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Predictive value of machine learning models for lymph node metastasis in gastric cancer: A two-center study

World Journal of Gastrointestinal Surgery 2024年第1期16卷 85-94页

作者： Tong lu Miao lu Dong Wu yuan-yuan Ding Hao-Nan Liu Tao-Tao Li Da-Qing Song Department of Emergency Medicine Jining No.1 People’s HospitalJining 272000Shandong ProvinceChina Wuxi Mental Health Center Wuxi 214000Jiangsu ProvinceChina Department of Gastroenterology Jining No.1 People’s HospitalJining 272000Shandong ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors in the digestive system,ranking sixth in incidence and fourth in mortality *** 42.5%of metastatic lymph nodes in gastric cancer belong to nodule type and peripheral type,the application of imaging diagnosis is *** To establish models for predicting the risk of lymph node metastasis in gastric cancer patients using machine learning(ML)algorithms and to evaluate their pre-dictive performance in clinical *** Data of a total of 369 patients who underwent radical gastrectomy at the Depart-ment of General Surgery of Affiliated Hospital of Xuzhou Medical University(Xuzhou,China)from March 2016 to November 2019 were collected and retro-spectively analyzed as the training *** addition,data of 123 patients who underwent radical gastrectomy at the Department of General Surgery of Jining First People’s Hospital(Jining,China)were collected and analyzed as the verifi-cation *** ML models,including decision tree,random forest,support vector machine(SVM),gradient boosting machine,naive Bayes,neural network,and logistic regression,were developed to evaluate the occurrence of lymph node metastasis in patients with gastric *** ML models were established fo-llowing ten cross-validation iterations using the training dataset,and subsequently,each model was assessed using the test *** models’performance was evaluated by comparing the area under the receiver operating characteristic curve of each *** Among the seven ML models,except for SVM,the other ones exhibited higher accuracy and reliability,and the influences of various risk factors on the models are *** The ML models developed exhibit strong predictive capabilities for lymph node metastasis in gastric cancer,which can aid in personalized clinical diagnosis and treatment.

关键词： Machine learning Prediction model Gastric cancer Lymph node metastasis

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Synergic catalysis of W and Ni originating from substitution of trivacant phosphotungstate for the selective oxidation of aniline to azoxybenzene

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Chinese Chemical Letters 2024年第2期35卷 558-563页

作者： Sheng Cai Xiao-yuan Wu Weiming Wu Sa-Sa Wang Can-Zhong lu CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Chinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

Partial substitution of polyoxometalate(POM)is an efficient route to modulate the catalytic property of maternal *** this work,a new Keggin type POM involving{Ni 6}cluster,{[Ni(H_(2) O)_(2)(Dach)_(2)][Ni(Dach)_(2)]_(2)}{[Ni_(6)Cl(μ-OH)_(3)(H_(2) O)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))][Ni_(6)(μ-OH)_(3)(H_(2) O)_(2)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))]}Cl·27H_(2) O,(1,Dach=1,2-diaminocyclohexane)was *** 1 shows excellent catalytic performance in the selective oxidation of aniline to azoxybenzene(AOB)in *** apparently different results from that with the matrix{PW 9 O_(3)_(4)}({PW9})suggest the successful regulation of the catalytic property of{PW9}by the introduction of the{Ni6}cluster into the *** experimental results indicate that the highlighted performance of 1 is contributed by the synergy of W and Ni sites,which are respectively responsible for the oxidation and condensation steps in the production of *** good selectivity to AOB is essentially attributed to the effective modulation of the reaction rates of oxidation and condensation steps by W and Ni sites,respectively.

关键词： Polyoxometalate {Ni6}cluster Modulated catalytic property Aniline oxidation Azoxybenzene

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A comprehensive review of recent advancements and developments in heat exchanger network synthesis techniques

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Science China(Technological Sciences) 2024年第2期67卷 335-356页

作者： XU Yue LIU WeiWei ZHANG lu CUI Guo Min XIAO yuan ZHANG GuanHua YANG QiGuo School of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China

The rapid development of computational technology and the increasing energy demand have improved heat exchanger network(HEN)*** HEN synthesis involves several optimizations of matches,distributions of heat loads,and stream splitting of heat ***,obtaining good results at high efficiency has been the main standard for evaluating the techniques in the research area of HEN *** paper first summarizes and analyzes the main contributions of the existing HEN synthesis *** compare related data quantitively,information on ten typical cases is presented in this ***,recently improved solutions for commonly encountered existing literature cases demonstrate the evolution and competition trends in the field of HEN *** comparison data presented in this paper not only provide a useful reference for future research but also present the optimization *** on the findings of this study,it is noted that there is still a large room for improvement,and current approaches are incapable of dealing with all HEN ***,it is still difficult to escape a local optimum and overcome structural constraints when seeking the global *** a follow-up to the current work,the parallel computing mode and adaptively coordinating the ratio of global and local searching abilities are major development trends for future investigation.

关键词： heat integration heat exchanger network synthesis sequential synthesis method simultaneous synthesis method optimization techniques development optimization quality

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Line-scanning microscopy with laterally symmetric imaging using simultaneous cross-line illumination

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Photonics Research 2024年第7期12卷 1513-1521页

作者： DAN SHEN YAFENG LI MENG WANG YUTONG HAN BOLIN lu HUI GONG QINGMING luO JING yuan Britton Chance Center for Biomedical Photonics and MoE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China HUST-Suzhou Institute for Brainsmatics JITRI Institute for BrainsmaticsSuzhou 215123China School of Biomedical Engineering Hainan UniversityHaikou 570228China

Using an on-the-fly scanning scheme, line confocal microscopy can obtain complex structures of large biological tissues with high throughput. Yet, it suffers from lateral imaging asymmetry and thus introduces the potential deformations of the observation results. Here, we propose cross-line illumination microscopy (cLIM) that acquires the imaging data of two perpendicular directions simultaneously through the same objective lens in a line scanning and utilizes two-direction deconvolution fusion to achieve lateral symmetric imaging *** fluorescence beads indicates that cLIM reduces lateral resolution asymmetry from 46.1%to 2.5%and improves lateral resolution by 31.0%, compared with traditional line-scanning imaging. Compared with commercial point-confocal microscopy, the cLIM has a 25.84×increase in imaging speed and 1.93×better background-suppressing ability when imaging an 11,306μm×7783μm×100μm mouse kidney slice. We also show the advantages of the cLIM in observing direction-sensitive texture features by imaging a muscular tissue slice. cLIM offers a novel solution to achieve laterally symmetric line-scanning imaging with simple modifications while maintaining high throughput and accuracy for imaging large-scale samples.

关键词： illumination simultaneous scanning

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Rotational Doppler effect of composite vortex beams with tailored OAM spectra

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Photonics Research 2024年第8期12卷 1665-1672页

作者： YUTIAN LIANG RUIJIAN LI JIE ZHAO XINGyuan lu TONG LIU ZHENGLIANG LIU yuan REN CHENGLIANG ZHAO Department of Aerospace Science and Technology Space Engineering University School of Physical Science and Technology Soochow University Department of Basic Course Space Engineering University

There recently has been increasing interest in the research and application of the rotational Doppler effect(RDE),which paves a promising way to detect rotating objects remotely. In order to obtain more information about the rotating object from the rotational Doppler signal, composite vortex beams by coaxial superposition of orbital angular momentum(OAM) modes are often used as the probe beam. However, to the best of our knowledge, the RDE of composite vortex beams with arbitrary OAM spectra has not yet been comprehensively studied. In this paper, the correspondence between the OAM spectrum of a probe beam and the frequency spectrum of a rotational Doppler signal is theoretically analyzed. It is explicitly revealed that the RDE frequency spectrum of scattered light is related to the product of two autocorrelation functions: one from the OAM spectrum of probe beam and the other from the spiral spectrum of rotating object. On the basis of this relation, one can regulate the RDE frequency spectrum on demand via tailoring the OAM spectrum of the probe beam. As a proof of concept we design a special composite vortex beam to eliminate the broadening of the RDE spectrum induced by misalignment. These findings are of practical value in applications such as remote sensing and optical metrology.

关键词： Circular polarization Doppler effect Light beams Optical vortex beams Remote sensing Spatial light modulators

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Dynamic recrystallization behavior and strengthening mechanism of a novel Mo-Ti_(3)AlC_(2) alloy at ultrahigh temperature

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Rare Metals 2024年第8期43卷 3946-3960页

作者： lu Yang Xin-yuan Zheng Yang Zhao Xi-Ran Wang Fang-Nao Xiao Shi-Zhong Wei School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials Henan University of Science and TechnologyLuoyang 471003China Department of Applied Mechanics Univ.Bourgogne FrancheComteFEMTO-ST InstituteCNRS/UF/ENSMM/UTBM25000BesangonFrance

Increasing the recrystallization temperature to achieve better high-temperature performance is critical in the development of molybdenum alloys for ultrahightemperature applications,such as the newest generation of multitype high-temperature nuclear *** this study,an innovative strategy was proposed to improve the performance of molybdenum alloys at high temperature by using the two-dimensional MAX(where M is an early transition metal,A is an A-group element and X is C or N)ceramic material Ti_(3)AlC_(2).The relationships between flow stress,strain rate and temperature were *** microstructure,distribution of misorientation and evolution of dislocations in the Mo-Ti_(3)AlC_(2) alloy were *** microscopic mechanism of the Ti_(3)AlC_(2) phase in the molybdenum alloy at high temperatures was *** experimental results showed that the peak flow stress of Mo-Ti_(3)AlC_(2) at 1600℃ reached 155 MPa,which was161.8% greater than that of pure *** activation energy of thermal deformation of Mo-Ti_(3)AlC_(2) was as large as537 kJ·mol~(-1),which was 17.6% more than that of pure *** recrystallization temperature reached 1600℃ or even *** topological reaction of the Ti_(3)AlC_(2) phase consumed a large amount of energy at high temperatures,resulting in increases in the deformation activation *** structures of AlTi_3 and Ti-O Magneli-phase oxides(Ti_nO_(2n-1)) were formed in-situ,which relied on kink bands and interlayer slip,resulting in many dislocations during ***,the special two-dimensional of the structure Ti_(3)AlC_(2) ceramic inhibited the recrystallization behavior of the Mo *** results of this study can provide theoretical guidance for the development of a new generation of molybdenum alloys for use in ultrahigh-temperature environments.

关键词： Mo alloy Two-dimensional reinforcement Dynamic recrystallization behavior Hot deformation Mechanical properties

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Non-coding RNAs expression in SARS-CoV-2 infection:pathogenesis,clinical significance,and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第1期9卷 55-78页

作者： Xiaoxing Liu Wandi Xiong Maosen Ye Tangsheng lu Kai yuan Suhua Chang Ying Han Yongxiang Wang Lin lu Yanping Bao Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)100191 BeijingChina Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking University100871 BeijingChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan University570228 HaikouChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences650204 KunmingYunnanChina National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Institute of Brain Science and Brain-inspired Research Shandong First Medical University&Shandong Academy of Medical Sciences250117 JinanShandongChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina School of Public Health Peking University100191 BeijingChina

The coronavirus disease 2019(COVID-19)pandemic has been looming globally for three years,yet the diagnostic and treatment methods for COVID-19 are still undergoing extensive exploration,which holds paramount importance in mitigating future *** non-coding RNAs(ncRNAs)display aberrations in the context of ***,microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)exhibit a close association with viral infection and disease *** this comprehensive review,an overview was presented of the expression profiles of host ncRNAs following SARS-CoV-2 invasion and of the potential functions in COVID-19 development,encompassing viral invasion,replication,immune response,and multiorgan deficits which include respiratory system,cardiac system,central nervous system,peripheral nervous system as well as long ***,we provide an overview of several promising host ncRNA biomarkers for diverse clinical scenarios related to COVID-19,such as stratification biomarkers,prognostic biomarkers,and predictive biomarkers for treatment *** addition,we also discuss the therapeutic potential of ncRNAs for COVID-19,presenting ncRNA-based strategies to facilitate the development of novel *** an in-depth analysis of the interplay between ncRNA and COVID-19 combined with our bioinformatic analysis,we hope to offer valuable insights into the stratification,prognosis,and treatment of COVID-19.

关键词： invasion therapeutic infection

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Evolution of interfacial heat transfer,contact behavior and microstructure during sub-rapid solidification of molten steel with different hydrogen contents

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Journal of Iron and Steel Research International 2024年第1期31卷 215-223页

作者： Cheng lu Wan-lin Wang Chen-yang Zhu Jie Zeng Xin-yuan Liu Hua-long Li School of Metallurgy and Environment Central South UniversityChangsha410083HunanChina National Center for International Research of Clean Metallurgy Central South UniversityChangsha410083HunanChina Institute of Research of Iron and Steel ShasteelZhangjiagang215625JiangsuChina

Typical Q235 low-carbon steel samples with different hydrogen contents(0.0004,0.0008,and 0.0013 wt.%)were prepared by adjusting the environment humidity and *** effects of hydrogen on interfacial heat transfer,contact behavior,and microstructure evolution were investigated using a novel droplet solidification *** results revealed that when the hydrogen content increases from 0.0004 to 0.0013 wt.%,the maximum heat flux between the molten steel and cooling substrate decreases from 8.01 to 6.19 MW/m^(2),and the total heat removed in the initial 2 s reduces from 10.30 to 8.27 MJ/m^(2).Moreover,the final contact angle between the molten steel and substrate increases from 103.741°to 113.697°,and the number of pores on the droplet bottom surface increases significantly from 21 to 210 with the increase in *** surface roughness of the droplet bottom surface increases from 20.902 to 49.181 *** addition,the average grain size of the droplet increases from 14.778 to 33.548 pm with the increase in the hydrogen *** interfacial contact condition becomes worse due to the escape of hydrogen from the steel matrix during the cooling process,which leads to the reduction in the interfacial heat transfer and the increase in the grain size.

关键词： Strip casting Hydrogen content Interfacial heat transfer behavior Contact behavior Microstructure evolution

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Timing and Tectonic Setting of the Gaoaobei TungstenMolybdenum Deposit in Nanling Range, South China

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Journal of Earth Science 2024年第3期35卷 890-904页

作者： Jianfeng Li Kemeng Ma Youyue lu Jianming Fu Shunbo Cheng yuan Li Chuanbiao Li College of Geographical Science Liaoning Normal UniversityDalian 116029China Wuhan Center of Geological Survey China Geological SurveyWuhan 430205China Granite Diagenesis and Mineralization Geology Research Center China Geological SurveyWuhan 430205China Mineral Resources Survey Institute of Hunan Province Changsha 410083China

The Gaoaobei tungsten-molybdenum deposit is a newly discovered large-scale quartzvein-type deposit in the Nanling metallogenic belt in South *** ore bodies are hosted in the Indosinian granites and the Cambrian Xiangnan Group slates and are controlled by NWW-oriented faults,which are obviously different from the“five-story building”model in southern Jiangxi *** magmatic rocks in the study area are dominated by medium-to coarse-grained biotite monzogranite,with a few NW-oriented fine-grained granite *** medium-to coarse-grained biotite monzogranite and fine-grained granite dykes have zircon U-Pb ages of 229.4±1.9 Ma(MSWD=1.5)and 164.9±3.3 Ma(MSWD=0.75),respectively,corresponding to the Indosinian and Yanshanian *** monzogranites have higher contents of FeO,CaO,K2O,P2O5,and TiO2,while the granite dykes have slightly higher contents of SiO2,Al2O3,MnO,and *** A/CNK values are 1.11-1.75 and 1.19-2.25,and the contents of CIPW normative corundum are 1.71%-6.66%and 2.41%-9.50%,suggesting both the monzogranites and granite dykes are S-type *** total amount of rare earth elements in the monzogranites(from 84.7 ppm to 129 ppm)is slightly lower than that in the granite dykes(from 128 ppm to 133 ppm).The Eu/Eu*values range from 0.12 to 0.30 in monzogranites and from 0.0011 to 0.0013 in granite dykes,indicating the fine-grained granites underwent more intense fractional *** monzogranite and granite dykes have high 87Sr/86Sri values of 0.7169-0.7193 and 0.72825-0.72880,lowεNd(t)values ranging from-10.2 to-9.6 and from-11.5 to-11.4,and TDM2 ages of 1835-1785 and 1957-1946 Ma,*** isotope data indicate their origin from the remelting of the Paleoproterozoic crustal *** with regional geology,it is concluded that the medium-to coarse-grained biotite monzogranite was formed in a post-collisional extensional *** addition,40Ar-39Ar dating of the greisen type tungsten-molybdenum ore gave

关键词： zircon U-Pb age 40Ar-39Ar age geochemistry tungsten molybdenum deposit Gaoaobei Nanling Range.

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Lonicera Japonica Caulis Ameliorates LPS and TNF-α-Induced HT-29 Cell Injury by Inhibiting the MAPK/ERK/JNK/p38 Pathway

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Biomedical and Environmental Sciences 2024年第7期37卷 805-810页

作者： Hanxiu lu Wei Yan Xiao yuan Yongbo Kang Zhongjian Liu Qiang Guo Faculty of Life science and Technology Kunming University of Science and TechnologyKunming 650031YunnanChina School of medicine Kunming University of Science and TechnologyKunming 650031YunnanChina Department of Gastroenterology The First People’s Hospital of Yunnan ProvinceKunming 650032YunnanChina Department of Gastroenterology The First People’s Hospital of Yuxi CityYuxi 653100YunnanChina Institute of Basic and Clinical Medicine The First People’s Hospital of Yunnan ProvinceKunming 650032YunnanChina

Inflammatory bowel disease(IBD)is characterized by chronic inflammation of the intestinal tract,and shows a high rate of *** have accumulated extensive experience in the treatment of IBD,with biologics and small molecule drugs having greatly expanded the therapeutic scope of IBD in recent ***,such treatments involve a high price and a single target of drug action.

关键词： drugs treatment p38

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