ACCURATELY DETERMINING PROPAGATION VELOCITY OF CORTICAL SPREADING DEPRESSION IN RATS BY OPTICAL INTRINSIC SIGNAL IMAGING
准确地确定皮层抑制的传播速度大鼠光内源信号成像出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2010年第3卷第2期
页 面：103-108页
核心收录：
基 金：This work is supported by the National High Technology Research and Development Program of China(Grant No.2007AA02Z303) the National Natural Science Foundation of China(Grant No.30970964,30801482,30800313) the Program for New Century Excellent Talents in University(Grant No.NCET-08-0213) the Ph.D.Programs Foundation of Ministry of Education of China(Grant No.20070487058,20090142110054)
主 题：Cortical spreading depression velocity optical intrinsic signal imaging electrophysiology accuracy
摘 要：Cortical spreading depression(CSD)is a wave of neuronal and glial depolarization that propagates across the cortex at a rate of 2–5mm/min accompanied by reversible electroencephalogram(EEG)suppression,a negative shift of direct current(DC)potential,and change of optical intrinsic signals(OIS).Propagation velocity of CSD is an important parameter used to study this *** is commonly determined in an electrophysiological way that measures the time required for a CSD wave to pass along two *** the electrophysiology technique fails to reveal the spreading pattern of CSD,velocity calculated in this manner might be *** this study,we combined the electrophysiological recording and OIS imaging(OISI)for detecting changes in DC potential and OIS during CSD *** optical method based on OISI to determine the CSD velocity,which is measured by generating a series of regions of interest(ROI)perpendicular to the advancing wavefront along propagation direction of CSD at different time points and then dividing by the distance between ROIs over time,is *** of the accuracy of the two approaches in determining the CSD velocity is made as *** average rate of 33 CSDs is 3.52±0.87mm/min by use of the optical method and 4.36±1.65mm/min by use of the electrophysiological *** of the information about spreading pattern of CSD provided optically,the velocity determined by OISI is of smaller deviation and higher accuracy.
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