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Pathway analysis provides insight into the genetic susceptibility to hepatocellular carcinoma and insight into immuno-therapy treatment response

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Hepatoma Research 2018年第6期4卷 41-50页

作者： Yih-kuang lu Jacob Morris Brill Ardesher Aghili Kenneth Howard Buetow Computational Sciences and Informatics Complex Adaptive SystemsArizona State UniversityTempeAZ 85287USA Center for Evolution and Medicine Arizona State UniversityTempeAZ 85287USA School of Life Sciences Arizona State UniversityTempeAZ 85287USA

Clear evidence exists for genetic susceptibility to hepatocellular carcinoma (HCC). Genome-wide association studies have identified multiple candidate susceptibility loci. These loci suggest that genetic variation in the immune system may underpin HCC susceptibility. Genes for the antigen processing and presentation pathway have been observed to be significantly enriched across studies and the pathway is identified directly through genome-wide studies of variation using pathway methods. Detailed analysis of the pathway indicates both variation in the antigen presenting loci and in the antigen processing are different in cases in controls. Pathway analysis at the transcriptional level also shows difference between normal liver and liver in individuals with HCC. Assessing differences in the pathway may prove important in improving immune therapy for HCC and in identifying responders for immune checkpoint therapy.

关键词： Hepatocellular carcinoma genetic susceptibility genome-wide association study pathway analysis antigen presentation and processing immune checkpoint therapy

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山西汾西选煤系统创新管理实践

煤炭工程 2019年第2期51卷 158-160页

作者：刘路矿山西汾西矿业(集团)有限责任公司山西介休032000

山西汾西矿业集团公司选煤系统围绕"保生存"行动目标,坚守安全、环保、经济运行三条底线,以"精煤生产"为工作重心,以"安全生产"为基础保障,以"抓两头、管中间"为重要抓手,通过规范管理制度、强化过程管控,充分发挥"管理、监督、考核、... 详细信息

山西汾西矿业集团公司选煤系统围绕"保生存"行动目标,坚守安全、环保、经济运行三条底线,以"精煤生产"为工作重心,以"安全生产"为基础保障,以"抓两头、管中间"为重要抓手,通过规范管理制度、强化过程管控,充分发挥"管理、监督、考核、指导、服务"的职能,完成了大量工作任务,保证了选煤系统的平稳健康运行。

关键词：选煤系统安全生产管理实践过程管控

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Inhibition of Inflammatory Responses by Armillariella Mellea Extract in RAW 264.7Macrophage and ***926 Cells

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Inhibition of Inflammatory Responses by Armillariella Mellea...

Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients

第十四届全国中药和天然药物学术研讨会

作者： Huu-Sheng lur Ching-Wen Chang Jing-Jy Cheng Mei-kuang lu National Research Institute of Chinese Medicine Ministry of Health and Welfare

＜正＞Armillariella mellea is an edible fungus used in the formulation of neutraceuticals and functional *** growth curve showed that the 49-day culture achieved the maximum dry mass accumulation with a value of 15.73 g/*** of the ethanolic extract of *** on lipopolysaccharide（LPS）-induced inflammation-related cytokines of tumor necrosis factor

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World Journal of Gastroenterology 2021年第42期27卷 7311-7323页

作者： Yung-Yu Hsieh Shui-Yi Tung Hung-Yu Pan Te-Sheng Chang Kuo-Liang Wei Wei-Ming Chen Yi-Fang Deng Chung-kuang lu Yu-Hsuan Lai Cheng-Shyong Wu Chin Li Department of Gastroenterology and Hepatology Chiayi Chang Gung Memorial HospitalChiayi 61301Taiwan College of Medicine Chang Gung UniversityTaoyuan 33302Taiwan Department of Applied Mathematics National Chiayi UniversityChiayi 60035Taiwan Department of Biomedical Sciences National Chung Cheng UniversityChiayi 62130Taiwan

BACKGROUND An increased amount of Fusobacterium nucleatum(***)is frequently detected in the gastric cancer-associated microbiota of the Taiwan Residents *** is known to exert cytotoxic effects and play a role in the progression of colorectal cancer,though the impact of *** colonization on gastric cancer cells and patient prognosis has not yet been *** To identify ***-dependent molecular pathways in gastric cancer cells and to determine the impact of *** on survival in gastric *** Coculture of *** with a gastric cancer cell line was performed,and changes in gene expression were *** with significant changes in expression were identified by RNA *** analysis was carried out to determine deregulated cellular functions.A cohort of gastric cancer patients undergoing gastrectomy was recruited,and nested polymerase chain reaction was performed to detect the presence of *** in resected cancer *** analysis was performed to determine whether *** colonization affects patient *** RNA sequencing and subsequent pathway analysis revealed a drastic interferon response induced by a high colonization *** response peaked within 24 h and subsided after 72 h of *** contrast,deregulation of actin and its regulators was observed during prolonged incubation under a low colonization load,likely altering the mobility of gastric cancer *** to the clinical specimen analysis,approximately one-third of the gastric cancer patients were positive for ***,and statistical analysis indicated that the risk for colonization increases in late-stage cancer *** analysis demonstrated that *** colonization was associated with poorer outcomes among patients also positive for Helicobacter pylori(***).CONCluSION *** colonization leads to deregulation of actin dynamics and likely changes cance

关键词： Fusobacterium nucleatum Helicobacter pylori Gastric cancer Survival Interferon Mobility

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全球M2/GDP水平和趋势探讨

上海金融 2009年第1期 14-18页

作者：都星汉卢瑶匡敏东华大学工商管理学院

本文以1971年作为信用货币制度确立的重要时点,对全球及不同经济发展水平国家的M2/GDP水平和趋势进行了分析,发现M2/GDP>1不只是中国独有的现象,世界平均M2/GDP持续上升。截至目前,在信用货币制度下并没有任何一个国家的M2/GDP呈现完整... 详细信息

本文以1971年作为信用货币制度确立的重要时点,对全球及不同经济发展水平国家的M2/GDP水平和趋势进行了分析,发现M2/GDP>1不只是中国独有的现象,世界平均M2/GDP持续上升。截至目前,在信用货币制度下并没有任何一个国家的M2/GDP呈现完整的'倒U'型,反而有更多的国家出现M2>GDP的现象,且差距会增大,即呈现喇叭口趋势。本文重点探讨了信用货币制度的内在规律:货币数量无限增长与实体经济运行所需货币量相对减少,这是货币数量的绝对增长超越经济规模的根本原因。信用货币制度的内在规律必然导致数额庞大的货币资产游离于实体经济之外,成为全球'流动性过剩'的根源,而现行的各国央行调控货币供求关系的工具最终会加速货币的繁衍,通胀和滞胀己成为经济运行中的常见现象,经济危机的形态也由生产过剩的危机演变为金融危机和货币危机。基于信用货币制度的内在规律,我们对在不改变信用货币制度前提下任何试图取代美元的国际货币新体系的努力持谨慎态度。

关键词：信用货币制度内在规律全球M2/GDP 倒“U”

基于超球体单形采样的BS-UKF算法在单站无源目标跟踪中的应用

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重庆邮电大学学报（自然科学版） 2010年第3期22卷 298-301,391页

作者：朱联祥况卢娟重庆邮电大学信号与信息处理重点实验室重庆400065

根据单站无源目标定位跟踪模型,提出了一种基于超球体采样策略的BS-UKF(backward-smoothing unscent-ed Kalman filter)算法,并将其应用于单站无源目标跟踪。仿真分析表明,与标准比例采样的UKF(unscented kalmanfilter)和基于超球体单... 详细信息

根据单站无源目标定位跟踪模型,提出了一种基于超球体采样策略的BS-UKF(backward-smoothing unscent-ed Kalman filter)算法,并将其应用于单站无源目标跟踪。仿真分析表明,与标准比例采样的UKF(unscented kalmanfilter)和基于超球体单形采样的UKF相比,该算法在滤波精度上有显著的提高,在时间复杂度上有一定的增加,适合用于对定位精度要求较高的情况。

关键词：超球体单形采样单站无源定位跟踪后向平滑滤波

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基于TEA5767的USB调频收音机设计

深圳职业技术学院学报 2010年第1期9卷 12-17,39页

作者：卢贶武汉软件工程职业学院湖北武汉430205

以TEA5767调频收音芯片和C8051F320微控制器为基础,结合USB通信技术,完成了调频收音机的设计.该调频收音机将收音芯片接收到的声音信号进行处理和数字化,通过USB接口将数字声音数据上传给上位机,任何具有USB连结功能的Windows个人计算... 详细信息

以TEA5767调频收音芯片和C8051F320微控制器为基础,结合USB通信技术,完成了调频收音机的设计.该调频收音机将收音芯片接收到的声音信号进行处理和数字化,通过USB接口将数字声音数据上传给上位机,任何具有USB连结功能的Windows个人计算机或笔记本电脑,只要通过USB接口连接本设计,就能通过计算机扬声器播放调频广播音频.

关键词： TEA5767 调频收音机 USB

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