Effect of liver cirrhosis on long-term outcomes after acute respiratory failure: A population-based study

作     者：Chih-Cheng Lai Chung-Han Ho Kuo-Chen Cheng Chien-Ming Chao Chin-Ming Chen Willy Chou 

作者机构：Department of Intensive Care MedicineChi Mei Medical Center Departments of Medical ResearchChi Mei Medical Center Internal MedicineChi Mei Medical Center Department of SafetyHealth and EnvironmentChung Hwa University of Medical Technology Department of Recreation and Health-Care ManagementChia Nan University of Pharmacy and Science 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第12期

页      面：2201-2208页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Liver cirrhosis Mechanical ventilation Outcome 

摘      要：AIM To assessed the effect of liver cirrhosis(LC) on the poorly understood long-term mortality risk after firstever mechanical ventilation(1-MV) for acute respiratory *** All patients in Taiwan given a 1-MV between 1997 and 2013 were identified in Taiwan s Longitudinal Health Insurance Database 2000. Each patient with LC was individually matched, using a propensity-score method, to two patients without LC. The primary outcome was death after a *** A total of 16653 patients were enrolled: 5551 LC-positive (LC^([Pos])) patients, including 1732 with cryptogenic LCs and 11102 LC-negative(LC^([Pos])) controls. LC^([Pos]) patients had more organ failures and were more likely to be admitted to medical department than were LC^([Pos]) controls. LC^([Pos]) patients had a significantly lower survival rate(AHR = 1.38, 95%CI: 1.32-1.44). Moreover, the mortality risk was significantly higher for patients with non-cryptogenic LC than for patients with cryptogenic LC(AHR = 1.43, 95%CI: 1.32-1.54) and patients without LC(AHR = 1.56, 95%CI: 1.32-1.54). However, there was no significant difference between patients with cryptogenic and without LC(HR = 1.05, 95%CI: 0.98-1.12).CONCLUSION LC, especially non-cryptogenic LC, significantly increases the risk of death after a 1-MV.