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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches

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Science China Life Sciences 2025年第1期 232-248页

作者： yaohan Jiang Xiao Chen Chundi Wang Liping lyu Saleh A.Al-Farraj Naomi A.Stover Feng Gao Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Marine College Shandong University Zoology Department College of ScienceKing Saud University Department of Biology Bradley University Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all *** protists, which contain both germline and somatic genomes within a single cell, have evolved a special form of sexual reproduction called conjugation that involves mitosis, meiosis, fertilization, nuclear differentiation, genome rearrangement, and the development of unique cellular structures. The molecular basis and mechanisms of conjugation vary dramatically among ciliates, and many details of the process and its regulation are still largely unknown. In order to better comprehend these processes and mechanisms from an evolutionary perspective, this study provides the first comprehensive overview of the transcriptome and proteome profiles during the entire life cycle of the newly-established marine model ciliate Euplotes vannus. Transcriptome analyses from 14 life cycle stages(three vegetative stages and 11 sexual stages) revealed over 26,000 genes that are specifically expressed at different stages, many of which are related to DNA replication,transcription, translation, mitosis, meiosis, nuclear differentiation, and/or genome rearrangement. Quantitative proteomic analyses identified 338 proteins with homologs associated with conjugation and/or somatic nuclear development in other ciliates, including dicer-like proteins, Hsp90 proteins, RNA polymerase Ⅱ and transcription elongation factors, ribosomal-associated proteins, and ubiquitin-related proteins. Four of these homologs belong to the PIWI family, each with different expression patterns identified and confirmed by RT-qPCR,which may function in small RNA-mediated genome rearrangement. Proteins involved in the nonhomologous end-joining pathway are induced early during meiosis and accumulate in the developing new somatic nucleus, where more than 80% of the germline sequences are eliminated from the somatic genome. A number of new candidate genes and proteins likely t

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体外冲击波联合高压氧治疗骨不连的随机对照研究

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天津医药 2019年第10期47卷 1081-1084页

作者：赵子星李宏宇尹东梁斌吕亚南盘晓荣黄青黄思城韦明照王宏润广西壮族自治区人民医院骨科 530021 广西壮族自治区人民医院康复推拿科 530021 广西壮族自治区人民医院高压氧科 530021

目的探讨体外冲击波(ESWT)联合高压氧治疗四肢长骨骨不连的临床疗效。方法选取我院60例四肢长骨骨不连患者为研究对象,按治疗方案不同分为3组,A组予ESWT治疗,B组予ESWT联合高压氧治疗,C组予手术治疗。所有患者随访至少12个月。观察各组... 详细信息

目的探讨体外冲击波(ESWT)联合高压氧治疗四肢长骨骨不连的临床疗效。方法选取我院60例四肢长骨骨不连患者为研究对象,按治疗方案不同分为3组,A组予ESWT治疗,B组予ESWT联合高压氧治疗,C组予手术治疗。所有患者随访至少12个月。观察各组患者治疗及随访期一般情况及并发症、治疗有效率(6、 9、 12个月)、碱性磷酸酶(A LP)含量(1、 2、 3、 4、 6周)和骨密度(6、 12、 24周)。结果所有患者均无远期并发症发生,B组皮肤并发症少于A、C组。B、 C组治疗后不同时间点有效率及ALP含量差异无统计学意义(P>0.05),但均优于A组(P<0.05)。A、B、 C组治疗各时点ALP均较治疗前升高,且随时间延长,整体呈升高趋势(P<0.05)。 B组治疗后不同时间点骨密度改善优于A组(P<0 .05)。 A、B组内治疗各时点骨密度均较治疗前升高,且随时间延长,整体亦呈升高趋势(P<0.05)。结论 ESWT联合高压氧治疗四肢长骨骨不连无创、安全、有效,且具有皮肤并发症少的特点。

关键词：高压氧体外冲击波骨不连

经筋理论指导下毫火针治疗寒湿型腰肌劳损的临床效果

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中国医药导报 2019年第9期16卷 154-157页

作者：王程吕亚南陈玉钊邓享强黄沃宁梁淑芬广西壮族自治区人民医院推拿科广西南宁530021 广西医科大学体育部广西南宁530021 广西中医药大学研究生学院广西南宁530021

目的探讨经筋理论指导下毫火针治疗寒湿型腰肌劳损的临床效果。方法收集2014年10月~2016年9月广西壮族自治区人民医院推拿科门诊70例腰肌劳损属寒湿证患者,按随机数字表法分为治疗组和对照组,每组35例;治疗组采用经筋理论指导下毫火针治... 详细信息

目的探讨经筋理论指导下毫火针治疗寒湿型腰肌劳损的临床效果。方法收集2014年10月~2016年9月广西壮族自治区人民医院推拿科门诊70例腰肌劳损属寒湿证患者,按随机数字表法分为治疗组和对照组,每组35例;治疗组采用经筋理论指导下毫火针治疗,对照组采用温针灸法治疗,两组均每天治疗1次,共治疗10次。比较两组治疗前后疼痛视觉模拟评分(VAS)、临床疗效。结果两组治疗后VAS评分均低于本组治疗前,差异有高度统计学意义(P <0.01),治疗后治疗组VAS评分低于对照组,差异有统计学意义(P <0.05)。治疗组临床疗效优于对照组,差异有高度统计学意义(P <0.01)。结论经筋理论指导下毫火针较温针灸对寒湿型腰肌劳损具有更好的临床治疗效果。

关键词：经筋理论腰肌劳损毫火针温针灸视觉模拟评分法

Feasibility of using Vis-NIR spectroscopy and PXRF spectrometry to estimate regional soil cadmium concentration

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Journal of Environmental Sciences 2024年第11期145卷 88-96页

作者： Mengxue Wan Fan ya’nan Wentao Jiao Wenyou Hu Mingchao lyu Weidong Li Chuanrong Zhang Biao Huang Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Department of Environmental Science Zhejiang UniversityHangzhou 310058China Guangdong Provincial Academy of Environmental Science Guangzhou 510045China Department of Geography University of ConnecticutStorrsCT 06269USA

Conventionally,soil cadmium(Cd)measurements in the laboratory are expensive and timeconsuming,involving complex processes of sample preparation and chemical *** study aimed to identify the feasibility of using sensor data of visible near-infrared reflectance(Vis-NIR)spectroscopy and portable X-ray fluorescence spectrometry(PXRF)to estimate regional soil Cd concentration in a time-and *** sensor data of Vis-NIR and PXRF,and Cd concentrations of 128 surface soils from Yunnan Province,China,were ***-product analysis(OPA)was used for synthesizing the sensor data and Granger-Ramanathan averaging(GRA)was applied to fuse the model *** neural network(ANN)models were built using Vis-NIR data,PXRF data,and OPA data,*** showed that:(1)ANN model based on PXRF data performed better than that based on Vis-NIR data for soil Cd estimation;(2)Fusion methods of both OPA and GRA had higher predictive power(R^(2))=0.89,ratios of performance to interquartile range(RPIQ)=4.14,and lower root mean squared error(RMSE)=0.06,in ANN model based on OPA fusion;R^(2)=0.88,RMSE=0.06,and RPIQ=3.53 in GRA model)than those based on either Vis-NIR data or PXRF *** conclusion,there exists a great potential for the combination of OPA fusion and ANN to estimate soil Cd concentration rapidly and accurately.

关键词： Artificial neural network Outer-product analysis Granger-Ramanathan averaging Soil Cd concentration Fusion method

本体感觉神经肌肉促进技术结合中医综合疗法对脊髓损伤患者康复疗效影响的临床研究

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中国临床新医学 2020年第5期13卷 478-482页

作者：楚野梁斌吕亚南丘德赞韦敏克韦建勋陈峰易波德刘新丹广西壮族自治区人民医院骨科南宁530021 广西壮族自治区人民医院推拿科南宁530021

目的探讨本体感觉神经肌肉促进技术(PNF)结合中医综合疗法对脊髓损伤患者的临床疗效。方法选择2012-10~2015-03该院收治的脊髓损伤并不全瘫患者141例,随机分为A组(n=42,PNF结合中医综合康复治疗)、B组(n=43,单纯PNF康复治疗)和C组(n=43... 详细信息

目的探讨本体感觉神经肌肉促进技术(PNF)结合中医综合疗法对脊髓损伤患者的临床疗效。方法选择2012-10~2015-03该院收治的脊髓损伤并不全瘫患者141例,随机分为A组(n=42,PNF结合中医综合康复治疗)、B组(n=43,单纯PNF康复治疗)和C组(n=43,单纯中医综合康复治疗)。比较三组康复治疗前后感觉评分、运动评分和Barthel指数评分。结果在康复治疗前三组运动评分、感觉评分和Barthel指数评分比较差异无统计学意义(P>0.05)。康复治疗后,三组各项评分均较治疗前提高,差异有统计学意义(P0.05)。结论采用PNF结合中医综合康复治疗脊髓损伤并不全瘫患者较单独应用PNF和中医综合康复治疗所取得的疗效更好,值得临床上推广应用。

关键词：本体感觉神经肌肉促进技术中医综合康复治疗脊髓损伤疗效

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德国英语教材价值观呈现研究

外语学刊 2025年第1期 70-77页

作者：葛囡囡北京外国语大学德语学院北京100089

近年来,教材中的价值观呈现愈加受到教材编写者和使用者的关注。本文以德国英语教材On Track为研究对象,探究其价值观呈现的情况。研究发现:在该教材呈现的德国主流价值观中,最常见的价值观类别是社群关系价值观、个人成长价值观、传统... 详细信息

近年来,教材中的价值观呈现愈加受到教材编写者和使用者的关注。本文以德国英语教材On Track为研究对象,探究其价值观呈现的情况。研究发现:在该教材呈现的德国主流价值观中,最常见的价值观类别是社群关系价值观、个人成长价值观、传统文化价值观和发展观念价值观。价值观呈现方式特点有三,即螺旋复现的价值观主题、追求真实的语言中介板块、以思辨能力为导向的素材选择和练习设计。此外,该教材的价值观呈现模态多样。最后,本文针对我国外语教材编写和教材使用如何助力价值观教育提出建议。

关键词：价值观英语教材德国外语教材呈现方式呈现模态

Synthesis of Sustainable Sulfur-Rich Copolymers as Mercury Sorbents at 130℃ Using Tung Oil as an Activator

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China Petroleum Processing & Petrochemical Technology 2023年第3期25卷 60-70页

作者： lyu ya Zhang Sai School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China

Sulfur-rich copolymers made through inverse vulcanization exhibit a wide range of potentially valuable applications, for example as adsorbents to capture mercury pollution. Among the diverse second monomers of the copolymers, vegetable oil is a renewable resource, and recycled cooking oils have an important role in saving natural products. However, they need relatively high temperatures(160–180 ℃) to react with sulfur. To develop a low-temperature(130 ℃) reaction process for non-conjugated vegetable oil, we incorporate a small amount of tung oil, which contains conjugated trienes that can produce highly active free radicals during reactions. A variety of analytical techniques(proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction, and dynamic mechanical analysis) are used to characterize the chemical structures and physical properties of the copolymers. The addition of tung oil is found to significantly improve the thermal stability and mechanical properties of the copolymers. We also investigate the effect of different ratios of raw materials on the gel time, free sulfur content, glass transition temperature T_(g), and degradation temperature of the copolymers. We find that increasing the amount of tung oil in the raw material mixture decreases the gel time and free sulfur content, but increases T_(g) and the degradation temperature. The copolymers exhibit a high adsorption capacity for mercury ions up to 33 mg Hg^(2+) per gram of adsorbent. These results demonstrate the feasibility of using sulfur-rich copolymers as effective mercury removal adsorbents, with the potential for further improvement by foaming the copolymers into porous materials.

关键词： sulfur vegetable oil polymer mercury reaction mechanism

Properties of a High Hydrolysis Stable Nitrogenous Benzo-heterocyclic Borates

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China Petroleum Processing & Petrochemical Technology 2020年第2期22卷 37-45页

作者： Tian Ying lyu ya East China University of Science and Technology Shanghai 200237

A benzotriazole-containing derivative was synthesized via the Mannich *** structure was characterized by NMR *** utilizing computational chemistry and molecular simulation,the calculation and mapping of atomic charge and frontier molecular orbitals with complex structure of the borate were carried *** acid number of BTBE(nitrogen-containing heterocyclic borate)was determined by the standard test method for acid number and the open observation *** results showed that BTBE had a low initial acid number,because the acid number was changed only after 72 hours of hydrolysis,and it was negative after the hydrolysis reached 120 *** extreme-pressure friction resistance of BTBE and other four base oils was also *** 5 kinds of base oils,the friction experiment was carried out under a load of 30 kgf,and the BTBE showed a lowest wear scar diameter(0.365 mm)along with a highest maximum non-seizure *** results showed that the EP friction resistance of BTBE was stronger than that of other four base oils under the same test *** results of hydrolysis performance showed that the synthesized nitrogencontaining heterocyclic borate had a high resistance to hydrolysis,while demonstrating broad application prospects.

关键词： borate Mannich reaction acid number hydrolysis EP friction resistance