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Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB

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Chinese Medical Journal 2010年第17期123卷 2440-2445页

作者： SONG Hong-shuo SHI Shuang lu xiao-zhi GAO Feng YAN Ling WANG Ying ZHUANG Hui Department of Microbiology Peking University Health Science Center Beijing 100191 China Department of Immunology Peking University Health Science Center Beijing 100191 China Duke Human Vaccine Institute Duke University Medical Center Durham NC 27710 USA

Background The CKLF-like MARVEL transmembrane domain-containing family （CMTM） is a novel family of proteins linking chemokines and TM4SF. Different members exhibit diverse biological functions. In this study, the effect of intracellular CMTM2 on regulating human immunodeficiency virus type-1 （HIV-1） transcription was *** The effects of CMTM2 on regulating full-length HIV-1 provirus and the HIV-1 long terminal repeat （LTR）-directed transcription were assessed by luciferase assay. Transcription factor assays, using the luciferase reporter plasmids of AP-1, CRE, and NF-κB were conducted to explore the signaling pathway（s） that may be regulated by CMTM2. The potential relationship between CMTM2 and the transcription factor AP-1 was further analyzed by Western blotting analyses to investigate the effect of CMTM2 on PMA-induced ERK1/2 *** The results from the current study revealed that CMTM2 acts as a negative regulator of HIV-1 ***2 exerted a suppressive action on both full-length HIV-1 provirus and HIV-1 LTR-directed *** factor assays showed that CMTM2 selectively inhibited basal AP-1 and CREB activity. Co-expression of HIV-1 Tat, a potent AP-1 and CREB activator, can not reverse CMTM2-mediated AP-1 and CREB inhibition, suggesting a potent and specific effect of CMTM2 on negatively regulating these two signaling *** Intracellular CMTM2 can negatively regulate HIV-1 transcription, at least in part, by targeting the AP-1 and CREB pathways. Exploring the mechanisms further may lead to new ways to control HIV-1 replication.

关键词： CMTM2 HIV-1 long terminal repeat regulation

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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao Wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

Interferometric measurement for the plasma produced by a Q-switched laser in air near the surface of an Al target

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Chinese Journal of Lasers 1993年第4期 41-46页

作者： Jian lu, xiao-wu Ni, An-zhi He(Department of Applied Physics, East China Institute of Technology, 200 xiaolingwei, Nanjing 210014,China)

An analysis the plasma produced by a Q-switched laser in air near the surface of an Al target and a series of M-Z interferograms for the production and growth of the plasma for different delay time are reported. The c... 详细信息

关键词： laser plasma Al target interferometric measurement.

Diagnosis of phasma in CCD damage process induced by laser

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Chinese Journal of Lasers 1993年第5期 81-85页

作者： Jian lu, xiao wu Ni, An-zhi He(Department of Applied Physics, Nanjing University of Science Technology, 200 xiaolingwei, Nanjing 210014 ,China)

In this paper, the shapes of plasma produced by a Q-switched YAG laser acted repeatedly upon a CCD with MOS structure are used, to investigate the destroying process of the optoelectronic device. The experimental resu... 详细信息

关键词： CCD device MOS structure laser damage optical breakdown plasma

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Solidwork在机械制图中的应用

数字技术与应用 2018年第1期36卷 112-112,114页

作者：卢晓智利泰五金制品(东莞)有限公司广东东莞523830

机械制图是一种工程语言,是机械设计者与机械制造者进行沟通与交流的重要途径,有效利用solidwork,能够显著提升机械制图的效率与质量。基于此,本文就solidwork在机械制图中的应用展开分析,简要介绍了solidwork的应用优势,重点分析了soli... 详细信息

机械制图是一种工程语言,是机械设计者与机械制造者进行沟通与交流的重要途径,有效利用solidwork,能够显著提升机械制图的效率与质量。基于此,本文就solidwork在机械制图中的应用展开分析,简要介绍了solidwork的应用优势,重点分析了solidwork在剖视图呈现、装配图设计、相贯线运用中的应用实践。

关键词： solidwork 机械制图装配图

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Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： xiaohong Zou Qian lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu xiaomin Xu xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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