C14-HSL limits the mycelial morphology of pathogen Trichosporon cells but enhances their aggregation:Mechanisms and implications

作     者：Xin Lu Haoran Sun Xiaomeng Li Chunrui Li Jinfeng Wang Dandan Zhou 

作者机构：Jilin Engineering Lab for Water Pollution Control and Resources RecoverySchool of the EnvironmentNortheast Normal UniversityChangchun 130117China State Key Laboratory of Pollution Control and Resource ReuseSchool of the EnvironmentNanjing UniversityNanjing 210023China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第6期

页      面：398-403页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 0703[理学-化学] 071005[理学-微生物学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.52070036,U20A20322) the Fundamental Research Funds for the Central Universities(No.2412018ZD042)for their financial support 

主　　题：Bacterial C14-HSL Mycelium Cell cycle Aggregation Aromatic proteins 

摘      要：The biosecurity hazards caused by pathogenic fungus have been widely *** the long-term coexistence of eukaryotic pathogens and quorum sensing bacteria in different habitats in environments,we hypothesized that they have social interactions via signal *** this work,we firstly discovered the well-known bacterial signal molecules play an adverse role in the cell morphology and metabolism in a model pathogen Trichosporon asahii.N-Tetradecanoyl-L-homoserine lactone(C14-HSL)was discovered to increase pathogen hazards of ***,which limited mycelium by 52%,but enhanced cell aggregation by 93%.Higher fluorescence intensity of tryptophan(59%)and aromatic protein(2-fold)contents after the treatment of C14-HSL,indicating that aromatic proteins helped aggregate Trichosporon and showed *** analysis revealed that C14-HSL upregulated the shikimate pathway(above1-fold)located in downstream of tricarboxylic acid cycle,which contributed to the synthesis of more aromatic proteins and the formation of larger *** limited mycelial growth of *** attributed to the up-regulated expressions of cell cycle *** fungal transboundary response to bacterial C14-HSL was controlled by signal transduction *** study provides new insights into the co-evolution of bacterial and pathogenic fungi in microecosystems.