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Establishment of a humanized ST6GAL1 mouse model for influenza research

Animal Models and Experimental Medicine 2024年第3期7卷 337-346页

作者： Lyu Chao Han Feng Gao Qian Lv Limin lu Ziwei lu Shuangshuang Li Xiaoyan Hu Yuechao Yang Mengjie Zhao Yingze Liu Jun lu Xuancheng Duo Shuguang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina Institute of Zoology Chinese Academy of SciencesBeijingChina NHC Key Laboratory of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Zhejiang Provincial Key Laboratory of Medical Genetics Key Laboratory of Laboratory MedicineMinistry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhouChina

Background:This study aimed to construct and characterize a humanized influenza mouse model expressing ***:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encoding gene,and luciferase gene,were microinjected into the fertilized eggs of *** manipulated embryos were transferred into the oviducts of pseudopregnant female *** offspring were identified using *** exhibiting elevated expression of the hST6GAL1 gene were selectively bred for propagation,and in vivo analysis was performed for *** of the humanized gene was tested by performing immunohistochemical(IHC)*** and biochemical analyses using the whole blood and serum of humanized hST6GAL1 mice were ***:Successful integration of the human ST6GAL1 gene into the mouse genome led to the overexpression of human SiaT *** mice were identified as carrying copies of the humanized gene,and the in vivo analysis indicated that hST6GAL1gene expression in positive mice mirrored influenza virus infection *** IHC results revealed that hST6GAL1 was expressed in the lungs of humanized ***,the hematologic and biochemical parameters of the positive mice were within the {4. ***:A humanized influenza mouse model expressing the hST6GAL1 gene was successfully established and characterized.

关键词： hST6GAL1 humanized mice influenza animal model

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CALDER6N-ZYGMUND OPERAORS ON THE HARDY SPACES OF WEIGHTED HERZ TYPE

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Analysis in Theory and Applications 1997年第2期13卷 1-10页

作者： Liu Weiquan and lu shanzhen(Beijing normal University,{3.)

Applying the decomposition theorems in [1] and [2] , we obtain the boundedness theorem of Calderbn-Zygmund operator of type 6 on the Hardy spaces of weighted Herz type and establish interpolation theorem of linear ope... 详细信息

关键词： II CALDER6N-ZYGMUND OPERAORS ON THE HARDY SPACES OF WEIGHTED HERZ TYPE Math

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WEIGHTED WEAK TYPE ESTIMATES INVOLVING SPACES GENERATED BY BLOCKS

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Analysis in Theory and Applications 1994年第1期10卷 58-64页

作者： lu shanzhen Guido Weiss Beijing normal University Washington University inst. Louis 1. Department of Mathematics Beijing Normal University 100875 Beijing P.R. china 2. Department of Mathematics Washington University in St. Louis 63130 MO U.S.A.

The problem studied in this paper is how to establish weighted estimates of weak type near L^1 for those operators that are not of weak type(1,1).

关键词： show Math WEIGHTED WEAK TYPE ESTIMATES INVOLVING SPACES GENERATED BY BLOCKS

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Electro-spraying/spinning: A novel battery manufacturing technology

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Green Energy & Environment 2024年第1期9卷 81-88页

作者： Zhuan Hu Jiaxin Hao Dongyang Shen Caitian Gao Zhaomeng Liu Jianguo Zhao Bingan lu school of Physics and Electronics Hunan UniversityChangsha410082China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan Provincial Key Laboratory of Multi-electron Based Energy Storage DevicesHunan UniversityChangsha410082China school of Physics and Electronic Information Luoyang Normal UniversityLuoyang471934China Section of Environmental Protection Key Laboratory of Eco-Industry School of MetallurgyNortheastern UniversityShenyangLiaoning110819China

Lithium-ion battery(LIB) industry seems to have met its bottle neck in cutting down producing costs even though much efforts have been put into building a complete industrial chain. Actually, manufacturing methods can greatly affect the cost of battery production. Up to now, lithium ion battery producers still adopt manufacturing methods with cumbersome sub-components preparing processes and costly assembling procedures, which will undoubtedly elevate the producing cost. Herein, we propose a novel approach to directly assemble battery components(cathode, anode and separator) in an integrated way using electro-spraying and electro-spinning technologies. More importantly, this novel battery manufacturing method can produce LIBs in large scale, and the products show excellent mechanical strength, flexibility, thermal stability and electrolyte wettability. Additionally, the performance of the as-prepaed Li Fe PO_(4.||graphite full cell produced by this new method is comparable or even better than that produced by conventional manufacturing approach. In brief, this work provides a new promising technology to prepare LIBs with low cost and better performance.

关键词： Electro-spraying Electro-spinning Integrated electrode Lithium-ion battery

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Syntheses of new di-nuclear and tetra-nuclear lanthanide 9-anthracenecarboxylates:Magnetocaloric effect,slow magnetic relaxation and luminescent properties

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Journal of Rare Earths 2024年第6期42卷 1101-1109,I0004页

作者： Xing Liu Ruonan Yang lu Zhang Jian Zhou Chunmei Huang Huahong Zou Zunhong Xiao Chongqing Key Laboratory of Inorganic Functional Materials College of ChemistryChongqing Normal UniversityChongqing401331China Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of china) School of Chemistry and Chemical Engineering of Guangxi Normal UniversityGuilin541004China school of Chemistry and Materials Guizhou Normal UniversityGuiyang550025China

Lanthanide complex-based materials with magnetic and luminescent properties have received a great deal of attention,owing to their importantly potential applications in diverse *** this work,the 9-anthracenecarboxylic acid(9-Haca)as bridging ligand was applied in combination with optically activeπ-conjugated 2,4.6-tri(2-pyridyl)-1,3.5-triazine(tptz)to construct a series of new di-nuclear and tetranuclear lanthanide 9-anthracenecarboxylates[La_(2)(9-aca)_(6)(tptz)_(2)(μ-H_(2)O)]·0.25H_(2)O(1),[Ln_(2)(9-aca)_(6)(tptz)_(2)(H_(2)O)_(2)]·0.5AQ·CH_(3.COOH_(2)H_(2)O[Ln=Sm(2a),Eu(2b),Gd(2c),Tb(2d),Dy(2e),Tm(2f);AQ=9,10-anthracenedione]and[Ln_(4.(9-aca)_(10)(tptz)_(2)(CH3.OO)2]·H_(2)O[Ln=Eu(3.),Gd(3.),Dy(3.)].1 displays a di-nuclear centrosymmetric moiety[La_(2)(9-aca)_(6)(tptz)_(2)(μ-H_(2)O)]built up from two complex[La(9-aca)_(2)(tptz)]groups bridged by one H_(2)O molecule and two syn-syn-μ2-η1:η1-9-aca-bridging ligands,while 2a-2f are isostructural and co mprise another di-nuclear centrosymmetric moieties[Ln_(2)(9-aca)_(6)(tptz)_(2)(H_(2)O)_(2)]based on two complex[Ln(9-aca)_(2)(tptz)(H_(2)O)]groups connected by two syn-syn-μ2-η1:η1-9-aca-bridging ligands,3.-3. are isostructural and show tetra-nuclear centro symmetric moieties[Ln4.9-aca)10(tptz)2(CH3.OO)2]containing three types of coordination modes of *** present compounds offer the only examples of lanthanide 9-anthracenecarboxylates decorated by optically active *** investigations of 2a,2c-2f,and 3.-3. indicate that 3. is typical of slow relaxation of the magnetization,while 2c and 3. show significant magnetocaloric effect(MCE)with the value of-ΔSm of 5.26 J/(kg·K)at 4.K and 15.65 J/(kg·K)at 2 K(ΔH=7 T),*** luminescent properties were also studied and reveal that the characteristic luminescent properties of the 7r-conjugated aromatic ligands are introduced into magnetic lanthanide 9-anthracenecarboxylates,simultaneously exhibiting slow magnetic relaxation(or MCE)and luminescen

关键词： Lanthanide complexes luminescence Magnetic properties Magnetocaloric effect Slow magnetic relaxation Rare earths

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WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3.signaling

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International Journal of Oral Science 2024年第1期16卷 85-96页

作者： Qingling Huang Yi Xiao Ting Lan Youguang lu Li Huang Dali Zheng Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Oral Diseases School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Preventive Dentistry School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Dentistry The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3.signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3.was observed, which positively correlated with tumor *** findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3.pathway as a promising strategy for precise treatment of HNSCC.

关键词： WNT squamous tumorigenesis

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Gradient-induced long-range optical pulling force based on photonic band gap

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Light(Science & Applications) 2024年第5期13卷 865-874页

作者： Wenlong lu Alexey V.Krasavin Sheng Lan Anatoly V.Zayats Qiaofeng Dai Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and DevicesSchool of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China Department of Physics and London Centre for Nanotechnology King’s College LondonLondon WC2R 2LSUK

Optical pulling provides a new degree of freedom in optical *** is generally believed that long-range optical pulling forces cannot be generated by the gradient of the incident ***,we theoretically propose and numerically demonstrate the realization of a long-range optical pulling force stemming from a self-induced gradient field in the manipulated *** analogy to potential barriers in quantum tunnelling,we use a photonic band gap design in order to obtain the intensity gradients inside a manipulated object placed in a photonic crystal waveguide,thereby achieving a pulling *** the usual scattering-type optical pulling forces,the proposed gradient-field approach does not require precise elimination of the reflection from the manipulated *** particular,the Einstein-Laub formalism is applied to design this unconventional gradient *** magnitude of the force can be enhanced by a factor of up to 50 at the optical resonance of the manipulated object in the waveguide,making it insensitive to *** developed approach helps to break the limitation of scattering forces to obtain longrange optical pulling for manipulation and sorting of nanoparticles and other *** developed principle of using the band gap to obtain a pulling force may also be applied to other types of waves,such as acoustic or water waves,which are important for numerous applications.

关键词： optical waveguide scattering

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C14.HSL limits the mycelial morphology of pathogen Trichosporon cells but enhances their aggregation:Mechanisms and implications

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Chinese Chemical Letters 2024年第6期35卷 398-403页

作者： Xin lu Haoran Sun Xiaomeng Li Chunrui Li Jinfeng Wang Dandan Zhou Jilin Engineering Lab for Water Pollution Control and Resources Recovery School of the EnvironmentNortheast Normal UniversityChangchun 130117China State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China

The biosecurity hazards caused by pathogenic fungus have been widely *** the long-term coexistence of eukaryotic pathogens and quorum sensing bacteria in different habitats in environments,we hypothesized that they have social interactions via signal *** this work,we firstly discovered the well-known bacterial signal molecules play an adverse role in the cell morphology and metabolism in a model pathogen Trichosporon asahii.N-Tetradecanoyl-L-homoserine lactone(C14.HSL)was discovered to increase pathogen hazards of ***,which limited mycelium by 52%,but enhanced cell aggregation by 93..Higher fluorescence intensity of tryptophan(59%)and aromatic protein(2-fold)contents after the treatment of C14.HSL,indicating that aromatic proteins helped aggregate Trichosporon and showed *** analysis revealed that C14.HSL upregulated the shikimate pathway(above1-fold)located in downstream of tricarboxylic acid cycle,which contributed to the synthesis of more aromatic proteins and the formation of larger *** limited mycelial growth of *** attributed to the up-regulated expressions of cell cycle *** fungal transboundary response to bacterial C14.HSL was controlled by signal transduction *** study provides new insights into the co-evolution of bacterial and pathogenic fungi in microecosystems.

关键词： Bacterial C14.HSL Mycelium Cell cycle Aggregation Aromatic proteins

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班主任互动风格与小学生自我概念的关系研究

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心理发展与教育 2004年第4期20卷 61-65页

作者：韩立敏卢谢峰江光荣南京政治学院南京210003 北京师范大学心理学院北京100875 华中师范大学心理系武汉430079

本研究采用问卷法,以73.名4.6年级小学生为被试,运用多层线性模型的分析方法,考察在个体水平和班级水平上班主任风格的两个维度与小学生自我概念的8个方面之间的关系。研究发现,除运动能力的自我概念以外,无论是在个体水平还是在班级水... 详细信息

本研究采用问卷法,以73.名4.6年级小学生为被试,运用多层线性模型的分析方法,考察在个体水平和班级水平上班主任风格的两个维度与小学生自我概念的8个方面之间的关系。研究发现,除运动能力的自我概念以外,无论是在个体水平还是在班级水平,班主任的互动风格都与小学生自我概念存在显著相关,不过这种相关关系在互动风格的两个维度之间存在一定的差别;此外,按分析层次看,在班级水平上班主任风格对小学生的整体自我概念的预测力远远高于在个体水平上班主任风格对小学生个体自我概念的预测力。

关键词：班主任班级小学生自我概念互动维度运动能力个体水平关系研究年级

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SOME GENERALIZATIONS ON THE BOUNDEDNESS OF BILINEAR OPERATORS

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Analysis in Theory and Applications 1997年第3期13卷 8-28页

作者： Li Xiaochun lu shanzhen Yang Dachun(Beijing normal University,{3.) 1. Department of Mathematics Beijing Normal University 100875 Beijing The People’s Republic of China

For denote the Lebesgue space for and the Hardy space for p <1 In this paper, the authors study mapping properties of bilinear operators given by finite sums of the products of the standard fractional integrals or the standard fractional integral with the Calderon-Zygmund operator. The authors prove that such mapping properties hold if and only if these operators satisfy certain cancellation conditions.

关键词： Math SOME GENERALIZATIONS ON THE BOUNDEDNESS OF BILINEAR OPERATORS

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