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粉防己碱对脂多糖诱导下RAW264.7细胞COX-2/PGE_2、iNOS/NO表达的影响

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中国药科大学学报 2011年第2期42卷 141-144页

作者：赵恒光罗福玲重庆医科大学附属第一医院重庆400016

本实验旨在观察粉防己碱(Tet)对脂多糖(LPS)诱导下RAW264.7细胞炎症模型的抗炎作用。采用LPS1μg/mL刺激生长良好的RAW264.7巨噬细胞建立细胞炎症模型。在不同浓度Tet(1×10-8,1×10-7,1×10-6 mol/L)作用下,用Western blotting检测各... 详细信息

本实验旨在观察粉防己碱(Tet)对脂多糖(LPS)诱导下RAW264.7细胞炎症模型的抗炎作用。采用LPS1μg/mL刺激生长良好的RAW264.7巨噬细胞建立细胞炎症模型。在不同浓度Tet(1×10-8,1×10-7,1×10-6 mol/L)作用下,用Western blotting检测各组细胞中环加氧酶-2(COX-2)和诱导性一氧化氮激酶(iNOS)的表达,用NO检测试剂盒检测细胞培养液中NO的含量,酶免疫分析法检测培养液中前列腺素E2(PGE2)含量。结果显示Tet剂量依赖性地抑制LPS诱导的RAW264.7细胞PGE2、NO的表达,同时抑制其合成酶COX-2和iNOS的表达。表明Tet具有抑制LPS诱导的RAW264.7细胞炎症反应的作用,其抗炎机制可能通过抑制COX-2、iNOS的表达,从而抑制其下游炎性介质NO、PGE2的表达有关。

关键词：粉防己碱环加氧酶-2 诱导性一氧化氮激酶一氧化氮前列腺素E2

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《野性的呼唤》之生态批评观解读

闽江学院学报 2011年第3期32卷 55-59页

作者：罗付灵福建生物工程职业技术学院福建福州350002

《野性的呼唤》是杰克.伦敦在20世纪初发表的一部长篇小说,也是他的成名作。在21世纪的今天,我们关注全球日益严重的生态问题的同时,以当今的"生态批评观"理论来分析透视作者在该小说中对人性本身、人与自然的关系所做的哲学思考与探索... 详细信息

《野性的呼唤》是杰克.伦敦在20世纪初发表的一部长篇小说,也是他的成名作。在21世纪的今天,我们关注全球日益严重的生态问题的同时,以当今的"生态批评观"理论来分析透视作者在该小说中对人性本身、人与自然的关系所做的哲学思考与探索,从中感受到他所提倡的重返自然的生活,恢复和重建人与人之间、人与自然之间的和谐稳定融洽之关系的种种设想,仍能起到现实的有益的借鉴和启发作用。

关键词：《野性的呼唤》生态批评观解读

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大学英语翻译教学之“跨文化交际”分析

成都大学学报（教育科学版） 2008年第7期22卷 69-72页

作者：罗付灵福建生物工程职业技术学院福建福州350002

人类文化及语言的共性奠定了语言互译的可能性,这是翻译的前提。但文化和语言的个性与差异是客观存在的,它又给翻译造成障碍和局限。翻译常被称为"跨文化交际的特殊形式",需要翻译者在熟悉自己的母语的同时,还要掌握相当多的与目的语相... 详细信息

人类文化及语言的共性奠定了语言互译的可能性,这是翻译的前提。但文化和语言的个性与差异是客观存在的,它又给翻译造成障碍和局限。翻译常被称为"跨文化交际的特殊形式",需要翻译者在熟悉自己的母语的同时,还要掌握相当多的与目的语相关的语言文化知识。在大学英语翻译教学中,教师要特别重视学生"跨文化交际",对中英文化的词汇、句型等进行异同比较:注意诠释词语的文化内涵和外延及联想,让学生掌握词语的文化内涵和外延及联想后,能在翻译中恰当地运用;注重从句式中的意合与形合、从大到小与从小到大、已知与未知、被动与主动、人称与物称、谓语动词的使用、物主代词和冠词的使用及具体动态与抽象静态等的表现手法和翻译手段进行差异分析,帮助学生学会正确翻译。

关键词：跨文化交际大学基础英语翻译教学

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英语谚语跨文化交际语境分析及其汉译策略

沈阳农业大学学报（社会科学版） 2014年第5期16卷 622-625页

作者：罗付灵福建生物工程职业技术学院公共基础部福建福州350002

本研究从跨文化交际的视角,在自然地理环境、宗教文化、民族习俗、历史文学、价值观和思维方式等六种英汉谚语形成的语境进行多维度对比分析,总结出用直译、意译、直译加意译、注释翻译、对称翻译和特殊句型翻译六种具体的策略来汉译英... 详细信息

本研究从跨文化交际的视角,在自然地理环境、宗教文化、民族习俗、历史文学、价值观和思维方式等六种英汉谚语形成的语境进行多维度对比分析,总结出用直译、意译、直译加意译、注释翻译、对称翻译和特殊句型翻译六种具体的策略来汉译英语谚语,以期能恰当地理解和运用谚语,使语言生动活泼风趣,增强表现力,助益于跨文化交流。

关键词：跨文化交际学语境英语谚语汉译

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内毒素耐受机制的研究进展

生理科学进展 2006年第4期37卷 319-324页

作者：罗福玲万敬员周岐新重庆医科大学重庆市生物化学与分子药理学重点实验室重庆400016

内毒素耐受(endotoxin tolerance)早在50多年前就已经引起人们的关注,但其具体的分子机制至今尚不清楚。Toll样受体4(Toll-like receptor-4,TLR4)作为脂多糖(LPS)的主要受体,参与LPS信号的跨膜转导,与LPS耐受密切相关。在内毒素耐受过程... 详细信息

内毒素耐受(endotoxin tolerance)早在50多年前就已经引起人们的关注,但其具体的分子机制至今尚不清楚。Toll样受体4(Toll-like receptor-4,TLR4)作为脂多糖(LPS)的主要受体,参与LPS信号的跨膜转导,与LPS耐受密切相关。在内毒素耐受过程中,TLR4转导通路中的信号蛋白及下游转录因子在数量、结构和功能上发生改变,可引起炎性因子释放减少、抗炎因子产生增加,并导致特定信号通路(如PI3K通路)和负性调节因子(如SHIP1、SOCS、FLN29等)的激活。除此之外,TLR2通路、G i蛋白、蛋白激酶C(protein kinase C,PKC)以及一些信号分子的剪接异构体等也参与了内毒素耐受现象的发生。总之,内毒素耐受是一个由多种原因引起的、多种生物物质参与的复杂病理生理过程,是机体抵抗G-细菌感染的重要保护机制。因此,探索内毒素耐受的机制,寻求机体内源性的抗炎机制将为败血症等一些致死性感染性疾病的治疗提供新的思路和理论依据。

关键词：脂多糖内毒素耐受性 Toll样受体信号转导

UVA1联合复方倍他米松注射液治疗瘢痕疙瘩疗效观察

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中国皮肤性病学杂志 2011年第4期25卷 278-279页

作者：赵恒光罗福玲李惠重庆医科大学附属第一医院皮肤科重庆400016 重庆医科大学附属第一医院药剂科重庆400016

目的探讨长波紫外线1（ultraviolet A1,UVA1）照射联合复方倍他米松注射液治疗瘢痕疙瘩的疗效。方法实验组予复方倍他米松注射液0.10-0.15mL/cm^2于瘢痕皮损内注射,1次/月,同时予以UVA1照射,隔日1次,初始剂量46.8J/cm^2,最大剂量93.6J/c... 详细信息

目的探讨长波紫外线1（ultraviolet A1,UVA1）照射联合复方倍他米松注射液治疗瘢痕疙瘩的疗效。方法实验组予复方倍他米松注射液0.10-0.15mL/cm^2于瘢痕皮损内注射,1次/月,同时予以UVA1照射,隔日1次,初始剂量46.8J/cm^2,最大剂量93.6J/cm^2;对照组仅予复方倍他米松注射液治疗。两组均连续治疗2-4月,治疗结束后10-12周时评价疗效。共随访9个月。结果治疗组总有效率（78.13%）显著高于对照组（62.16%）,差异有统计学意义（P=0.043）。但治疗组有6例在大剂量照射时（78J/cm^2）出现局部红肿等不良反应,而对照组无该现象。结论 UVA1联合复方倍他米松注射液治疗瘢痕疙瘩能显著促进其临床症状改善,但高剂量时可能具有一定的皮肤刺激反应。

关键词： UVA1 复方倍他米松瘢痕疙瘩

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun lingyun Nie Jing Zhang Xue Fang Hongmei luo Chuanhai fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-ling Liao Xiao-Li Pu Zhi-Yi Zheng Jie luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(Pfunctional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

Continuous high-temperature rapid nanomanufacturing of electrocatalysts

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Nano Research 2025年第1期18卷 225-235页

作者： Xiaoyang Wang Ziyi luo Baihua Cui Ziqi fu Yanchang Liu Weidi Liu Jia Ding Jianrong Zeng Yanan ChenWenbin Hu School of Materials Science and Engineering Tianjin UniversityTianjin 300350China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt.LuciaBrisbane 4072Australia Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

Encapsulating metal nanoparticles in carbon shells(Metal@C)to enhance catalytic activity and stability has been certified ***,most existing methods for preparing Metal@C are complex,time-consuming,and lack of *** this study,a novel method that couples the high-temperature shock(HTS)with ultrasonic spray pyrolysis is reported,which can realize facile and scalable production of various Metal@C through the pyrolysis of glucose and metal chloride *** proposed HTS ultrasonic spray pyrolysis offers several advantages,including compact size,short reaction time(~120 ms),and uniform *** the Ni@C-40 nanocomposite as an example,the ultrasmall Ni nanoparticles(~10 nm)with thin carbon protective shells(~2 nm)are uniformly dispersed in the carbon matrix and applied for oxygen evolution reaction(OER)in alkaline *** Ni@C-40 optimized by tuning the thickness of carbon shell exhibits significantly enhanced OER activity with low overpotential of 242 mV at 10 mA·cm^(-2) and stability,which is attributed to the optimized interactions between Ni nanoparticles and carbon *** method also shows promise for continuous pyrolysis synthesis of various extreme materials at ultra-high temperatures using alternative electric heating materials.

关键词： ultrasonic spray pyrolysis high-temperature shock carbon shell oxygen evolution reaction Metal@C nanocomposite