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18613例急诊科患者流行病学特点及疾病谱构成

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创伤与急诊电子杂志 2013年第4期1卷 32-36页

作者：陶惠明冷巧云汪传文夏绿池户洁九江市第一人民医院急诊科江西九江332000

目的探讨2013年本院急诊科1613例患者的流行病学特点及疾病谱构成。方法回顾性分析2013年1月至2013年12月本院急诊科门诊患者的基本资料,总结其流行病学特点,分析此期急诊科门诊疾病谱构成。采用icd-10进行疾病分类。结果入选病例1613例... 详细信息

目的探讨2013年本院急诊科1613例患者的流行病学特点及疾病谱构成。方法回顾性分析2013年1月至2013年12月本院急诊科门诊患者的基本资料,总结其流行病学特点,分析此期急诊科门诊疾病谱构成。采用icd-10进行疾病分类。结果入选病例1613例,平均年龄44(29~60)岁,高峰年龄36~50岁;其中死亡34例,内科住院率1.4%,外科住院率13.9%;男:女比为1.2:1,女性患者外科住院率远低于男性;随着年龄增长,内科住院率逐渐增多;晚上(1:00~23:59)接诊病例数占首位,接诊高峰时间为1:00~21:59,低谷时间为4:00~5:59,上午(6:00~11:59)的内科住院率最高;伤害和中毒疾病、消化系统疾病及呼吸系统疾病居就诊病因的前三位;女性患者伤害和中毒疾病较男性少,神经系统疾病较男性多;老年组(51~0岁)及高龄组(1~9岁)患者神经系统及循环系统疾病高于其余年龄组。结论 1可根据患者的流行病学特点加强急诊科人员在数量及时间上的合理配置;2根据疾病谱构成可对医务人员进行重点培训,以提高本院急诊医疗水平;3重视男性的安全防范教育、女性的心理卫生教育及老年人的疾病预防宣教。

关键词：急诊科流行病学疾病谱

Effect of high Na2O addition on distribution of phosphorus in lowbasicity converter slag

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Journal of Iron and Steel Research International 2019年第1期26卷 42-51页

作者： Chang Su Ning-ning lv Jin-xing Yang Liu-shun Wu Hai-chuan Wang Yuan-chi Dong School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032AnhuiChina Key Laboratory of Metallurgical Emission Reduction and Resources Recycling(Anhui University of Technology) Ministry of EducationMa'anshan 243002AnhuiChina

In order to improve the dephosphorization efficiency of low-basicity converter slag and decrease the consumption of solid CaO,the effect of high Na2O addition(0-15 mass%)on the distribution of P2O5 between solid solution and matrix phase was *** thermodynamic properties of slag samples were calculated by FactSage 7.0 ***,the dissolution behavior of phosphorus element from slag was *** results show that the mass fraction of 2CaO*SiO2-2CaO*Na2O*P2O5 solid solution increases when the Na2O content is increased in ***,the amount of formed solid solution changes little when the Na2O addition is more than 10 mass%.Moreover,the content of Na2O in solid solution would reach saturation when adding 15 mass%Na2O into the *** the increase in Na2O content in slag,the distribution ratio of P2O5 between solid solution and matrix phase *** values are evidently higher than the results reported in the ***,the activity of P2O5 in matrix phase and the activity coefficient of P2O5 in solid solution are decreased with increasing the Na2O content in ***,the dissolution ratio of phosphorus in citric acid solution could be improved by adding Na2O into slag,but the increment of dissolution ratio would decrease when the Na2O content exceeds 10 mass%in slag.

关键词： Na2O addition-Low-basicity converter slag Phosphorus distribution ratio Thermodynamic property Phosphorus dissolution behavior

METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils

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Protein & Cell 2024年第3期15卷 223-229页

作者： Dan Cao Mengyue lv chi Hu Shukai Li Siwen Wang Chao Xu Wen Pan Department of Digestive Disease The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technologyof ChinaHefei230001China Division of Life Sciences and Medicine The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesInstitute of ImmunologyUniversity of Science and Technology of ChinaHefei 230027China Division of Life Sciences and Medicine MOE Key Laboratory for Cellular DynamicsHefei National Center for Cross-Disciplinary SciencesUniversity of Science and Technology of ChinaHefei 230027China

Dear Editor,Protein histidine methylation has been found to be a widespread post-translational modification(PTM)in mammalian cells and represents more than 13%of all protein methylation events in the human methylome(Ning et al.,2016;Kapell and Jakobsson,2021).Recently,we and other groups independently identified METTL9 as the first broad-specificity histidine N1 methyltransferase in mammals(Davydova et al.,2021;lv et al.,2021).METTL9 methylates a variety of substrates with a common x-His-x-His motif(His is for histidine;the second x is preferably small amino acids:A/C/G/S)and catalyzes methyl transfer to the last histidine.

关键词： S100A9 specificity

Identification and Validation of the Hsa_circ_0001726/miR-140-3p/KRAS Axis in Hepatocellular Carcinoma Based on Microarray Analyses and Experiments

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Journal of Clinical and Translational Hepatology 2024年第11期12卷 897-906页

作者： Xiaobin chi Zhijian Chen Jianda Yu Xiaohua Xie Zerun Lin Yongbiao Chen Lizhi lv Department of Hepatobiliary Surgery 900TH Hospital of Joint Logistics Support ForceFuzhouFujianChina

Background and Aims:Hepatocellular carcinoma(HCC)is one of the most fatal *** mechanisms have revealed that noncoding RNAs,such as microRNAs(miRNAs)and circular RNAs(circRNAs),are involved in HCC *** study aimed to construct a circRNA-miRNAmRNA network in HCC and validate one axis within the ***:HCC-related transcriptome data were obtained from the Gene Expression Omnibus,and HCC-related genes were sourced from GeneCards to identify differentially expressed circRNAs and *** targeting relationships between circRNA-miRNA and miRNA-mRNA interactions were *** involvement of the hsa_circ_0001726/miR-140-3p/KRAS axis in HCC was evaluated through cellular experiments and survival ***:We identified six differentially expressed circRNAs in HCC,which were linked to 13 miRNAs and 88 mRNAs.A network containing 34 circRNA-miRNA pairs and 194 miRNA-mRNA pairs was *** proliferation and migration assays confirmed the role of hsa_circ_0001726 in promoting HCC progression,possibly through the miR-140-3p/KRAS *** analysis verified that hsa_circ_0001726 was a prognostic factor for overall survival in patients with *** hsa_circ_0001726/miR-140-3p/KRAS axis also mediates lenvatinib resistance in HCC ***:The HCC circRNA/miRNA/mRNA network provides new insights into the post-transcriptional regulatory mechanism of *** hsa_circ_0001726/miR-140-3p/KRAS axis is involved in HCC progression and lenvatinib resistance.

关键词： Circular RNA microRNA Prognosis Hepatocellular cancer Bioinformatics Tyrosine kinase inhibitor

单中心151例机器人直肠肿瘤手术效果与体会

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中华腔镜外科杂志（电子版） 2014年第5期7卷 1-5页

作者：吕赤张成李瑾高广荣李达蒋会勇单永琪张雪峰沈阳军区总医院普通外科沈阳110840

目的：探讨达芬奇机器人手术系统应用于直肠肿瘤手术的效果，总结手术经验。方法回顾性分析我院2012年1月－2014年7月行达芬奇机器人直肠手术151例的临床资料。结果150例手术顺利完成，1例中转开腹。其中前切除术106例，APR 手术39例，H... 详细信息

目的：探讨达芬奇机器人手术系统应用于直肠肿瘤手术的效果，总结手术经验。方法回顾性分析我院2012年1月－2014年7月行达芬奇机器人直肠手术151例的临床资料。结果150例手术顺利完成，1例中转开腹。其中前切除术106例，APR 手术39例，Hartmann 手术6例。平均手术时间分别为240 min，239 min 和260 min，术中平均失血量53 ml，清扫淋巴结数量平均13．2枚。术后排气时间1～7 d，平均3 d。术后肠梗阻3例，吻合口瘘2例，吻合口出血1例，均行保守治疗。1例因肠系膜血管出血时气腹机故障而中转开腹止血。无死亡病例。结论达芬奇机器人行直肠肿瘤手术安全、可靠、优势明显。

关键词：机器人手术系统直肠肿瘤直肠癌根治术

Hazard-evaluation-oriented Moving Horizon Parallel Steering Control for Driver-Automation Collaboration During Automated Driving

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IEEE/CAA Journal of Automatica Sinica 2018年第6期5卷 1062-1073页

作者： Hongyan Guo Linhuan Song Jun Liu Fei-Yue Wang Dongpu Cao Hong Chen Chen lv Partick chi-Kwong Luk State Key Laboratory of Automotive Simulation and Control and the Department of Con-trol Science and Engineering Jilin University(Campus Nanling)Changchun130025China State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Research Center for Military Computational Experiments and Parallel Systems Technology National University of Defense TechnologyChangsha 410073China Mechanical and Mechatronics Engineering Department at the University ot Waterloo 200 University Avenue West WaterlooONNZL3G1Canada Department of Automotive Engineering Cranfield UniversityBedfordshire MK43 0ALUK School of Water Energy and EnvironmentCranfield UniversityBedfordshire MK43 0ALUK

Prompted by emerging developments in connected and automated vehicles, parallel steering control, one aspect of parallel driving, has become highly important for intelligent vehicles for easing the burden and ensuring the safety of human drivers. This paper presents a parallel steering control framework for an intelligent vehicle using moving horizon *** framework considers lateral stability, collision avoidance and actuator saturation and describes them as constraints, which can blend the operation of a human driver and a parallel steering controller effectively. Moreover, the road hazard and the steering operation error are employed to evaluate the operational hazardous of an intelligent vehicle. Under the hazard evaluation,the intelligent vehicle will be mainly operated by the human driver when the vehicle operates in a safe and stable *** automated steering driving objective will play an active role and regulate the steering operations of the intelligent vehicle based on the hazard evaluation. To verify the effectiveness of the proposed hazard-evaluation-oriented moving horizon parallel steering control approach, various validations are conducted, and the results are compared with a parallel steering scheme that does not consider automated driving situations. The results illustrate that the proposed parallel steering controller achieves acceptable performance under both conventional conditions and hazardous conditions.

关键词： Hazard evaluation intelligent vehicle atera stability moving horizon optimization paralle steering control

Hierarchical porous carbon heterojunction flake arrays derived from metal organic frameworks and ionic liquid for H2O2 electrochemical detection in cancer tissue

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Nano Research 2021年第5期14卷 1335-1343页

作者： Yan Zhang Qiying lv Kai chi Qilin Li Huiling Fan Bo Cai Fei Xiao Shuai Wang Zheng Wang Lin Wang Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China

The development of hierarchical nanostructure is demonstrated as an effective strategy to improve catalytic activity and stability of ***,a novel leaf-like hierarchically porous heterojunction flake arrays(FAs),integrated graphitic N-doped carbon(NC)with amorphous B,N-doped carbon(BNC),has been designed and grown on flexible carbon fiber(CF)using metal-organic framework(MOF)FAs and green ionic liquids as *** hierarchical heterojunction structure possesses micro-and nano-scaled pores,large surface areas,and exposed high-density catalytic active sites,which enhances electronic conductivity and offers accessible transport channels for effectively decreasing mass transport *** results of discrete Fourier transform(DFT)calculations and experiments also suggest that the catalytic activity has been promoted by the heterojunction structure through narrowing the banding ***,the resultant nanohybrid microelectrode exhibits remarkable electrochemical sensing performance towards H2O2 with a low detection limit of 50 nM,and a high sensitivity of 213μA×mM-1×cm-2,as well as good anti-interference *** practical application of nanohybrid fiber microelectrode has been explored by real-time monitoring H2O2 released from live colon cells and surgically-resected fresh colon cancer tissue,which can provide important information for the identification of different types of cells as well as distinguish cancer cells from normal *** believe this research will pave the way towards the development of advanced carbon nanomaterials for application in the fields of electrochemistry,biosensing,and cancer diagnosis.

关键词： carbon heterojunction structure hierarchical flake arrays heteroatoms doping electrochemical sensor cancer biomarker detection

Dithienylmaleimide-based D-A Conjugated Polymer Film:Photo-responsive Behavior and Application in Electrical Memory and Logic Gates

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chinese Journal of Polymer Science 2021年第9期39卷 1177-1184页

作者： Wei lv Chun Wang Xing-chi Lin Xiao-Fei Mei Wen Wang E Yang Qi-Dan Ling Zheng-Huan Lin College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Fujian Provincial Key Laboratory of Polymer Materials Fujian Normal UniversityFuzhou 350007China

Solid-stated smart polymers responsive to external stimuli have attracted much attention for potential application in the field of photoelectron devices,logic gates,sensor,data storage and ***,it is a bigger challenge for polymers than that for small molecules in solid state to acquire stimuli-responsive properties,because polymers with high molecular weight are not as easy to change the packing structure as small molecules under external ***,a D-A type alternating copolymer PTMF-o containing 3,4-bisthienylmaleimide(A unit)and fluorene(D unit)is designed and *** irradiation of sunlight,PTMF-o film exhibits a photo-response with the color altering from purple to *** is attributed to the structure of copolymer transformed from ring-opening form(PTMF-o)to ring-closure form(PTMF-c),resulting from the oxidative photocyclization of 3,4-bisthienylmaleimide ***,the ability of charge transfer(CT)from fluorene to 3,4-bisthienylmaleimide unit in PTMF-o can be easily weakened by light ***-o film displays a WORM-type resistive storage performance for the strong ***,after exposure,the electrical memory behavior in situ transfers into FLASH type,due to weak CT in ***-o film can also be employed as smart material to construct NAND and NOR logic gates by using light as input *** work provides a simple way to modify the electronic properties of polymers and realize stimuli-response in solid states.

关键词： Dithienylmaleimide Photo-response Electrical memory Logic gate

N-Heterocyclic carbene catalyzed C-acylation reaction for access to linear aminoenones

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chinese Chemical Letters 2023年第1期34卷 357-361页

作者： Jie lv Yingling Nong Kai Chen Qingyun Wang Jiamiao Jin Tingting Li Zhichao Jin Yonggui Robin chi State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of EducationGuizhou UniversityGuiyang 550025China

An N-heterocyclic carbene(NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N-sulfonyl imines is developed for access to linearβ-aminoenone ***β-aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild *** reaction features excellent trans-diastereoselectivities and the desired aminoenone products are all afforded as Z-isomers.

关键词： N-Heterocyclic carbene Organocatalysis C-Acylation reaction Animoenone synthesis