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Biocompatible hierarchical zwitterionic polymer brushes with bacterial phosphatase activated antibacterial activity

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Journal of Materials Science & Technology 2022年第31期126卷 191-202页

作者： Liwei Sun Lingjie Song Xu Zhang Shuaishuai Yuan Shifang luan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China Key Laboratory of Biobased Polymer Materials of Shandong Provincial Education Department College of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao 266042China National Engineering Laboratory for Medical Implantable Devices WEGO Co.Ltd.Weihai 264210China

Hierarchical polymer brushes have been considered as an effective and promising method for preventing implant-associated infections via multiple antibacterial ***,a bacterial phosphatase re-sponsive surface with hierarchical zwitterionic structures was developed for timely dealing with the poly-meric implant-associated bacterial *** hierarchical polymeric architecture was subtly realized on model polypropylene(PP)substrate by sequential photo living grafting of poly(2-(dimethylamino)ethyl methacrylate(PDMAEMA)bottom layer and zwitterionic poly(sulfobetaine methacrylate)(PSBMA)upper layer,followed by the conversion of the PDMAEMA into the zwitterionic structure via succes-sive quaternization and phosphorylation *** to shielding the bottom polycations,the hi-erarchical zwitterionic polymer brushes guaranteed the surface with the optimal biocompatibility under the normal physiological *** bacteria are invaded,the surface bactericidal activity of the bottom layer can be rapidly and automatically activated owing to the transition triggered by bacterial phosphatase from zwitterion to ***,ameliorated by the upper layer,the hierarchical surface showed obvious adhesion resistance to dead bacterial cells and notably migrated the cytotoxic-ity of exposed polycation after completion of the bactericidal *** a proof-of-principle demonstration,this self-adaptive hierarchical surface with sensitive bacterial responsiveness and biocompatibility showed great potential in combating hernia mesh-related *** work provides a promising and universal strategy for the on-demand prevention of medical device-associated infections.

关键词： Bacterial infection Self-adaptive surface Bactericidal Antifouling Hierarchical polymer brushes

Effect of long-period ordered stacking on twinning behavior and mechanical properties of Mg-Al-Y alloy during uniaxial hot compression

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Journal of Materials Science & Technology 2023年第11期142卷 152-166页

作者： Shuai Yuan Jinhui Wang Lei Zhang Shiyu luan Peipeng Jin Qinghai Provincial Key Laboratory of New Light Alloys Qinghai Provincial Engineering Research Center of High Performance Light Metal Alloys and FormingQinghai UniversityXining 810016China School of Material Science and Engineering Shenyang University of TechnologyShenyang 110870China

Two alloys with(T4-4h)and without(T4-8h)long-period stacking ordered(LPSO)phase were obtained by solution treatment of as-cast Mg-1Al-12Y alloy at 540℃ for 4 h and 8 h,*** compressive tests(300-450℃,ε=0.01s^(-1))showed that the strengthening effect of LPSO in T4-4h alloy gradually disappeared with temperature *** addition,the corresponding compression deformation behavior of the two alloys was also investigated by electron backscatter diffraction(EBSD).It was found that the twinning of the two alloys was dominated by{1012}extension twins,and the large amount of lamellar LPSO in T4-4 h alloy inhibited the activation and growth of ***[0001]//compression direction(CD)texture formed after deformation is mostly attributed to the activation and growth of extension *** analyzing the activated twin variants,it was found that the activation of twin variants mainly depended on Schmid factor(SF).For twin variants with smaller SF,they may be activated due to local stress *** on the analysis results of in-grain misorientation axis(IGMA)and SF,the deformation mechanism of the alloys at elevated temperature is dominated by basal slip and non-basal *** stronger mechanical properties of T4-4h alloy than those of T4-8h are attributed to the obstruction of non-basal slip movement by LPSO.

关键词： LPSO strengthening Hot deformation Twinning behavior

A Critical Review of Real Gas Effects on the Regenerative Refrigerators

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Journal of Thermal Science 2021年第3期30卷 782-806页

作者： CAO Qiang luan Mingkai LI Peng WEI Li WU Yan Institute of Refrigeration and Cryogenics School of Mechanical EngineeringTongji UniversityShanghai 201804China Shanghai Key Laboratory of Vehicle Aerodynamics and Vehicle Thermal Management Systems Tongji UniversityShanghai 201804China Department of Electrical Engineering School of Electronics and Information EngineeringTongji UniversityShanghai 201804China

The regenerative refrigeration is an important reverse work-heat conversion cycle with a theoretical coefficient of performance(COP)identical to the Carnot *** regenerative refrigerators are capable of working down to 4 K and largely fulfill the refrigeration requirement of modern technologies in many fields,especially for space ***,the enthalpy flow associated with the pressure dependence,abbreviated as pressure-induced enthalpy flow,brought about by real gas effects degrades the theoretical COP of the refrigerator to below about 30% of the Carnot efficiency at the temperatures of below the critical *** paper reviews the long history of exploring the real gas effects which dates back to the 1970 s and continues to *** explorations of uncovering the loss mechanism and reducing such losses are *** theories that are in accordance with experimental results and simulation results are *** further carry out analyses on the expansion components,including the pulse tube and the clearance *** inferences are made in order to explore the long-lasting puzzles about real gas *** is emphasized that the underlying cause of the loss in the regenerator is an indirect effect of the real gas *** study about carrying out a direct verification of the theory is proposed.

关键词： real gas effects regenerative refrigerators loss mechanism reduction methods

Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture

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Genes & Diseases 2024年第3期11卷 427-437页

作者： Yukun Mao Xueying Hou Su Fu Jie luan Breast Plastic and Reconstructive Surgery Center Plastic Surgery HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100144China

Capsular contracture is a prevalent and severe complication that affects the post-operative outcomes of patients who receive silicone breast *** present,prosthesis replacement is the major treatment for capsular contracture after both breast augmentation procedures and breast reconstruction following breast cancer ***,the mecha-nism(s)underlying breast capsular contracture remains *** study aimed to identify the biological features of breast capsular contracture and reveal the potential underlying mechanism using RNA *** tissues from 12 female patients(15 breast capsules)were divided into low capsular contracture(LCC)and high capsular contracture(HCC)groups based on the Baker ***,41 lipid metabolism-related genes were identified through enrichment analysis,and three of these genes were identified as candidate genes by SVM-RFE and LASSO *** then compared the proportions of the 22 types of im-mune cells between the LCC and HCC groups using a CIBERSORT analysis and explored the Cor-relation between the candidate hub features and immune ***,PRKAR2B was positively correlated with the differentially clustered immune cells,which were M1 macro-phages and follicular helper T cells(area under the ROC=0.786).In addition,the expression of PRKAR2B at the mRNA or protein level was lower in the HCC group than in the LCC *** molecular mechanisms were identified based on the expression levels in the high and low PRKAR2B *** findings indicate that PRKAR2B is a novel diagnostic biomarker for breast capsular contracture and might also influence the grade and progression of capsularcontracture.

关键词： Biomarker Breastcapsular contracture Immune infiltration Machinelearning algorithms PRKAR2B

A 6-gene panel as a signature to predict recovery from advanced heart failure using transcriptomic analysis

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Genes & Diseases 2022年第5期9卷 1178-1180页

作者： Shangjie Zou Bee luan Khoo Department of Biomedical Engineering City University of Hong KongHong KongPR China Hong Kong Center for Cerebro-Cardiovascular Health Engineering(COCHE) Hong KongPR China

To the Editor:Heart failure(HF)is a global health problem with a high mortality *** various stimuli associated with HF can cause maladaptive remodeling,gradually weakening car-diac *** ventricular assist device(LVAD)can improve advanced HF patients’cardiac functions,termed“reverse remodeling”.1 However,only a small percentage of patients who have received LVAD have experienced reverse remodeling.

关键词： mortality remodeling patients

Effects of nitrogen addition on clonal integration between mother and daughter ramets of Moso bamboo: a ^(13)C-CO_(2) pulse labeling study

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Journal of Plant Ecology 2022年第4期15卷 756-770页

作者： Wanlu Zhai Yi Wang Junwei luan Shirong Liu Key Laboratory of Bamboo and Rattan Science and Technology State Forestry AdministrationInstitute of Resources and EnvironmentInternational Centre for Bamboo and RattanBeijing 100102China Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Research Institute of Forest EcologyEnvironment and ProtectionChinese Academy of ForestryBeijing 100091China

Resource sharing among connected ramets(*** integration)is one of the distinct traits of clonal *** integration confers Moso bamboo(Phyllostachys pubescens)a strong adaptability to different environmental *** the mechanisms of how clonal integration makes Moso bamboo has better performance are still poorly *** this study,acropetal and basipetal translocation of photosynthates between Moso bamboo ramets were analyzed separately to investigate how clonal fragments obtain higher benefits under heterogeneous N *** fragments of Moso bamboo consisting of two interconnected mother–daughter ramets were used,each of the ramets was subjected to either with or without N *** acropetal and basipetal translocation of ^(13)C-photosynthates was separated via single-ramet ^(13)C-CO_(2)-*** ramets translocated more ^(13)C-photosynthates to daughter ramets with N addition,and the translocation of ^(13)C-photosynthates to mother ramets was more pronounced when daughter ramets were treated with N *** ^(13)C-photosynthates that were translocated from mother ramets without and with N addition were mainly invested in the leaves and roots of daughter ramets with N addition,from daughter ramets with N addition were mainly invested in the leaves and roots of mother ramets with and without N addition,*** results suggest that mother ramets preferentially invest more resources in nutrient-rich daughter ramets,and that daughter ramets serve as efficient resource acquisition sites to specialize in acquiring abundant resources based on the resource conditions of mother *** plants can improve their resource acquisition efficiency and maximize the overall performance in this way.

关键词： carbon allocation habitat heterogeneity ^(13)C-CO_(2)labeling resource integration Moso bamboo

An Analytical Solution for Wave Propagation in a Pipe Pile with Multiple Defects

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Acta Mechanica Solida Sinica 2020年第2期33卷 251-267页

作者： Xuanming Ding Lubao luan Changjie Zheng Guoxiong Mei Hang Zhou Key Laboratory of New Technology for Construction of Cities in Mountain Area College of Civil EngineeringChongqing UniversityChongqing 400045China School of Civil Engineering Fujian University of TechnologyFuzhou 350118China Key Laboratory of Disaster Prevention and Structural Safety of Ministry of Education College of Civil Engineering and ArchitectureGuangxi UniversityNanning 530004China

An analytical solution is developed in this paper to conduct the low-strain integrity testing for a pipe pile with multiple *** derived solution allows simulating the pipe pile as a three-dimensional model by considering the wave propagation in the vertical,circumferential and radial *** solutions of the pile are obtained by the Laplace transform and separation of ***,time-domain responses of the solution are deduced by the inverse Fourier transform *** solution is validated against the published solutions for an intact pile and a pile with a single *** studies are conducted to identify and characterize the velocity responses on the top of pipe piles with multiple *** results suggest that the reflected waves generated by the deep defects are affected by the secondary reflections from the shallow defects.A new detecting method is proposed to decrease the influence of high-frequency interferences and to predict the defective depth,which suggests putting the receiver at the point of 90°along the circumferential direction.

关键词： Wave propagation Pipe pile Multiple defects Low-strain dynamic testing

Interaction between temperature and photoperiod in regulation of flowering time in rice

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Science China(Life Sciences) 2012年第3期55卷 241-249页

作者： SONG YuanLi GAO ZhiChao luan WeiJiang Tianjin Key Laboratory of Cyto-Genetical and Molecular Regulation College of Life SciencesTianjin Normal UniversityTianjin 300387China

Photoperiod and temperature are two pivotal regulatory factors of plant flowering. The floral transition of plants depends on accurate measurement of changes in photoperiod and temperature. The flowering time of rice （Oryza sativa） as a facultative short-day （SD） plant is delayed under long-day （LD） and/or low temperature conditions. To elucidate the regulatory functions of photoperiod and temperature on flowering time in rice, we systematically analyzed the expression and regulation of several key genes （Hd3a, RFT1, Ehdl, Ghd7, RID1/Ehd2/OsIdl, Se5） involved in the photoperiodic flowering regulatory pathway under different temperature and photoperiod treatments using a photoperiod-insensitive mutant and wild type plants. Our re- sults indicate that the Ehdl-Hd3a/RFT1 pathway is common to and conserved in both the photoperiodic and temperature flow- ering regulatory pathways. Expression of Ehdl, Hd3a and RFT1 is dramatically reduced at low temperature （23~C）, suggesting that suppression of Ehdl, Hd3a and RFT1 transcription is an essential cause of delayed flowering under low temperature con- dition. Under LD condition, Ghd7 mRNA levels are promoted at low temperature （23~C） compared with normal temperature condition （28℃）, suggesting low temperature and LD treatment have a synergistic role in the expression of Ghd7. Therefore, upregulation of Ghd7 might be a crucial cause of delayed flowering under low temperature condition. We also analyzed Hdl regulatory relationships in the photoperiodic flowering pathway, and found that Hdl can negatively regulate Ehdl transcription under LD condition. In addition, Hdl can also positively regulate Ghd7 transcription under LD condition, suggesting that the heading-date of rice under LD condition is also regulated by the Hdl-Ghd7-Ehdl-RFT1 pathway.

关键词： rice photoperiod temperature flowering regulation interaction

The Fabrication of Gas-driven Bionic Soft Flytrap Blade and Related Feasibility Tests

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Journal of Bionic Engineering 2023年第2期20卷 628-644页

作者： Yangwei Wang Jie Yan Jian Li Meizhen Huang Zhibo luan College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin150000China

Unlike most animals,plants fail to move bodily at ***,movements also occur in every single part of plants out of energy and nutrients needs,spanning from milliseconds to hours on a time *** with the growing understanding of plant movement in the academic community,bionic soft robots based on plant movement principles are increasingly studied and are considered by scientists as a source of inspiration for innovative engineering *** this paper,through the study of the biological morphology,microstructure,and motion mechanism of the flytrap,we developed chambered design rules,and designed and fabricated a gas-driven bionic flytrap blade,intending to investigate its feasibility of performing complex bending *** experimental result shows that the bionic flytrap blade can achieve multi-dimensional bending deformation,and complete the bending and closing action within 2 *** performance of the bionic flytrap blade fabricated is in high agreement with the real flytrap blade in terms of bending and deformation,achieving an excellent bionic design *** this study,the chambered design rules of the bionic flytrap blade were proposed and developed,and the possibility of its deformation was *** effects of different chamber types and different flow channel design precepts on the bending deformation of the bionic flytrap blade were revealed,together with the relationship between the response time and flow rate of the bionic flytrap *** last,this study provides new ideas for the study of plant blade motion mechanism in a hope to expand the application fields of bionic robots,especially hope to offer solutions for plant-type robotics.

关键词： Gas drive Bionic soft flytrap blade Feasibility test Plant bionic design