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Chinese Chemical Letters 1997年第9期8卷 755-758页

作者： Dai Qing SHI Yuan GAO Lai Laong MU zai sheng lu Gui Yuan DAI(Department of Chemistry, Xuzhou Normal University, Xuzhou 221009) Department of Chemistry Xuzhou Normal University Xuzhou 221009 China

The condensation of aromatic aldehydes with isopropylidene malonate or 5,5-dimethyl-1,3-cyclohexanedione is carried out by DMF as solvent without catalyst.

关键词： IR HNMR Cl ppm Condensation of Aromatic Aldehydes with Isopropylidene Malonate or 5,5-Dimethyl-1,3-cyclohexanedione without Catalyst KBr

当归芍药散对肾病综合征大鼠水肿的改善作用及机制

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中国药理学通报 2024年第6期40卷 1172-1178页

作者：马晓雯范胜楠许在平项庆镇宣自华王运来许钒安徽中医药大学药学院中药复方安徽省重点实验室安徽合肥230012

目的探究当归芍药散对肾病综合征大鼠水肿的改善作用及作用机制。方法将大鼠随机分为正常组、模型组、当归芍药散组(17.2 g·kg^(-1)·d^(-1))、氯沙坦组(30 mg·kg^(-1)·d^(-1))、托伐普坦组(3 mg·kg^(-1)·d^(-1))。尾静脉注射阿霉... 详细信息

目的探究当归芍药散对肾病综合征大鼠水肿的改善作用及作用机制。方法将大鼠随机分为正常组、模型组、当归芍药散组(17.2 g·kg^(-1)·d^(-1))、氯沙坦组(30 mg·kg^(-1)·d^(-1))、托伐普坦组(3 mg·kg^(-1)·d^(-1))。尾静脉注射阿霉素建立肾病综合征大鼠模型。给药4周后,检测各组大鼠肾功能指标及24 h尿蛋白含量变化;免疫组化法检测肾组织中水通道蛋白2(aquaporin 2,AQP2)和pS256-AQP2的分布;放射免疫法测定血浆精氨酸加压素(arginine vasopressin,AVP)和血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)水平;Western blot和RT-PCR法分别检测肾脏AQP2、pS256-AQP2、血管紧张素1型受体(angiotensin type 1 receptor,AT1R)、精氨酸加压素受体2(arginine vasopressin receptor 2,V2R)蛋白及mRNA的表达。结果3种药物均可改善肾病综合征大鼠肾功能,减轻蛋白尿,降低血浆AVP及AngⅡ水平,下调AQP2、pS256-AQP2蛋白和mRNA表达。当归芍药散与托伐普坦对于降低血浆AVP水平的效果优于氯沙坦。结论当归芍药散可能通过降低AVP及AngⅡ水平,进而调节AQP2的表达,改善肾病综合征大鼠水肿。

关键词：肾病综合征水肿水通道蛋白2 精氨酸加压素血管紧张素Ⅱ 当归芍药散

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扬子西缘羊场磷矿地球化学特征及其对成磷环境的指示

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岩石矿物学杂志 2024年第5期43卷 1119-1138页

作者：周骞米云川赵勇黄太平王加昇胡清华夏建峰宰西昆明理工大学国土资源工程学院云南昆明650093 云南省地质调查院(云南省地质科学研究院) 云南昆明650216 自然资源部三江成矿作用及资源勘查利用重点实验室云南昆明650051 云南省三江成矿作用及资源勘查利用重点实验室云南昆明650051 云南省地质调查局云南昆明650051

寒武纪生命大爆发与海水氧化还原条件息息相关,上扬子地区下寒武统磷块岩较完整记录了早寒武世古海洋环境信息。扬子西缘羊场磷矿床是赋存于下寒武统梅树村组的超大型磷矿床,可重建该时期古海洋环境。本文采用ICP-MS等手段,分析羊场磷... 详细信息

寒武纪生命大爆发与海水氧化还原条件息息相关,上扬子地区下寒武统磷块岩较完整记录了早寒武世古海洋环境信息。扬子西缘羊场磷矿床是赋存于下寒武统梅树村组的超大型磷矿床,可重建该时期古海洋环境。本文采用ICP-MS等手段,分析羊场磷矿床磷块岩及其围岩的元素地球化学组成特征,探讨其形成时的环境条件。结果表明,羊场磷矿床磷块岩CIA值为46.40~65.60,平均57.43,显示其风化程度较低,稀土元素总量ΣREE相对较低(140.0×10^(-6)~237.4×10^(-6)),但较富集Y(87.0×10^(-6)~183.2×10^(-6));北美页岩标准化的稀土元素配分模式曲线相对平缓,LREE/HREE值为4.22~7.50,显示出轻重稀土元素分异不明显,具有明显的Ce负异常(δCe=0.22~0.42),Eu异常不明显(δEu=0.90~1.21),U/Th值为2.55~27.68,反映了磷块岩成矿过程中受到热水活动的影响;结合δCe、V/Cr、Y/Ho、Sr/Cu等元素分析认为,由底部震旦纪灯影组,到含磷层寒武纪梅树村组,直至上覆牛蹄塘组,古海洋氧化还原环境由底部的相对还原环境,向上变为氧化环境,直至顶部变为相对还原环境。古气候环境表现为寒冷干燥-温暖湿润交替出现的变化规律,古海水盐度表现为由咸水→半咸水→咸水→淡水的演化过程。综合分析后认为,羊场磷矿床磷块岩形成于相对氧化的咸水和较为干旱的古气候环境,并有热水活动参与成矿。

关键词：磷块岩梅树村组沉积环境羊场磷矿床扬子地块西缘

Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma

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World Journal of Gastroenterology 2021年第21期27卷 2871-2894页

作者： zai-sheng Ye Miao Zheng Qin-Ying Liu Yi Zeng sheng-Hong Wei Yi Wang Zhi-Tao Lin Chen Shu Qiu-Hong Zheng lu-Chuan Chen Department of Gastrointestinal Surgical Oncology Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina Department of Clinical Laboratory Fujian Maternity and Child Health HospitalAffiliated Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Fujian Provincial Key Laboratory of Tumor Biotherapy Fujian Cancer Hospital&Fujian Medical University Cancer HospitalFuzhou 350014Fujian ProvinceChina

BACKGROUND Alternative splicing(AS)increases the diversity of mRNA during transcription;it might play a role in alteration of the immune microenvironment,which could influence the development of immunotherapeutic strategies against *** To obtain the transcriptomic and clinical features and AS events in stomach adenocarcinoma(STAD)from the *** overall survival data associated with AS events were used to construct a signature prognostic model for *** Differentially expressed immune-related genes were identified between subtypes on the basis of the prognostic *** STAD,2042 overall-survival-related AS events were significantly enriched in various pathways and influenced several cellular ***,the network of splicing factors and overallsurvival-associated AS events indicated potential regulatory mechanisms underlying the AS events in *** An eleven-AS-signature prognostic model(CD44|14986|ES,PPHLN1|21214|AT,RASSF4|11351|ES,KIAA1147|82046|AP,PPP2R5D|76200|ES,LOH12CR1|20507|ES,CDKN3|27569|AP,UBA52|48486|AD,CADPS|65499|AT,SRSF7|53276|RI,and WEE1|14328|AP)was constructed and significantly related to STAD overall survival,immune cells,and cancer-related *** differentially expressed immune-related genes between the high-and low-risk score groups were significantly enriched in cancer-related *** This study provided an AS-related prognostic model,potential mechanisms for AS,and alterations in the immune microenvironment(immune cells,genes,and pathways)for future research in STAD.

关键词： Stomach adenocarcinoma Alternative splicing Tumor microenvironment Immune-related genes and pathways

腰椎间盘突出症行UBE内镜下髓核摘除术后连续臭氧椎管内注射的疗效观察

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中国实用医药 2024年第11期19卷 31-34页

作者：王凤林刘圣莲李再宝临沂市康复医院疼痛科 276034 临沂市中医医院药剂科 276002 临沂市第四人民医院疼痛科 276002

目的观察腰椎间盘突出症(LDH)患者行单侧双通道内镜技术(UBE)内镜下髓核摘除术后连续臭氧椎管内注射治疗的疗效。方法选取60例腰椎间盘突出症患者,随机分为观察组和对照组,各30例。所有患者均行UBE内镜下髓核摘除术,观察组术后连续臭... 详细信息

目的观察腰椎间盘突出症(LDH)患者行单侧双通道内镜技术(UBE)内镜下髓核摘除术后连续臭氧椎管内注射治疗的疗效。方法选取60例腰椎间盘突出症患者,随机分为观察组和对照组,各30例。所有患者均行UBE内镜下髓核摘除术,观察组术后连续臭氧椎管内注射治疗,对照组常规切口缝合、覆盖无菌辅料。比较两组手术前后腰腿痛评分及术后切口肿胀和渗出评分。结果对照组术前1 d及术后1、5、12 d的视觉模拟评分法(VAS)评分分别为(6.65±1.59)、(5.13±1.18)、(3.92±1.15)、(2.28±1.18)分,观察组分别为(6.62±1.15)、(3.87±1.27)、(2.31±1.10)、(1.11±0.92)分;两组术前1 d VAS评分比较差异无统计学意义(P>0.05);术后1、5、12 d,两组VAS评分均低于术前1 d,且观察组均低于对照组,差异有统计学意义(P<0.05)。对照组术后1、5、12 d的肿胀评分和渗出评分分别为(2.16±0.58)、(1.33±0.79)、(0.42±0.12)分和(2.31±0.63)、(1.60±0.27)、(0.91±0.29)分,观察组分别为(1.82±0.47)、(0.89±0.83)、(0.15±0.16)分和(1.95±0.58)、(1.32±0.21)、(0.43±0.21)分;术后5、12 d,两组肿胀评分和渗出评分均低于术后1 d,差异有统计学意义(P<0.05);术后12 d,两组肿胀评分和渗出评分均低于术后5 d,差异有统计学意义(P<0.05);观察组术后1、5、12 d肿胀评分和渗出评分均低于对照组,差异有统计学意义(P<0.05)。结论腰椎间盘突出症行UBE内镜下髓核摘除术后连续臭氧椎管内注射,可有效改善患者腰腿痛症状,且切口肿胀和渗出情况较轻,值得在临床上推广应用。

关键词：单侧双通道内镜技术腰椎间盘突出症髓核摘除术椎管臭氧

沉水植物苦草及其微生物对沉积物中多环芳烃修复作用

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环境生态学 2024年第7期6卷 101-107页

作者：卫昊明严海峰王鸿洋晏再生中国科学院南京地理与湖泊研究所湖泊与环境国家重点实验室江苏南京210008 中国科学院大学北京100049 南京大学环境学院江苏南京210023 哈尔滨师范大学黑龙江哈尔滨150025

沉水植物苦草(Vallisneria natans)可以有效地修复受多环芳烃(PAHs)污染沉积物,但其微生物作用机制有待进一步阐明。本研究选取东太湖大水港这一典型的苦草生长及PAHs污染区域为研究对象,考察不同灭菌处理条件下,苦草对PAHs的修复效果... 详细信息

沉水植物苦草(Vallisneria natans)可以有效地修复受多环芳烃(PAHs)污染沉积物,但其微生物作用机制有待进一步阐明。本研究选取东太湖大水港这一典型的苦草生长及PAHs污染区域为研究对象,考察不同灭菌处理条件下,苦草对PAHs的修复效果。结果表明,经过15 d的苦草修复试验,沉积物灭菌处理组PAHs去除率最高(41.81%),苦草根表灭菌处理组次之(31.81%),二者均灭菌处理组去除率较低(25.19%)。微生物群落结构表明,苦草的根际与非根际沉积物中微生物主要由变形菌门(Proteobacteria)、绿弯菌门(Chloroflexi)、酸杆菌门(Acidobacteria)、拟杆菌门(Bacteroidetes)以及放线菌门(Actinobacteria)等组成,而苦草的根表及根内同样富集了显著不同微生物,苦草根表及根内主要为变形菌门(Proteobacteria),其丰度分别为88.5%、67.7%。进一步分析显示富集的优势菌属主要为不动杆菌属(Acinetobacter)、假单胞菌属(Pseudomonas)以及草螺菌属(Herbaspirillum)。由此表明,大水港地区沉积物中微生物及苦草根系微生物均对促进沉积物中PAHs去除有效果。在保持苦草根系活性情况下,苦草生长可能促进了灭菌沉积物中微生物降解潜力的部分恢复,并协同苦草根表根内微生物加速降解沉积物中PAHs。

关键词：苦草多环芳烃沉积物微生物修复

Relationship between cell adhesion molecules expression and the biological behavior of gastric carcinoma

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World Journal of Gastroenterology 2008年第13期14卷 1990-1996页

作者： Yong-Quan Chu zai-Yuan Ye Hou-Quan Tao Yuan-Yu Wang Zhong-sheng Zhao Wenzhou Medical College Wenzhou 325035 Zhejiang Province China Department of Gastroenterology Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China Department of Pathology Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China

AIM: To evaluate the relationship between the expression of cell adhesion molecules (CAMs) and the biological behavior of gastric carcinoma. METHODS: Expression of syndecan-1, E-cadherin and integrin β3 were evaluated by immunohistochemical study in a total of 118 gastric carcinomas and 20 non- tumor gastric mucosas. RESULTS: The expressions of syndecan-1 and E-cadherin were significantly lower in gastric carcinoma compared to non-tumor gastric mucosa, and the low expression rates were positively correlated to the tumor invasion depth, vessel invasion, lymph node metastasis and distant metastasis (P 0.05, P > 0.05 and P > 0.05 respectively). Positive correlation was observed between the expressions of syndecan-1 and E-cadherin, but they which were negatively correlated to the expression of integrin β3 (P 0.05, P > 0.05 respectively). CONCluSION: The low expression of syndecan-1 and E-cadherin and the high expression of integrin β3 are significantly correlated with the invasion and metastasis of gastric carcinoma, and t

关键词： Cell adhesion molecules Gastric Carcinoma,Invasion, Metastasis Prognosis

BloomRouter:A Framework for Dissemination of Compressed XML Stream

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 100-106页

作者： BAO Xiao-yuan TANG Shi-wei YANG Dong-qing SONG zai-sheng WU Ling Computer and Information Engineering College Tianjin Normal University Tianjin 300074 China Computer Science Department Peking UniversityBeijing 10087i China

As our best knowledge, in the Publish/Subscribe application environment, few research work has been done on the dissemination and routing of compressed XML （extended markup language） data. A high-speed compressed XML data routing and dissemination framework BloomRouter is proposed. In BloomRouter, a Bloom Filter based prefilte ring mechanism is used to filter out compressed XML elements that users do not care; after that an interval tree dis seminator forwards target elements to the corresponding end users by matching the incomming compressed XML elements with indexed users＇ query regions. Based on this framework, we can efficiently filter/query the compressed incoming XML data, and then route the query result to the corresponding subseriber.

关键词： XML bloom filters compression data stream

Subtle Alignment of Organic Semiconductors at the Donor/Acceptor Heterojunction Facilitates the Photoelectric Conversion Process

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Chinese Journal of Polymer Science 2022年第8期40卷 951-959,I0010页

作者： Yu-Xuan Liu Liang Wang Ke Zhou Hong-Bo Wu Xiao-Bo Zhou zai-Fei Ma sheng-Wei Guo Wei Ma State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China School of Materials Science&Engineering North Minzu UniversityYinchuan750021China Center for Advanced Low-dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai201620China

The aligned molecular packing structure is vital to the anisotropic charge transport in conjugated polymer and small molecule thin ***,how this molecular packing motif influences the photoelectric conversion process at the donor/acceptor heterojunction is still ***,we employed a PM6/Y6 bilayer model to investigate the long-range alignment of molecular packing induced photoelectric conversion *** PM6 and Y6 layers were properly controlled to exhibit the uniaxially oriented molecular packing compared to their as-cast counterparts,as revealed by the polarized absorption spectra and transmission electron *** analyzing the photovoltaic performance of bilayer devices,the smaller energy loss,lower energetic disorder,and longer charge carrier lifetime can be observed in the bilayer devices with aligned Y6 molecules,which contribute to a higher power conversion efficiency(PCE)than the as-cast *** the molecular packing structure of PM6 layer exhibited negligible influence on the device performance,probably resulting from the intrinsic semicrystalline nature of PM6 *** results indicate that the alignment of small molecular acceptor at the donor/acceptor interfaces should be a powerful strategy to facilitate the photoelectric conversion process,which will definitely pave the way to highly efficient bulk heterojunction photovoltaic device.

关键词： Molecular packing Photoelectric conversion process Planar heterojunction Organic solar cells

Magnetic field annealing of FeCo-based amorphous alloys to enhance thermal stability and Curie temperature

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Rare Metals 2023年第6期42卷 2000-2006页

作者： zai-Dao Li Wei-Wei Zhang Ge-Tian Li Song-Song Li Hong-sheng Ding Tao Zhang Yu-Jun Song Center for Modern Physics Technology Department of Applied PhysicsBeijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceUniversity of Science and Technology BeijingBeijing100083China School of Materials Science and Engineering Beihang UniversityBeijing100191China

Annealing temperatures and applied magnetic fields are two important parameters for the performance modification of magnetic *** article investigated the effect of different annealing temperatures on crystallization condition,magnetic properties and thermal stability of the amorphous magnetic alloy Co_(36)Fe_(36)Si_(4.8)B1_(9.2)Nb_(4)(at%).Results indicate that the annealing temperature can significantly affect the size and content of precipitated nanocrystals in the amorphous alloy,and the precipitation of nanocrystalline phases can result in the distinct change of magnetic properties and Curie *** the annealing was performed at 595 ℃ for 30 min under an applied transverse external magnetic field of 9550.0A·m^(-1),the amorphous alloy shows excellent soft magnetic properties with the saturation magnetization of alloy reaching 110.00 mA·m^(2)·g^(-1),the residual magnetic induction intensity of 4 × 10^(-6) T and the coercivity as low as57.3 A·m^(-1).Furthermore,the Curie temperature of the field-annealed samples can reach up to 440 0C,approximately 58℃ higher than that of the as-quenched species.

关键词： Soft magnetic alloys Amorphous alloy Field annealing