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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi Michael qJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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淫羊藿苷预处理增强人牙周膜干细胞对M1型巨噬细胞的影响

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中国组织工程研究 2025年第7期29卷 1328-1335页

作者：喻婷吕冬梅邓浩孙涛程钎西南医科大学口颌面修复重建和再生泸州市重点实验室四川省泸州市646000 西南医科大学口腔医学研究所四川省泸州市646000 西南医科大学附属口腔医院正畸科四川省泸州市646000 西南医科大学口腔医学院四川省泸州市646000

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养... 详细信息

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养原代人牙周膜干细胞,并进行鉴定。对THP-1细胞进行诱导,采用免疫荧光染色及PCR进行M1型巨噬细胞鉴定。用含浓度10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷的α-MEM完全培养基培养人牙周膜干细胞1,3,5,7 d,采用CCK-8法筛选合适的淫羊藿苷浓度进行实验。将α-MEM完全培养基、未处理的人牙周膜干细胞α-MEM条件培养基及淫羊藿苷预处理24 h的人牙周膜干细胞α-MEM条件培养基与RPMI-1640完全培养基以1∶1的比例对M1型巨噬细胞进行条件培养,分别为对照组、未处理组及预处理组,24 h后RT-PCR法检测M1型巨噬细胞炎症因子的mRNA表达情况;ELISA法检测M1型巨噬细胞炎症因子的蛋白表达情况;Western blot检测M1/M2型巨噬细胞表面标记物及核转录因子κB通路相关蛋白的表达。结果与结论:(1)CCK-8检测结果显示,10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷对人牙周膜干细胞均无细胞毒性,且从第5天起,各浓度都提高了细胞活力,促进细胞增殖,选择10^(-4)mol/L淫羊藿苷进行后续实验。(2)RT-PCR法及ELISA检测结果显示,与对照组相比,未处理组及预处理组均降低了M1型巨噬细胞白细胞介素1β、白细胞介素6及肿瘤坏死因子α的表达与分泌(P<0.05),且预处理组低于未处理组(P<0.05)。(3)Western blot检测结果显示,与未处理组相比,预处理组CD86的表达明显降低(P<0.05);与对照组相比,未处理组和预处理组M2型巨噬细胞表面标志物CD206的表达均升高(P<0.01),且预处理组明显高于未处理组(P<0.01);M1型巨噬细胞经24 h条件培养后,与对照组相比,核转录因子κB/P65的表达在未处理组和预处理组均有降低(P<0.01),p-IκBα的表达仅在预处理组降低(P<0.01);与未处理组相比,预处理组核转录因子κB/P65和p-IκBα的表达均显著降低(P<0.05),而IκBα在3组中的表达差异无显著性意义。(4)上述结果证实,淫羊藿苷增强了人牙周膜干细胞对M1型巨噬细胞的抑制作用,此作用可能与抑制了巨噬细胞的核转录因子κB信号通路相关。

关键词：人牙周膜干细胞淫羊藿苷巨噬细胞条件培养基共培养表面标志物炎症因子抗炎核转录因子κB信号通路

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Initial Bounds for a Subclass of Analytic and Bi-Univalent Functions Defined by Chebyshev Polynomials and q-Differential Operator

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Journal of Mathematical Research with Applications 2019年第5期39卷 506-516页

作者： Dong GUO En ao Huo TANG Liangpeng XIONG Foundation Department Chuzhou Vocational and Technical College School of Mathematics and Statistics Chifeng University School of Mathematics and Statistics Wuhan University

In this paper, we investigate the coefficient estimate and Fekete-Szeg? inequality of a subclass of analytic and bi-univalent functions defined by Chebyshev polynomials and qdifferential operator. The results presente... 详细信息

关键词： analytic functions bi-univalent functions coefficient estimates Fekete-Szeg? inequality Chebyshev polynomials q-differential operator

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A Deep Reinforcement Learning-Based Power Control Scheme for the 5G Wireless Systems

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China Communications 2023年第10期20卷 109-119页

作者： Renjie Liang Haiyang lyu Jiancun Fan School of Electronic and Information Engineering Xi’an Jiaotong UniversityXi’anShaanxi 710049China School of Cyber Science and Engineering Xi’an Jiaotong UniversityXi’anShaanxi 710049China

In the fifth generation(5G)wireless system,a closed-loop power control(CLPC)scheme based on deep q learning network(DqN)is introduced to intelligently adjust the transmit power of the base station(BS),which can improve the user equipment(UE)received signal to interference plus noise ratio(SINR)to a target threshold ***,the selected power control(PC)action in DqN is not accurately matched the fluctuations of the wireless *** the experience replay characteristic of the conventional DqN scheme leads to a possibility of insufficient training in the target deep neural network(DNN).As a result,the q-value of the sub-optimal PC action exceed the optimal *** solve this problem,we propose the improved DqN *** the proposed scheme,we add an additional DNN to the conventional DqN,and set a shorter training interval to speed up the training of the DNN in order to fully train ***,the proposed scheme can ensure that the q value of the optimal action remains *** multiple episodes of training,the proposed scheme can generate more accurate PC actions to match the fluctuations of the wireless *** a result,the UE received SINR can achieve the target threshold range faster and keep more *** simulation results prove that the proposed scheme outperforms the conventional schemes.

关键词： reinforcement learning closed-loop power control(CLPC) signal-to-interference-plusnoise ratio(SINR)

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Kinetic Model of Fixed Bed Reactor with Immobilized Microorganisms for Removing Low-Concentration SO_2

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Journal of Natural Gas Chemistry 2007年第1期16卷 86-91页

作者： Bing Huang YanyanWang Shiling Zhang Yong ao Faculty of Environmental Science ＆ Engincering Kunming University of Science and Technology Kunming 650093 Yunnan China Faculty of Science Kunming University of Science and Technology Kunming 650093 Yunnan China

On the basis of the analysis of the process of treating low concentrations of sulfur dioxide （SO2） gas in a fixed bed reactor, a kinetic model is proposed for this process after taking into consideration the effects of internal diffusion, cell concentration, and production yield of microorganisms but ignoring the effect of external diffusion. The results obtained from the model simulation show that this model can indicate the influence of the process factors, Cin, η μmax, Cx, A, h, Kin, and q, on the removal of SO2 and that the prediction of the results by this model is also satisfactory. This kinetic model can also provide some very important indications regarding the preparation of immobilized microorganisms, selection and domestication of proper species of microorganisms, as well as the design of bioreactors.

关键词： fixed bed reactor kinetic model immobilized microorganisms removal sulfur dioxide

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A Survey on Automatic Delineation of Radiotherapy Target Volume based on Machine Learning

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Data Intelligence 2023年第3期5卷 841-856页

作者： Zhenchao Tao Shengfei lyu School of Data Science University of Science and Technology of ChinaHefeiAnhui 230026China The First Affliated Hospital of USTC School of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031China Nanyang Technological University Singapore 639798Singapore

Radiotherapy is one of the main treatment methods for cancer,and the delineation of the radiotherapy target area is the basis and premise of precise *** intelligence technology represented by machine learning has done a lot of research in this area,improving the accuracy and efficiency of target *** article will review the applications and research of machine learning in medical image matching,normal organ delineation and treatment target delineation according to the procudures of doctors to delineate the target volume,and give an outlook on the development prospects.

关键词： Automatic delineation Machine learning Radiotherapy target volume Medical image matching Cancer

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Generation of unsteady waves by concentrated disturbances in an inviscid fluid with an inertial surface

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Acta Mechanica Sinica 2008年第3期24卷 267-275页

作者： D.q.Lu S.q.Dai Shanghai Institute of Applied Mathematics and Mechanics Shanghai University200072 ShanghaiChina Shanghai Key Laboratory of Mechanics in Energy and Environment Engineering 200072 ShanghaiChina

The surface waves generated by unsteady concentrated disturbances in an initially quiescent fluid of infinite depth with an inertial surface are analytically investigated for two- and three-dimensional cases. The fluid is assumed to be inviscid, incompressible and homogenous. The inertial surface represents the effect of a thin uniform distribution of non-interacting floating matter. Four types of unsteady concentrated disturbances and two kinds of initial values are considered, namely an instantaneous/oscillating mass source immersed in the fluid, an instantaneous/oscillating impulse on the surface, an initial impulse on the surface of the fluid, and an initial displacement of the surface. The linearized initial-boundary-value problem is formulated within the framework of potential flow. The solutions in integral form for the surface elevation are obtained by means of a joint Laplace-Fourier transform. The asymptotic representations of the wave motion for large time with a fixed distance- to-time ratio are derived by using the method of stationary phase. The effect of the presence of an inertial surface on the wave motion is analyzed. It is found that the wavelengths of the transient dispersive waves increase while those of the steady-state progressive waves decrease. All the wave amplitudes decrease in comparison with those of conventional free-surface waves. The explicit expressions for the freesurface gravity waves can readily be recovered by the present results as the inertial surface disappears.

关键词： Waves Inertial surface Concentrated disturbances Asymptotic representation

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Axisymmetric wetting of a liquid droplet on a stretched elastic membrane

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Applied Mathematics and Mechanics(English Edition) 2023年第6期44卷 997-1006页

作者： C.q.RU Department of Mechanical Engineering University of AlbertaEdmontonAB T6G 2G8Canada

Wetting of a liquid droplet on another liquid substrate is governed by the well-known Neumann *** present work aims to develop an explicit modified version of the Neumann equations for axisymmetric wetting of a liquid droplet on a highly stretched elastic membrane of non-zero bending *** explicit modified form of the Neumann equations is derived to determine the two contact angles,which is reduced to Young's equation for a liquid droplet on a rigid membrane or to the Neumann equations for a liquid droplet on another liquid *** implications of the modified Neumann equations are examined by comparison with some previous results reported in the recent literature,particularly considering the ranges of material and geometrical parameters of the liquid droplet-membrane system which have not been recently addressed in the literature.

关键词： Neumann equation Young's equation liquid droplet membrane pretension

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Interfacial Instability of Two Bonded Elastic Bodies Driven by Interface or Bulk Residual Stress

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Acta Mechanica Solida Sinica 2023年第6期36卷 914-920页

作者： C.q.Ru Department of Mechanical Engineering University of AlbertaEdmonton T6G 2G8Canada

Inspired by recent research interest in the interface wrinkling of bonded materials in diverse areas of 3D printing,the present work studies the interfacial instability of two bonded elastic bodies driven by negative interfacial tension or compressible bulk residual *** interfacial instability modes decaying exponentially with distance from the interface,the present model is formulated for two bonded elastic half-spaces with a planar interface under plane *** explicit expression is given for the wavenumber of interfacial instability driven by negative interfacial tension,and a critical condition is derived for interfacial instability driven by compressive bulk residual *** derived results are validated with comparison to known results on surface instability of an elastic half-space,and the role of shear modulus ratio and Poisson’s ratios of two bonded elastic bodies in interfacial instability,an issue to be addressed in literature,is studied with specific reference to material parameters used in some areas of 3D printing.

关键词： Interfacial tension Surface tension Interfacial instability 3D printing Interface wrinkling

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Alectinib: a novel second generation anaplastic lymphoma kinase(ALK) inhibitor for overcoming clinically-acquired resistance

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Acta Pharmaceutica Sinica B 2015年第1期5卷 34-37页

作者： Zilan Song Meining Wang ao Zhang CAS Key Laboratory of Receptor Research Synthetic Organic & Medicinal Chemistry LaboratoryShanghai Institute of Materia Medica (SIMM) Chinese Academy of Sciences

The development of inhibitors for the tyrosine anaplastic lymphoma kinase (ALK) has advanced rapidly, driven by biology and medicinal chemistry. The first generation ALK inhibitor crizotinib was granted US FDA approval with only four years of preclinical and clinical testing. Although this drug offers significant clinical benefit to the ALK-positive patients, resistance has been developed through a variety of mechanisms. In addition to ceritinib, alectinib is another second-generation ALK inhibitor launched in 2014 in Japan. This drug has a unique chemical structure bearing a 5H-benzo[b] carbazol-11(611)-one structural scaffold with an IC50 value of 1.9 nmol/L, and is highly potent against ALK bearing the gatekeeper mutation L1196M with an IC50 of 1.56 nmoL/L. In the clinic, alectinib is highly efficacious in treatment of ALK-positive non-small cell lung cancer (NSCLC), and retains potency to combat crizotinib-resistant ALK mutations L11.96.M, F1174L, R1275q and C1156Y. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved.

关键词： Tyrosine anaplastic lymphoma kinase Alectinib Crizotinib Non-suaall cell lung cancer Resistance ALK mutations EML4-ALK

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