Correlation of DNA methylation patterns to the phenotypic features of Tibetan elite alpinists in extreme hypoxia

作     者：Zhuoma Basang Shixuan Zhang La Yang Deji Quzong Yi Li Yanyun Ma Meng Hao WeiLin Pu Xiaoyu Liu Hongjun Xie Meng Liang Jiucun Wang Qiangba Danzeng Zhuoma Basang;Shixuan Zhang;La Yang;Deji Quzong;Yi Li;Yanyun Ma;Meng Hao;WeiLin Pu;Xiaoyu Liu;Hongjun Xie;Meng Liang;Jiucun Wang;Qiangba Danzeng

作者机构：High Altitude Medical Research Center of Tibet University/Center of Tibetan Studies(Everest Research Institute)Tibet University10 East Zangda RoadLhasaTibet 850000China State Key Laboratory of Genetic EngineeringSchool of Life Sciences&Human Phenome InstituteFudan UniversityShanghai 200438China Institute for Six-sector EconomyFudan UniversityShanghai 200433China Ministry of Education Key Laboratory of Contemporary AnthropologyDepartment of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200438China Tibet University-Fudan University Joint Laboratory for Biodiversity and Global ChangeTibet University10 East Zangda RoadLhasaTibet 850000China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2021年第48卷第10期

页      面：928-935页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：The Science and Technology Department of Tibet(08080002) 2019 School-level Cultivation Project of Tibet University(ZDTSJH19-08) the Special Funds from the Central Finance to Support the Development of Local Universities(ZFYJY201902011.Index of Tibetan Finance and EducationNo.54,No.1-19,No.79) This work was also supported by the Postdoctoral Science Foundation of China(2018M640333) Shanghai Municipal Science and Technology Major Project(2017SHZDZX01) Science and Technology Committee of Shanghai Municipality(18490750300) Major Project of Special Development Funds of Zhangjiang National Independent Innovation Demonstration Zone(ZJ2019-ZD-004) 

主　　题：Adaptive potentials Extreme hypoxia environment DNA methylation Phenotype association Elite alpinists Mountaineering 

摘      要：High altitude is an extreme environment that imposes hypoxic pressure on physiological processes,and natives living at high altitudes are more adaptive in certain physiological *** far,epigenetic modifications under extreme changes in hypoxic pressures are relatively less ***,we recruit 32 Tibetan elite alpinists(TEAs),who have successfully mounted Everest(8848 m)at least five *** samples and physiological phenotypes of TEAs and 32 matched non-alpinist Tibetan volunteers(non-TEAs)are collected for ***-wide DNA methylation analysis identifies 23,202 differentially methylated CpGs(P_(adj)0.1)between the two *** differentially methylated CpGs are in hypoxia-related genes such as PPP1R13L,MAP3K7CL,SEPTI-9,and *** addition,Gene ontology enrichment analysis reveals several inflammation-related *** analysis indicates that 12 phenotypes are significantly different between the two *** particular,TEAs exhibit higher blood oxygen saturation levels and lower neutrophil count,platelet count,and heart *** DNA methylation association analysis,we find that two CpGs(cg16687447,cg06947206)upstream of PTEN were associated with platelet *** conclusion,extreme hypoxia exposure leads to epigenetic modifications and phenotypic alterations of TEA,providing us clues for exploring the molecular mechanism underlying changes under extreme hypoxia conditions.