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The current role of dendritic cells in the progression and treatment of colorectal cancer

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Cancer Biology & Medicine 2024年第9期21卷 769-783页

作者： Yuanci Zhang Songtao Ji Ge Miao Shuya Du Haojia Wang xiaohua Yang Ang Li Yuanyuan lu Xin Wang Xiaodi Zhao State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers National Clinical Research Center for Digestive Diseases Xijing Hospital Fourth Military Medical University Department of Gastroenterology Tangdu Hospital Fourth Military Medical University Department of Experimental Surgery Xijing Hospital Fourth Military Medical University Department of Gastroenterology the 988th Hospital of PLA Joint Logistics Support Force

Colorectal cancer(CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide. Dendritic cells(DCs) constitute a heterogeneous group of antigen-presenting cells that are important for initiating and regulating both innate and adaptive immune responses. As a crucial component of the immune system, DCs have a pivotal role in the pathogenesis and clinical treatment of CRC. DCs cross-present tumor-related antigens to activate T cells and trigger an antitumor immune response. However, the antitumor immune function of DCs is impaired and immune tolerance is promoted due to the presence of the tumor microenvironment. This review systematically elucidates the specific characteristics and functions of different DC subsets, as well as the role that DCs play in the immune response and tolerance within the CRC microenvironment. Moreover, how DCs contribute to the progression of CRC and potential therapies to enhance antitumor immunity on the basis of existing data are also discussed, which will provide new perspectives and approaches for immunotherapy in patients with CRC.

关键词： Colorectal cancer dendritic cells treatment strategies tumor progression

名誉侵权纠纷中传媒责任确定规则——关于两个审理名誉权案件司法解释的几点讨论

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中国广播电视学刊 2007年第8期 46-48页

作者：陆小华新华社新闻研究所

现代社会的重要特征之一．是人们的注意力、思维活动与行为决策深深地受传媒提供的信息和观点的影响，传媒活动及影响形成了特殊的社会环境。在这样的环境中，名誉权作为所有民事主体“对自己在名誉上的利益所享有的权利”，越来越成为... 详细信息

现代社会的重要特征之一．是人们的注意力、思维活动与行为决策深深地受传媒提供的信息和观点的影响，传媒活动及影响形成了特殊的社会环境。在这样的环境中，名誉权作为所有民事主体“对自己在名誉上的利益所享有的权利”，越来越成为人们维护自身权益的重点．人们的社会综合评价与自我评价越来越与传媒活动，特别是传媒的报道活动及结果紧密相关。

关键词：传媒责任名誉权司法解释确定规则侵权纠纷案件审理社会环境

Application of Multi-team Blood Glucose Management Model in Perioperative Period of General Surgery Patients

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Journal of Clinical and Nursing Research 2020年第2期4卷 68-74页

作者： Weirong Li Yan Zhou xiaohua lu Yan Liu Minpin Deng Xiaolan Wang The frist affiliated Hospital of Jinan University in Guangdong Guangzhou 510630China

Objective:In order to explore the application effect of blood glucose management mode of multiteam cooperation in perioperative period of general surgery ***:The perioperative blood glucose control of 94 patients undergoing surgical treatment in general surgery from January 2016 to March 2019 was reviewed by *** to the perioperative blood glucose management model of multi-team cooperation,the patients were divided into intervention group and control *** January 2016 to January 2018,64 patients who did not implemented the multi-team blood glucose management model were the control group and from February 2018 to March 2019,30 patients who implemented the multi-team blood glucose management model were the intervention group,compared with two group about the differences in perioperative blood ***:It is no statistically significant about two group in highest and lowest blood sugar levels under fasting stats;during the fluid diet the blood sugar level of the intervention group was lower than control group(Pluid or food-feeding period,the highest and lowest blood sugar level is that the intervention group was lower than control group(Plusion:If we adopt multiteam blood glucose management model can better control the perioperative blood glucose of patients undergoing general sugar.

关键词： Multi-team blood sugar management model Patients undergoing general sugary Effect evaluation

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传媒变革与超级媒体的崛起

新视野 2010年第2期 81-83页

作者：陆小华新华社音视频部

传媒变革的总体趋向是在移动化中变革,表现为报纸小型化、杂志大小两极化、广播重新崛起、电视移动化、传媒移动化与读者移动化的互动、手机媒体化、移动互联与无线城市等等。从世界范围看,超级媒体正在崛起,其类型有:从全媒体到超级媒... 详细信息

传媒变革的总体趋向是在移动化中变革,表现为报纸小型化、杂志大小两极化、广播重新崛起、电视移动化、传媒移动化与读者移动化的互动、手机媒体化、移动互联与无线城市等等。从世界范围看,超级媒体正在崛起,其类型有:从全媒体到超级媒体、从媒体到信息龙头、从搜索引擎到超级媒体等等。超级媒体的崛起给了我们重要启示:要更好地整合内部和外部的信息源和信息,要进一步做好满足分类需求,要快速变革传统媒体的服务观念,不仅提供信息,更要提供服务。

关键词：媒体传媒变革超级媒体

Heterogeneous interfacial engineering of Pd/TiO2 with controllable carbon content for improved direct synthesis efficiency of H2O2

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Chinese Journal of Catalysis 2020年第2期41卷 312-321页

作者： Wei Yan Rui Sun Meng Li Licheng Li Zhuhong Yang Zelin Hua xiaohua lu Chang Liu State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009JiangsuChina College of Chemical Engineering Innovation Research Center of Lignocellulosic Functional MaterialsNanjing Forestry UniversityNanjing 210037JiangsuChina

Series of heterogeneous interfacial engineered TiO2(C-TiO2) with controllable carbon content were facilely synthesized by incipient-wet impregnation using glucose and subsequent thermal carbonization. The obtained C-TiO2 were used as catalytic supports to load Pd nanoparticles for H2 O2 direct synthesis from H2 and O2. The as-prepared samples were systematically studied by transmission electron microscopy(TEM), X-ray photoelectron spectroscopy(XPS), air isothermal microcalorimeter, temperature-programmed reduction of H2(H2-TPR), and so on. The catalytic results showed that H2 O2 productivity and H2O2 selectivity of Pd/C-TiO2 firstly rose with increasing carbon content and then declined. Pd/C-TiO2 catalyst with 1.89 wt% of carbon content showed the best catalytic performance that had 61.2% of selectivity and 2192 mmol H2O2/g Pd/h of productivity, which were significantly better than those of pristine Pd/TiO2(45.2% and 1827 mmol H2O2/g Pd/h). Various characterization results displayed that the carbon species were heterogeneously dispersed on TiO2 surface. Moreover, no obvious geometric transformation in supports and Pd nanoparticles were observed among different catalysts. The superficial hydrophobicity of Pd/C-TiO2 was gradually promoted with increasing carbon content, which led to the corresponding decrease in adsorption energy of H2O2 with catalysts. According to structure-performance relationship analyses, the heterogeneous interfacial engineering of carbon could maintain the interaction of Pd nanoparticles with TiO2 and simultaneously accelerate the H2O2 desorption. Both factors further determined the excellent H2O2 direct synthesis performance of Pd/C-TiO2.

关键词： Direct synthesis of H2O2 TiO2 Carbon Heterogeneous interfacial engineering Pd

Daily consumption of Siraitia grosvenorii alleviated lipid accumulation and colon barrier injury via modulation of gut microbiota in high-fat diet C57BL/6 mice

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Food Science and Human Wellness 2024年

作者： Jingru Song Yulu Wei xiaohua Jiang Hongwei Liu Xiaojie Yan Dianpeng Li Fenglai lu Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization， Guangxi Institute of Botany， Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences State Key Laboratory of Mycology， Institute of Microbiology， Chinese Academy of Sciences， No.1 Beichenxi Road Engineering Research Center of Innovative Traditional Chinese， Zhuang and Yao Materia Medica， Ministry of Education， Guangxi University of Chinese Medicine

Siraitia grosvenorii (SG)， a traditional edible medicine in China， has shown potential application in health foods due to multiple bioactivities. However， few comparative studies have investigated the effect of daily intake of SG products by traditional drinking way on alleviating metabolic disorders caused by long-term high fat and high sugar diet (HF-HSD). This study investigated the effects of two commercial SG products (SG juice containing comprehensive compositions and mogrosides extract containing high content mogroside V) supplement on fat content， lipid accumulation， colon barrier and gut microbiota in a 38-week HF-HSD mice trial. Results showed that the SG intervention could decrease the weight gain and body fat content， alleviated lipid accumulation， low-grade inflammation and colon barrier injury. SG juice intake was found to increase the antioxidant enzyme activities of serum glutathione peroxidase (GSH-Px) and liver superoxide dismutase (SOD). 16S rDNA analysis found that SG could restore the gut microbiota with downregulation of harmful bacteria increased by HF-HSD and enhancement of the abundances of beneficial genus. In particular， SG juice significantly enriched taxonomic family Prevotellaceae and genus Alloprevotella. These results indicated that SG might be a functional additive to prevent disease risk caused by excess fat and sugar diet， and active ingredients resulting to the discrepancy of performance especially on gut microbiota are worthy of in-depth investigation.

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非平衡热力学在摩擦领域聚合物复合材料设计中的应用

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化工学报 2014年第5期65卷 1629-1635页

作者：穆立文史以俊冯新陆小华南京工程学院材料工程学院江苏南京211167 南京工业大学材料化学工程国家重点实验室江苏南京210009 瑞典吕勒奥工业大学机械系瑞典吕勒奥97187

以自润滑材料和摩擦材料为例,基于非平衡热力学原理从热量产生和传递的根本问题出发,研究摩擦系数和热导率对材料接触面温度的影响,指导聚合物基复合材料的设计。对于自润滑材料来说,将摩擦热量产生和传递过程假设成两个过程的串联,发... 详细信息

以自润滑材料和摩擦材料为例,基于非平衡热力学原理从热量产生和传递的根本问题出发,研究摩擦系数和热导率对材料接触面温度的影响,指导聚合物基复合材料的设计。对于自润滑材料来说,将摩擦热量产生和传递过程假设成两个过程的串联,发现摩擦热产生是摩擦系统整体稳定运行的关键控制因素。对于摩擦材料来说,将摩擦热量传递过程假设成传递热量和分配热量两个过程的并联,发现需采用降低刹车片热导率的逆向思维降低接触面温度。

关键词：热力学复合材料自润滑材料摩擦材料摩擦热产生传热

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数字图书馆收费问题浅议

图书馆 2004年第1期 86-87,93页

作者：卢小华长沙电力学院图书馆长沙410015

在现阶段 ,由于法律和现实环境等原因 ,数字图书馆应该收取一定的合理费用以维持其生存和发展。收费的方式可以多种多样 ,但从经济学角度来看 ,用差别收费的方法可以提供较好的经济和社会的综合效益。

关键词：数字图书馆收费成本版权费

Improved RF power performance via electrostatic shielding effect using AlGaN/GaN/graded-AlGaN/GaN double-channel structure

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Science China(Information Sciences) 2024年第4期67卷 341-342页

作者： Chunzhou SHI Ling YANG Meng ZHANG Hao lu Mei WU Bin HOU Xuerui NIU Qian YU Wenliang LIU Wenze GAO xiaohua MA Yue HAO School of Advanced Materials and Nanotechnology Xidian University State Key Discipline Laboratory of Wide Bandgap Semiconductor Technology Xidian University

GaN-based high-electric-mobility transistors(HEMTs) have been investigated thoroughly because of their promising applications in high-frequency,-voltage, and-power applications. However, the theoretical material limit prevents conventional single-heterostructure GaN HEMTs from achieving high performance despite numerous efforts [1–3].

关键词： Drain current