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本科院校助产专业“双师型”教师核心胜任力指标体系的构建

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中华护理教育 2024年第5期21卷 532-538页

作者：张明娜齐艺李邱雪郭黎刘均娥刘维维首都医科大学护理学院北京市100069

目的构建本科院校助产专业“双师型”教师核心胜任力指标体系。方法基于文献研究法,拟定本科院校助产专业“双师型”教师核心胜任力指标体系初稿。2023年4月—5月,向15名专家进行2轮函询,构建本科院校助产专业“双师型”教师核心胜任力... 详细信息

目的构建本科院校助产专业“双师型”教师核心胜任力指标体系。方法基于文献研究法,拟定本科院校助产专业“双师型”教师核心胜任力指标体系初稿。2023年4月—5月,向15名专家进行2轮函询,构建本科院校助产专业“双师型”教师核心胜任力指标体系。结果2轮专家函询有效问卷的回收率均为100%;专家权威系数均为0.94;肯德尔和谐系数分别为0.359、0.394(P均<0.001)。最终确立的本科院校助产专业“双师型”教师核心胜任力指标体系由5个一级指标、16个二级指标及51个三级指标构成。结论本科院校助产专业“双师型”教师核心胜任力指标体系的构建过程具有良好的科学性与可靠性,可为我国本科院校助产专业“双师型”教师的选拔、培养及评价考核提供依据。

关键词：本科助产 “双师型”教师核心胜任力指标体系构建

A Branch and Bound-Based Algorithm for the Weak Linear Bilevel Programming Problems

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Wuhan University Journal of Natural Sciences 2018年第6期23卷 480-486页

作者： liu june HONG Yunfei ZHENG Yue School of Management Huaibei Normal UniversityHuaibei 235000 Anhui China School of Information and Mathematics Yangtze University Jingzhou 434023 Hubei China

Most real-world optimization problems are hierarchical involving non-cooperative objectives. Many of these problems can be formulated in terms of the first（upper level） objective function being minimized over the solution set mapping of the second（lower level） optimization problem. Often the upper level decision maker is risk-averse. The resulting class of problem is named weak bilevel programming problem. This paper presents a new algorithm which embeds a penalty function method into a branch and bound algorithm to deal with a weak linear bilevel programming problem. An example illustrates the feasibility of the proposed algorithm.

关键词： bilevel programming penalty function branch andbound algorithm

A New Variant of Penalty Method for Weak Linear Bilevel Programming Problems

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Wuhan University Journal of Natural Sciences 2018年第4期23卷 328-332页

作者： liu june HONG Yunfei ZHENG Yue School of Management Huaibei Normal University Huaibei235000 Anhui China School of Information and Mathematics Yangtze UniversityJingzhou 434023 Hubei China

We present a new variant of penalty method, which is different from the existing penalty methods, for solving the weak linear bilevel programming problems. We then transform it into a single-level optimization problem using Kuhn-Tucker optimality condition and discuss the relations between them. Finally, two examples are used to illustrate the feasibility of the proposed penalty method.

关键词： bilevel programming pessimistic formulation penalty method

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： june-Ha Shin Hwa-Ryeon Kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

An Objective Penalty Method for Optimistic Bilevel Programming Problems

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Journal of the Operations Research Society of China 2020年第1期8卷 177-187页

作者： june liu Tao Zhang Yu-Xin Fan Bing Han Yue Zheng School of Management Huaibei Normal UniversityHuaibei 235000AnhuiChina School of Information and Mathematics Yangtze UniversityJingzhou 434023HubeiChina Huazhong University of Science and Technology Wuhan 430074China

In this paper,we consider an optimistic nonlinear bilevel programming *** some conditions,we first show that the sequence of solutions to penalty problems converges to the optimal solution of the original bilevel programming *** then present an objective penalty method to solve such a ***,some numerical experiments are performed to illustrate its feasibility.

关键词： Bilevel programming Optimistic formulation Penalty method Objective penalty method

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老年人应对慢性病共病体验的Meta整合

中华护理杂志 2022年第6期57卷 748-755页

作者：孙柳王莹梁嘉贵陈少华刘均娥首都医科大学护理学院北京市100069

目的系统评价老年人应对慢性病共病的体验。方法检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方数据库、维普中文期刊全文数据库,检索时限为建库至2021年8月,检索老年人应对慢性病共病体验的质性研究文献,依据2... 详细信息

目的系统评价老年人应对慢性病共病的体验。方法检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方数据库、维普中文期刊全文数据库,检索时限为建库至2021年8月,检索老年人应对慢性病共病体验的质性研究文献,依据2016版澳大利亚乔安娜布里格斯研究所循证卫生保健中心质性研究质量评价标准评价文献质量,采用Meta整合方法分析结果。结果共纳入15篇文献,提炼出60个研究结果,整合成10个新的类别,综合为3个整合结果:慢性病共病协同衰老所致改变;对慢性病共病的反思和反应;调适以维持正常生活。结论慢性病共病协同衰老给老年人生活造成多方面的挑战,医护人员应关注其对共病不同应对方式,重视源于其智慧总结的应对策略,设计、开发可行的应对共病的干预性支持项目。

关键词：老年人慢性病共病多病共存 Meta整合应对调适护理

Fortifying Smart Grids: A Holistic Assessment Strategy against Cyber Attacks and Physical Threats for Intelligent Electronic Devices

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Computers, Materials & Continua 2024年第8期80卷 2579-2609页

作者： Yangrong Chen june Li Yu Xia Ruiwen Zhang Lingling Li Xiaoyu Li Lin Ge School of Computer Science Zhengzhou University of AeronauticsZhengzhou450046China Henan Xin’an Century Technology Co. Ltd.Henan Data Security Engineering Technology Research CenterZhengzhou450046China Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of EducationSchool of Cyber Science and EngineeringWuhan UniversityWuhan430072China

Intelligent electronic devices(IEDs)are interconnected via communication networks and play pivotal roles in transmitting grid-related operational data and executing control *** the context of the heightened security challenges within smart grids,IEDs pose significant risks due to inherent hardware and software vulner-abilities,as well as the openness and vulnerability of communication *** grid security,distinct from traditional internet security,mainly relies on monitoring network security events at the platform layer,lacking an effective assessment mechanism for ***,we incorporate considerations for both cyber-attacks and physical faults,presenting security assessment indicators and methods specifically tailored for ***,we outline the security monitoring technology for IEDs,considering the necessary data sources for their security ***,we classify IEDs and establish a comprehensive security monitoring index system,incorporating factors such as running states,network traffic,and abnormal *** index system contains 18 indicators in 3 ***,we elucidate quantitative methods for various indicators and propose a hybrid security assessment method known as GRCW-hybrid,combining grey relational analysis(GRA),analytic hierarchy process(AHP),and entropy weight method(EWM).According to the proposed assessment method,the security risk level of IEDs can be graded into 6 levels,namely 0,1,2,3,4,and *** higher the level,the greater the security ***,we assess and simulate 15 scenarios in 3 categories,which are based on monitoring indicators and real-world situations encountered by *** results show that calculated security risk level based on the proposed assessment method are consistent with actual ***,the reasonableness and effectiveness of the proposed index system and assessment method are validated.

关键词： Smart grid intelligent electronic device security assessment abnormal behaviors network traffic running states

A Novel Smoothing Method for Symmetric Conic Linear Programming

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A Novel Smoothing Method for Symmetric Conic Linear Programm...

Etanercept-synthesizing adipose-derived stem cell secretome:A promising therapeutic option for inflammatory bowel disease

The 2011 International Conference on Computing,Information and Control(ICCIC 2011)

作者： Xiaoni Chi june liu College of Mathematics and Information Science Huanggang Normal University

We present a novel smoothing method for solving the symmetric conic linear programming based on the Chen-Harker-Kanzow-Smale（CHKS） smoothing function. Unlike interior point methods, the proposed algorithm can start from an arbitrary point. Our algorithm solves only one linear system of equations and performs only one line search at each iteration. Without uniform nonsingularity, the proposed algorithm is shown to be globally convergent. Numerical results indicate that our algorithm is promising.

关键词： symmetric conic linear programming smoothing method ChenHarker-Kanzow-Smale smoothing function global convergence

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 882-892页

作者： Say-june Kim Ok-Hee Kim Ha-Eun Hong Ji Hyeon Ju Do Sang Lee Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract,with tumor necrosis factor(TNF)-αplaying a key role in its ***,a decoy receptor for TNF,is used to treat inflammatory *** secretome derived from adipose-derived stem cells(ASCs)has anti-inflammatory effects,making it a promising therapeutic option for *** To investigate the anti-inflammatory effects of the secretome obtained from ASCs synthesizing etanercept on colon cells and in a dextran sulfate sodium(DSS)-induced IBD mouse *** ASCs were transfected with etanercept-encoding mini-circle plasmids to create etanercept-producing *** secretory material from these cells was then tested for anti-inflammatory effects both in vitro and in a DSS-induced IBD mouse *** This study revealed promising results indicating that the group treated with the secretome derived from etanercept-synthesizing ASCs[Etanercept-Secretome(Et-Sec)group]had significantly lower expression levels of inflammatory mediators,such as interleukin-6,Monocyte Chemoattractant Protein-1,and TNF-α,when compared to the control secretome(Ct-Sec).Moreover,the Et-Sec group exhibited a marked therapeutic effect in terms of preserving the architecture of intestinal tissue compared to the *** These results suggest that the secretome derived from ASCs that synthesize etanercept has potential as a therapeutic agent for the treatment of IBD,potentially enhancing treatment efficacy by merging the anti-inflam-matory qualities of the ASC secretome with etanercept's targeted approach to better address the multifaceted pathophysiology of IBD.

关键词： Adipose-derived stem cells Etanercept Inflammatory bowel disease Secretome Tumor necrosis factor-α