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“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： lai shanshan~1,shen ning~2,li chaojun~2,xue bin~2 1.the medical school of nanjing university,nanjing 210093, 2.china jiangsu key laboratory for molecular and medical biotechnology,nanjing normal university,nanjing 210097,china

Background & Aims:liver regeneration comprises a series of complicated processes,in which several transcription factors play an important ***-1 is rapidly induced as part of the immediate-early gene response of the regenerating *** studies indicate that EGR-1-/- exhibits delayed hepatocellular mitotic progression after partial hepatectomy and increased liver injury after carbon tetrachloride(CC14) *** the mechanism of Egr-1 in regulates regeneration progress is still *** aim is to reveal an important signal pathway mediated by Egr-1 in this ***:70%partial hepatectomy(PH) were performed using mice tail vein injection of adenoviral vectors expressing GFP (Ad-GFP),Egr-l(Ad-Egr-l) or Dominant negative Egr-l(Ad-DNEgr-l) to increase or down-regulate hepatic Egr-1 levels,and mice lack of ggpps in hepatocyte(GGPPS-/-).Animals were sacrificed at intervals after the surgery,and the remnant liver was harvested and *** in vitro study,serum starvation recovery model was used to mimic liver regeneration process in normal human *** signal pathway was detected by western ***:Loss of Egr-1 function in mice liver caused a delayed liver regeneration process reflected by regeneration ratio and expression of cell-cycle related proteins, increased ALT and AST level and ***-expressed Egr-1 can promoted GGPPS transcription increased Ras prenylation and finally caused Erk1/2 activation in ***-1/GGPPS/ ERK pathway contributes to the expression of cyclins in serum or partial hepatectomy induced cell cycle of hepatocytes. GGPPS-/- mice also shows decreased PCNA,CyclinD and CyclinE ***:Egr-1 plays an important role in regulating the cell cycle of hepatocytes induced by partial ***-1 contributes to the expression of cyclins through activating ggpps transcription,which leads to the activation of Ras/Raf/MAPK ***-1 gives positive feedback to MAPK pathway,whi

关键词： early growth response 1 liver regeneration GGPPS

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Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice

Egr-1 decreases adipocyte insulin sensitivity by tilting PI3...

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“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Xiao Yu~(3#),ning shen~(1#),Ming-liang Zhang~(4#),Fei-Yan Pan~1,Chen Wang~4,Wei-Ping Jia~4,Chang liu~3,Qian Gao~1, Xiang Gao~1,bin xue~1,Chao-Jun li~(1,2) 1.MOE key laboratory of Model Animals for Disease Study,Model Animal Research Center and the medical school of nanjing university,National Resource Center for Mutant Mice.nanjing 210061,china 2.Zhcjiang Provincial key Lab for Technology & Application of Model Organisms,school of life Sciences,Wenzhou medical College, university Park,Wenzhou 325035,china. 3.The jiangsu key laboratory for molecular and medical biotechnology,College of life Sciences,nanjing normal university,nanjing 210046,china 4.Department of Endocrinology and Metabolism,Shanghai Diabetes Institute Shanghai Clinical Center of Diabetes Shanghai key laboratory of Diabetes Mellitus,Shanghai Jiao Tong university Affiliated Sixth People’s Hospital,Shanghai 200233,china

It is well-known that insulin can activate both PDK/Akt pathway,which is responsible for glucose uptake,and MAPK pathway,which is crucial for insulin resistance *** it is unclear exactly how the two pathways coordinate to regulate insulin sensitivity upon hyperinsulinism stress of type 2 diabetes mellitus(T2DM).Here we show that an early response transcription factor Egr-1 could tilt the signaling balance by blocking PI3K/Akt signaling through PTEN and augmenting Erk/MAPK signaling through GGPPS,resulting in insulin resistance in ***-1,PTEN and GGPPS are upregulated in the fat tissue of T2DM patients and db/db ***-1 overexpression in epididymal fat induced systematic insulin resistance in wild-type mice,and loss of Egr-1 function improved whole-body insulin sensitivity in diabetic mice,which is mediated by Egr-1 controlled PDK/Akt and Erk/MAPK signaling balance. Therefore,we have revealed,for the first time,the mechanism by which Egr-1 induces insulin resistance under hyperinsulinism stress,which provides an ideal pharmacological target since inhibiting Egr-1 can simultaneously block MAPK and augment PDK/Akt activation during insulin stimulation.

关键词： Egr-1 GGPPS insulin rsistance

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HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to light-to-Dark Conversion and Nitrogen Starvation

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molecular Plant 2020年第3期13卷 515-531页

作者： Chao Yang Wenjin shen lianming Yang Yun Sun Xibao li Minyi lai Juan Wei chaojun Wang Yingchao Xu Faqiang li Shan liang Chengwei Yang Shangwei Zhong Ming Luo Caiji Gao Guangdong Provincial key laboratory of biotechnology for Plant Development School of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial key laboratory of Applied Botany Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic ImprovementSouth China Botanical GardenCore Botanical GardensChinese Academy of SciencesGuangzhou 510650China College of life Sciences Leshan Normal UniversityLeshan 614004China College of life Sciences South China Agricultural UniversityGuangzhou 510642China school of Advanced Agricultural Sciences and school of life Sciences Peking University100871 BeijingChina Center of Economic Botany Core Botanical GardensChinese Academy of SciencesGuangzhou 510650China These authors contributed equally to this article

light is arguably one of the most important environmental factors that determines virtually all aspects of plant growth and development,but the molecular link between light signaling and the autophagy pathway has not been elucidated in *** this study,we demonstrate that autophagy is activated during light-to-dark conversion though transcriptional upregulation of autophagy-related genes(ATGs).We showed that depletion of the ELONGATED HYPOCOTYL 5(HY5),a key component of light signaling,leads to enhanced autophagy activity and resistance to extended darkness and nitrogen starvation treatments,contributing to higher expression ***5 interacts with and recruits HISTONE DEACETYLASE 9(HDA9)to ATG5 and ATG8e loci to repress their expression by deacetylation of the Lys9 and Lys27 of histone ***,we found that both darkness and nitrogen depletion induce the degradation of HY5 via 26S proteasome and the concomitant disassociation of HDA9 from ATG5 and ATG8e loci,leading to their depression and thereby activated *** analysis further confirmed that HY5 and HDA9 act synergistically and function upstream of the autophagy ***,our study unveils a previously unknown transcriptional and epigenetic network that regulates autophagy in response to light-to-dark conversion and nitrogen starvation in plants.

关键词： autophagy histone acetylation HY5 HDA9 light-to-dark shift nitrogen starvation

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Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong shen Yanpeng Gao Chao Qin Hao li Tong Zhang Natàlia Corcoll Min liu Daniel SAlessi Hui li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo lizhong Zhu Xiangdong li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State key laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China university of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical university of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany school of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education key laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong key laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education key laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA school of Environment Tsinghua UniversityBeijing 100084China school of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA key laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China school of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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MDSCs: friend or foe in systemic lupus erythematosus

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Cellular & molecular Immunology 2019年第12期16卷 937-939页

作者： Jianjian Ji Pengfei li Cunsi shen Huan Dou Tingting Wang liyun Shi Yayi Hou jiangsu key laboratory of Pediatric Respiratory Disease Institute of PediatricsAffiliated Hospital of Nanjing University of Chinese Medicine210023 NanjingChina The State key laboratory of Pharmaceutical biotechnology Division of Immunology and Hospital of StomatologyMedical SchoolNanjing UniversityNanjingChina key laboratory of Inflammation and Immunoregulation School of Medical and Life ScienceNanjing University of Chinese Medicine210046 NanjingChina Department of Clinical laboratory Jiangsu Province Hospital of Traditional Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029 JiangsuChina

Meyoid derived suppressor cells(MDSCs)are heterogeneous myeloid cell populations that expand in pathological conditions such as cancer,autoimmunity,and infection;these cells are also known to exert strong immunosuppressive effects on primitive Tcell responses.1 MDSCs are derived from myeloid progenitors and are arrested at an immature phase of *** mice,normal bone marrow contains~20–30%cells exhibiting the MDSC phenotype.2 In contrast,a very low number of MDSCs are found in naive spleens(2–4%),and these cells are completely absent in lymph nodes.

关键词： MDSCs spleen myeloid

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Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma

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Genes & Diseases 2023年第1期10卷 69-71页

作者： Tingming liang lin Jia Rui Duan Lulu shen Dekang Ren Yujie Ren Yuyang Dou li Guo jiangsu key laboratory for molecular and medical biotechnology School of Life ScienceNanjing Normal UniversityNanjingJiangsu210023China Department of Bioinformatics Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu ProvinceSchool of Geographic and Biologic InformationNanjing University of Posts and TelecommunicationsNanjingJiangsu 210023China

Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective nonsurgical treatment and early clinical diagnosis markers,patients have high mortality and low overall survival rates in cholangiocarcinoma(CCA).

关键词： diagnosis mortality alone

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血管紧张素Ⅱ对乳腺癌细胞迁移的影响

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南京师大学报（自然科学版） 2018年第1期41卷 83-87页

作者：曹令森沈玮曹祥荣南京师范大学生命科学学院江苏省分子医学生物技术重点实验室江苏南京210023

乳腺癌是女性发病率高且恶性程度高的肿瘤,肿瘤侵袭转移是导致患者死亡的重要原因,研究与癌细胞转移相关的因子或指标具有重要意义.本实验采用血管紧张素Ⅱ(AngⅡ)处理乳腺癌细胞MDA-MB-231,可促进肿瘤细胞迁移,增强到1.51倍.Q-PCR检测... 详细信息

乳腺癌是女性发病率高且恶性程度高的肿瘤,肿瘤侵袭转移是导致患者死亡的重要原因,研究与癌细胞转移相关的因子或指标具有重要意义.本实验采用血管紧张素Ⅱ(AngⅡ)处理乳腺癌细胞MDA-MB-231,可促进肿瘤细胞迁移,增强到1.51倍.Q-PCR检测结果表明,AngⅡ能够明显刺激MDA-MB-231细胞中u PA(2.97倍)和u PAR的表达.因此,AngⅡ刺激乳腺癌细胞u PA和u PAR的表达,可能是AngⅡ促进乳腺癌细胞迁移的原因之一.

关键词：血管紧张素Ⅱ uPA 乳腺癌细胞

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