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Breakdown of Raman selection rules by Frohlich interaction in few-layer WS_(2)

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Nano Research 2021年第1期14卷 239-244页

作者： Qing-Hai Tan yu-jia Sun Xue-lu Liu Kai-Xuan Xu yuan-fei gao Shu-Liang Ren Ping-Heng Tan Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsCenter of Materials Science and Optoelectronics EngineeringCAS Center of Excellence in Topological Quantum ComputationUniversity of Chinese Academy of SciencesBeijing 100083China Beijing Academy of Quantum Information Science Beijing 100193China

The polarization selection rule of Raman scattering is crucial in symmetry analysis of elementary excitations in semiconductors and correlated electron *** we reported the observation of breakdown of Raman selection rules in few-layer WS_(2) by using resonant Raman *** the excitation energy is close to the dark A exciton state,we observed some infrared active modes and backscattering forbidden ***,we found that all observed phonon modes follow the same paralleled-polarization *** to the electron-phonon coupling near the band edge in WS_(2),we proposed a theoretical model based on the intraband Frohlich *** this case,the polarization response of the scattering signal is no longer determined by the original Raman tensor of scattered ***,it is determined by a new isotropic Raman tensor that generated from this intraband Frohlich interaction between dark A exciton and *** found that this theoretical model is in excellent agreement with the observed *** breakdown of Raman selection rules can violate the conventional limitations of the optical response and provide an effective method to control the polarization of Raman scattering signals in two-dimensional materials.

关键词： WS_(2) resonant Raman scattering dark exciton Raman section rules Frohlich interaction

Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles:Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus

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Bioactive Materials 2023年第9期27卷 409-428页

作者： Qing-Song Deng yuan gao Bi-yu rui Xu-Ran Li Po-Lin Liu Zi-Yin Han Zhan-Ying Wei Chang-Ru Zhang fei Wang Helen Dawes Tong-He Zhu Shi-Cong Tao shang-Chun Guo Department of Orthopedic Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RoadShanghai200233China School of Medicine Shanghai Jiao Tong University227 South Chongqing RoadShanghai200025China Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RoadShanghai200233China Department of Rheumatology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityNo.29XinglongxiangTianning DistrictChangzhou213000China shanghai Clinical Research Centre of Bone Diseases Department of Osteoporosis and Bone DiseasesShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011China Clinical and Translational Research Center for 3D Printing Technology Medical 3D Printing Innovation Research CenterShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200125China Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin Second RoadShanghai200025China Faculty of Health and Life Science Oxford Brookes UniversityHeadington RoadOxfordOX30BPUK NIHR Oxford Health Biomedical Research Centre OxfordOX37JXUK College of Medicine and Health St Lukes CampusUniversity of ExeterHeavitree RoadExeterEX12LUUK School of Chemistry and Chemical Engineering Shanghai Engineering Research Center of Pharmaceutical Intelligent EquipmentShanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-Coding RNAInstitute for Frontier Medical TechnologyShanghai University of

Diabetic wound healing has become a serious healthcare *** high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction,resulting in chronic inflammation,abnormal vascular function,and tissue *** solve these issues,we developed a double-network hydrogel,constructed with pluronic F127 diacrylate(F127DA)and hyaluronic acid methacrylate(HAMA),and enhanced by SS31-loaded mesoporous polydopamine nanoparticles(MPDA NPs).As components,SS31,a mitochondria-targeted peptide,maintains mitochondrial function,reduces mitochondrial reactive oxygen species(ROS)and thus regulates macrophage polarization,as well as promoting cell proliferation and migration,while MPDA NPs not only scavenge ROS and exert an anti-bacterial effect by photothermal treatment under near-infrared light irradiation,but also control release of SS31 in response to *** F127DA/HAMA-MPDA@SS31(FH-M@S)hydrogel has characteristics of adhesion,superior biocompatibility and mechanical properties which can adapt to irregular wounds at different body sites and provide sustained release of MPDA@SS31(M@S)*** addition,in a diabetic rat full thickness skin defect model,the FH-M@S hydrogel promoted macrophage M2 polarization,collagen deposition,neovascularization and wound ***,the FH-M@S hydrogel exhibits promising therapeutic potential for skin regeneration.

关键词： Mesoporous polydopamine nanoparticles(MPDA NPs) SS31 Photothermal antibacterial Mitochondrial function maintenance Diabetic wound healing

Results of 23 yr of Pulsar Timing of PSR J1453-6413

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Research in Astronomy and Astrophysics 2023年第10期23卷 357-366页

作者： Wei Li Shi-Jun Dang jian-Ping yuan Lin Li Wei-Hua Wang lun-Hua shang Na Wang Qing-Ying Li Ji-Guang lu fei-fei Kou Shuang-Qiang Wang Shuo Xiao Qi-Jun Zhi yu-Lan Liu Ru-Shuang Zhao Ai-Jun Dong Bin Zhang Zi-Yi You Yan-Qing Cai Ya-Qin Yang Ying-Ying Ren yu-jia Liu Heng Xu School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China Guizhou Radio Astronomy Observatory Guizhou UniversityGuiyang 550025China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China School of Physics Science and Technology Xinjiang UniversityUrumqi 830046China College of Mathematics and Physics Wenzhou UniversityWenzhou 325035China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

In this paper,we presented the 23.3 yr of pulsar timing results of PSR J1456-6413 based on the observations of Parkes 64 m radio *** detected two new glitches at MJD 57093(3)and 59060(12)and confirmed its first glitch at MJD 54554(10).The relative sizes(Δν/ν)of these two new glitches are 0.9×10^(-9)and 1.16×10^(-9),*** the“Cholesky”timing analysis method,we have determined its position,proper motion,and two-dimensional transverse velocities from the data segments before and after the second glitch,***,we detected exponential recovery behavior after the first glitch,with a recovery timescale of approximately 200 days and a corresponding exponential recovery factor Q of approximately 0.15(2),while no exponential recovery was detected for the other two *** interestingly,we found that the leading component of the integral pulse profile after the second glitch became stronger,while the main component became *** results will expand the sample of pulsars with magnetosphere fluctuation triggered by the glitch event.

关键词： Stars (stars:)pulsars:individual(PSR J1453-6413) stars:neutron

Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma:A comprehensive review

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World Journal of Hepatology 2024年第4期16卷 537-549页

作者： Jing-Jing Li jia-Xi Mao Han-Xiang Zhong yuan-yu Zhao fei Teng Xin-Yi lu Li-Ye Zhu Yang gao Hong Fu Wen-yuan Guo Department of Liver Surgery and Organ Transplantation Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003China

The tumor microenvironment is a complex network of cells,extracellular matrix,and signaling molecules that plays a critical role in tumor progression and *** and blood vessels are major routes for solid tumor metastasis and essential parts of tumor drainage ***,recent studies have shown that lymphatic endothelial cells(LECs)and blood endothelial cells(BECs)also play multifaceted roles in the tumor microenvironment beyond their structural functions,particularly in hepatocellular carcinoma(HCC).This comprehensive review summarizes the diverse roles played by LECs and BECs in HCC,including their involvement in angiogenesis,immune modulation,lymphangiogenesis,and *** providing a detailed account of the complex interplay between LECs,BECs,and tumor cells,this review aims to shed light on future research directions regarding the immune regulatory function of LECs and potential therapeutic targets for HCC.

关键词： Lymphatic endothelial cells Blood endothelial cells Hepatocellular carcinoma Tumor microenvironment

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： ZHU yuan yue ZHENG rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU yu CHEN yu Hong yu Xue Feng YAN Li WANG Tian Ge ZHAO Zhi yun QIN Gui Jun WAN Qin CHEN Gang gao Zheng Nan SHEN fei Xia luO Zuo jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO jia Jun CHEN lu lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian lu jie Li BI yu Fang Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin University Changchun 130021JinlinChina Qilu Hospital of Shandong University Jinan 250012ShandongChina Affiliated Hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to shanghai jiaotong University School of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical University Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical University Nanning 530021GuangxiChina jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical University Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of shanghai jiading District Shanghai 201800China jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical University Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62,361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

不同去趋势方法对哈思山地区树轮宽度年表气候信号的影响

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干旱区地理 2014年第4期37卷 676-683页

作者：贾飞飞鲁瑞洁尚媛田丽慧陈原北京师范大学环境演变与自然灾害教育部重点实验室北京100875

利用采自甘肃哈思山的油松(Pinus tabulaeformis)树木年轮资料,采用区域曲线(Regional Curve)、负指数曲线(Negative Exponential Curve)和样条函数(Smoothing Spline,30 a步长和67%样本序列长度步长)3种不同类型的去趋势方法,分别建立... 详细信息

利用采自甘肃哈思山的油松(Pinus tabulaeformis)树木年轮资料,采用区域曲线(Regional Curve)、负指数曲线(Negative Exponential Curve)和样条函数(Smoothing Spline,30 a步长和67%样本序列长度步长)3种不同类型的去趋势方法,分别建立了RCS、NEL、SP30和SP67四个树轮宽度年表。通过比较不同树轮宽度指数序列和它们对温度、降水的响应发现:4个树轮宽度指数序列的波动趋势十分一致,但波动幅度有所差异;4个年表对降水的响应较差,对温度的响应差异较大,其中,RCS和NEL年表对温度的响应更为敏感,保留了较多的温度信息;温度对研究区树木生长限制作用较强。利用功率谱方法分析了不同去趋势方法对不同频域气候信号的影响,结果显示:不同去趋势方法得到的年表保留低频变化信息的能力差别较大,其中用区域曲线和负指数函数方法建立的年表保留低频信息的能力较强,而用样条函数建立的年表保留低频信息的能力较差。通过综合比较分析,认为负指数函数是比较适合研究区油松树轮资料的一种去趋势方法。

关键词：哈思山树轮去趋势方法年表

The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population:a two-year follow-up

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Science China(Life Sciences) 2017年第12期60卷 1357-1363页

作者： Joseph O.Obameso Hong Li Hao jia Min Han Shiyan Zhu Canping Huang yuhui Zhao Min Zhao yu Bai fei yuan Honglan Zhao Xia Peng Wen Xu Wenjie Tan Yingze Zhao Kwok-yung yuen William J.Liu Lin lu George F.gao CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China yunnan Provincial Center for Disease Control and Prevention Kunming 650022China University of Chinese Academy of Sciences Beijing 100049China College of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China Key Laboratory of Medical Virology and Viral Diseases Ministry of Health of People's Republic of ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong Kong Special Administrative RegionHong KongChina

Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source of recent human-susceptible coronaviruses, i.e. SARS-COV and MERS-CoV. Our previous study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1. In this report, through a two-year follow-up of a special bat population in one specific cave of south China, we illustrate that Ro-BatCoV GCCDC1 persistently circulates among bats. Notably, through the longitudinal observation, we identified the dynamic evolution of Ro-BatCoV GCCDC1 in bats represented by continuously recombination events. Our study provides the first glimpse of the virus evolution in one longitudinally observed bat population cohort and underlines the surveillance and pre-warning of potential interspecies transmittable viruses in bats.

关键词： coronavirus bat population evolution

TMEM16A contributes to endothelial dysfunction through accelerating Nox2 NADPH oxidase-derived ROS generation in hypertension

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中国药理学与毒理学杂志 2016年第10期30卷 1049-1050页

作者： MA Ming-ming gao Min GUO Kai-min LI Xiang-yu WANG Mi ZENG Xue-lin SUN lu Lyu Xiao-fei DU Yan-hua WANG Guan-lei ZHOU jia-guo GUAN Yong-yuan Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-Sen University Department of Pharmacy the Sixth Affiliated Hospital of Sun Yat-Sen University Department of Obstetrics and Gynecology Guangzhou Women and Children Medical Center affiliated to Guangzhou Medical University Department of Cardiology the Second Xiangya Hospital of Central South University

OBJECTIVE The Ca2+-activated Cl-channel(Ca CC)plays a crucial role in various physiological *** evidences suggest TMEM16A encodes CaC C in various cells,including endothelial ***,the role of TMEM16A in the vascular endothelial dysfunction in hypertension is *** In the study,RT-PCR,Western blotting,co-immunopricipitation,confocal imaging,patch-clamp,and endothelial-specific TMEM16A transgenic and knockout mice were *** We found that TMEM16A was expressed abundantly and functioned as Ca CC in endothelial ***Ⅱ(AngⅡ)induced endothelial dysfunction with an increase in TMEM16A expression,which was alleviated by TMEM16A *** studies revealed that TMEM16A endothelial-specific knockout significantly lowered the blood pressure and ameliorated endothelial dysfunction in AngⅡ-induced hypertension,whereas,TMEM16A endothelial-specific overexpression showed the opposite *** results were related to the increased reactive oxygen species(ROS)generation,NADPH oxidase activation,and Nox2,p22phox expression facilitated by TMEM16A upon AngⅡ-induced hypertensive ***,TMEM16A directly interacted with Nox2 monomer and reduced the degradation of Nox2 through the proteasome-dependent endoplasmic recticulum-associated degradation ***16A also potentiated the translocation of p47phox and p67phox from cytosol to cell membrane and the subsequent interaction with *** Our results demonstrated that TMEM16A,as Ca CC,is a positive regulator of ROS generation via upregulating the activation of Nox2 NADPH oxidase in the vascular endothelium,and therefore facilitates endothelial dysfunction and *** of TMEM16A may be a novel therapeutic strategy for endothelial dysfunction-associated cardiovascular diseases.

关键词： TMEM16A endothelial dysfunction ROS NADPH oxidase Nox2 angiotensinⅡ

The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation

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Nuclear Science and Techniques 2023年第1期34卷 51-85页

作者： Nan‑Shun Huang Zi‑Peng Liu Bang‑jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing yuan fei gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang jiang Meng‑Qi Duan yuan Zhuan Xue‑Fang Huang Peng‑Cheng Dong Zhong‑Liang Li shang‑yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao Zhangjiang Laboratory Shanghai 201210China School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China European XFEL Schenefeld 22869Germany shanghaiTech University Shanghai 201210China

The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic *** general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific *** the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly *** this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE.

关键词： X-ray free-electron laser Free electron laser oscillator Fully coherent X-ray