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Carvedilol Versus Other Nonselective Beta Blockers for Variceal Bleeding Prophylaxis and Death: A Network Meta-analysis

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Journal of Clinical and translational Hepatology 2023年第5期11卷 1143-1149页

作者： Ka-shing Cheung Chiu-Hang Mok lok-Ka Lam Xian-Hua Mao Lung-Yi Mak Wai-Kay seto Man-Fung Yuen Department of Medicine School of Clinical MedicineThe University of Hong KongQueen Mary HospitalHong KongChina Department of Medicine The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina school of Clinical Medicine The University of Hong KongHong KongChina state Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background and Aims:We aimed to perform a network meta-analysis(NWM)to examine comparative effectiveness of non-selective beta blockers(NsBBs)on prophylaxis of gastroesophageal variceal bleeding(GVB)and mortality ***:MEDLINE(OVID)and EMBAsE databases were searched for eligible randomized clinical trials(RCts)from inception to July 3,*** of interest included primary/secondary prophylaxis of GVB,failure to achieve hepatic venous pressure gradient(HVPG)decremental response,liver-related and all-cause mortality.A Bayesian NWM was performed to derive relative risk(RR)with 95%credible intervals(CrIs).the ranking probability of each NsBB was assessed by surface under cumulative ranking curve(sUCRA).Results:thirty-three RCts including 3,188 cirrhosis patients with gastroesophageal varices were *** with placebo,nadolol ranked first for reducing variceal bleeding[RR:0.25,(95%CrI:0.11–0.51);sUCRA:0.898],followed by carvedilol[RR:0.33,(95%CrI:0.11–0.88);sUCRA:0.692]and propranolol[RR:0.52,(95%CrI:0.37–0.75);sUCRA:0.405].Carvedilol was more effective than propranolol in achieving HVPG decremental response[RR:0.43,(95%CrI:0.26–0.69)].Carvedilol ranked first for reducing all-cause mortality[RR:0.32,(95%CrI:0.17–0.57);sUCRA:0.963],followed by nadolol[RR:0.48,(95%CI:0.29–0.77);sUCRA:0.688],and propranolol[RR:0.77,(95%CI:0.58–1.02);sUCRA:0.337].similar findings were observed for liver-related *** ranked the *** RR of adverse events was 4.38,(95%CrI:0.33–161.4);sUCRA:0.530,followed by propranolol[RR:7.54,(95%CrI:1.90–47.89);sUCRA:0.360],and nadolol[RR:18.24,(95%CrI:91.51–390.90);sUCRA:0.158].Conclusions:Carvedilol is the preferred NsBB with better survival benefit and lower occurrence of adverse events among patients with gastroesophageal varices.

关键词： NsBB Carvedilol Nadolol Propranolol Varices Cirrhosis CPsH

seropharmacological study on Osteogenic Effects of Post-Absorption Ingredients of An Osteoprotective Herbal Formula

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Chinese Journal of Integrative Medicine 2017年第1期23卷 25-32页

作者： sIU Wing-sum KO Chun-hay WONG Hing-lok GAO si sHUM Wai-ting LAU Clara Bik-san HUNG Lung-kim LEUNG Ping-chung Institute of Chinese Medicine Chinese University of Hong KongHong KongChina state Key Laboratory of Phytochemistry and Plant Resources in West China Chinese University of Hong KongHong KongChina Department of Orthopaedics and traumatology Chinese University of Hong KonqHong KongChina

Objective： to further investigate the in vitro effects of an osteoprotective herbal formula ＂ELP＂（Herba Epimedii, Fructus Ligustri Lucidi and Fructus Psora/eae） using seropharmacological approach. Methods： Rats were fed with ELP or its individual component herbs for 2 days. the serum containing the post-absorbed ingredients of the herbal items were collected for cell culture using UMR106 cell, RAW264.7 cell and mesenchymal stem cell （MsC） isolated from the bone marrow of the rats. the effects of the herbal-containing serum on cell toxicity were detected by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay; bromodeoxyuridine assay was conducted to measure the cell proliferation of UMR106 cell and MsC; cell activity was measured using colorimetric method, and mRNA expression of runt-related transcription factor 2 （Runx2）, alkaline phosphatase （ALP） and osteopontin （OPN） of UMR106 and MsC as well as matrix metalloproteinase 9 （MMP-9）, tartrate-resistant acid phosphatase （tRAP） and cathepsin K of RAW264.7 were analyzed using real-time reverse-transcription polymerase chain reaction. Results： ELP and its component serum exhibited no cytotoxic effects on the cells. the ELP-containing serum increased the proliferation of UMR106 cell and MsC by 25.7% and 14.4%, respectively and the alkaline phosphatase activity of MsC was increased by 42.6%. On the contrary, it inhibited the RAW264.7 cell differentiation by 29.2%. ELP serum upregulated the Runx2 expression of UMR and MsC by 1.18 fold and 1.27 fold, respectively. It also upregulated ALP and OPN expression in MsC by 1.69- and 2.12-fold, respectively. On the other hand, ELP serum down-regulated MMP-9 and cathepsin K expression of RAW264.7 cell by 0.46- and 0.36-fold, respectively. Conclusions： the serum of the animals fed with ELP contains active ingredients which are effective in promoting osteogenesis and inhibiting osteoclastogenesis.

关键词： osteoporosis seropharmacology osteogenesis herbal formula

适当的患者教育可以改进中国农村丙型肝炎患者的疾病知识及对抗病毒治疗的接受程度

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中华肝脏病杂志 2018年第11期26卷 824-828页

作者：杨明饶慧瑛封波 El izabeth Wu 魏来 Anna s. lok 北京大学人民医院北京大学肝病研究所丙型肝炎和肝病免疫治疗北京市重点实验室 100044 美国密歇根大学医学院胃肠及肝病科 48109

目的评估丙型肝炎教育对中国农村慢性丙型肝炎（CHC）患者疾病知识和抗病毒治疗接受程度的影响。方法河北省某县CHC项目的农村患者接受HCV教育，包括医生给予讲座和随后进行的互动式讨论，并完成教育前后测试。结果总共纳入151例CHC患... 详细信息

目的评估丙型肝炎教育对中国农村慢性丙型肝炎（CHC）患者疾病知识和抗病毒治疗接受程度的影响。方法河北省某县CHC项目的农村患者接受HCV教育，包括医生给予讲座和随后进行的互动式讨论，并完成教育前后测试。结果总共纳入151例CHC患者。平均年龄为57．3岁，50．3％为男性，51．0％患者的受教育程度为小学或文盲，76．2％的家庭月收入低于3000元。98.0％的患者将其基线丙型肝炎知识定义为“无”或“只有一点”。多因素分析显示，年龄和家庭收入与基线知识总分相关。教育后，患者知识总分的平均分（范围：0-28分）从13．1升至23．0（P〈0．001），题目回答正确患者的平均百分比从46．8％升至82．1％（P〈0．001），患者对抗病毒治疗的接受程度从33．9％升至65．6％（P〈0．001）。结论虽然中国农村患者的受教育程度较低，按患者选择的方式进行的丙型肝炎教育可以显著改善患者的疾病知识和抗病毒治疗的接受程度。

关键词：肝炎病毒,丙型预防传播治疗阻碍

Robot-assisted minimally invasive procedures for complicated biliary stone disease

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Hepatobiliary surgery and Nutrition 2018年第3期7卷 185-188页

作者： Kit Fai Lee Andrew K. Y. Fung Hon ting lok Anthony K. W. Fong Charing C. N. Chong Paul B. s. Lai Division of Hepatobiliary and Pancreatic surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Introduction A big advancement in endoscopic management for biliary stone diseases was seen in the past three decades. Bile duct stones can be removed after sphincterotomy or balloon sphincteroplasty with stone basket... 详细信息

关键词： balloon biliary diseases

慢性乙型肝炎患者的乙型肝炎表面抗原会消失吗?——西方观点

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中国医学前沿杂志（电子版） 2013年第7期5卷 19-20页

作者： Anna s.lok 美国密歇根大学安娜堡48109

乙肝表面抗原（HBsAg）发现迄今已有50年历史，随着研究的进展，人们对HBsAg的认识越来越深入。那么，HBsAg会消失吗？HBsAg消失后患者的预后会有何变化？

关键词： HBsAg CHB 自发清除 HBeAg 乙型

Pattern of disease recurrence and its implications for postoperative surveillance after curative hepatectomy for hepatocellular carcinoma: experience from a single center

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Hepatobiliary surgery and Nutrition 2018年第5期7卷 320-330页

作者： Kit-Fai Lee Charing C. N. Chong Anthony K. W. Fong Andrew K. Y. Fung Hon-ting lok Yue-sun Cheung John Wong Paul B. s. Lai Department of surgery Division of Hepatobiliary and Pancreatic Surgery Prince of Wales Hospital the Chinese University of Hong Kong Hong Kong China

Background: Hepatectomy is a widely accepted curative treatment for hepatocellular carcinoma (HCC). However, the disease frequently recurs after a curative hepatectomy. the objective of this study is to provide a better understanding of the pattern of disease recurrence and the risk factors involved so as to improve the postoperative surveillance. Methods: A retrospective study for all patients receiving hepatectomy for HCC between 2003 and 2014 was performed. Emphasis was made on the timing and pattern of recurrent disease, and type of treatment given. Results: there were 506 patients in the study. Median follow-up was 43.7 months. the 1-, 3-, 5-, 10-year overall and disease free survival were 89.5%, 74.1%, 63.9%, 49.0% and 69.5%, 54.3%, 43.4%, 30.9%respectively. Recurrent disease occurred in 267 patients, 47.2% occurred within 9 months of hepatectomy and 80.1% recurred only in liver. Median survival was shorter for recurrence occurring within 9 months compared with those occurring between 10 months and 2 years postoperatively (36.2 vs. 65.7 months, Pst less curative treatment was offered for patients with early (within 9 months) intrahepatic alone recurrence (22.2% vs. 51.7%, Ptivariate analysis revealed tumor size >3.5 cm and history of rupture were risk factors for recurrence within 9 months. Conclusions: these findings suggest that recurrent diseases are common after curative hepatectomy for HCC and most recurrences occur in the remnant liver. since almost half of recurrences occurred within first 9 months after hepatectomy, a more stringent postoperative surveillance with target imaging of liver in this period is needed. Early diagnosis of recurrent disease and curative retreatment hopefully can bring about a longer survival.

关键词： Hepatectomy hepatocellular carcinoma (HCC) recurrence

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乙型肝炎表面抗原的发现

中国医学前沿杂志（电子版） 2013年第7期5卷 1-2页

作者： Anna s.lok 美国密歇根大学安娜堡48109

在20世纪60年代，Baruch s. Blumberg正致力于遗传学、不同人群的疾病遗传易感性和多态性系统研究。当时的观点认为，大量输血的患者常会针对供体血液中的“多态性血浆蛋白（polymorphic serum proteins）”产生抗体，因而Blumberg设想... 详细信息

在20世纪60年代，Baruch s. Blumberg正致力于遗传学、不同人群的疾病遗传易感性和多态性系统研究。当时的观点认为，大量输血的患者常会针对供体血液中的“多态性血浆蛋白（polymorphic serum proteins）”产生抗体，因而Blumberg设想，通过“琼脂胶双向扩散（double diffusion in agar gel）”的方法，这些患者的血液样本可以用于鉴定不同人群的遗传多态性和疾病易感性。

关键词：澳抗家族聚集性阳性率家系病毒传染性肝炎病毒病病毒性肝炎先天愚型唐氏综合征

Virtual Reality simulation of Fuzzy-logic Control during Underwater Dynamic Positioning

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Journal of Marine science and Application 2015年第1期14卷 14-24页

作者： Midhin Das thekkedan Cheng siong Chin Wai lok Woo school of Marine science and technology Newcastle University NEI 7RU United Kingdom school of Electrical and Electronic Engineering Newcastle University NE I 7R U United Kingdom

In this paper, graphical-user-interface （GUI） software for simulation and fuzzy-logic control of a remotely operated vehicle （ROV） using MAtLABtM GUI Designing Environment is proposed. the proposed ROV＇s GUI platform allows the controller such as fuzzy-logic control systems design to be compared with other controllers such as proportional-integral-derivative （PID） and sliding-mode controller （sMC） systematically and interactively. External disturbance such as sea current can he added to improve the modelling in actual underwater environment. the simulated results showed the position responses of the fuzzy-logic control exhibit reasonable performance under the sea current disturbance.

关键词： graphical-user-interface (GUI) fuzzy-logic control remotely operated vehicle (ROV) proportional-integral-derivative (PID) sliding-mode controller (sMC) underwater dynamic positioning

the interplay of aging,genetics and environmental factors in the pathogenesis of Parkinson’s disease

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translational Neurodegeneration 2019年第1期8卷 279-289页

作者： shirley Yin-Yu Pang Philip Wing-lok Ho Hui-Fang Liu Chi-ting Leung Lingfei Li Eunice Eun seo Chang David Boyer Ramsden shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongPeople’s Republic of China Institute of Metabolism and systems Research University of BirminghamBirminghamUK

Background:Parkinson’s disease(PD)is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies(LB).During the course of disease,misfoldedα-synuclein,the major constituent of LB,spreads to different regions of the brain in a prion-like fashion,giving rise to successive non-motor and motor *** is likely multifactorial,and involves interplay among aging,genetic susceptibility and environmental *** body:the prevalence of PD rises exponentially with age,and aging is associated with impairment of cellular pathways which increases susceptibility of dopaminergic neurons to cell ***,the majority of those over the age of 80 do not have PD,thus other factors in addition to aging are needed to cause *** of neurotoxins which can result in parkinsonism led to efforts in identifying environmental factors which may influence PD ***,the causality of most environmental factors is not conclusively established,and alternative explanations such as reverse causality and recall bias cannot be *** lack of geographic clusters and conjugal cases also go against environmental toxins as a major cause of *** mutations as well as common variants in genes such as sNCA,LRRK2 and GBA are associated with risk of PD,but Mendelian causes collectively only account for 5%of PD and common polymorphisms are associated with small increase in PD *** of PD has been estimated to be around 30%.thus,aging,genetics and environmental factors each alone is rarely sufficient to cause PD for most ***:PD is a multifactorial disorder involving interplay of aging,genetics and environmental *** has implications on the development of appropriate animal models of PD which take all these factors into *** converging pathways likely include mitochondrial dysfunction,impaired autophagy,oxidative stress and neuroinflammation,which are

关键词： Parkinson’s disease Genetics Aging Environmental toxins