The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population:a two-year follow-up

作     者：Joseph O.Obameso Hong Li Hao Jia Min Han Shiyan Zhu Canping Huang Yuhui Zhao Min Zhao Yu Bai Fei Yuan Honglan Zhao Xia Peng Wen Xu Wenjie Tan Yingze Zhao Kwok-Yung Yuen William J.Liu Lin Lu George F.Gao 

作者机构：CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China Yunnan Provincial Center for Disease Control and PreventionKunming 650022China University of Chinese Academy of SciencesBeijing 100049China College of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou 325035China Key Laboratory of Medical Virology and Viral DiseasesMinistry of Health of People's Republic of ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Emerging Infectious DiseasesThe University of Hong KongHong Kong Special Administrative RegionHong KongChina 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2017年第60卷第12期

页      面：1357-1363页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2017YFC1200202) the National Natural Science Foundation of China(81290342,81461168030) the Major Special Projects for Infectious Disease Research of China(2016ZX10004222-003) China National Grand S&T Special Project(2014ZX10004-001-006) supported by CAS-TWAS President’s Fellowship of the University of Chinese Academy of Sciences(UCAS)and The World Academy of Sciences(TWAS) a leading principle investigator of the NSFC Innovative Research Group(81621091) 

主　　题：coronavirus bat population evolution 

摘      要：Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source of recent human-susceptible coronaviruses, i.e. SARS-COV and MERS-CoV. Our previous study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1. In this report, through a two-year follow-up of a special bat population in one specific cave of south China, we illustrate that Ro-BatCoV GCCDC1 persistently circulates among bats. Notably, through the longitudinal observation, we identified the dynamic evolution of Ro-BatCoV GCCDC1 in bats represented by continuously recombination events. Our study provides the first glimpse of the virus evolution in one longitudinally observed bat population cohort and underlines the surveillance and pre-warning of potential interspecies transmittable viruses in bats.