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妊娠期高血压疾病患者左心室收缩功能及升主动脉弹性的研究

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中国超声医学杂志 2024年第5期40卷 541-544页

作者：王琴刘罗娜潘璐马鑫宁夏医科大学总医院心脏中心功能检查部西安交通大学第二附属医院医用超声研究室

目的应用三维斑点追踪技术(3D-STI)评价妊娠期高血压疾病(HDP)患者左心室收缩功能及升主动脉弹性的改变。方法收集36例HDP患者作为病例组，并收集同期常规产检的20例健康妊娠妇女作为对照组，两组均进行常规超声心动图检查及三维斑点... 详细信息

目的应用三维斑点追踪技术(3D-STI)评价妊娠期高血压疾病(HDP)患者左心室收缩功能及升主动脉弹性的改变。方法收集36例HDP患者作为病例组，并收集同期常规产检的20例健康妊娠妇女作为对照组，两组均进行常规超声心动图检查及三维斑点追踪，获取左心室收缩、舒张功能及升主动脉弹性指标，并分析其相关性。结果病例组患者la、IVSD、LVPWD、LVM、A、a均较对照组高，E/A、e/a、e值均减低，且e/a<1,差异均具有统计学意义(P<0.05);与对照组相比，病例组患者GLS、GRS、GCS均减低，SDI增高，差异均有统计学意义(P<0.05);与对照组相比，病例组患者Ep、ASI均明显增高，AS明显减低，差异均具有统计学意义(P<0.05)。SDI与Ep存在显著正相关性(r=1.000,P<0.05)。结论 HDP患者左心室收缩功能降低、不同步指数增高，且不同步指数增高与升主动脉弹性减低相关。

关键词：妊娠期高血压疾病升主动脉弹性三维斑点追踪技术

仿突变生物合成调控对土曲霉C23-3次生代谢产物的影响

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生物技术通报 2024年第8期40卷 275-287页

作者：马小翔马泽源刘亚月周龙建和羿帆张翼广东海洋大学食品科技学院广东省水产品加工与安全重点实验室广东省海洋生物制品工程实验室广东海洋大学深圳研究院湛江市脑健康相关海洋药物与营养品重点实验室湛江524088 南方海洋科学与工程广东省实验室(湛江) 湛江524006 海洋食品精深加工关键技术省部共建协同创新中心大连工业大学大连116034 加州大学圣地亚哥分校斯克里普斯海洋研究所海洋生物技术与生物医药中心美国拉霍亚92093

【目的】丁内酯I是土曲霉(Aspergillus terreus)产生的一种具有多样生物活性的小分子天然产物,对其结构多样性拓展的探索具有重要意义。以一株高产丁内酯I的海洋来源土曲霉C23-3作为基础菌株,研究丁内酯前体小分子类似物和前体合成酶抑... 详细信息

【目的】丁内酯I是土曲霉(Aspergillus terreus)产生的一种具有多样生物活性的小分子天然产物,对其结构多样性拓展的探索具有重要意义。以一株高产丁内酯I的海洋来源土曲霉C23-3作为基础菌株,研究丁内酯前体小分子类似物和前体合成酶抑制剂对其次生代谢的影响。【方法】以海水马铃薯液体培养基为基础培养基,以3种前体小分子类似物和3种对羟基苯丙酮酸的合成酶抑制剂作为化学诱导剂,在静置发酵条件下进行菌株的化学调控培养。采用高效液相色谱、高效液相色谱-离子阱质谱联用及基于质谱的分子网络和数据库挖掘分析次生代谢产物的产量和多样性。【结果】多数前体小分子类似物和合成酶抑制剂对丁内酯I产量均有不同程度抑制,而高浓度的前体小分子类似物3,4-二羟基苯丙酮酸、两种合成酶抑制剂联用及这三者的联用表现出了较强的抑制效果;并且在丁内酯I的合成受到强烈抑制条件下,丁内酯类、土震素类、洛伐他汀类等多类次生代谢产物的合成也下降,但一种环肽类化合物产量超过10倍的大幅提升,可能是菌体对作为群体感应信号及全局性转录因子lae A诱导子的丁内酯I合成受到压制胁迫的一种应激反应,具体机制有待深入研究。【结论】丁内酯I的前体确为对羟基苯丙酮酸,3,4-二羟基苯丙酮酸及对羟基苯丙酮酸合成酶抑制剂可用作抑制丁内酯I合成的小分子工具,以用于仿突变生物合成的进一步探索以获得多样化丁内酯衍生物,也可诱导产生环肽类化合物。

关键词：海洋真菌化学调控仿突变生物合成丁内酯前体类似物合成酶抑制剂 LC-MS/MS 分子网络

Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer

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Nano-Micro Letters 2020年第10期12卷 36-52页

作者： Yanlei Liu Jingxing Yang Bin Liu Wen Cao Jingpu Zhang Yuming Yang Lijun ma Jesus martinez de la Fuente Jie Song Jian Ni Chunfu Zhang Daxiang Cui Institute of Nano Biomedicine and Engineering Key Laboratory for Thin Film and Microfabrication of Ministration of EducationShanghai Engineering Research Centre for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240People’s Republic of China National Engineering Center for Nanotechnology Shanghai 200240People’s Republic of China Department of Nuclear Medicine Rui Jin HospitalSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508People’s Republic of China Tongren Hospital Shanghai Jiao Tong University School of Medicine1111 XianXia RoadShanghai 200336People’s Republic of China

How to trigger strong anti-tumor immune responses has become a focus for tumor ***,we report the human-induced pluripotent stem cells(iPSs)to deliver MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy(PDT)and enhanced ***6 photosensitizer was attached on manganese dioxide(MnO2)nanoparticles,and resultant MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 *** iPS-MnO2@Ce6 actively targeted in vivo tumors,the acidic microenvironment triggered interaction between MnO2 and H2O2,released large quantities of oxygen,alleviated hypoxia in *** PDT,singlet oxygen formed,broken iPSs released tumor-shared antigens,which evoked an intensive innate and adaptive immune response against the tumor,improving dendritic cells matured,effector T cells,and natural killer cells were ***,regulatory T cells were reduced,and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by MnO2@Ce6(Pmarkedly inhibited tumor growth and metastasis and reduced mortality in mice models with *** iPS s loaded with MnO2-based nanoprobes are a promising strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect.

关键词： Human iPS MnO2@Ce6 nanoprobes Photodynamic therapy Immunotherapy Cancer

八面体形貌及la、Ti共掺杂对锰酸锂的改性研究

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电源技术 2024年第7期48卷 1212-1218页

作者：马皓皓陈进中叶有明桂林理工大学材料科学与工程学院广西桂林541004 桂林理工大学有色金属及材料加工新技术教育部重点实验室广西桂林541004 桂林理工大学有色金属矿产勘查与资源高效利用省部共建协同创新中心广西桂林541004 广西科技师范学院食品与生化工程学院广西来宾546199

以高纯四氧化三锰、碳酸锂等为原料,经过高速球磨混合后,采用高温固相法制备Lila_(0.01)Ti_(0.01)Mn1.98O_(4)正极材料,基于四氧化三锰的八面体形貌及la、Ti共掺杂对锰酸锂的性能进行优化。通过透射电子显微镜(TEM)、X射线衍射(XRD)、... 详细信息

以高纯四氧化三锰、碳酸锂等为原料,经过高速球磨混合后,采用高温固相法制备Lila_(0.01)Ti_(0.01)Mn1.98O_(4)正极材料,基于四氧化三锰的八面体形貌及la、Ti共掺杂对锰酸锂的性能进行优化。通过透射电子显微镜(TEM)、X射线衍射(XRD)、扫描电子显微镜(SEM)等表征手段对材料的物相和形貌进行分析,通过X射线光电子能谱仪对Mn的化合价进行分析,通过循环伏安(CV)、恒电流充放电等测试分析材料的电化学性能。结果表明:在1C条件下Lila_(0.01)Ti_(0.01)Mn1.98O_(4)正极材料首次放电比容量为114.06 mah/g,循环100次后容量保持率为97.79%,基于八面体形貌,并结合la、Ti共掺杂对锰酸锂协同改性后材料循环性能得到有效改善。

关键词：锂离子电池正极材料尖晶石型LiMn_(2)O_(4) 镧钛共掺杂八面体形貌

镧、锆改性氢氧化铝在硫酸锌电解液中的除氟性能

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中南大学学报（自然科学版） 2024年第3期55卷 895-906页

作者：张自恒梁李斯弥晗马洪月李林波西安建筑科技大学冶金工程学院陕西西安710055

针对目前工业吸附剂除氟效果差、吸附容量低等问题,通过共沉淀法制备出了一种介孔Al-la-Zr复合吸附材料有效地去除硫酸锌溶液中的氟离子。首先,探究了掺杂金属的种类及比例对除氟率的影响,获得了制备最佳掺杂比例;其次,采用BET、XRD、SE... 详细信息

针对目前工业吸附剂除氟效果差、吸附容量低等问题,通过共沉淀法制备出了一种介孔Al-la-Zr复合吸附材料有效地去除硫酸锌溶液中的氟离子。首先,探究了掺杂金属的种类及比例对除氟率的影响,获得了制备最佳掺杂比例;其次,采用BET、XRD、SEM等手段对吸附剂进行了表征,了解吸附剂的主要物相、比表面积和形貌;再次,研究了吸附剂用量、吸附温度、接触时间和p H对吸附效率及吸附容量的影响,明确了工艺优化条件;最后,对吸附过程进行动力学和热力学分析,并结合吸附前后吸附剂的表征结果进一步揭示介孔Al-la-Zr复合吸附剂的吸附机理。研究结果表明:材料的主要物相为Al(OH)_(3),材料表面具有丰富的孔径结构,这有利于提升材料的比表面积(127.16 m^(2)/g),增加吸附容量;当吸附温度为30℃,p H为4.7,吸附时间为3 h,吸附剂用量为5 g/L时,吸附平衡脱氟效率为78.32%,平衡容量为15.66 mg/g;吸附过程符合拟二阶动力学模型,线性Freundlich可以很好描述吸附等温线,吸附过程为自发放热过程。吸附机理涉及离子交换、静电吸附以及金属对氟的络合作用。

关键词：氟化物吸附作用硫酸锌溶液复合吸附剂

Correlation of DNA methylation patterns to the phenotypic features of Tibetan elite alpinists in extreme hypoxia

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Journal of Genetics and Genomics 2021年第10期48卷 928-935页

作者： Zhuoma Basang Shixuan Zhang la Yang Deji Quzong Yi Li Yanyun ma Meng Hao WeiLin Pu Xiaoyu Liu Hongjun Xie Meng Liang Jiucun Wang Qiangba Danzeng High Altitude Medical Research Center of Tibet University/Center of Tibetan Studies(Everest Research Institute) Tibet University10 East Zangda RoadLhasaTibet 850000China State Key laboratory of Genetic Engineering School of Life Sciences&Human Phenome InstituteFudan UniversityShanghai 200438China Institute for Six-sector Economy Fudan UniversityShanghai 200433China Ministry of Education Key laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200438China Tibet University-Fudan University Joint laboratory for Biodiversity and Global Change Tibet University10 East Zangda RoadLhasaTibet 850000China

High altitude is an extreme environment that imposes hypoxic pressure on physiological processes,and natives living at high altitudes are more adaptive in certain physiological *** far,epigenetic modifications under extreme changes in hypoxic pressures are relatively less ***,we recruit 32 Tibetan elite alpinists(TEAs),who have successfully mounted Everest(8848 m)at least five *** samples and physiological phenotypes of TEAs and 32 matched non-alpinist Tibetan volunteers(non-TEAs)are collected for ***-wide DNA methylation analysis identifies 23,202 differentially methylated CpGs(P_(adj)0.1)between the two *** differentially methylated CpGs are in hypoxia-related genes such as PPP1R13L,maP3K7CL,SEPTI-9,and *** addition,Gene ontology enrichment analysis reveals several infla.ma.ion-related *** analysis indicates that 12 phenotypes are significantly different between the two *** particular,TEAs exhibit higher blood oxygen saturation levels and lower neutrophil count,platelet count,and heart *** DNA methylation association analysis,we find that two CpGs(cg16687447,cg06947206)upstream of PTEN were associated with platelet *** conclusion,extreme hypoxia exposure leads to epigenetic modifications and phenotypic alterations of TEA,providing us clues for exploring the molecular mechanism underlying changes under extreme hypoxia conditions.

关键词： Adaptive potentials Extreme hypoxia environment DNA methylation Phenotype association Elite alpinists Mountaineering

Encapsulating a Ni（Ⅱ） molecular catalyst in photoactive metal–organic framework for highly efficient photoreduction of CO2

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Science Bulletin 2019年第14期64卷 976-985页

作者： Zhi-Hao Yan Bo ma Shu-Rong Li Junxue Liu Rong Chen Ming-Hao Du Shengye Jin Gui-Lin Zhuang la-Sheng Long Xiang-Jian Kong lan-Sun Zheng Collaborative Innovation Center of Chemistry for Energy materials State Key Laboratory of Physical Chemistry of Solid Surface and Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China State Key laboratory of Molecular Reaction Dynamics and Collaborative Innovation Center of Chemistry for Energy materials Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China College of Chemical Engineering Zhejiang University of Technology Hangzhou 310032 China

Photocatalytic reduction of CO2 to CO is a promising strategy for reducing atmospheric CO2 levels and storing solar radiation as chemical ***,we demonstrate that a molecular catalyst[NiⅡ(bpet)(H2O)2]successfully encapsulated into a highly robust and visible-light responsive metal–organic framework(Ru-UiO-67)to fabricate composite catalysts for photocatalytic CO2 *** composite Ni@Ru-UiO-67 photocatalysts show efficient visible-light-driven CO2 reduction to CO with a TON of 581 and a selectivity of 99% after 20-h illumination,because of the facile electron transfer from Ru-photosensitizer to Ni(Ⅱ)active sites in Ni@Ru-UiO-67 *** mechanistic insights into photoreduction of CO2 have been studied based on thermodynamical,electrochemical,and spectroscopic investigation,together with density functional theory(DFT)*** work shows that encapsulating molecular catalyst into photoactive MOF highlights opportunities for designing efficient,stable and recyclable photocatalysts.

关键词： Metal-organic frameworks CO2 reduction Transient absorption Photocatalysis DFT calculations

Echocardiographic Measurements in Normal Chinese Adults(EMINCA)II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography

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Frontiers of Medicine 2024年第4期18卷 649-663页

作者： Yingbin Wang Yu Zhang Guihua Yao Hong Tang Lixin Chen Lixue Yin Tiangang Zhu Jianjun Yuan Wei Han Jun Yang Xianhong Shu Ya Yang Yulin Wei Yanli Guo Weidong Ren Dongmei Gao Guilin Lu Ji Wu Hongning Yin Yuming Mu Jiawei Tian Lijun Yuan Xiaojing ma Hongyan Dai Yunchuan Ding Mingyan Ding Qing Zhou Hao Wang Di Xu Mei Zhang Yun Zhang State Key laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan250012China Department of Cardiology Qilu Hospital of Shandong University(Qingdao)Qingdao266000China Department of Ultrasonography West China HospitalSichuan UniversityChengdu610041China Department of Ultrasonography Shenzhen People’s Hospital/The Second Clinical Medical College of Jinan UniversityShenzhen518020China Department of Ultrasonography Electronic Science and Technology University of ChinaThe Affiliated Sichuan Provincial People’s HospitalChengdu610072China Department of Cardiology Peking University People’s HospitalBeijing100044China Department of Ultrasonography Henan Provincial People’s HospitalZhengzhou463599China Department of Cardiology The First Affiliated Hospital of Harbin Medical UniversityHarbin150007China Department of Echocardiology The First Affiliated Hospital of China Medical UniversityShenyang110001China Department of Echocardiology Zhongshan HospitalFudan UniversityShanghai200032China Department of Echocardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing100029China Department of Cardiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Department of Ultrasonography The Southwest Hospital of AMUChongqing400038China Department of Ultrasonography Shengjing Hospital of China Medical UniversityShenyang110136China Department of Ultrasonography China-Japan Union hospital of Jilin UniversityChangchun130033China Department of Ultrasonography First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi832000China Department of Ultrasonography The First Affiliated Hospital of Guangxi Medical UniversityNanning537406China Department of Echocardiology The Second Hospital of Hebei Medical Uni

Current guidelines encourage large studies in a diverse population to establish normal reference ranges for three-dimensional(3D)echocardiography for different ethnic *** study was designed to establish the normal values of 3D-left ventricular(LV)and left atrial(la)volume and function in a nationwide,population-based cohort of healthy Han Chinese adults.A total of 1117 healthy volunteers aged 18–89 years were enrolled from 28 collaborating laboratories in *** sets of 3D echocardiographic instruments were used,and full-volume echocardiographic images were recorded and transmitted to a core laboratory for image analysis with a vendor-independent off-line ***,866 volunteers(mean age of 48.4 years,402 men)were qualified for final *** parameters exhibited substantial differences between different sex and age groups,even after indexation by body surface *** normal ranges of 3D-LV and 3D-la volume and function differed from those recommended by the American Society of Echocardiography and the European Association of Cardiovascular Imaging guidelines,presented by the World Alliance Societies of Echocardiography(WASE)study,and from the 2D values in the EMINCA *** normal reference values of 3D echocardiography-derived LV and la volume and function were established for the first time in healthy Han Chinese *** ranges of 3D-LV and 3D-la echocardiographic measurements stratified with sex,age,and race should be recommended for clinical applications.

关键词： three-dimensional echocardiography left ventricle left atrium normal reference values Chinese adults

Bi^(3+)、Eu^(3+)共掺杂la_(4)GeO_(8)荧光粉的制备及可调发光

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发光学报 2024年第3期45卷 450-457页

作者：张文娜黎仲寅马纪涛陈娅鹏杨菲郭海南宁理工学院文理学院广西南宁530100 浙江师范大学物理系浙江金华321004

为了开发出高效稳定的单一基质白光发射荧光材料,本工作通过高温固相法成功合成了一系列la_(4)GeO_(8)∶Bi^(3+),Eu^(3+)荧光粉样品,并通过X射线衍射、室温光谱、变温光谱等手段研究了实验样品的结构与发光性能。研究发现,Bi^(3+)离子... 详细信息

为了开发出高效稳定的单一基质白光发射荧光材料,本工作通过高温固相法成功合成了一系列la_(4)GeO_(8)∶Bi^(3+),Eu^(3+)荧光粉样品,并通过X射线衍射、室温光谱、变温光谱等手段研究了实验样品的结构与发光性能。研究发现,Bi^(3+)离子在该结构中占据两种不同的格位(Bi^(3+)(Ⅰ)和Bi^(3+)(Ⅱ)),且在紫外光激发下呈现两个峰值分别在475 nm和620 nm的宽带发射。对于Bi^(3+)、Eu^(3+)共掺样品,由于Bi^(3+)(Ⅰ)与Eu^(3+)之间的竞争吸收、Bi^(3+)(Ⅰ)至Bi^(3+)(Ⅱ)以及Bi^(3+)(Ⅱ)至Eu^(3+)的能量传递作用,可实现蓝色至红色、橙红色至红色的可调发光。特别地,样品la_(4)GeO_(8)∶0.07Bi^(3+),0.06Eu^(3+)在313 nm光激发下可获得CIE值为(0.335,0.319)的优异白色发光。此外,该白光发射材料具有较佳的发光热稳定性,当温度升高至380 K时,发光积分强度仍然为室温的59%,表明其在白光二极管上具有潜在的应用价值。

关键词： la_(4)GeO_(8)∶Bi^(3+),Eu^(3+) 可调发光发光热稳定性白光二极管