检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

FROM THE EDITOR

Journal of Innovative Optical Health Sciences 2008年第1期1卷 I0001-I0002页

作者： qingming luo 不详

Welcome to the inaugural issue of the Journal of Innovative Optical Health *** the past decades,we have witnessed how the combination of photonics and health sciences has benefited and touched our *** products and techniques such as spectroscopy,lasers,microscopy,imaging and fiber optics,the science of biomedical photonics has shown great potential in solving clinical and research problems in diverse *** this consideration,the JIOHS has been founded to serve as an international forum for the publication of the latest developments in all areas of biomedical photonics.

关键词： fiber EDIT optics

Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer’s disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2023年第5期16卷 7459-7469页

作者： Liding Zhang Ying Su Xiaohan Liang Kai Cao qingming luo Haiming luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology(HUST)Wuhan 430074China MoE Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical EngineeringHainan UniversityHaikou 570228China Research Unit of Multimodal Cross Scale Neural Signal Detection and Imaging Chinese Academy of Medical SciencesHUST-Suzhou Institute for BrainsmaticsJiangsu Industrial Technology Research Institute(JITRI)Suzhou 215123China

Phosphorylation of tau at Ser(396,404)(p-tau^(396,404))is one of the earliest phosphorylation events,plasma p-tau^(396,404) level appears to be a potentially promising biomarker of Alzheimer’s disease(AD).The low abundance and easy degradation of p-tau in the plasma make the lateral flow assay(LFA)a suitable choice for point-of-care detection of plasma p-tau^(396,404) ***,based on our screening of a pair of p-tau^(396,404)-specific antibodies,we developed a colorimetric and surface-enhanced Raman scattering(SERS)dual-readout LFA for the rapid,highly sensitive,robust detection of plasma p-tau^(396,404) *** LFA realized a detection limit of 60 pg/mL by the naked eye or 3.8 pg/mL by SERS without cross-reacting with other tau *** importantly,LFA rapidly and accurately differentiated AD patients from healthy controls,suggesting that it has the potential for clinical point-of-care application in AD *** dual-readout LFA has the advantages of simple operation,rapid,ultra-sensitive detection,providing a new way for early AD diagnosis and intervention,especially in primary and community AD screening.

关键词： Alzheimer’s disease p-tau^(396,404) plasma detection surface-enhanced Raman scattering lateral flow assay

Constructing the rodent stereotaxic brain atlas:a survey

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2022年第1期65卷 93-106页

作者： Zhao Feng Anan Li Hui Gong qingming luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMOE Key Laboratory for Biomedical PhotonicsHuazhong University of Science and TechnologyWuhan 430074China HUST-Suzhou Institute for Brainsmatics Suzhou 215123China School of Biomedical Engineering Hainan UniversityHaikou 570228China

The stereotaxic brain atlas is a fundamental reference tool commonly used in the field of *** we provide a brief history of brain atlas development and clarify three key conceptual elements of stereotaxic brain atlasing:brain image,atlas,and *** also refine four technical indices for evaluating the construction of atlases:the quality of staining and labeling,the granularity of delineation,spatial resolution,and the precision of spatial location and ***,we discuss state-of-the-art technologies and their trends in the fields of image acquisition,stereotaxic coordinate construction,image processing,anatomical structure recognition,and publishing:the procedures of brain atlas *** believe that the use of single-cell resolution and micron-level location precision will become a future trend in the study of the stereotaxic brain atlas,which will greatly benefit the development of neuroscience.

关键词： brain atlas stereotaxic cytoarchitecture brainsmatics

ACCURATELY DETERMINING PROPAGATION VELOCITY OF CORTICAL SPREADING DEPRESSION IN RATS BY OPTICAL INTRINSIC SIGNAL IMAGING

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2010年第2期3卷 103-108页

作者： XIAOLI SUN PENGCHENG LI WEIHUA luo BIYING GONG qingming luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 P.R.China

Cortical spreading depression(CSD)is a wave of neuronal and glial depolarization that propagates across the cortex at a rate of 2–5mm/min accompanied by reversible electroencephalogram(EEG)suppression,a negative shift of direct current(DC)potential,and change of optical intrinsic signals(OIS).Propagation velocity of CSD is an important parameter used to study this *** is commonly determined in an electrophysiological way that measures the time required for a CSD wave to pass along two *** the electrophysiology technique fails to reveal the spreading pattern of CSD,velocity calculated in this manner might be *** this study,we combined the electrophysiological recording and OIS imaging(OISI)for detecting changes in DC potential and OIS during CSD *** optical method based on OISI to determine the CSD velocity,which is measured by generating a series of regions of interest(ROI)perpendicular to the advancing wavefront along propagation direction of CSD at different time points and then dividing by the distance between ROIs over time,is *** of the accuracy of the two approaches in determining the CSD velocity is made as *** average rate of 33 CSDs is 3.52±0.87mm/min by use of the optical method and 4.36±1.65mm/min by use of the electrophysiological *** of the information about spreading pattern of CSD provided optically,the velocity determined by OISI is of smaller deviation and higher accuracy.

关键词： Cortical spreading depression velocity optical intrinsic signal imaging electrophysiology accuracy

ASSESSING WORKING MEMORY IN REAL-LIFE SITUATIONS WITH FUNCTIONAL NEAR-INFRARED SPECTROSCOPY

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2009年第4期2卷 423-430页

作者： TING LI LI LI qingming luo HUI GONG Britton Chance Center for Biomedical Photonics National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 P.R.China

Working memory is one of the most important functions in our brain,which has been widely studied with unreal-life measured technologies.A functional near-infrared spectroscopy(fNIRS)instrument with a portable and low-cost design is developed,which is capable of providing hemodynamic measurement associated with brain function in real-life *** this instrument,we performed working memory studies involved in Chinese words encoding,verbal,and spatial stem recognition,which are mainly studied with other *** results show that fNIRS can well assess working memory activities,in comparison with the reported results mainly using other ***,we find that hemodynamic change in the prefrontal cortex during all working memory tasks is highly associated with subjects’behavioral *** is shown to be a promising alternative to the current methodologies for studying or assessing functional brain activities in natural condition.

关键词： Functional near-infrared spectroscopy(fNIRS) working memory prefrontal cortex(PFC) oxy-hemoglobin deoxy-hemoglobin

IMPROVE OPTICAL CLEARING OF SKIN IN VITRO WITH PROPYLENE GLYCOL AS A PENETRATION ENHANCER

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2009年第3期2卷 269-278页

作者： ZHONGWEI ZHI ZHENZHEN HAN qingming luo DAN ZHU Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China

In order to enhance the optical clearing effect of topically applied optical clearing agents(OCAs),we evaluated the effect of propylene glycol(PG)as a chemical penetration enhancer(PE)on optical clearing of skin in vitro by observation and measurement of optical-transmittance and diffuse-reflectance *** OCAs,i.e.,glycerol,D-sorbitol and PEG400,and two other penetration enhancers,Azone and Thiazone,were used in this *** results indicated that the decrease of reduced scattering coefficient caused by OCA/PG was larger than that by pure OCA,and the change by OCA/water was the least after the same treatment *** were significant differences for the reduced scattering coefficient at 630 nm after 120 min application of agents between OCA and OCA/*** efficacy of optical clearing caused by OCA/PG depended on the OCA *** PEG400 was mixed with three different PEs,we found the optical clearing were *** penetration enhancing ability of PG was much better compared to Azone,and suboptimal to ***,this study provides evidence for the use of PG as a PE in order to improve skin optical clearing.

关键词： Skin penetration enhancer propylene glycol optical clearing agent.

Femtosecond pulse laser scanning using Acousto-Optic Deflector

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2009年第5期52卷 685-692页

作者： ZENG ShaoQun luo qingming LI DeRong Lü XiaoHua Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China

Acousto-optic modulation of the femtosecond laser beam has wide potential in various fields such as microscopic imaging, micromachining and optical storage because of its rapidity, high accuracy and good repeatability. This paper reviews the latest research on acousto-optic modulation of femtosecond laser, describes the effects of spatial and temporal dispersion of such lasers after acousto-optic modulation, introduces the theoretical outcomes on pulse width evolution of the Gaussian laser pulses after acousto-optic modulation, discusses the characteristics of contemporary dispersion-compensating techniques for the acousto-optic modulation of femtosecond laser, and finally refers to the challenges of this technique.

关键词： femtosecond laser acousto-optic modulation dispersion microscopic imaging laser machining optical storage

Challenges of Processing and Analyzing Big Data in Mesoscopic Whole-brain Imaging

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2019年第4期17卷 337-343页

作者： Anan Li Yue Guan Hui Gong qingming luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China MOE Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China HUST-Suzhou Institute for Brainsmatics JITRI Institute for BrainsmaticsSuzhou 215125China

The brain is recognized as the most complex organ on *** complex neuronal network in the human brain consists of approximately 86 billion neurons and more than one hundred trillion connections[1].Even the mouse brain,which is commonly used as a model in neuroscience studies,contains more than 71 million *** the great efforts made by the neuroscientists,our knowledge about the brain is still limited and studies on small model animals have only provided preliminary results[2–4].To improve the situation,brainsmatics studies try to accelerate neuroscience research by providing a standard whole-brain spatial coordinate system and standardized labeling tools,imaging the brain,as well as discovering new neuronal cell types,neuronal circuits,and brain vascular structures.

关键词： Whole spite coordinate

GRAPHICS PROCESSING UNIT CLUSTER ACCELERATED MONTE CARLO SIMULATION OF PHOTON TRANSPORT IN MULTI-LAYERED TISSUES

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2012年第2期5卷 1-9页

作者： CHAO JIANG HENG HE PENGCHENG LI qingming luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China Key Laboratory of Biomedical Photonics of Ministry of Education Huazhong University of Science and Technology Wuhan 430074 China

We present a graphics processing unit(GPU)cluster-based Monte Carlo simulation of photon transport in multi-layered *** cluster is composed of multiple computing nodes in a local area network where each node is a personal computer equipped with one or several GPU(s)for parallel *** this study,the MPI(Message Passing Interface),the OpenMP(Open Multi-Processing)and the CUDA(Compute Unified Device Architecture)technologies are employed to develop the *** is demonstrated that this designing runs roughly N times faster than that using single GPU when the GPUs within the cluster are of the same type,where N is the total number of the GPUs within the cluster.

关键词： Photon transport in tissues Monte Carlo simulation GPU cluster