Biocompatible hierarchical zwitterionic polymer brushes with bacterial phosphatase activated antibacterial activity

作     者：Liwei Sun Lingjie Song Xu Zhang Shuaishuai Yuan Shifang Luan Liwei Sun;Lingjie Song;Xu Zhang;Shuaishuai Yuan;Shifang Luan

作者机构：State Key Laboratory of Polymer Physics and ChemistryChangchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China University of Science and Technology of ChinaHefei 230026China Key Laboratory of Biobased Polymer Materials of Shandong Provincial Education DepartmentCollege of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao 266042China National Engineering Laboratory for Medical Implantable DevicesWEGO Co.Ltd.Weihai 264210China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2022年第126卷第31期

页      面：191-202页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.51873213) the Natural Science Foundation of Jilin Province(No.20210101385JC) the High-Tech Research&Development Program of CAS-WEGO Group the Major Science and Technology Innovation Project of Shandong Province(No.2019JZZY011105) 

主　　题：Bacterial infection Self-adaptive surface Bactericidal Antifouling Hierarchical polymer brushes 

摘      要：Hierarchical polymer brushes have been considered as an effective and promising method for preventing implant-associated infections via multiple antibacterial ***,a bacterial phosphatase re-sponsive surface with hierarchical zwitterionic structures was developed for timely dealing with the poly-meric implant-associated bacterial *** hierarchical polymeric architecture was subtly realized on model polypropylene(PP)substrate by sequential photo living grafting of poly(2-(dimethylamino)ethyl methacrylate(PDMAEMA)bottom layer and zwitterionic poly(sulfobetaine methacrylate)(PSBMA)upper layer,followed by the conversion of the PDMAEMA into the zwitterionic structure via succes-sive quaternization and phosphorylation *** to shielding the bottom polycations,the hi-erarchical zwitterionic polymer brushes guaranteed the surface with the optimal biocompatibility under the normal physiological *** bacteria are invaded,the surface bactericidal activity of the bottom layer can be rapidly and automatically activated owing to the transition triggered by bacterial phosphatase from zwitterion to ***,ameliorated by the upper layer,the hierarchical surface showed obvious adhesion resistance to dead bacterial cells and notably migrated the cytotoxic-ity of exposed polycation after completion of the bactericidal *** a proof-of-principle demonstration,this self-adaptive hierarchical surface with sensitive bacterial responsiveness and biocompatibility showed great potential in combating hernia mesh-related *** work provides a promising and universal strategy for the on-demand prevention of medical device-associated infections.