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注射用胸腺五肽联合纤支镜灌洗治疗对支气管扩张症合并肺部感染患者血清炎症指标水平的影响

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药物生物技术 2024年第1期31卷 85-89页

作者：郭静张健刘壮河北省邢台市第三医院河北邢台054000

观察注射用胸腺五肽联合纤支镜灌洗治疗对支气管扩张症(BE)合并肺部感染患者血清炎症指标水平的影响。纳入2021年3月至2022年3月期间150例BE合并肺部感染患者,采用随机数字表法分为对照组、纤支镜组、联合组各50例,对照组予以常规对症... 详细信息

观察注射用胸腺五肽联合纤支镜灌洗治疗对支气管扩张症(BE)合并肺部感染患者血清炎症指标水平的影响。纳入2021年3月至2022年3月期间150例BE合并肺部感染患者,采用随机数字表法分为对照组、纤支镜组、联合组各50例,对照组予以常规对症支持治疗,纤支镜组在对照组的基础上联合纤维支气管镜灌洗治疗,联合组在纤支镜组的基础上联合胸腺五肽治疗。比较三组临床疗效、恢复时间及治疗前后肺功能、动脉血气指标、血清炎症因子水平。纤支镜组与联合组治疗总有效率均高于对照组,且联合组高于纤支镜组(P<0.05);纤支镜组与联合组咳嗽咳痰、发热恢复时间及住院时间均短于对照组,且联合组短于纤支镜组(P<0.05);治疗7 d后纤支镜组与联合组呼气峰流速(PEF)、第一秒用力呼气容积占用力肺活量百分比(FEV_(1)/FVC)、动脉血氧分压(PaO_(2))、氧合指数(PaO_(2)/FiO_(2))均高于对照组,且联合组高于纤支镜组(P<0.05);治疗7 d后纤支镜组与联合组血清白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、淀粉样蛋白A(SAA)水平均低于对照组,且联合组低于纤支镜组(P<0.05)。注射用胸腺五肽联合纤支镜灌洗治疗BE合并肺部感染可促进症状和体征恢复,改善肺功能和动脉血气,控制炎症反应。

关键词：支气管扩张症肺部感染胸腺五肽纤支镜灌洗肺功能炎症因子

Wear Resistance of TiN_x/CF_y Coatings Deposited by RF Magnetron Co-Sputtering

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Journal of Materials Science & Technology 2015年第12期31卷 1207-1216页

作者： Lin Zhu Jinwu Wang zhuang liu College of Engineering Northeast Agricultural University School of Light Industry Harbin University of Commerce

TiN x/CF y composite coatings were prepared by RF magnetron co-sputtering using twin cylindrical tube targets with Ar and N 2 *** composition of the coatings deposited at various positions was analyzed by X-ray photoelectron spectroscopy（XPS） and Rutherford back-scattering spectrometry（RBS）.The results revealed that the composition of the deposited coatings has a wide range of TiN x and CFy contents at different deposition positions,which leads to different structures and *** hardness of the composite coatings increases from 32 to 1603 HV with increasing the TiN x *** static contact angle of water ranges from 20° to 102° and decreases upon the incorporation of more TiN x into the CF y *** presence of the CF y groups enhances the contact angle between the coating and the solutions dropped onto it,which could effectively protect the coating from corrosion and improve the wear resistance properties in high relative humidity（RH）.The brittleness of the coatings decreases due to the softness of the CF y component,which can bear most of the load and result in less probability of crack *** results demonstrate the existence of a Ti-（C N） chemical bond in the composite coatings,which improves the wear resistance of the *** is indicated that the wear resistance of the TiN x/CF y coatings is independent of the ***,these properties depend on the uniform structure and the existence of chemical bonding between the TiN x and CF y ***,a specific ratio between the soft CF y phase and the hard TiN x phase can produce coatings with good wear resistance.

关键词： TiNx/CFy composite coatings Magnetron co-sputtering Wear resistance

Recent advances in functional nanomaterials for X-ray triggered cancer therapy

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Progress in Natural Science:Materials International 2020年第5期30卷 567-576页

作者： Teng liu Kai Yang zhuang liu State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RADX) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University

X-ray is a form of ionizing radiation with high energy and strong tissue-penetrability, which has been widely used for cancer therapy, including radiation therapy(RT) as one of the mainstream cancer treatments and radiodynamic therapy(RDT) as an emerging treatment modality. However, the nonspecific absorption of X-ray and peculiar tumor microenvironment would lead to the unsatisfied therapeutic effect and severe damage to normal tissues. The fast progress of nanotechnology has provided great opportunities for the development of functional nanoparticles and strategies to solve these problems. In this review, we will summarize the recent advances in functional nanomaterials and the related strategies, discuss how they solve the challenges in order to improve the therapeutic efficacy and safety of RT and RDT, and moreover comment on the challenges and prospects for efficient X-ray triggered cancer therapy based on nanomedicine.

关键词： X-ray irradiation Nanomaterials Cancer therapy Radiation therapy Radiodynamic therapy

Precise regulation of intermembrane spacing with DNA nanojunctions for enhanced T-cell receptor triggering

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Science China Chemistry 2023年第8期66卷 2157-2159页

作者： Lele Sun zhuang liu School of Life Sciences Shanghai UniversityShanghai200444China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Lab Carbon Based Functional Materials and DevicesSoochow UniversitySuzhou215123China

It is well known that adaptive immunity involving T cells plays a crucial role in combating many diseases.T-cell activation is initiated by the engagement of T-cell receptors(TCRs)to peptide-loaded major histocompatibility complexes(p MHCs)on antigen-presenting cells(APCs),which triggers a cascade of signaling events that ultimately lead to T-cell activation[1].

关键词： immunity spacing initiated

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釜溪河自贡城区段季节性低氧成因研究

中国环境监测 2024年第2期40卷 95-104页

作者：刘壮魏峣陈强刘晓聪袁基刚张静怡张李玲四川省生态环境科学研究院四川成都610046 四川轻化工大学化学与环境工程学院四川自贡643002

釜溪河为沱江一级支流,在自贡城区段设有国考碳研所断面。收集碳研所断面近10年来水质自动站数据,分析溶解氧(DO)变化特征,采样调查釜溪河自贡城区段水质及河道底泥污染状况,采用相关性分析、数值模拟等,研究分析釜溪河自贡城区段溶解... 详细信息

釜溪河为沱江一级支流,在自贡城区段设有国考碳研所断面。收集碳研所断面近10年来水质自动站数据,分析溶解氧(DO)变化特征,采样调查釜溪河自贡城区段水质及河道底泥污染状况,采用相关性分析、数值模拟等,研究分析釜溪河自贡城区段溶解氧分布特征及碳研所断面季节性低氧成因。研究结果表明,碳研所断面的溶解氧质量浓度变化特征呈现春末夏初最低,白天高晚上低的特征。釜溪河碳研所断面河水耗氧类污染物质量浓度较沱江流域内其他断面高,耗氧强度较大,溶解氧质量浓度较沱江流域其他断面偏低;其次,研究河段中釜溪河污水厂以下河段受污水厂低氧水排入和金子凼堰底层低氧水下泄影响,其溶解氧水平整体较污水厂以上河段低;最后,河段底泥有机质含量较高,春夏季气温升高将导致微生物分解活性增强大量消耗溶解氧,同时,闸坝和外来水体排入的水文扰动造成污水厂以下河段水温梯度弱,表层溶解氧易受底层低氧水影响,促使断面形成季节性低氧现象。溶解氧预测模型结果也进一步证实了温度变化和垂向温度梯度弱是碳研所断面溶解氧质量浓度季节性偏低的主要因素。

关键词：城市河流溶解氧分布特征温度梯度底泥低氧

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门静脉血栓动物模型的建立和应用

临床肝胆病杂志 2024年第1期40卷 29-32页

作者：刘壮陈纪宏祁兴顺许向波诸葛宇征北部战区总医院消化内科沈阳110840 中国医科大学研究生院沈阳110122 大连医科大学研究生院辽宁大连116044 南京大学医学院附属鼓楼医院消化内科南京210008

门静脉血栓(PVT)是指在肝外门静脉主干和/或肝内门静脉分支内发生的血栓栓塞。PVT是由多种因素共同作用的结果,但其发病机制尚未完全阐明。建立动物模型是研究PVT病理生理机制的重要方法。本文根据不同的动物种类,对现有PVT动物模型的... 详细信息

门静脉血栓(PVT)是指在肝外门静脉主干和/或肝内门静脉分支内发生的血栓栓塞。PVT是由多种因素共同作用的结果,但其发病机制尚未完全阐明。建立动物模型是研究PVT病理生理机制的重要方法。本文根据不同的动物种类,对现有PVT动物模型的建立方法、原理、优缺点和应用情况进行综述。

关键词：门静脉血栓疾病模型动物发病机制

Carbon nanotubes in biology and medicine:An overview

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Chinese Science Bulletin 2012年第2期57卷 167-180页

作者： WANG XiaoJing liu zhuang Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft MaterialsSoochow UniversitySuzhou 215123China

Rapid development in the field of nanomedicine is bringing novel opportunities for improved disease diagnosis and drug *** various nanomaterials involved in nanomedicine,carbon nanotubes(CNTs) possessing a unique one-dimensional structure with interesting intrinsic mechanical,physical,and chemical properties have been extensively explored for a wide range of applications in biology and *** review article provides an overview of how CNTs are used in different aspects of biomedicine including drug delivery and cancer treatment,bio-sensing,biomedical imaging,as well as tissue *** recent developments,future perspective,and major challenges in this field are discussed.

关键词：生物医学成像碳纳米管生物学药物输送纳米材料一维结构 CNTs 化学性质

Word-Based Method for Chinese Part-of-Speech via Parallel and Adversarial Network

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Chinese Journal of Electronics 2022年第2期31卷 337-344页

作者： HUANG Kaiyu CAO Jingxiang liu zhuang HUANG Degen School of Computer Science and Technology Dalian University of Technology School of Foreign Languages Dalian University of Technology School of Applied Finance Dongbei University of Finance and Economics

Chinese part-of-speech(POS) tagging is an essential task for Chinese downstream natural language processing tasks. The accuracy of the Chinese POS task will drop dramatically by word-based methods because of the segmentation errors and the word ***, there are several Chinese POS tagging sets with different criteria. Some of them only have a small-scale annotated corpus and are hard to train. To this end, we propose a modified word-based transformer neural network architecture. Meanwhile, we utilize an adversarial transfer learning method that splits the architecture into shared and private parts. This work directly improves the ability of the word-based model, instead of adopting a joint character-based method. Extensive experiments show that our method achieves state-of-the-art performance on all datasets, and more importantly, our method improves performance effectively for the word-based Chinese sequence labeling task.

关键词： Chinese downstream natural language processing tasks modified word-based transformer neural network architecture word-based Chinese sequence labeling task word sparsity adversarial transfer learning method Chinese part-of-speech tagging neural nets word processing word-based method adversarial network Chinese POS task text analysis Chinese POS tagging sets word-based model learning (artificial intelligence) joint character-based method natural language processing small-scale annotated corpus

Powder transport behavior in RH degasser with powder injection through up snorkel: a transient numerical model

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Journal of Iron and Steel Research International 2023年第6期30卷 1156-1170页

作者： zhuang liu Wen-tao Lou Miao-yong Zhu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

A transient numerical model was established to predict the dispersion,distribution,and circulation behavior of the powder injected through the up snorkel in a Ruhrstahl–Heraeus(RH)*** effects of the powder diameter,the lifting gas flow rate,and the powder injection rate on the powder transport were *** powder concentration was measured by a cold *** results showed that the predicted powder concentration agreed well with the *** powder injection process is divided into three periods,named dispersion period,aggregation and circulation period,and dynamically stable period according to the powder transport *** powder diameter has a great effect on the particle *** the particles size changes from 30 to 500μm,the powder dispersion characteristic index changes from 0.110 to 0.741,and the ladle top zone powder mass ratio changes from 0.118 to *** powder circulation mass flow rate increases to 101.0 kg min^(-1)(150μm)and then decreases to 46.6 kg min^(-1)(500μm).Powders with a diameter of more than 220μm can change the steel flow mode in the RH *** the lifting gas flow could slightly improve the powder *** in the powder injection rate has almost no effect on the powder dispersion.

关键词： RH degasser Powder injection Numerical simulation Eulerian-granular flow Powder transport behavior Optical probe