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Activation of NRF2 by celastrol increases antioxidant functions and prevents the progression of osteoarthritis in mice

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Chinese Journal of Natural Medicines 2024年第2期22卷 137-145页

作者： LIU Mingming GUO Jiatian ZHAO Jing LI Hongye FENG Xiaoxiao LIU Haojun ZHANG Hao JIA Xuejun WEI Rushuai LI Fang CHEN Chong HOU Mingzhuang lv nanning XU Haiyan Department of human anatomy Xuzhou Medical UniversityXuzhou 221004China Department of Orthopedic Surgery The Affiliated Lianyungang Clinical College of Xuzhou Medical University(The Second People’s Hospital of Lianyungang)Lianyungang 222003China Department of Orthopaedics The First Afliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Institute of Hematology Xuzhou Medical UniversityXuzhou 221004China

Excessive oxidative stress impairs cartilage matrix metabolism balance,significantly contributing to osteoarthritis(OA)development.Celastrol(CSL),a drug derived from Tripterygium wilfordii,has recognized applications in the treatment of cancer and immune system disorders,yet its antioxidative stress mechanisms in OA remain underexplored.This study aimed to substantiate CSL’s chondroprotective effects and unravel its underlying mechanisms.We investigated CSL’s impact on chondrocytes under both normal and inflammatory conditions.In vitro,CSL mitigated interleukin(IL)-1β-induced activation of proteinases and promoted cartilage extracellular matrix(ECM)synthesis.In vivo,intra-articular injection of CSL ameliorated cartilage degeneration and mitigated subchondral bone lesions in OA mice.Mechanistically,it was found that inhibiting nuclear factor erythroid 2-related factor 2(NRF2)abrogated CSL-mediated antioxidative functions and exacerbated the progression of OA.This study is the first to elucidate the role of CSL in the treatment of OA through the activation of NRF2,offering a novel therapeutic avenue for arthritis therapy.

关键词： Osteoarthritis Celastrol Articular cartilage Extracellular matrix NRF2

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Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

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Regenerative Biomaterials 2024年第1期3卷 44-57页

作者： Xi Hua Mingzhuang Hou Lei Deng nanning lv Yong Xu Xuesong Zhu Huilin Yang Qin Shi Hao Liu Fan He Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Suzhou Medical CollegeSoochow UniversitySuzhou 215000China Department of Orthopedics Suzhou Wuzhong People’s HospitalSuzhouJiangsu Province 215128China Department of Orthopedic Surgery Lianyungang Clinical College of Xuzhou Medical UniversityLianyungang 222003China

The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone defects.The challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture site.However,the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of proosteogenic factors.In this study,a poly(L-lactic acid)(PLLA)/hyaluronic acid(HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning technique.The incorporation of irisin into the core-shell structure of PLLA/HA nanofibers(PLLA/HA@Irisin)achieved its sustained release.In vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable biocompatibility.The osteogenic differentiation of bone marrow mesenchymal stem cells(BMMSCs)was improved by PLLA/HA@Irisin,as evidenced by a significant increase in alkaline phosphatase activity and matrix mineralization.Mechanistically,PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMSCs via the activation of the sirtuin 3 antioxidant pathway.To assess the therapeutic effectiveness,PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in rats.The results at 4 and 8 weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation,as demonstrated by the enhancement of bone matrix synthesis and the development of new blood vessels.The results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum,showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMSCs.

关键词： periosteum irisin mitochondrial function critical-sized bone defect redox homeostasis

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Theoretical and experimental investigation of the resonance responses and chaotic dynamics of a bistable laminated composite shell in the dynamic snap-through mode

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 581-602页

作者： Meiqi WU Pengyu lv Hongyuan LI Jiale YAN Huiling DUAN Wei ZHANG State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceBIC-ESATCollege of EngineeringPeking UniversityBeijing 100871China Nanchang Innovation Institute of Peking University Nanchang 330096China Department of Mechanics Guangxi UniversityNanning 530004China

The dynamic model of a bistable laminated composite shell simply supported by four corners is further developed to investigate the resonance responses and chaotic behaviors.The existence of the 1:1 resonance relationship between two order vibration modes of the system is verified.The resonance response of this class of bistable structures in the dynamic snap-through mode is investigated,and the four-dimensional(4D)nonlinear modulation equations are derived based on the 1:1 internal resonance relationship by means of the multiple scales method.The Hopf bifurcation and instability interval of the amplitude frequency and force amplitude curves are analyzed.The discussion focuses on investigating the effects of key parameters,e.g.,excitation amplitude,damping coefficient,and detuning parameters,on the resonance responses.The numerical simulations show that the foundation excitation and the degree of coupling between the vibration modes exert a substantial effect on the chaotic dynamics of the system.Furthermore,the significant motions under particular excitation conditions are visualized by bifurcation diagrams,time histories,phase portraits,three-dimensional(3D)phase portraits,and Poincare maps.Finally,the vibration experiment is carried out to study the amplitude frequency responses and bifurcation characteristics for the bistable laminated composite shell,yielding results that are qualitatively consistent with the theoretical results.

关键词： bistable laminated composite shell dynamic snap-through mode Hopf bifurcation chaotic dynamics vibration experiment

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Simple nucleophile/H_(2)O promoted defluorinative ring-opening of gem-difluorocyclopropenes

Green Synthesis and Catalysis

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Green Synthesis and Catalysis 2024年第1期5卷 14-19页

作者： Yimiao He Jingwen Yuan Wen-Xin lv Peng Liu Fan Teng Qijin Mo Zihua Wu Chusheng Huang Qianwen Liu Honggen Wang Guangxi Key Laboratory of Natural Polymer Chemistry and Physics College of Chemistry and MaterialsNanning Normal UniversityNanning530001China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological University117543Singapore Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou510530China Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang330063China

A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented,providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio-and stereoselectivities.The reaction is performed under mild conditions with no need of using an excess amount of nucleophilic reagents.Water plays a crucial role in this transformation.

关键词： gem-difluorocyclopropene Ring-opening defluorination 2-Fluoropropenal 2-Fluorobuta-1,3-diene Water

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Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-Fu Wang Jie Zheng Yi-Ming Lei Zhong-Yuan Chen Yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang lv Hong-Hong Wang Juan-Juan Xie Yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in humans.Here,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and immunohistochemistry.We compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and mice.Results showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and CHGA.Biochemical analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal glands.Furthermore,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association studies.Overall,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal gland.Our comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

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汉英双语幼儿早期多语码词汇发展个案研究

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陕西学前师范学院学报 2024年第6期40卷 70-76页

作者：吕燕广西大学外国语学院广西南宁530004

儿童早期词汇的获得和发展对儿童具有重要意义,研究儿童词汇量增长是早期语言发展研究的一个重要方面。本文追踪了一名汉英双语多语码儿童出生后到两岁之间的普通话、粤语和英语的早期词汇获得,从最初词汇、五十个词的里程碑、词汇爆发... 详细信息

儿童早期词汇的获得和发展对儿童具有重要意义,研究儿童词汇量增长是早期语言发展研究的一个重要方面。本文追踪了一名汉英双语多语码儿童出生后到两岁之间的普通话、粤语和英语的早期词汇获得,从最初词汇、五十个词的里程碑、词汇爆发和非常规意义匹配四个方面进行研究,结果发现该名儿童的普通话词汇发展与汉语儿童的相似,且词汇语义快速发展的标志为泛化现象明显增加,与情感因素挂钩;粤语和英语词汇发展缓慢,有日趋停止的可能。

关键词：汉英双语儿童多语码词汇发展个案研究

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大藤峡水利枢纽工程兴宾库区征地工作难点分析

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广西水利水电 2024年第3期 132-134页

作者：吕杰广西水利电力勘测设计研究院有限责任公司南宁530023

以兴宾库区为例对大藤峡水利枢纽工程库区征地工作的主要难点进行梳理,并提出了解决方法与措施建议,为今后同类工程项目的征地工作的开展提供参考经验。

关键词：土地测量地类认定河流岸坡地土地权属争议大藤峡水利枢纽

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融合改进鲸鱼算法解缠的梧州市地面沉降InSAR监测

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遥感信息 2024年第1期39卷 52-58页

作者：赵凤阳周吕魏玉业桂林理工大学土木与测绘工程系南宁530001 桂林理工大学测绘地理信息学院广西桂林541004

针对基于InSAR地面沉降研究中干涉图解缠易陷入局部最优及地面沉降影响因子较多且复杂的情况,提出了一种结合全局鲸鱼算法寻优的InSAR解缠方法并以广西壮族自治区梧州市为研究区,构建人类扰动指数,探索其2018—2023年地面沉降状况及分... 详细信息

针对基于InSAR地面沉降研究中干涉图解缠易陷入局部最优及地面沉降影响因子较多且复杂的情况,提出了一种结合全局鲸鱼算法寻优的InSAR解缠方法并以广西壮族自治区梧州市为研究区,构建人类扰动指数,探索其2018—2023年地面沉降状况及分析其驱动力因子。结果表明,改进鲸鱼优化算法从全局角度寻找枝切线最短路径,有效避免了陷入局部最优的问题。基于上述解缠方法获取了2018—2023年研究区地面沉降状况,并选取两个特征区域探究影响地面沉降的驱动力因子。经相关性分析,研究区地面沉降与城市扩张及重要交通枢纽建设密切相关,两个特征区域地面沉降速率与梧州市区建设用地面积的拟合优度R 2分别为0.9386和0.9842。本文研究结果可以为研究区城市规划建设及应急防灾提供决策支持。

关键词：地面沉降 SBAS-InSAR 人类扰动指数驱动力分析改进鲸鱼算法

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“一线七治”民族互嵌社区现代化治理模式及其运行机制

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广西民族研究 2024年第1期 27-36页

作者：张晓华龚永辉吕广文广西民族大学民族学与社会学学院广西南宁530006 广西财经学院桂林理工大学南宁分校广西南宁530001

在我国人口大规模、高频次流动的当下,基于民族互嵌社区场域的治理情境,探索民族互嵌社区现代化治理模式,是对党的二十大报告提出的“在社会基层坚持和发展新时代‘枫桥经验’”和“健全城乡社区治理体系”的现实回应。广西南宁市中华... 详细信息

在我国人口大规模、高频次流动的当下,基于民族互嵌社区场域的治理情境,探索民族互嵌社区现代化治理模式,是对党的二十大报告提出的“在社会基层坚持和发展新时代‘枫桥经验’”和“健全城乡社区治理体系”的现实回应。广西南宁市中华中路社区在治理实践中以我国基层社会基本治理体系“三治融合”为原型,以人民为中心,以铸牢中华民族共同体意识为主线,多元主体在协商共治中将法治、德治、情治、语治、文治、智治等多种治理方式深度融合,探索出了“一线七治”的民族互嵌社区现代化治理模式。在“一线七治”模式下,多项机制联动发力,中华中路社区内的信息流与情感流持续交互,丰富充裕的信息与浓厚深切的情感深度融合,实现了各族居民的居住互嵌、语言互通、生活互依、文化互认、情感互融,社区治理效能得到了显著提升。

关键词：民族互嵌社区中华民族共同体意识现代化治理三治融合

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持续推进新疆吉木乃口岸发展的对策建议

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东北亚经济研究 2024年第3期8卷 111-120页

作者：吕韬吴昊周涛广西大学经济学院广西南宁530004

口岸是国家间交通运输网络枢纽和贸易交往的重要门户。新疆吉木乃口岸作为中国与哈萨克斯坦两国最北端口岸,不仅是中哈两国更是向第三方国家开放经贸合作交流的重要平台。基于对吉木乃口岸实地走访调研和资料搜集整理,从贸易发展、旅游... 详细信息

口岸是国家间交通运输网络枢纽和贸易交往的重要门户。新疆吉木乃口岸作为中国与哈萨克斯坦两国最北端口岸,不仅是中哈两国更是向第三方国家开放经贸合作交流的重要平台。基于对吉木乃口岸实地走访调研和资料搜集整理,从贸易发展、旅游发展、口岸政策、口岸管理等方面阐述其发展现状,进而针对其存在的问题和困难,从国家间政策优惠、多层次协作、口岸设施、口岸腹地体系和大安全观等方面提出加强对吉木乃口岸建设的对策建议,以持续推进其稳步发展。

关键词：吉木乃口岸新疆协作对策建议

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