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Development of AR-V7 as a putative treatment selection marker for metastatic castration-resistant prostate cancer

Asian Journal of Andrology 2016年第4期18卷 580-585页

作者： jun luo Department of Urology James Buchanan Brady Urological Institute Johns Hopkins University Baltimore MD USA.

Prostate cancer cells demonstrate a remarkable ＂addiction＂ to androgen receptor （AR） signaling in all stages of disease progression. As such, suppression of AR signaling remains the therapeutic goal in systemic treatment of prostate cancer. A number of molecular alterations arise in patients treated with AR-directed therapies. These molecular alterations may indicate the emergence of treatment resistance and may be targeted for the development of novel agents for prostate cancer. The presence of functional androgen receptor splice variants may represent a potential explanation for resistance to abiraterone and enzalutamide, newer AR-directed agents developed to treat metastatic castration-resistant prostate cancer （mCRPC）. In the last 8 years, many androgen receptor splice variants have been identified and characterized. Among these, androgen receptor splice variant-7 （AR-V7） has been investigated extensively. In AR-V7, the entire COOH-terminal ligand-binding domain of the canonical AR is truncated and replaced with a variant-specific peptide of 16 amino acids. Functionally, AR-V7 is capable of mediating constitutive nuclear localization and androgen receptor signaling in the absence of androgens, or in the presence of enzalutamide. In this review, we will focus on clinical translational studies involving detection/measurement of AR-V7. Methods have been developed to detect AR-V7 in clinical mCRPC specimens. AR-V7 can be reliably measured in both tissue and circulating tumor cells derived from mCRPC patients, making it possible to conduct both cross-sectional and longitudinal clinical correlative studies. Current evidence derived from studies focusing on detection of AR-V7 in mCRPC support its potential clinical utility as a treatment selection marker.

关键词： androgen receptor androgen receptor splice variant-7 (AR-V7) castration-resistance prostate cancer circulating tumorcells treatment selection

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Effect of Au film pre-deposited at different durations as inner electrode on the electrical properties and interface microstructures of Na_2O-PbO-Nb_2O_5-SiO_2 multi-layer glass-ceramic capacitors

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Acta Metallurgica Sinica(English Letters) 2011年第6期24卷 449-456页

作者： jun ZHU jun luo Qingmeng ZHANG jun DU Advanced Electronic Materials Institute General Research Institute for Nonferrous Metals Beijing 100088 China

To further study the effect of sputtered Au film as transition electrode layer on the electrical properties and interface microstructures of Na20-PbO-Nb2O5-SiO2 multilayer glass-ceramic capacitors, Au films pre-deposited at different time were prepared by DC magnetron sputtering. Compared with the single paste electrode structure, samples with Au films pre-deposited from 6 to 18 min have the consistent perfor- mance to effectively improve the electrical properties of the capacitors, resulting in the doubled breakdown strength, an increase of equivalent capacitance by 22% and a decrease of leakage current by an order of magnitude. SEM observations indicate that the Au films with deposition time from 6 to 18 min would all help the formation of a dense electrode/dielectric interface and inhibit the diffusion of Ag. The results reveal that Au film pre-deposited for 6 min as inner electrode was sufficient to improve the interface microstructure and therefore to inhibit the Ag diffusion and enhance the overall performance of the multi-layer glass-ceramic capacitors.

关键词： Inner electrode Deposition time Glass-ceramic Multi-layer capacitor

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Effect of magnetic field on dislocation morphology and precipitation behaviour in ultrafine-grained 7075 aluminium alloy

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Journal of Materials Science & Technology 2021年第34期93卷 128-146页

作者： jun luo Hongyun luo Tianshu Zhao Runze Wang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100191China

The influence of magnetic field(1 T)on dislocation morphology and precipitation behaviour of ultrafinegrained(UFG)Al 7075 alloy was investigated after ageing from 90 to 200℃ via wide angle X-ray scattering(WAXS),small angle X-ray scattering(SAXS),and transmission electron microscopy(TEM).Experimental results reveal that the improved precipitation kinetics of alloys in the thickness plane(denoted as sample II)as compared to those in the rolling plane(denoted as sample I),which arises due to a higher dislocation density(morphology of dislocation cells)of the thickness plane than that of the rolling plane(morphology of dislocations and dislocation tangles).Specifically,because of different dislocation morphologies,the magnetic field positively and negatively affects the dislocation activity in samples I and II,leading to enhanced and suppressed precipitation behaviors,***,nucleation of theηphase is facilitated in the UFG alloy at the critical temperature(140℃)because it affords a faster rate of atom diffusion and a higher dislocation density as compared to those exhibited by its coarse-grained *** systematic and comprehensive study provides new insights into dislocation morphology and precipitation behaviour of the UFG 7075 Al alloy,while enabling the optimization of precipitation kinetics.

关键词： Ultrafine-grained Al alloy Precipitation behaviors Magnetic field Dislocation morphology Critical temperature

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Fokker-Planck Type Equations with Sobolev Diffusion Coefficients and BV Drift Coefficients

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Acta Mathematica Sinica,English Series 2013年第2期29卷 303-314页

作者： De jun luo Institute of Applied Mathematics Academy of Mathematics and Systems ScienceChinese Academy of Sciences

Combining Le Bris and Lions＇ arguments with Ambrosio＇s commutator estimate for BV vector fields, we prove in this paper the existence and uniqueness of solutions to the Fokker-Planck type equations with Sobolev diff... 详细信息

关键词： DiPerna-Lions theory Fokker-Planck equation stochastic differential equation BV reg-ularity commutator estimate

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Weakly Algebraic Ideal Topology of Effect Algebras

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Acta Mathematica Sinica,English Series 2015年第5期31卷 787-796页

作者： Qing jun luo Guo jun WANG School of Statistics Xi'an University of Finance and Economics School of Mathematics and Information Shaanxi Normal University

In this paper, we show that every weakly a uniform topology （weakly algebraic ideal topology, algebraic ideal of an effect algebra E induces for short） with which E is a first-countable, zero-dimensional, disconnected, locally compact and completely regular topological space, and the operation ＋ of effect algebras is continuous with respect to these topologies. In addition, we prove that the operation - of effect algebras and the operations A and V of lattice effect algebras are continuous with respect to the weakly algebraic ideal topology generated by a Riesz ideal.

关键词： Effect algebra weakly algebraic ideal uniform topology continuity

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A high-order multidimensional gas-kinetic scheme for hydrodynamic equations

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Science China(Technological Sciences) 2013年第10期56卷 2370-2384页

作者： luo jun XU Kun Mathematics Department Hong Kong University of Science and TechnologyClear Water BayKowloon Hong Kong China

This paper concerns the development of high-order multidimensional gas kinetic schemes for the Navier-Stokes *** the current approach,the state-of-the-art WENO-type initial reconstruction and the gas-kinetic evolution model are used in the construction of the *** order to distinguish the physical and numerical requirements to recover a physical solution in a discretized space,two particle collision times will be used in the current high-order gas-kinetic scheme(GKS).Different from the low order gas dynamic model of the Riemann solution in the Godunov type schemes,the current method is based on a high-order multidimensional gas evolution model,where the space and time variation of a gas distribution function along a cell interface from an initial piecewise discontinuous polynomial is fully used in the flux *** high-order flux function becomes a unification of the upwind and central difference *** current study demonstrates that both the high-order initial reconstruction and high-order gas evolution model are important in the design of a high-order numerical ***,for a compact method,the use of a high-order local evolution solution in both space and time may become even more important,because a short stencil and local low order dynamic evolution model,i.e.,the Riemann solution,are contradictory,where valid mechanism for the update of additional degrees of freedom becomes limited.

关键词： WENO reconstruction gas-kinetic schemes Euler Navier-Stokes high-order methods

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Regularization by Noise for the Point Vortex Model of mSQG Equations

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Acta Mathematica Sinica,English Series 2021年第3期37卷 408-422页

作者： De jun luo Martin SAAL Key Laboratory of RCSDS Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190P.R.China School of Mathematical Sciences University of the Chinese Academy of SciencesBeijing 100049P.R.China Department of Mathematics TU DarmstadtSchlossgartenstr.764289 DarmstadtGermany

We consider the point vortex model associated to the modified Surface Quasi-Geostrophic(mSQG) equations on the two dimensional torus. It is known that this model is well posed for almost every initial conditions. We show that, when the system is perturbed by a certain space-dependent noise, it admits a unique global solution for any initial configuration. We also present an explicit example for the deterministic system on the plane where three different point vortices collapse.

关键词： Point vortices modified Surface Quasi-Geostrophic equations space-dependent noise absolute continuity

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Analytical Expression of Ampere’s Force Between Two Current Rings in a Compensated Torsion Balance

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Chinese Physics Letters 1994年第3期11卷 141-144页

作者： luo jun FAN Shuhua Center for Gravitational Experiment Huazhong University of Science and TechnologyWuhan 430074

An analytical expression of ampere’s force between two current rings in a compensated torsion balance is deduced here,the properties and stability of this force are *** result of numerical estimation for typical experimental parameters shows that the uncertainties of the force are smaller than 1×10^(-4) orders,which is very important for precise measurement of gravitational constant G.

关键词： torsion precise rings

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Target models and waveform design for detection in MIMO radar

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Science China(Information Sciences) 2014年第1期57卷 268-279页

作者： TANG jun luo jun TANG Bo DU JinSong Electronic Engineering Department of Tsinghua University China Marine Development & Research Center Shenyang Institute of Automation Chinese Academy of Sciences

In this paper,we propose a general target model for multiple-input multiple-output(MIMO)*** types of targets are *** each type of target,we develop a corresponding optimum waveform designing method to optimize detection *** on Chernof-Stein lemma,we use relative entropy as the performance *** show that the optimum waveform designing method can obtain better detection performance than traditional orthogonal waveform designing method.

关键词： MIMO radar waveform designing relative entropy

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A Novel Design of Efficient Multi-channel UART Controller Based on FPGA

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Chinese Journal of Aeronautics 2007年第1期20卷 66-74页

作者： HU Zhe ZHANG jun luo Xi-ling Department of Electronic Information Engineering BeO＇ing University of Aeronautics and Astronautics Beijing 100083 China

In traditional universal asynchronous receiver transmitter （UART） controller, the data transmission is inefficient and the data bus utilization ratio is low. A novel design is provided to solve these problems. The architecture of the system is introduced, the flow charts of data processing as well as the implementation state machine are also presented in detail. This paper is concluded by comparing the performance of this design, which is realized on field programmable gate army （FPGA） using Verilog hardware description language （HDL）, with other traditional UART controllers.

关键词： serial communication UART multi-channel FPGA

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