by Ni2＋-NTA affinity chromatography. The expression level of B cell-activating factor receptor （BAFF-R） on BALL-1 cells was assessed by real-time PCR. The receptor binding capacity of recombinant protein was determined by cell fluorescent assay. The specific cytotoxicity of recombinant protein on BALL-1 cells was detected by 3-（4,5-dimethylthiazolyl-2）-2,5-diphenyltetrazolium bromide （MTT） assay. Results： The expression level of recombinant protein was 50% of total bacterial proteins in E. coli, and the recombinant protein could bind to BAFF-R-positive BALL-1 cells and thereby produce a cytotoxic effect on the cells. Conclusion： The fusion protein expression vector DT388sBAFF was successfully constructed and the recombinant protein with selective cytotoxicity against BALL-1 cells was obtained, providing foundation for further study of the therapy of human B-lineage acute lymphoblastic leukemia.

关键词： B cell-activating factor B-lineage acute lymphoblastic leukemia Diphtheria toxin Fusion protein

A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 293-299页

作者： Man-Hin Lui Jason Chun ho Lam Yi Lee Kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan lai Pak Lun Yuen Wai Yiu Lam ho Yan Chan Yiu Fai Wong Jimmy Shiu Ming lai Kendrick Co Shih Li Ka Shing Faculty of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y,female 51%）.No statistical significant relationship was established between noncompliance and any single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality of *** societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma eye drop compliance quality of life

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对白盒SMS4实现的一种有效攻击

软件学报 2013年第9期24卷 2238-2249页

作者：林婷婷来学嘉上海交通大学计算机科学与工程系上海200240

传统的密码模型都假设密码系统的运行终端和计算环境是可信任的,但是,随着攻击方式的发展,这样的模型显得越来越脆弱.而白盒攻击环境是指攻击者除了能够获得与传统密码模型同样的资源以外,还对密码系统的内部运行完全可见,并完全掌控执... 详细信息

传统的密码模型都假设密码系统的运行终端和计算环境是可信任的,但是,随着攻击方式的发展,这样的模型显得越来越脆弱.而白盒攻击环境是指攻击者除了能够获得与传统密码模型同样的资源以外,还对密码系统的内部运行完全可见,并完全掌控执行环境.因此,能够抵抗白盒攻击的密码算法具有更高层次的安全意义.2009年提出的SMS4算法的白盒实现,其目标是在白盒攻击环境下能够防止SMS4算法的密钥被恢复.在回顾已有研究的基础上,针对该SMS4算法的白盒实现提出了一种有效的攻击,并详细解释了如何以低于247的时间复杂度找出嵌入其中的轮密钥,说明了该白盒设计方法的不可靠性,并为设计安全的白盒实现提供了一种参考.

关键词：白盒 SMS4 攻击

Ultra-wideband FMCW ISAR imaging with a large rotation angle based on block-sparse recovery

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Frontiers of Information Technology & Electronic Engineering 2017年第12期18卷 2058-2069页

作者： Ke JIN Tao lai Gong-quan LI ting WANG Yong-jun ZHAO Zhengzhou Institute of Information Science and Technology Zhengzhou 450000 China

Ultra-wideband frequency modulated continuous wave （FMCW） radar has the ability to achieve high-range resolution. Combined with the inverse synthetic aperture technique, high azimuth resolution can be realized under a large rotation angle. however, the range-azimuth coupling problem seriously restricts the inverse synthetic aperture radar （ISAR） imaging performance. Based on the turntable model, traditional match-filter-based, range Doppler algorithms （RDAs） and the back projection algorithm （BPA） are investigated. To eliminate the sidelobe effects of traditional algorithms, compressed sensing （CS） is preferred. Considering the block structure of a signal at high resolution, a block-sparsity adaptive matching pursuit algorithm （BSAMP） is proposed. By matching pursuit and backtracking, a signal with unknown sparsity can be recovered accurately by updating the support set iteratively. Finally, several experiments are conducted. In comparison with other algorithms, the results from processing the simulation data, some simple targets, and a complex target indicate the effectiveness and superiority of the proposed algorithm.

关键词： Frequency modulated continuous wave (FMCW) Inverse synthetic aperture radar (ISAR) Match-filter-basedalgorithm Compressed sensing Block sparsity

The Planning and Scheduling of Business Process in Agile Supply Chain System

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厦门大学学报（自然科学版） 2002年第S1期41卷 285-286页

作者： lai Guo-ming, CHAI Yue-ting, LIU Yi (Department of Automation, Tsinghua University, Beijing 100084, China)

The rapidly developing global competition is leadin g to the worldwide enterprise alliance, with which the geographical dispersion of production, assembly and distribution operations comes into being. Supply chain system is such a kind of enterprise alliance, managing the material and informat ion flows both in and between enterprises, such as vendors, manufacturing and assembly plants and distribution centers. In the present research work, we can see that supply chain system can quickly respond to customer needs and adapt to the dynamic change of the market so as to improve the competence of enterprises in the chain. Thus, in supply chain system, it’s most important to enhance the speed with which the products are produced and distributed to the customers who order them and reduce the operating costs at the same time. however, because of the special characteristics, such as dynamic and distributed , etc., often in Agile Supply Chain System (ASCS), there are many dynamic tasks, and many urgent changes of the processes, which make the planning work and mana gement become very difficult and complex. Thus, in Agile Supply Chain System, we first need an efficient planning work, which can program the processes properly to get a primary scheme. And then the local scheduling work based on the primar y scheme will play a important role to deal with the dynamic and distributed pro blems in the business process in ASCS. So, this paper will be organized as below . At the first of this paper, we will discuss the situation in which Agile Suppl y Chain System is applied, and then we will elaborate the characteristics of Agi le Supply Chain System. With that, the shortcomings of the process managements t hat are, at present, used in Supply Chain Systems will be displayed clearly. Sec ond, we will introduce the planning methods in our research work. And then, the local scheduling will be discussed in detail, based on the primarily planned wor kflow. To realize the goal, first we bu

关键词： ASCS urgent order planning local scheduling

Flexible Workflow Management in Agile Supply Chain System

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厦门大学学报（自然科学版） 2002年第S1期41卷 238-239页

作者： lai Guo-ming, CHAI Yue-ting, LIU Yi (Department of Automation, Tsinghua University, Beijing 100084, China)

With the vehement development of global competition , Agile Supply Chain (ASC) becomes an effective approach that supports dynamic ent erprise alliance and realizes agile manufacturing, as for the enterprises to cap ture market opportunities rapidly and strengthen their anti-risk ability. As Ag ile Supply Chain System (ASCS) is dynamic and distributed, the realization of it ’s processes needs to be much flexible. Often in Agile Supply Chain System (ASCS ), there are many dynamic tasks, many changes of the processes, and cooperative workflows, which need the workflows able to be adjusted agilely and smoothly, no t much affecting others. This paper will propose a flexible workflow management for achieving the agility and compatibility. At the first of the paper, we will discuss the situation in which Agile Supply C hain System is applied, and then we will elaborate the characteristics of Agile Supply Chain System. So with that, the shortcomings of the process managements t hat are, at present, used in Supply Chain Systems will be displayed clearly. The n, the proposal will be given in the paper, to resolve the problems in the prese nt process management in ASCS. We will see supply chain systems implemented mult i-agent-based technology to adapt to the dynamic environment, however in many systems, coordination of the workflows is executed by the explicit messages comm unicated between the agents. This will lead to a tightly coupled system. To over come it, the paper suggests the workflow management in agent-based ASCS using t he Events-Triggering mechanism, instead of the explicit messages. We create Eve nts-Triggering contents and rules, having push-pull mechanism, event-state se t and triggering-conditions, and store them in the distributed database subject ed to the corresponding agents. Adjusting the Events-Triggering data will be us ed to adapt to the dynamic tasks and the changes of processes. In sum, we will p resent the methods of process modeling, the system s

关键词： Agile Supply Chain ASCS flexible workflow manag ement Events-Triggering exception-handling

Insight in obsessive-compulsive disorder:conception,clinical characteristics,neuroimaging,and treatment

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Psychoradiology 2023年第1期3卷 107-117页

作者： Yueqi Huang Yazhu Weng Lan Lan Cheng Zhu ting Shen Wenxin Tang Hsin-Yi lai Department of Psychiatry Affiliated Mental Health Center and Hangzhou Seventh People’s HospitalZhejiang University School of MedicineHangzhou 310007China Fourth Clinical School of Zhejiang Chinese Medical University Hangzhou 310053China Department of Psychology and Behavior Science Zhejiang UniversityHangzhou 310058China Frontotemporal Degener ation Center Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphia 19104PAUSA Department of Neurology of the Second Affiliated hospital Interdisciplinary Institute of Neuroscience and TechnologyKey Laboratory of Medical Neurobiology of Zhejiang Pro vinceZhejiang University School of MedicineHangzhou 310029China MOE Frontier Science Center for Brain Science and Brain-Machine Integration State Key Laboratory of Brain-machine IntelligenceSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou 311121China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310027China

Obsessive-compulsive disorder(OCD)is a chronic disabling disease with often unsatisfactory therapeutic *** fifth edition of the Diagnostic and Statistical Manual of Mental Disorders(DSM-5)has broadened the diagnostic criteria for OCD,acknowledging that some OCD patients may lack insight into their *** studies have demonstrated that insight can impact therapeutic efficacy and prognosis,underscoring its importance in the treatment of mental disorders,including *** recent years,there has been a growing interest in understanding the influence of insight on mental disorders,leading to advancements in related ***,to the best of our knowledge,there is dearth of comprehensive reviews on the topic of insight in *** this review article,we aim to fill this gap by providing a concise overview of the concept of insight and its multifaceted role in clinical characteristics,neuroimaging mechanisms,and treatment for OCD.

关键词： obsessive-compulsive disorder insight mental health neuroimaging