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Pathological Observation of Blood Stasis Syndrome in Non-diabetic Peripheral Neuropathies:A Retrospective Analysis Based on Nerve Biopsy

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Chinese Journal of Integrative Medicine 2020年第10期26卷 776-782页

作者： XU min CHEN Hai SHI Zai-xiang DA yu-wei luo yu-min GAO Li LU Yan WANG min DI Li Neurology Department Xuanwu Hospital Capital Medical UniversityBeijing(100053)China Integrative Medicine Department of Cardiology China-Japan Friendship HospitalBeijing(100029)China

Objective To investigate the pathological features of blood stasis syndrome(BSS)in non-diabetic peripheral *** Clinical data of 31 patients with non-diabetic peripheral neuropathy who had undergone nerve biopsy during December 2004 and December 2010 in Xuanwu Hospital Capital Medical University were retrospectively *** to Chinese medicine(CM)syndrome differentiation and signs,26 patients were blood stasis type and 5 patients were non-blood stasis *** and pathological data were compared in *** Clinically,although both groups shared similar symptoms of limb numbness,weakness and sensory disturbances,the prevalence of neuralgia was much grievous in BSS group(73.1%,26/31)compared with the non-BSS group(0%,0/5).As for signs,dermal nutrients disturbance(84.6%,22/26),dark or purple tongue(100.0%,26/26),and sublingual varices(80.7%,21/26)were more common in the BSS group than the non-BSS group(0%,60%,20%,respectively).The prevalence of qi deficiency cases(19/26)in the BSS group was significantly higher compared with the non-BSS group(1/5).The unique histological manifestations of BSS were axonal degeneration(16/26 vs 2/5 in non-BSS group),which was the hallmark of *** with BSS had prominent microangiopathy(61.5%,16/26),manifested as epineurium vasculitis(inflammatory cell infiltrated to the vessel wall,obliteration and recanalization,vascular proliferation,extravascular hemosiderin deposition),angiotelectasis,proliferation and hyaline degeneration of endoneurium *** the BSS group,impaired blood-nerve barrier was indicated by sub-perineurial edema(46.2%,11/26)and endoneurial edema(15.4%,4/26).The Renaut body(15.4%,4/26)and amyloid deposition(3.8%,1/26)found in the BSS group were absent in the non-BSS *** BBS was common in non-diabetic peripheral *** nerves exhibited ischemic alteration of primary axon degeneration and secondary *** interstitial tissue revealed micr

关键词： Chinese medicine blood stasis syndrome non-diabetic peripheral neuropathy biopsy pathologic alteration

Unique MicroRNAs Signature of Lymphocyte of Yang and Yin Syndromes in Acute Ischemic Stroke Patients

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Chinese Journal of Integrative Medicine 2019年第8期25卷 590-597页

作者： ZHAO Hai-ping LIU Ping XU Chang-min LI Guang-wen GAO Li luo yu-min Cerebrovascular Diseases Research Institute and Department of Neurology Xuanwu Hospital of Capital Medical University Beijing (100053)China Beijing Geriatric Medical Research Center Beijing (100053)China Beijing Institute for Brain Disorders Beijing (100053)China Key Laboratory of Neurodegenerative Diseases of ministry of Education and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases Beijing (100053)China

Objective: To identify the differentially expressed microRNAs (miRNAs) profiles of yang and yin syndromes in patients with acute ischemic stroke, and to provide the molecular basis of the classification of these two syndrome types in acute ischemic stroke patients. Methods: A microarray assay was performed to assess the expression pattern of miRNAs in the lymphocyte of acute ischemic stroke patients. Target genes for the deregulated miRNAs were predicated using the online bioinformatic algorithms and functional annotation via Kyoto encyclopedia of genes and genomes pathway analysis for miRNAs predicted targets was carried out. Based on the predicted target genes of differentially expressed miRNAs, the miRNA-gene-network and miRNA-pathway network were constructed. Results: Yang score based on tongue texture, urine, dejecta, and appearance, etc. showed that clinical symptoms were distinct between yang and yin syndromes. There were significantly higher total leukocyte number and lower total protein level in patients with yang syndrome compared with those in patients with yin syndrome (P<0.05). Comprehensive miRNA analysis identified 36 unique down-regulated miRNAs in yang syndrome group, and 20 unique down-regulated and 2 unique up-regulated miRNAs in yin syndrome group. The key regulatory miRNAs, gene, and pathways in the yang syndrome were hsa-miR-93-5p and -320b, enabled homolog, the metabolic pathways and mitogen-activated protein kinase signaling pathways, respectively, while those in the yin syndrome were hsa-miR-424-5p and -106b-5p, CNOT4, hepatitis B and pathways in cancer, respectively. Conclusion: These results offered insight into the molecular basis underlying the different pathogenesis of yang or yin syndrome, providing clues for the individualized therapeutic strategies of acute ischemic stroke.

关键词： acute ischemic stroke yang syndrome yin syndrome microRNAs profile diagnosis Chinese medicine

纳米改性环氧树脂增强CFRP-混凝土体系粘结及滑移性能研究

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热固性树脂 2024年第2期39卷 23-29页

作者：冉洪宇张若兰雷真杨昌波罗煜民赵容晨云南大学建筑与规划学院云南昆明650032

为研究TiO_(2)/有机蒙脱土(OMMT)/环氧树脂(EP)复合材料对CFRP-混凝土界面粘结及滑移性能的影响,对TiO_(2)/OMMT/环氧复合材料配比进行优化并将其应用于CFRP-混凝土体系的双搭接剪切实验。结果表明:在OMMT/EP复合材料中加入适量的纳米Ti... 详细信息

为研究TiO_(2)/有机蒙脱土(OMMT)/环氧树脂(EP)复合材料对CFRP-混凝土界面粘结及滑移性能的影响,对TiO_(2)/OMMT/环氧复合材料配比进行优化并将其应用于CFRP-混凝土体系的双搭接剪切实验。结果表明:在OMMT/EP复合材料中加入适量的纳米TiO_(2)可显著提高蒙脱土的剥离程度,当填料(TiO_(2)+OMMT)的质量分数为2%时,复合材料的拉伸强度、断裂伸长率以及冲击强度分别为纯环氧树脂的153.06%、159.09%和159.19%。作为胶粘剂用于CFRP-混凝土体系时,TiO_(2)/OMMT/EP复合材料增强了纤维与混凝土基体之间的界面附着力及载荷传递,从而提高了界面的极限承载力。与纯环氧树脂双剪试件相比,CFRP-混凝土界面的粘结强度和界面断裂能分别提升了129.83%和168.82%。引入纳米改性胶粘剂/CFRP-混凝土界面粘结综合影响系数α,建立了相应的CFRP-混凝土界面粘结-滑移模型,模型的计算曲线与实验曲线吻合较好。

关键词：二氧化钛蒙脱土纳米改性环氧树脂碳纤维增强复合材料混凝土粘结强度界面断裂能

An advanced 2D/3D g-C_(3)N_(4)/TiO_(2)@MnO_(2) multifunctional membrane for sunlight-driven sustainable water purification

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Nano Research 2024年第4期17卷 2368-2380页

作者： Fan yu Chunjia luo Xiaohan Niu min Chao Pengfei Zhang Luke Yan Polymer Materials&Engineering Department School of Materials Science&EngineeringChang’an UniversityXi’an 710064China Key Laboratory of Road Construction Technology and Equipment MOEChang’an UniversityXi’an 710064China School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an 710064China

Graphitic carbon nitride(g-C_(3)N_(4))nanosheets have attracted widespread interest in the construction of advanced separation ***,dense stacking and a single functionality have limited the membrane ***,an advanced two-/three-dimensional(2D/3D)g-C_(3)N_(4)/TiO_(2)@MnO_(2) membrane is constructed by intercalating 3D TiO_(2)@MnO_(2) nanostructures into g-C_(3)N_(4) *** 3D flower-like nanostructures broaden the transport channels of the composite *** membrane can effectively separate five oil-in-water(O/W)emulsions,with a maximum flux of 3265.67±15.01 L·m^(-2)·h^(-1)·bar^(-1) and a maximum efficiency of 99.69%±0.45%for toluene-in-water emulsion(T/W).Meanwhile,the TiO_(2)@MnO_(2) acts as an excellent electron acceptor and provides positive spatial separation of electrons–holes(e^(-)–h^(+)).The formation of 2D/3D heterojunctions allows the material with wider light absorption and smaller bandgap(2.10 eV).These photoelectric properties give the membrane good degradation of three different pollutants,with about 100%degradation for methylene blue(MB)and malachite green(MG).The photocatalytic antibacterial efficiency of the membrane is also about 100%.After cyclic experiment,the membrane maintains its original separation and photocatalytic *** remarkable multifunctional and self-cleaning properties of the g-C_(3)N_(4) based membrane represent its potential value for complex wastewater treatment.

关键词： graphitic carbon nitride(g-C_(3)N_(4))based membrane three-dimensional(3D)nanostructures self-cleaning multifunction

Study on viscosity mechanism of caffeine crystallization solutions Author links open overlay panel

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Particuology 2024年第8期91卷 341-350页

作者： Linjing yu min Su School of Chemical Engineering Hebei University of TechnologyTianjin300130China

The solid-liquid viscous system formed by high viscosity crystallization solution impacts the flow and separation ***,it is very important to study the viscosity mechanism to improve viscosity and regulate crystallization,ensuring a seamless production ***,the viscosity of crystallization solution was taken as the measurement parameter of caffeine as a model *** investigated the viscosity mechanism of caffeine crystallization solutions by combining experiment and *** results indicated that the weak interactions between caffeine and water result in increased viscosity of the caffeine crystallization ***,caffeine crystals possess elongated needle-like shapes,featuring a substantial specific surface ***,there isπ-πstacking occurring between the(200)crystal face and(110)crystal face,effectively fostering coalescence of the crystals towards the radial side of the crystal along its elongated axis,resulting in a more viscous crystallization *** results contribute to comprehending the viscosity mechanism of crystal systems and provide theoretical foundation to enhance engineering efficiency in crystallization.

关键词： Crystallization Caffeine Viscosity mechanism Molecular simulation

Short-time maritime target detection based on polarization scattering characteristics

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Journal of Systems Engineering and Electronics 2024年第1期35卷 55-64页

作者： CHEN Shichao luo Feng TIAN min Lyu Wanghan College of Computer and Information Engineering(College of Artificial Intelligence) Nanjing Tech UniversityNanjing 211816China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200China

In this paper,a detection method combining Cameron decomposition based on polarization scattering characteristics in sea clutter background is ***,the Cameron decomposition is exploited to fuse the radar echoes of full polarization channels at the data *** to the artificial material structure on the surface of the target,it can be shown that the non-reciprocity of the target cell is stronger than that of the clutter ***,based on the analysis of the decomposition results,a new feature with scattering geometry characteristics in polarization domain,denoted as Cameron polarization decomposition scattering weight(CPD-SW),is extracted as the test statistic,which can achieve more detailed descriptions of the clutter scattering characteristics utilizing the difference between their scattering ***,the superiority of the proposed CPD-SW detector over traditional detectors in improving detection performance is verified by the IPIX measured dataset,which has strong stability under short-time observation in threshold detection and can also improve the separability of feature space zin anomaly detection.

关键词： sea clutter small target radar detection Cameron decomposition characteristics analysis

Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 79-89页

作者： Ao-Han Li Su Bu Ling Wang Ai-min Liang Hui-yu luo Department of Anesthesiology Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Cardiothoracic Surgery Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Rehabilitation Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Internal Medicine-Cardiovascular Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina

BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric ***,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this *** To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric *** A total of 80 patients were involved in this *** subjects were divided into two groups:Propofol group and sevoflurane *** evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also *** The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane ***,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol *** sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol ***,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol *** Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric *** anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative *** anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental ***,the selection of anesthetic agents should be based on the individual patient's specific circumstances.

关键词： Propofol Sevoflurane Radical resection of gastric cancer Anesthetic effect Cognitive function Negative emotion

Characteristics of Paleontological Communities in Surface Sediments of the Southern South China Sea and Their Paleoclimatic and Paleoenvironmental Significance

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Journal of Earth Science 2024年第1期35卷 144-154页

作者： Jing Zhao Li Zhang Xiaoyan Wang Jinglian Ge min Xu Wei Chen Mao luo Qianyong Liang Qiuhua yu Shuaibing luo Wenkun Qie Key Laboratory of Marine mineral Resoures Ministry of Natural ResourcesGuangzhou Marine Geological SurveyChina Geological SurveyGuangzhou 511458China National Engineering Research Center for Gas Hydrate Exploration and Development Guangzhou 511458China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China

Understanding the spatial and temporal distribution of different paleontological communities in the southern South China Sea(SCS)is fundamental to explore its paleoclimatic and paleoenvironmental *** this study,foraminifera,pollen and diatoms from 100 surface sediment samples covering 40000 km^(2) of sea floor in the southern SCS were comprehensively investigated in terms of their assemblage and *** results showed the existence of abundant foraminifera and pollen in most of the samples,although diatom communities were relatively *** were dominated by ***,***,***,while diatoms were characterized by ***,*** and ***,indicating a typical tropical marine *** pollen assemblages showed a better reflection of montane rainforest,tropical rainforest and *** spatial differences among foraminifera assemblages may indicate the effect of water depth and a warmer environment in the southeast part of the study area,while the spatial patterns of diatom and pollen assemblages imply the influence of coastal *** study also noted that the compositions of paleontological communities in the SCS can vary significantly in a short distance,and synthesized studies on multiple biological groups are needed to reconstruct the Quaternary climate and the oceanographic environment.

关键词： southern South China Sea sediments foraminifera diatom pollen

Monte Carlo method for evaluation of surface emission rate measurement uncertainty

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Nuclear Science and Techniques 2024年第7期35卷 126-136页

作者： yuan-Qiao Li min Lin Li-Jun Xu Rui luo yu-He Zhang Qian-Xi Ni yun-Tao Liu China Institute of Atomic Energy Beijing102413China National Key Laboratory for Metrology and Calibration Techniques Beijing102413China Department of Radiation Oncology Hunan Cancer HospitalChangsha410031China The Affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha410031China

The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter *** study used the Monte Carlo method (MCM) to validate the conventional Guide to the Expression of Uncertainty in Measurement (GUM) method.A dead time measurement model for the two-source method was established based on the characteristics of a single-channel measurement system,and the voltage threshold correction factor measurement function was indirectly obtained by fitting the threshold correction *** uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of *** MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized with a complete and complex mathematical *** results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty’s consistency E_(n)<0.070 for the comparison of each source,and the uncertainty results of the GUM were all lower than those of the ***,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.

关键词： Surface emission rate Monte Carlo method Metrology Probability distribution function Dead time Low-energy loss correction Least-squares method