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FedTC:A Personalized Federated LearningMethod with Two Classifiers

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Computers, Materials & Continua 2023年第9期76卷 3013-3027页

作者： Yang liu Jiabo Wang Qinbo liu Mehdi Gheisari Wanyin Xu zoe L.Jiang Jiajia Zhang School of Computer Science and Technology Harbin Institute of TechnologyShenzhen518055China Guangdong Provincial Key Laboratory of Novel Security Intelligence Technologies Shenzhen518055China Research Center for Cyberspace Security Peng Cheng LaboratoryShenzhen518055China

Centralized training of deep learning models poses privacy risks that hinder their *** learning(FL)has emerged as a solution to address these risks,allowing multiple clients to train deep learning models collaborativelywithout sharing ***,FL is vulnerable to the impact of heterogeneous distributed data,which weakens convergence stability and suboptimal performance of the trained model on local *** is due to the discarding of the old local model at each round of training,which results in the loss of personalized information in the model critical for maintaining model accuracy and ensuring *** this paper,we propose FedTC,a personalized federated learning method with two classifiers that can retain personalized information in the local model and improve the model’s performance on local *** divides the model into two parts,namely,the extractor and the classifier,where the classifier is the last layer of the model,and the extractor consists of other *** classifier in the local model is always retained to ensure that the personalized information is not *** receiving the global model,the local extractor is overwritten by the globalmodel’s extractor,and the classifier of the globalmodel serves as anadditional classifier of the localmodel toguide local *** FedTCintroduces a two-classifier training strategy to coordinate the two classifiers for local model *** results on Cifar10 and Cifar100 datasets demonstrate that FedTC performs better on heterogeneous data than current studies,such as FedAvg,FedPer,and local training,achieving a maximum improvement of 27.95%in model classification test accuracy compared to FedAvg.

关键词： Distributed machine learning federated learning data hetero-geneity non-independent identically distributed

Hyperdense artery sign, symptomatic infarct swelling and effect of alteplase in acute ischaemic stroke

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Stroke & Vascular Neurology 2021年第2期6卷 238-243页

作者： Simiao Wu Grant Mair Geoff Cohen zoe Morris Anders von Heijne Nick Bradey Lesley Cala Andre Peeters Andrew J Farrall Alessandro Adami Gillian Potter Ming liu Richard I Lindley Peter A G Sandercock Joanna M Wardlaw the IST-3 Collaborative Group Department of Neurology West China HospitalSichuan UniversityChengduSichuanChina Centre for Clinical Brain Sciences The University of EdinburghEdinburghUK Department of Clinical Sciences Danderyd HospitalStockholmSweden Neuroradiology James Cook University HospitalSouth Tees Hospital NHS TrustMiddlesbroughUK Division of Pathology and Laboratory Medicine School of MedicineThe University of Western AustraliaPerthWestern AustraliaAustralia Department of Neurology Cliniques universitaires Saint-LucBruxellesBelgium Stroke Center IRCCS Sacro Cuore Don CalabriaVeronaItaly Department of Neuroradiology Manchester Centre for Clinical NeurosciencesSalford Royal NHS Foundation TrustSalfordUK Westmead Applied Research Centre Westmead Clinical SchoolThe University of SydneySydneyNew South WalesAustralia The George Institute for Global Health NewtownNew South WalesAustralia UK Dementia Research Institute Centre at the University of Edinburgh EdinburghUnited Kingdom 不详

Background Alteplase improves functional outcomes of patients with acute ischaemic stroke,but its effects on symptomatic infarct swelling,an adverse complication of stroke and the influence of CT hyperdense artery sign(HAS)are *** substudy of the Third International Stroke Trial aimed to investigate the association between HAS and symptomatic infarct swelling and effect of intravenous alteplase on this *** We included stroke patients whose prerandomisation scan was non-contrast ***,masked to clinical information,assessed baseline(prerandomisation)and follow-up(24-48 hours postrandomisation)CT scans for HAS,defined as an intracranial artery appearing denser than contralateral *** infarct swelling was defined as clinically significant neurological deterioration≤7 days after stroke with radiological evidence of midline shift,effacement of basal cisterns or uncal *** Among 2961 patients,HAS presence at baseline was associated with higher risk of symptomatic infarct swelling(OR 2.21;95% CI 1.42 to 3.44).Alteplase increased the risk of swelling(OR 1.69;95% CI 1.11 to 2.57),with no difference between patients with and those without baseline HAS(p=0.49).In patients with baseline HAS,alteplase reduced the proportion with HAS at follow-up(OR 0.67;95% CI 0.50 to 0.91),where HAS disappearance was associated with reduced risk of swelling(OR 0.25,95% CI 0.14 to 0.47).Conclusion Although alteplase was associated with increased risk of symptomatic infarct swelling in patients with or without baseline HAS,it was also associated with accelerated clearance of HAS,which in return reduced swelling,providing further mechanistic insights to underpin the benefits of alteplase.

关键词： infarct swelling effect

LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 790-808页

作者： Eunice Eun Seo Chang Philip Wing-Lok Ho Hui-Fang liu Shirley Yin-Yu Pang Chi-Ting Leung Yasine Malki zoe Yuen-Kiu Choi David Boyer Ramsden Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongPok Fu LamHong KongChina Institute of Metabolism and Systems Research University of BirminghamBirminghamUK.

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological similarities between LRRK2-associated PD (LRRK2-PD) and sporadic PD, suggesting that LRRK2 is a potential disease modulator and a thera-peutic target in PD. LRRK2 mutant knock-in (KI) mouse models display subtle alterations in pathological aspects that mirror early-stage PD, including increased susceptibility of nigrostriatal neurotransmission, development of motor and non-motor symptoms, mitochondrial and autophagy-lysosomal defects and synucleinopathies. This review provides a rationale for the use of LRRK2 KI mice to investigate the LRRK2-mediated pathogenesis of PD and implications from current findings from different LRRK2 KI mouse models, and ultimately discusses the therapeutic potentials against LRRK2-associated pathologies in PD.

关键词： Parkinson’s disease LRRK2 Knock-in mouse model Neurotransmission Motor dysfunction Autophagy Lysosome Mitochondrial dysfunction Synucleinopathy Hyperkinase activity LRRK2 inhibitor

Preparation and Characterization of CaO/ZnO Core-shell Structured Nanoparticles

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Chemical Research in Chinese Universities 2020年第5期36卷 970-975页

作者： WANG Lili liu Yanan PENG Xiaoxing SUN Yuanqing liu Xiaohua liu Huimin LIN Quan SUN Hongchen YANG Bai LI Xiangwei School of Stomatology Jilin UniversityChangchun 130021P.R.China Hospital Attached to Changchun University of Chinese Medicine Changchun 130041P.R.China State Key Laboratory of Supramol ecular Structure and Materials Jilin UniversityChangchun 130012P.R.China Department of Biomedical Sciences Texas A&M UniversityCollege of DentistryDallasTX 75246USA

Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical *** promote the antibacterial and sealing eftects of a root canal filling,core-shell structured CaO/ZnO nanospheres were synthesized using a precipitation method based on a traditional root canal sealer,zinc oxide-eugenol(zoe).The obtained CaO/ZnO particles had a size of 80—90 nm and a core-shell *** film thickness,flow rate,pH,and calcium ion release of the core-shell structured CaO/ZnO nanospheres-eugenol paste were *** pH and calcium ion release results showed a slight increase in the prepared nanospheres,with a flow rate of 24.22 mm and a formed film thickness of 30 pm,which are basically consistent with ISO 6876:2001 standards(regarding dental root canal sealing materials).Cytotoxicity tests showed that the cytocompatibility of the CaO/ZnO nanospheres-eugenol paste was much higher than that of the zoe or iRoot SP groups(Pzoe and iRoot SP sealers(P<0.05).The core-shell structured CaO/ZnO nano sphere paste displayed excellent sealing and antibacterial properties,and it has promising application potential in endodontics.

关键词： CaO ZnO Antibacterial activity Core-shell stnictured naiiosphere Microleakage

LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 869-882页

作者： Shirley Yin-Yu Pang Rachel Cheuk Nam Lo Philip Wing-Lok Ho Hui-Fang liu Eunice Eun Seo Chang Chi-Ting Leung Yasine Malki zoe Yuen-Kiu Choi Wing Yan Wong Michelle Hiu-Wai Kung David Boyer Ramsden Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina Institute of Metabolism and Systems Research University of BirminghamBirminghamUK.

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regulates macroautophagy via activation of the mitogen activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) kinase (MEK) and the calcium-dependent adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathways. Phosphorylation of Rab GTPases by LRRK2 regulates lysosomal homeostasis and endosomal trafficking. Mutant LRRK2 impairs chaperone-mediated autophagy, resulting in α-syn binding and oligomerization on lysosomal membranes. Mutations in GBA reduce glucocerebrosidase (GCase) activity, leading to glucosylceramide accumulation, α-syn aggregation and broad autophagic abnormalities. LRRK2 and GBA influence each other: GCase activity is reduced in LRRK2 mutant cells, and LRRK2 kinase inhibition can alter GCase activity in GBA mutant cells. Clinically, LRRK2 G2019S mutation seems to modify the effects of GBA mutation, resulting in milder symptoms than those resulting from GBA mutation alone. However, dual mutation carriers have an increased risk of PD and earlier age of onset compared with single mutation carriers, suggesting an additive deleterious effect on the initiation of PD pathogenic processes. Crosstalk between LRRK2 and GBA in PD exists, but its exact mechanism is unclear. Drugs that inhibit LRRK2 kinase or activate GCase are showing efficacy in pre-clinical models. Since LRRK2 kinase and GCase activities are also altered in idiopathic PD (iPD), it remains to be seen if these drugs will be useful in disease modification of iPD.

关键词： Parkinson’s disease Interaction LRRK2 GBA GCase Mutation Autophagy α-Synuclein

产量与经济效益共赢的高效生态农业模式：以弘毅生态农场为例

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科学通报 2017年第4期62卷 289-297页

作者：蒋高明郑延海吴光磊刘慧池云花冯素飞李勇李彩虹李宗奉苏本营董群乌云塔娜 LUCAS Mario LEFORT zoe REGOLINI Margot 曾祥伟贺新华郭立月战丽杰唐海龙韦继光周平曾彦杨煜宋守宽刘秀甄珍刘海涛孟杰李静李霄李占丁娜博文静虞晓凡程达梁啸天李立君徐磊谷仙宋彦洁 MUMINOV A. Mahmud 刘滨扬赫晓霞刘美珍宁堂原王空军徐玉新陈文浩中国科学院植物研究所植被与环境变化国家重点实验室北京100093 中国科学院大学资源与环境学院北京100040 山东农业大学农学院泰安271018 山东农业大学资源与环境学院泰安271018 河北农业大学林学院保定071001 Natural Sciences at RWTH Aachen University Aachen 52074Germany Forestry School of Engineers Nancy 54000France 弘毅生态农场有限公司平邑273305 中国农业大学生物学院北京100094

化学物质的大量投入以及元素不能循环导致农田生态系统退化,耕地质量和产量均呈下降趋势,食物链受到污染.本研究从低产田开始,通过秸秆养牛、腐熟牛粪还田恢复地力;以物理+生物方法控制虫害;以人工+机械管理杂草,停用农药、化肥和除草剂... 详细信息

化学物质的大量投入以及元素不能循环导致农田生态系统退化,耕地质量和产量均呈下降趋势,食物链受到污染.本研究从低产田开始,通过秸秆养牛、腐熟牛粪还田恢复地力;以物理+生物方法控制虫害;以人工+机械管理杂草,停用农药、化肥和除草剂,同时不用地膜、人工合成激素、转基因种子生产优质安全食品,并在线上与线下销售.10年的长期实验结果表明,所在村庄农田生态环境改善,减少农药用量58.3%;物理+生物控虫效果明显,每盏灯年捕获量从2009年的33 kg下降到2014年的2.1 kg,下降93.8%;年消耗秸秆1000 t,秸秆利用率从1.1%提高到62.5%.有机肥还田提高了土壤生物多样性,有机果园蚯蚓数量317条m^(-2),而普通果园只有16条m^(-2);大量有机肥还田(75 t hm^(-2)),土壤有机质从实验初期的0.7%提高到2.4%.粮食产量从最初的11.43 t hm^(-2)提高到目前的17.43 t hm^(-2),其中冬小麦(Triticum aestivum)、夏玉米(Zea mays)、大豆(Glycine max(Linn.)Merr.)和花生(Arachis hypogaea Linn.)产量分别超出山东省平均水平42.6%,60.9%,32.2%和38.1%.由于质量好,产品已销售往除西藏以外的30个省、市、自治区,经济效益明显,平均每公顷效益是普通农田的3~5倍,带动所在村庄67户农民从事高效生态农业.本研究可为国家制定生态农业发展规划、精准扶贫、农村环境保护等提供科学依据.

关键词：高效生态农业秸秆害虫控制杂草管理产量经济效益

11世纪拜占庭历史书写转型探析——以邹伊和塞奥多拉的“紫衣女性”形象为例

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世界历史 2018年第6期 135-150,160页

作者：刘宇方天津师范大学欧洲文明研究院

11世纪拜占庭的历史书写经历了重要转型。一方面,它强调以人为本的叙事理念,确立了以统治者为叙事核心的写作方式,并开始大量运用插叙与倒叙的写作技巧,从而突破了传统编年史体例贬低人的叙述价值的局限,打破了传统编年史严格遵循事件... 详细信息

11世纪拜占庭的历史书写经历了重要转型。一方面,它强调以人为本的叙事理念,确立了以统治者为叙事核心的写作方式,并开始大量运用插叙与倒叙的写作技巧,从而突破了传统编年史体例贬低人的叙述价值的局限,打破了传统编年史严格遵循事件发展顺序的纪年叙述标准。另一方面,它创造出包含刻画人物外貌、性格和心理活动三个层次的写作模式,形成了由外及内、形象的视觉效果与抽象的情绪思维活动相结合的系统化写作特点,从而能层层深入地刻画出富有生活气息、复杂又完整的人物形象,弥补了以往历史书写程式化的写作缺陷。在这一转型中,被史家成功塑造出的邹伊和塞奥多拉的"紫衣女性"形象尤为全面地涵盖了转型的内容与特征。总体而言,取得绝对主导权的基督教文化在创造性地吸收和融合古典文化后所产生的新书写范式即是此阶段历史书写转型的本质。古典元素与基督教元素的有机结合,以及由此带来的人在思想境界上的升华,促使拜占庭文化最终发展至最高阶的成熟形态。

关键词：拜占庭史历史书写邹伊紫衣女性塞奥多拉

不同方法预备根管对根管治疗后牙齿冠渗漏的影响

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华西口腔医学杂志 2012年第5期30卷 522-525页

作者：刘雁马卫东高蔚虹大连市口腔医院特诊科大连116021

目的采用3种不同方法预备根管,评价其对根管治疗后牙齿冠渗漏的影响。方法48颗单根管离体牙随机分为4组,使用不同的根管预备方法去除根管壁的玷污层。A组为对照组,采用生理盐水和过氧化氢溶液冲洗根管;B组采用乙二胺四乙酸(EDTA)凝胶和5... 详细信息

目的采用3种不同方法预备根管,评价其对根管治疗后牙齿冠渗漏的影响。方法48颗单根管离体牙随机分为4组,使用不同的根管预备方法去除根管壁的玷污层。A组为对照组,采用生理盐水和过氧化氢溶液冲洗根管;B组采用乙二胺四乙酸(EDTA)凝胶和5.25%次氯酸钠溶液冲洗;C组采用Odontoson-M型超声波治疗仪荡洗;D组采用脉冲Nd:YAG激光照射。每组取2颗牙,于扫描电子显微镜(SEM)下观察冠部玷污层的去除情况;其余10颗牙采用ObturaⅡ高温注射式热牙胶垂直加压法充填根管,氧化锌丁香油黏固剂封闭根管口,浸于质量浓度20 g.L-1亚甲基蓝溶液中染色7 d,脱水脱钙制作透明牙标本,体视显微镜下测量染料渗入的深度。结果SEM观察:A组整个根管内壁被覆玷污层及大量碎屑,牙本质小管被堵塞;B组与C组根管内壁清洁,玷污层消失,牙本质小管开放;D组根管内壁牙本质小管封闭或半封闭,玷污层熔融消失。A、B、C、D组染料渗入深度分别为(2.15±0.38)、(1.75±0.28)、(2.04±0.40)、(1.73±0.36)mm。A组的渗入深度明显高于B、D组,其差异有统计学意义(P<0.05)。结论使用不同的方法预备根管去除玷污层,可以减少根管治疗后牙齿的冠渗漏。

关键词：玷污层超声波冠渗漏 Nd:YAG激光根管治疗

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纳米材料根管封闭剂根尖封闭性能的实验研究

实用口腔医学杂志 2008年第3期24卷 437-441页

作者：刘志东任吉芳山西长治医学院附属和济医院口腔科 046000

目的:观察纳米材料的根尖封闭性能。方法:选取40个直根管的上前牙,随机分为4个试验组(每组各8个)和2个对照组(对照1组和对照2组各4个),采用逐步后退法预备根管,用侧向加压法进行充填。4个试验组所用根管封闭剂分别为氧化锌丁香油糊剂组(... 详细信息

目的:观察纳米材料的根尖封闭性能。方法:选取40个直根管的上前牙,随机分为4个试验组(每组各8个)和2个对照组(对照1组和对照2组各4个),采用逐步后退法预备根管,用侧向加压法进行充填。4个试验组所用根管封闭剂分别为氧化锌丁香油糊剂组(zoe),羟磷灰石糊剂组(HA),纳米氧化锌糊剂组(NZO),纳米羟磷灰石糊剂组(NHA),置于微渗漏模型,于第1、2、4、7、10、15、20、25、30天检测从冠方向根方漏出的葡萄糖量,根据葡萄糖微渗漏情况,评价根尖封闭性。结果:经葡萄糖氧化酶法检测,4组材料的葡萄糖渗漏量有显著性差异(F值=16523.5,Pzoe>HA>NHA>NZO组(Pzoe上升趋势最显著。结论:纳米氧化锌糊剂具有良好的根尖封闭性能,羟磷灰石糊剂和纳米羟磷灰石糊剂次之,氧化锌糊剂根尖封闭性能最差。

关键词：纳米材料根尖封闭葡萄糖氧化酶法