检索结果-南通市图书馆

Targeting ferroptosis and ferritinophagy:new targets for cardiovascular diseases

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 1-22页

作者： Yi luan Yang YANG Ying luan Hui LIU Han xing Jinyan PEI Hengdao LIU Bo QIN Kaidi REN Clinical Systems Biology Research Laboratories Translational Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of PhysicsPeking UniversityBeijing100871China School of Laboratory Medicine Xinxiang Medical UniversityXinxiang453003China Quality Management Department Henan No.3 Provincial People’s HospitalZhengzhou450052China Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Center for Translational Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Henan Key Laboratory of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou450052China Henan Engineering Research Center for Application&Translation of Precision Clinical Pharmacy Zhengzhou UniversityZhengzhou450052China

Cardiovascular diseases(CVDs)are a leading factor driving mortality worldwide.Iron,an essential trace mineral,is important in numerous biological processes,and its role in CVDs has raised broad discussion for decades.Iron-mediated cell death,namely ferroptosis,has attracted much attention due to its critical role in cardiomyocyte damage and CVDs.Furthermore,ferritinophagy is the upstream mechanism that induces ferroptosis,and is closely related to CVDs.This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy,and the regulatory pathways and molecular targets involved in ferritinophagy,and to determine their roles in CVDs.Furthermore,we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs.Collectively,this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.

关键词： Cardiovascular disease Iron Ferroptosis Ferritinophagy Therapeutic target

Demixing microwave signals using system-on-chip photonic processor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第3期13卷 399-401页

作者： sheng Gao Chu Wu xing Lin Department of Electronic Engineering Tsinghua University100084 BeijingChina Beijing National Research Center for Information Science and Technology Tsinghua University100084 BeijingChina

The integrated photonic processor,co-packaged with electronic peripherals,is proposed for blind source separation of microwave signals,which separates signal-of-interest from dynamic interference with real-time adapta... 详细信息

关键词： processor microwave mixing

Cohomology groups of a new class of Kadison-Singer algebras

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第3期67卷 593-606页

作者： Guangyu An xing Cheng Jun sheng School of Mathematics and Data Science Shaanxi University of Science and TechnologyXi’an 710021China

Let N be a maximal discrete nest on an infinite-dimensional separable Hilbert space H,ξ=∑^(∞)_(n=1)en/2n be a separating vector for the commutant N',E_(ξ)be the projection from H onto the subspace[Cξ]spanned by the vectorξ,and Q be the projection from K=H⊕H⊕H onto the closed subspace{(η,η,η)^(T):η∈H}.Suppose that L is the projection lattice generated by the projections(E_(ξ) 0 0 0 0 0 0 0 0),{(E 0 0 0 0 0 0 0 0):E∈N},(I 0 0 0 I 0 0 0 0) and Q.We show that L is a Kadison-Singer lattice with the trivial commutant.Moreover,we prove that every n-th bounded cohomology group H~n(AlgL,B(K))with coefficients in B(K)is trivial for n≥1.

关键词： Kadison-Singer algebra Kadison-Singer lattice derivation cohomology group

Oxidation behavior of low-grade vanadiferous titanomagnetite concentrate with high titanium

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2024年第2期31卷 329-341页

作者： Jin-sheng Liu Zhen-xing xing Gong-jin Cheng Xue-yong Ding Xiang-xin Xue School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Liaoning Key Laboratory of Recycling Science for Metallurgical Resources Shenyang110819LiaoningChina Innovation Research Institute of Vanadium and Titanium Resource Industry Technology Northeastern UniversityShenyang110819LiaoningChina

In order to clarify the oxidation mechanisms and make better use of the low-grade vanadiferous titanomagnetite concentrate with high titanium(LVTC),the oxidation behavior of LVTC was investigated.The results showed that oxidation degree was achieved within 90 min when temperature was not lower than 700°C,and the main phases of the oxidized LVTC consisted of Fe9TiO15,Fe2O3,CaSiTiO5 and a small amount of Fe2.75Ti0.25O4.Increasing temperature is favorable to the formation of Fe2TiO5.The surface of LVTC gradually becomes rough,with fine particles of needle-like and granular shape appearing on the surface,which finally turn from laminar to creamy,spread out,and are interspersed with many tiny holes.The phase oxidation paths in LVTC were as follows:(1)Fe2.75Ti0.25O4→Fe9TiO15+Fe2O3;(2)Fe2.75Ti0.25O4→Fe2O3+FeTiO3→Fe2TiO5;(3)FeTiO3→Fe2O3+Fe2Ti3O9→Fe2TiO5.LVTC is predominantly mesoporous whether oxidized or not,with the pores mainly distributed in the range of 2–40 nm,and the specific surface area of LVTC decreases significantly with increasing temperature.

关键词： Low-grade vanadiferous titanomagnetite concentrate Oxidation degree Phase transformation Micromorphology Oxidation path Pore structure

In-situ embedded ultrafine Bi_(12)O_(17)Br_(2)nanotubes in MOF-derived hierarchical porous carbon for enhanced photocatalytic CO_(2)conversion to CO

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第4期171卷 47-53页

作者： xing Sun Mengxia Ji Yi Zhang Qingzeng xing Zihan Liu Nianhua Liu Emmanuel Nkudede Huaming Li sheng Yin Jiexiang Xia School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu UniversityZhenjiang 212013China Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Provincial Key Laboratory of Resources Chemistry of Salt LakesQinghai Institute of Salt LakesChinese Academy of SciencesXining 81008China

Increasing the utilization efficiency of photogenerated electrons is highly recognized as one of the ef-ficient approaches to boost the photocatalytic CO_(2)conversion efficiency.Herein,ZIF-67-derived porous carbon(PC)material was employed for the construction of PC@ultrafine Bi_(12)O_(17)Br_(2)nanotubes(PC@BOB NTs)composites through a facile solvothermal synthesis in order to optimize the use of excited elec-trons in the BOB NTs.Photoelectrochemical characterization results revealed that the introduction of PC material achieved a faster charge separation rate in the PC@BOB composites,ensuring more photogener-ated electrons participate in the CO_(2)adsorption and activation process.Moreover,the pore structures of ZIF-67-derived PC material provided abundant confined spaces for the enrichment of CO_(2)molecules.Af-ter 5 h of Xenon lamp irradiation,PC@BOB composites exhibited obviously increased photocatalytic CO_(2)reduction activity in the pure water.When the addition amount of PC was 5 wt%,the PC@BOB-2 com-posite showed the highest CO evolution rate of 359.70μmol/g,which was 2.95 times higher than that of the pure BOB NTs.This work provides some independent insights into the applications of Metal-Organic Framework(MOF)-derived hierarchical porous structures to strengthen the CO_(2)enrichment,as well as the excited charge utilization efficiency,thus achieving a high solar-to-fuel conversion efficiency.

关键词： Bi_(12)O_(17)Br_(2)nanotubes Hierarchical porous structure CO_(2)enrichment Charge separation CO_(2)photoreduction

Microphase Separation of Semiflexible Ring Diblock Copolymers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第2期42卷 267-276,I0011页

作者： Dan-Yan Qin sheng-Da Zhao Zhi-Xin Liu Jing Zhang xing-Hua Zhang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing100044China

Aiming at the difficult problem of solving the conformation statistics of complex polymers, this study presents a novel and concise conformation statistics theoretical approach based on Monte Carlo and Neural Network method. This method offers a new research idea for investigating the conformation statistics of complex polymers, characterized by its simplicity and practicality. It can be applied to more complex topological structure, more higher degree of freedom polymer systems with higher dimensions, theory research on dynamic self-consistent field theory and polymer field theory, as well as the analysis of scattering experimental data. The conformation statistics of complex polymers determine the structure and response properties of the system. Using the new method proposed in this study, taking the semiflexible ring diblock copolymer as an example, Monte Carlo simulation is used to sample this ring conformation to construct the dataset of polymer. The structure factor describing conformation statistics are expressed as continuous functions of structure parameters by neural network supervised learning. This is the innovation of this work. As an application, the structure factors represented by neural networks were introduced into the random phase approximation theory to study the microphase separation of semiflexible ring diblock copolymers. The influence of the ring's topological properties on the phase transition behavior was pointed out.

关键词： Ring copolymer Diblock copolymers Semiflexible The order-disorder transition

Nitrogen-doped carbon dots as photocatalysts for organic synthesis:Effect of nitrogen content on catalytic activity

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 4825-4833页

作者： Kai-Kai Niu Chao-Qun Ma Rui-Zhi Dong Hui Liu sheng-sheng Yu Ling-Bao xing School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China

Regulating the doping of carbon dots(CDs)and the generation of reactive oxygen species(ROS)is essential to selectively control their application in photocatalytic organic reactions.This study successfully synthesized five newly developed nitrogen-doped carbon dots(CDs 1-5)with varying nitrogen content,which have the ability to generate ROS when exposed to light radiation,specifically superoxide anion radicals(O_(2)•-)and singlet oxygen(^(1)O_(2)).The utilization of the aforementioned nitrogen-doped CDs as photocatalysts enables the realization of their potential in facilitating efficient photocatalytic organic conversion.Simultaneously,it was observed that the photocatalytic efficiency exhibited a gradual decrease when the nitrogen content in the CDs increased.In order to provide more evidence for this claim,we employed a set of five CDs in the context of photocatalytic dehalogenation ofα-bromoacetophenone,photocatalytic oxidative coupling reaction of amines to imines,photooxidation reaction of sulfides to sulfoxides,and cross-dehydrogenation coupling(CDC)reaction,in which it was further observed that there was a steady decrease in the yields of photocatalytic organic reactions as the nitrogen content in CDs increased.Notably,CDs 1 exhibited the best photocatalytic efficiency,thereby reinforcing the hypothesis that a higher nitrogen content corresponds to a decreased catalytic efficiency.This study not only investigates the impact of the nitrogen content on the catalytic performance of CDs,but also offers valuable insights for the future utilization of CDs for photocatalytic organic reactions in water.

关键词： carbon dots nitrogen-doped reactive oxygen species photocatalysis

Treatment of bilateral developmental dysplasia of the hip joint with an improved technique:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第7期12卷 1320-1325页

作者： xing-xing Yu Jian-Ye Chen Hong-sheng Zhan Ming-Da Liu Yun-Fei Li Yu-Yan Jia College of Traditional Chinese Medicine Changchun University of Traditional Chinese MedicineChangchun 130117Jilin ProvinceChina Shi's Traumatology Medical Center Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China College of Traditional Chinese Medicine The Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina

BACKGROUND Developmental dysplasia of the hip(DDH)is a common osteoarticular deformity in pediatric orthopedics.A patient with bilateral DDH was diagnosed and treated using our improved technique"(powerful overturning acetabuloplasty)"combined with femoral rotational shortening osteotomy.CASE SUMMARY A 4-year-old girl who was diagnosed with bilateral DDH could not stand normally,and sought surgical treatment to solve the problem of double hip extension and standing.As this child had high dislocation of the hip joint and the acetabular index was high,we changed the traditional acetabuloplasty to"powerful turnover acetabuloplasty"combined with femoral rotation shortening osteotomy.During the short-term postoperative follow-up(1,3,6,9,12,and 15 months),the child had no discomfort in her lower limbs.After the braces and internal fixation plates were removed,formal rehabilitation training was actively carried out.CONCLUSION Our"powerful overturning acetabuloplasty"combined with femoral rotational shortening osteotomy is feasible in the treatment of DDH in children.This technology may be widely used in the clinic.

关键词： Developmental dysplasia of the hip Improved technique Case report

Nitrogen–sulfur co-doped porous carbon derived from asphalt as efficient catalyst for oxygen reduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第1期43卷 380-388页

作者： Jing-sheng Ma Ming-Zai Wu Ling Chen Li-xing Zhang Ying Xiong Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of EducationInstitute of EnergyHefei Comprehensive National Science CenterAnhui UniversityHefei 230601China

As an environment-friendly and low-cost petrochemical by-product, asphalt has great potential in the preparation of metal-free oxygen reduction electrocatalysts with excellent performance and outstanding stability. In this paper, we converted asphalt into porous carbon nanosheets by a simple activation method, using potassium citrate as the swelling agent.

关键词： stability porous catalyst