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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao Zhang Shang-Xi lai Hua-Ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

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Enhancing Deepfake Detection:Proactive Forensics Techniques Using Digital Watermarking

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Computers, Materials & Continua 2025年第1期82卷 73-102页

作者： Zhimao lai Saad Arif Cong Feng Guangjun Liao Chuntao Wang School of Automation Guangdong University and TechnologyGuangzhou510006China School of Immigration Administration(Guangzhou) China People’s Police UniversityGuangzhou510663China Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa31982Saudi Arabia Cyber Police Division Guangzhou Public Security BureauGuangzhou510030China School of Forensic Science and Technology Guangdong Police CollegeGuangzhou510320China College of Mathematics and Informatics South China Agricultural UniversityGuangzhou510642China

With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly *** paper examines the advancements inDeepfake detection and defense technologies,emphasizing the shift from passive detection methods to proactive digital watermarking *** detection methods,which involve extracting features from images or videos to identify forgeries,encounter challenges such as poor performance against unknown manipulation techniques and susceptibility to counter-forensic *** contrast,proactive digital watermarking techniques embed specificmarkers into images or videos,facilitating real-time detection and traceability,thereby providing a preemptive defense againstDeepfake *** offer a comprehensive analysis of digitalwatermarking-based forensic techniques,discussing their advantages over passivemethods and highlighting four key benefits:real-time detection,embedded defense,resistance to tampering,and provision of legal ***,the paper identifies gaps in the literature concerning proactive forensic techniques and suggests future research directions,including cross-domain watermarking and adaptive watermarking *** systematically classifying and comparing existing techniques,this review aims to contribute valuable insights for the development of more effective proactive defense strategies in Deepfake forensics.

关键词： Deepfake proactive forensics digital watermarking traceability detection techniques

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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疫情防控常态化期间温州一线医务人员心理健康状况及影响因素

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温州医科大学学报 2023年第2期53卷 166-172,F0003页

作者：宋羽雅赖炘懿林洁温州医科大学组织部浙江温州325035 温州医科大学精神医学学院浙江温州325035 温州医科大学公共卫生与管理学院浙江温州325035

目的:了解疫情防控常态化期间一线医务人员心理健康状况及其影响因素,为及时有效地开展相关心理健康预防与干预提供依据。方法:于2022年3至4月采用方便取样方法,通过问卷星对581名温州市一线抗疫医务人员在线施测一般资料问卷、工作压... 详细信息

目的:了解疫情防控常态化期间一线医务人员心理健康状况及其影响因素,为及时有效地开展相关心理健康预防与干预提供依据。方法:于2022年3至4月采用方便取样方法,通过问卷星对581名温州市一线抗疫医务人员在线施测一般资料问卷、工作压力量表、社会支持量表、工作-家庭冲突问卷、抑郁-焦虑-压力量表简版(DASS-21)以及失眠严重程度指数量表(ISI),共回收558份有效问卷。通过一般资料问卷、DASS-21量表以及ISI量表评估一线医务人员心理健康现状,并就人口学变量作差异比较;同时,利用逐步线性回归分析探索其心理健康的潜在影响因素。结果:所有受试的一线医务人员中,280人(50.18%)存在焦虑症状,272人(48.75%)存在抑郁症状,356人(63.80%)存在失眠问题。女性一线医务人员的焦虑得分显著高于男性(P3~5年(β=2.77,P5~10年(β=2.16,P<0.05)分别是抑郁和失眠的风险性因素;护士(β=-2.34,P<0.01;β=-1.39,P<0.05)是焦虑和失眠的高风险人群。结论:在疫情常态化时期需要高度关注一线医务人员的心理健康状况,建议政府带头联动多方,通过降低一线医务职业压力,充分发挥社会支持的正向作用,开设个性化心理援助等心理服务以完善一线医务人员的心理预防与干预体系。

关键词：疫情防控常态化一线医务人员工作压力社会支持心理健康

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乡村振兴:延伸民俗节庆品牌价值链的研究——基于广东肇庆河台镇“开耕节”的考察

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科教导刊 2018年第14期 152-154页

作者：赖新旖赖利明陈丽晖广州大学新闻与传播学院广东广州510006 肇庆学院厚德书院广东肇庆526061

习近平总书记在十九大报告中提出实施"乡村振兴战略",为新时代新农村的发展指明了方向。乡村振兴需要寻找和培育具有现实优势和潜在优势的行业作为突破口,重点打造,延伸价值链,培育第三产业,融合一二产业,走一二三产业融合发展之路。研... 详细信息

习近平总书记在十九大报告中提出实施"乡村振兴战略",为新时代新农村的发展指明了方向。乡村振兴需要寻找和培育具有现实优势和潜在优势的行业作为突破口,重点打造,延伸价值链,培育第三产业,融合一二产业,走一二三产业融合发展之路。研究选取广东肇庆河台镇"开耕节"作为考察对象,分析河台镇作为一个山区镇,"开耕节"节庆品牌已经打响,但要把品牌优势转化为产业优势的现状和存在问题,并结合该镇第三产业培育和走一二三产业融合发展之路提出乡村振兴对策。

关键词：乡村振兴节庆品牌开耕节价值链第三产业

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Design and characterization study of dual D-shaped no-core fiber based SPR sensor for refractive index and temperature measurement

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Optoelectronics Letters 2025年

作者： Liu Yinggang Li Rui Li Fei Xu xinyi Zhou Rui Shaanxi Engineering Research Center of Oil and Gas Resource Optical Fiber Detection & Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas wells， Xi'an Shiyou University

To address the issue of temperature cross-sensitivity in refractive index （RI） measurement， a fiber-optic Surface Plasmon Resonance （SPR） sensor based on dual D-shaped no-core fiber （NCF） is proposed and designed. The sensor mainly consists of D-shaped NCF， Ag/Fe2O3composite film， and polydimethylsiloxane （PDMS）， where the silver and Fe2O3are successively coated on both D-shaped surfaces of NCF to generate SPR and enhance the oxidation resistance. The layer of PDMS coated on one D-shaped surface acts as a tunable ambient medium sensing the temperature variation and affecting the transmission spectrum of the sensor. Since the surface plasmon waves are excited in the two D-shaped surfaces with different films， the two RI and temperature-dependent spectral resonance peaks with different wavelengths will be produced. Research results demonstrate that the two peaks’ wavelengths have different responses to the variations of ambient RI and temperature. In the refractive index range of 1.36-1.376 and temperature range of 10-100 °C， the RI and temperature sensitivities reach to 5000 nm/RIU and -0.546 nm/°C， respectively. With the sensitivity coefficient matrix， simultaneous measurement of refractive index and temperature can be realized， and the corresponding accuracy is superior to 0.4×10-5RIU and 0.037°C.

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基于液相色谱-串联质谱肽组学技术鉴定地龙制剂中的多肽及含量检测

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分析科学学报 2024年第2期40卷 199-205页

作者：张美铃赖心仪林珠灿李琦胡筱余丽双福建中医药大学药学院福建福州350122

建立了液相色谱-串联质谱(LC-MS/MS)肽组学鉴定多肽地龙蛋白压片糖果中多肽及高效液相色谱(HPLC)检测多肽含量新方法。本文联用LC-MS/MS与De novo分离初步鉴定多肽地龙蛋白压片糖果中多肽成分,采用化学合成法制备多肽,进一步利用HPLC验... 详细信息

建立了液相色谱-串联质谱(LC-MS/MS)肽组学鉴定多肽地龙蛋白压片糖果中多肽及高效液相色谱(HPLC)检测多肽含量新方法。本文联用LC-MS/MS与De novo分离初步鉴定多肽地龙蛋白压片糖果中多肽成分,采用化学合成法制备多肽,进一步利用HPLC验证并测定其多肽含量。总共鉴定出482个多肽序列,对相对强度和评分较高的10条多肽进行化学合成,成功在多肽地龙蛋白压片糖果实际样品中验证到氨基酸序列为LAPVNKPGRF(LF-10)的多肽,实验测得LF-10的含量为0.00182%。LC-MS/MS与De novo的联用为地龙多肽类成分的鉴定分析提供有力的支持,建立的LF-10多肽HPLC定量分析方法简便易行、准确可靠,有助于多肽地龙蛋白压片糖果的质量控制及地龙多肽的进一步研究。

关键词：高效液相色谱法质谱地龙多肽鉴定

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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基于时间序列神经分层插值模型的光伏功率超短期多步预测

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智慧电力 2024年第4期52卷 69-77页

作者：李楠刘佳佳赖心怡杨志远王泽亮文福拴国网湖北荆门供电公司湖北荆门448000 浙江大学海南研究院海南三亚572025

针对光伏功率预测准确性受数据质量和外部变量影响的问题,提出一种结合外生变量分析、数据质量控制以及时间序列神经分层插值(N-HiTS)模型的光伏功率超短期多步预测方法。首先,提出用于筛选外生变量的综合相关性度量(ICM)指标,并采用K近... 详细信息

针对光伏功率预测准确性受数据质量和外部变量影响的问题,提出一种结合外生变量分析、数据质量控制以及时间序列神经分层插值(N-HiTS)模型的光伏功率超短期多步预测方法。首先,提出用于筛选外生变量的综合相关性度量(ICM)指标,并采用K近邻(KNN)算法与线性插值策略处理数据缺失问题。然后,引入N-HiTS长时间序列预测模型,通过多尺度信号采样和分层插值提高模型对长时间序列数据的处理能力。最后,通过算例对所提方法与传统光伏功率预测方法进行对比分析,验证了所提方法的预测准确性。

关键词：光伏功率预测时间序列神经分层插值模型(N-HiTS) 综合相关性度量(ICM) K近邻(KNN) 线性插值

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