C14-HSL limits the mycelial morphology of pathogen Trichosporon cells but enhances their aggregation:Mechanisms and implications
作者机构:Jilin Engineering Lab for Water Pollution Control and Resources RecoverySchool of the EnvironmentNortheast Normal UniversityChangchun 130117China State Key Laboratory of Pollution Control and Resource ReuseSchool of the EnvironmentNanjing UniversityNanjing 210023China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2024年第35卷第6期
页 面:398-403页
核心收录:
学科分类:0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 0703[理学-化学] 071005[理学-微生物学] 10[医学]
基 金:the National Natural Science Foundation of China(Nos.52070036,U20A20322) the Fundamental Research Funds for the Central Universities(No.2412018ZD042)for their financial support
主 题:Bacterial C14-HSL Mycelium Cell cycle Aggregation Aromatic proteins
摘 要:The biosecurity hazards caused by pathogenic fungus have been widely *** the long-term coexistence of eukaryotic pathogens and quorum sensing bacteria in different habitats in environments,we hypothesized that they have social interactions via signal *** this work,we firstly discovered the well-known bacterial signal molecules play an adverse role in the cell morphology and metabolism in a model pathogen Trichosporon asahii.N-Tetradecanoyl-L-homoserine lactone(C14-HSL)was discovered to increase pathogen hazards of ***,which limited mycelium by 52%,but enhanced cell aggregation by 93%.Higher fluorescence intensity of tryptophan(59%)and aromatic protein(2-fold)contents after the treatment of C14-HSL,indicating that aromatic proteins helped aggregate Trichosporon and showed *** analysis revealed that C14-HSL upregulated the shikimate pathway(above1-fold)located in downstream of tricarboxylic acid cycle,which contributed to the synthesis of more aromatic proteins and the formation of larger *** limited mycelial growth of *** attributed to the up-regulated expressions of cell cycle *** fungal transboundary response to bacterial C14-HSL was controlled by signal transduction *** study provides new insights into the co-evolution of bacterial and pathogenic fungi in microecosystems.