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Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid

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Zoological Research 2024年第3期45卷 520-534页

作者： Lin Liu ya Zhang Meng-Di Yuan Dong-Miao Xiao Wei-hua Xu Qi Zheng Qi-Wei Qin You-hua huang Xiao-Hong huang College of Marine Sciences South China Agricultural UniversityGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouGuangdong 510642China nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511464China Southern Marine Science and Engineering guangdong Laboratory ZhuhaiGuangdong 519082China

Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate;however,the molecular mechanisms underpinning its pathogenesis are not well ***,a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus(SgIV),focusing on the roles of key *** showed that SgIV induced obvious histopathological damage and changes in metabolic enzymes within the ***,SgIV significantly reduced the contents of lipid droplets,triglycerides,cholesterol,and *** analysis indicated that the altered metabolites were enriched in 19 pathways,with a notable down-regulation of lipid metabolites such as glycerophosphates and alpha-linolenic acid(ALA),consistent with disturbed lipid homeostasis in the *** of transcriptomic and metabolomic data revealed that the top enriched pathways were related to cell growth and death and nucleotide,carbohydrate,amino acid,and lipid metabolism,supporting the conclusion that SgIV infection induced liver metabolic *** integrative transcriptomic and proteomic analysis indicated that SgIV infection activated crucial molecular events in a phagosome-immune depression-metabolism dysregulation-necrosis signaling *** note,integrative multi-omics analysis demonstrated the consumption of ALA and linoleic acid(LA)metabolites,and the accumulation of L-glutamic acid(gA),accompanied by alterations in immune,inflammation,and cell death-related *** experimental data showed that ALA,but not gA,suppressed SgIV replication by activating antioxidant and anti-inflammatory responses in the ***,these findings provide a comprehensive resource for understanding host response dynamics during fish iridovirus infection and highlight the antiviral potential of ALA in the prevention and treatment of iridoviral diseases.

关键词： Iridovirus Liver damage Metabolic reprogramming SgIV Alpha-linolenic acid Antiinflammatory

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Impact of body mass index on adverse kidney events in diabetes mellitus patients: A systematic-review and meta-analysis

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World Journal of Clinical Cases 2024年第3期12卷 538-550页

作者： Jing-Fang Wan yan Chen Tian-hua yao ya-Zhou Wu huan-Zi Dai Department of Nephrology Army Medical UniversityChongqing 400042China Department of Nephrology Chongqing Western HospitalChongqing 400052China Health Statistics Army Medical UniversityChongqing 400038China Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China

BACKgROUND The incidence of chronic kidney disease among patients with diabetes mellitus(DM)remains a global ***-term obesity is known to possibly influence the development of type 2 diabetes ***,no previous meta-analysis has assessed the effects of body mass index(BMI)on adverse kidney events in patients with *** To determine the impact of BMI on adverse kidney events in patients with *** A systematic literature search was performed on the PubMed,ISI Web of Science,Scopus,Ovid,google Scholar,EMBASE,and BMJ *** included trials with the following characteristics:(1)Type of study:Prospective,retrospective,randomized,and non-randomized in design;(2)participants:Restricted to patients with DM aged≥18 years;(3)intervention:No intervention;and(4)kidney adverse events:Onset of diabetic kidney disease[estimated glomerular filtration rate(egFR)ofg/g Cr],serum creatinine increase of more than double the baseline or end-stage renal disease(egFRg 801 patients with DM were *** BMI(≥25 kg/m2)was significantly associated with higher blood pressure(BP)[systolic BP by 0.20,95%confidence interval(CI):0.15–0.25,Pg,95%CI:0.04–0.37,P=0.010],serum albumin,triglycerides[standard mean difference(SMD)=0.35,95%CI:0.29–0.41,Pgh-density lipoprotein(SMD=–0.36,95%CI:–0.51 to–0.21,Pg/m2).Our analysis showed that high BMI was associated with a higher risk ratio of adverse kidney events than low BMI(RR:1.22,95%CI:1.01–1.43,P=0.036).CONCLUSION The present analysis suggested that high BMI was a risk factor for adverse kidney events in patients with DM.

关键词： Obesity Body mass index Diabetes mellitus Adverse kidney events Systematic-review Meta-analysis

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Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk a multicenter maternal-fetal medicine study

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World Journal of Pediatrics 2024年第6期20卷 621-632页

作者： huan Wang yan-Ping Ruan Sheng Ma ya-Qi Wang Xiao-Yu Wan Yi-hua He Jing Li Zhi-Yong Zou Institute of Child and Adolescent Health School of Public HealthNational Health Commission Key Laboratory of Reproductive HealthPeking UniversityNo.38 Xueyuan RdHaidian DistrictBeijing 100191China Echocardiography Medical Center Beijing Anzhen Hospital.Capital Medical UniversityMaternal-Fetal Medicine center in Fetal Heart DiseaseBeijing Anzhen HospitalNo.2 Anzhen RdChaoyang DistrictBeijing 100029China

Background Evidence remains limited on the association between maternal ozone(O,)exposure and congenital heart defects(CHDs)in offspring,and few studies have investigated the interaction and modification of paternal smoking on this *** Using a sample including pregnant women at high risk of fetal CHD(with metabolic disease,first-trimester viral infection,family history of CHD,etc.)from a maternal-fetal medicine study covering 1313 referral hospitals in China during 2013-2021,we examined the associations between maternal O_(3)exposure during 3-8 weeks of gestational age and fetal CHD in offspring and investigated the interaction and modification of paternal smoking on this *** was diagnosed by fetal echocardiograms,maximum daily 8-hour average O,exposure data at a 10 km×10 km spatial resolution came from the Tracking Air Pollution in China dataset,and paternal smoking was collected using *** regression models were used to estimate adjusted odds ratios(ORs)and 95%confidence intervals(CIs).Results Among 27,834 pregnant women at high risk of fetal CHD,17.4%of fetuses were diagnosed with *** 10μg/m^(3)increase in maternal O_(3)exposure was associated with a 17%increased risk of CHD in offspring(OR=1.17,95%CI=1.14-1.20).Compared with paternal nonsmoking and maternal low O_(3)exposure,the ORs(95%CI)of CHD for smoking and low O_(3)exposure,nonsmoking and high O_(3)exposure,and smoking and high O_(3)exposure were 1.25(1.08-1.45),1.81(1.56-2.08),and 2.23(1.84-2.71),*** smoking cessation seemingly mitigated the increased risk of *** Maternal O_(3)exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring,which calls for effective measures to decrease maternal exposure to O_(3)pollution and secondhand smoke for CHDprevention.

关键词： Congenital heart defects Fetal heart development Ozone exposure Tobacco smoking

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Ultrathin surface coating of Cu enabling long-life Zn metal anodes

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Rare Metals 2024年第5期43卷 2125-2135页

作者： Sang-Sang Liu ya-Ru lia.g Wen-Long Chen Ze-hua Wang Yi-Long Dai Fu-gang Qi Zeng-Sheng Ma Xiao-Ping Ouyang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education Xiangtan UniversityXiangtan 411105China

Aqueous zinc-ion batteries(AZIBs)are regarded as promising energy storage devices due to their low cost,high capacity,and ecological ***,the severe dendritic growth and side reactions hinder their practical applicability ***,an ultrathin Cu coating layer(~200 nm)is decorated on zinc foils via filtered cathodic vacuum arc deposition technology,aiming to achieve high-performance *** Cu layer effectively suppresses chemical corrosion and hydrogen evolution reactions and enables preferential(002)Zn deposition during the stripping/plating ***,the Cu@Zn anode represents an elongated cycle life over 4,000 h at 2 mA·cm^(-2)/2 mAh·cm^(-2).Even in conditions of high current density of 5 and 10 mA·cm^(-2),the Cu@Zn anode shows prolonged cycling stability exceeding 4000 and 2000 h,*** advantages also bring high Coulombic efficiency of 99.87%under 5 mAh·cm^(-2)in Cu@Ti||Zn half-cell over 1500 ***,the Cu@Zn||MnO_(2)full cell demonstrates a superior cyclability with a specific capacity of 203 mAh·g^(-1)after 500 cycles a1 A·g^(-1).

关键词： Zn ion battery Zn metal anode Zn(002)plane Cu coating

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High critical current density in Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) electrolyte via interfacial engineering with complex hydride

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Rare Metals 2024年第2期43卷 692-701页

作者： Ying-Tong Lv Teng-Fei Zhang Zhao-Tong Hu guang-Lin Xia Ze-ya huang Zhen-hua Liu Li-hua Que Cai-Ting Yuan Fang-Qin guo Takayuki Ichikawa Xue-Bin Yu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China Centre for Hydrogenergy College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing210016China Department of Materials Science Fudan UniversityShanghai200433China graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-Hiroshima739-8527Japan

garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and ***,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical ***,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)was simply coated with complex hydride(Li_(4)(BH_(4))_(3)I(3L1L))in various mass ratios n(Li_(4)(BH_(4))_(3)I)-(100−n)LLZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric Li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable Li/LLZTO interface,which would promote the development of solid-state batteries.

关键词： Hydrides Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO) Critical current density Solid-state electrolytes(SSEs) Lithium-sulfur batteries

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UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI Ming-xuan WANg Xiao-hui QIN Yuan-yuan WANg ya-hui TAN Jin-hua SU lia.-lin yaN Shuai Department of general Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of general Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(Pgroup,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

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青藏高原地表土壤重金属元素组成分布特征及其影响因素研究

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中国环境科学 2024年第4期44卷 2198-2207页

作者：刘小莉高文华魏婷董志文 Shao ya-ping 河南大学地理与环境学院国家级实验教学示范中心河南开封475000 中国地质大学地理与信息工程学院湖北武汉430074 中国科学院西北生态环境资源研究院甘肃兰州730000 德国科隆大学地球物理与气象研究所德国科隆50923

由于青藏高原生态系统的脆弱性和对人类活动的敏感性,近年来高原环境中与人类活动相关的重金属污染研究受到越来越多的关注.本文通过2021~2022年间采集的青藏高原表土样品,结合同时期采集的周边高海拔冰川区雪冰样品,分析测定了As、Cr... 详细信息

由于青藏高原生态系统的脆弱性和对人类活动的敏感性,近年来高原环境中与人类活动相关的重金属污染研究受到越来越多的关注.本文通过2021~2022年间采集的青藏高原表土样品,结合同时期采集的周边高海拔冰川区雪冰样品,分析测定了As、Cr、Co、Ni、Cu、Mo、Cd、Pb和Sb共9种重金属元素的含量和组成特征.结果表明,青藏高原表土中重金属的含量(均值为256.5μg/g)远高于雪冰中重金属(均值为14.6μg/L)的含量.其中As的I geo平均值为1.32,总体处于中度污染水平,而土壤中其他重金属以无污染特征为主.表土中重金属的组成和空间分布与周边冰川区雪冰中表现出明显不同特征,而且不同区域表土重金属的空间分布、组成和富集系数(EFs)没有明显差别.结合相关性、主成分分析和APCS-MLR等方法,发现表土中重金属有3个主要来源,分别为居民生活和工业用煤有关的煤燃烧源(42.3%)、局地地表自生土壤来源(20.6%)和交通排放源(14.2%).高海拔雪冰和表土中重金属的组成、分布存在差异,可能是由于地表样品中重金属受到自然风化、和人类活动影响导致远距离输入源的贡献被掩盖,而雪冰中重金属则更多受到大气环流远距离输入污染源的影响.本研究较为全面的展示了目前青藏高原大范围区域表土中重金属组成状况,反映出部分元素的明显富集(例如As)和整体上重金属元素含量仍然表现为清洁的自然状况.

关键词：重金属元素地表土壤青藏高原组成特征源解析

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基于反常热传导的分数阶热弹耦合理论

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Acta Mechanica Sinica 2024年第5期40卷 141-149页

作者：尉亚军吴华邓子辰 School of Mechanics Civil Engineering and Architecture Northwestern Polytechnical University Xi’an China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical University Xi’an China State Key Laboratory for Strength and Vibration of Mechanical Structures Xi’an Jiaotong University Xi’an China

原子模拟和实验研究表明低维纳米材料具有反常热传导特性,建立唯象反常热弹耦合模型,研究强热传导导致的热力耦合响应,对微纳器件的安全稳定运行至关重要.本文旨在从反常热传导的视角重新审视分数阶热弹耦合模型。反常热传导由第二声效... 详细信息

原子模拟和实验研究表明低维纳米材料具有反常热传导特性,建立唯象反常热弹耦合模型,研究强热传导导致的热力耦合响应,对微纳器件的安全稳定运行至关重要.本文旨在从反常热传导的视角重新审视分数阶热弹耦合模型。反常热传导由第二声效应引起,考虑波动热传导理论,建立了波动热传导与粘弹性理论的类比,阐明了Cattaneo-Vernotte模型和green-naghdi模型的关联.通过引入分数阶导数,构建了基于Cattaneo-Vernotte和green-naghdi理论的分数阶热弹耦合模型。数值结果表明:对分数阶次区间[O,1],分数阶Cattaneo-Vernotte(FCV)I模型和分数阶green-naghdi(FgN)I-III模型都能预测反常热弹耦合响应:比经典热弹性理论更高的温度和应力;温度和应力随时间的变化显示:FgNII模型在所有时间范围内都能得到反常响应.对green-naghdi模型及其分数阶模型的进一步系统研究,有助于揭示反常热传导和热弹耦合机理,并促进纳米材料的广泛应用.

关键词：粘弹性理论分数阶导数热弹耦合热弹性理论热传导低维纳米材料分数阶模型微纳器件

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Performance improvements in complementary metal oxide semiconductor devices and circuits based on fin field-effect transistors using 3-nm ferroelectric Hf_(0.5)Zr_(0.5)O_(2)

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Rare Metals 2024年第7期43卷 3242-3249页

作者： Zhao-Hao Zhang yan-na Luo gao-Bo Xu Jia-Xin yao Zhen-hua Wu Hong-Bin Zhao Qing-Zhu Zhang hua-Xiang Yin Jun Luo Wen-Wu Wang Hai-Ling Tu Integrated Circuit Advanced R&D Center Institute of Microelectronics of Chinese Academy of SciencesBeijing 100029China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Advanced Materials for Smart Sensing General Research Institute for Nonferrous MetalsBeijing 100088China

In this work,a conventional HfO_(2) gate dielectric layer is replaced with a 3-nm ferroelectric(Fe) HZO layer in the gate stacks of advanced fin field-effect transistors(FinFETs).Fe-induced characteristics,e.g.,negative drain induced barrier lowering(N-DIBL) and negative differential resistance(NDR),are clearly observed for both p-and n-type HZO-based *** characteristics are attributed to the enhanced ferroelectricity of the 3-nm hafnium zirconium oxide(HZO) film,caused by Al doping from the TiAlC capping *** mechanism is verified for capacitors with structures similar to the *** to the enhanced ferroelectricity and N-DIBL phenomenon,the drain current(I_(DS))of the HZO-FinFETs is greater than that of HfO_(2)-FinFETs and obtained at a lower operating ***,circuits based on HZO-FinFET achieve higher performance than those based on HfO_(2)-FinFET at a low voltage drain(V_(DD)),which indicates the application feasibility of the HZO-FinFETs in the ultralow power integrated circuits.

关键词： FinFET Ferroelectric Hafnium zirconium oxide Subthreshold swing Low power

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Electrochemical anodic oxidation assisted fabrication of memristors

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International Journal of Extreme Manufacturing 2024年第3期6卷 250-272页

作者： Shuai-Bin hua Tian Jin Xin guo School of Materials Science and Engineering State Key Laboratory of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Owing to the advantages of simple structure,low power consumption and high-density integration,memristors or memristive devices are attracting increasing attention in the fields such as next generation non-volatile memories,neuromorphic computation and data ***,the deposition of memristive films often requires expensive equipment,strict vacuum conditions,high energy consumption,and extended processing *** contrast,electrochemical anodizing can produce metal oxide films quickly(e.g.10 s) under ambient *** means of the anodizing technique,oxide films,oxide nanotubes,nanowires and nanodots can be fabricated to prepare *** film thickness,nanostructures,defect concentrations,etc,can be varied to regulate device performances by adjusting oxidation parameters such as voltage,current and *** memristors fabricated by the anodic oxidation technique can achieve high device consistency,low variation,and ultrahigh yield *** article provides a comprehensive review of the research progress in the field of anodic oxidation assisted fabrication of ***,the principle of anodic oxidation is introduced;then,different types of memristors produced by anodic oxidation and their applications are presented;finally,features and challenges of anodic oxidation for memristor production are elaborated.

关键词： anodic oxidation anodized aluminium oxide memristor resistive switching electrical properties

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