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Gold nanoparticles cause size-dependent inhibition of embryonic development during murine pregnancy

Nano Research 2018年第6期11卷 3419-3433页

作者： Xiaowei Ma Xiaolong Yang Yufei Wang juan liu Shubin jin Shuyi Li Xing-Jie Liang Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China No. 11 First North Road Zhongguancun Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China College of Biotechnology Tianjin University of Science & Technology Tianjin 300457 China Tissue Engineering Lab Beijing Institute of Transfusion Medicine Beijing 100850 China Beijing Municipallnstitute of Labour Protection No. 55 Taoranting Road Xicheng District Beijing 100054 China

Gold nanoparticles （Au NPs） have been widely utilized in biomedical appli- cations owing to their attractive features and biocompatibility, which greatly increase the risk of humans＂ being exposed to Au NPs, including pregnant women. In contrast to mature cells, embryos are more susceptible to outside disruptive stimuli. Nonetheless, a possible inhibitory effect of nanomaterials on embryonic development is usually ignored as long as the NPs do not have significant cytotoxic effects. According to our results, a minimal ＂nontoxic＂ concentration of Au NPs during early pregnancy can have lethal inhibitory effects on embryos in vivo and in vitro. We conducted important experiments on the influence of Au NPs on embryonic development and found that Au NPs can disturb embryonic development in a size- and concentration-dependent manner. Au NPs of 15 nm in diameter downregulated the expression pattern of distinct germ layer markers both at mRNA and protein levels; this action prevented differentiation of all three embryonic germ layers. Consequentl~ fetal resorption was observed. Our work reveals the impact of Au NPs on embryonic development and will provide an important guidance and serve as a reference for biomedical applications of Au NPs with minimal side effects.

关键词： gold nanoparticles embryonic development fetal resorption differentiation

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Bended probe diagnostics of the plasma characteristics within an ECR ion source with a rectangular waveguide

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Plasma Science and Technology 2018年第8期20卷 29-34页

作者： juan YANG Yuliang FU Xianchuang liu Haibo MENG Yizhou jin School of Astronautic Northwestern Polytechnical UniversityXi＇an 710072People＇s Republic of China

To reveal the argon plasma characteristics within the entire region of an electron cyclotron resonance（ECR） ion source, the plasma parameters were diagnosed using a bended Langmuir probe with the filament axis perpendicular to the diagnosing plane. Experiments indicate that,with a gas volume flow rate and incident microwave power of 4 sccm and 8.8 W, respectively,the gas was ionized to form plasma with a luminous ring. When the incident microwave power was above 27 W, the luminous ring was converted to a bright column, the dark area near its axis was narrowed, and the microwave power absorbing efficiency was increased. This indicates that there was a mode transition phenomenon in this ECR ion source when the microwave power increased. The diagnosis shows that, at an incident microwave power of 17.4 W, the diagnosed electron temperature and ion density were below 8 eV and 3×10^17 m^-3, respectively, while at incident microwave power levels of 30 W and 40 W, the maximum electron temperature and ion density were above 11 eV and 6.8×10^17 m^-3, respectively. Confined by magnetic mirrors, the higher density plasma region had a bow shape, which coincided with the magnetic field lines but deviated from the ECR layer.

关键词： ECR plasma probe diagnosing ion thruster

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FUZZY COMPREHENSIVE EVALUATION MODEL OF ECOLOGICAL DEMONSTRATION AREA

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Chinese Geographical Science 2005年第4期15卷 303-308页

作者： YU Ya-juan GUO Huai-cheng liu Yong WANG Shu-tong WANG jin-feng College of Environmental Sciences Peking University Beijing 100871 P. R. China

Ecological demonstration area (EDA) is an authorized nomination, which should be assessed from several aspects, including ecological, social, environmental, economic ones and so on. It is difficult to advance an exact developing level index of EDA due to its indicator system’s complexity and disequilibrium. In this paper, a framework of indicators was set to evaluate, monitor and examine the comprehensive level of ecological demonstration area (EDA). Fuzzy logic method was used to develop the fuzzy comprehensive evaluation model (FCEM), which could quantitatively reveal the developing degree of EDA. Huiji District of Zhengzhou, Henan Province, one of the 9th group of national EDAs, was taken as a study case. The framework of FCEM for the integrated system included six subsystems, which were social, economic, ecological, rural, urban and accessorial description ones. The research would be valuable in the comprehensive quantitative evaluation of EDA and would work as a guide in the construction practices of Huiji ecological demonstration area.

关键词： fuzzy comprehensive evaluation model (FCEM) ecological demonstration area (EDA) fuzzy logic system dynamics Huiji District of Zhengzhou

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Calibration of the space-borne microwave humidity sounder based on real-time thermal emission from lunar surface

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Science China Earth Sciences 2021年第3期64卷 494-502页

作者： Niutao liu Yaqiu jin Key Laboratory of Information Science of Electromagnetic Waves(MoE) Fudan UniversityShanghai200433China

Calibration is a key issue for quantitative application of meteorological satellite data. The complex space environment may cause many uncertainties in data calibration. A highly stable and reliable calibrator in flight is needed. Because the Moon has no atmosphere and no environmental variation, the physical and chemical properties of its surface are stable in the long term. The Moon might be an ideal candidate for in-flight thermal calibration. In advanced satellite-borne microwave remote sensing such as NOAA-18, the deep space view(DSV) of the microwave humidity sounder(MHS) has viewed the Moon many times every *** the thermal-physical properties of the lunar regolith derived from the Diviner infrared(IR) brightness temperature(TB) data,we solve the one-dimensional heat conduction equation to obtain the temperature profile of the near side of the lunar regolith medium. The loss tangents of the regolith medium are retrieved from microwave TB data of the Chinese satellite Chang’e-2. The integrated radiative transfer equation is used to simulate the weighted disk-average TB of the lunar surface for the MHS channels at89, 157, and 183 GHz for the year 2011. The Moon is taken as an extended circular target. The simulated TBs are used to correct the full width at half maximum(FWHM) fitted with the MHS counts. We analyze the influences of the distance between the satellite and the Moon, the lunar phase angle, and the FWHM of the radiometer on the inverted FWHM. The corrected TB data are compared with the simulation. This paper presents a new method for thermal calibration of spaceborne in-flight microwave and millimeter-wave radiometers with the weighted disk-average TB of the lunar surface.

关键词： Microwave humidity sounder Tb calibration Thermal emission of lunar surface FWHM

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基于能值法对区域系统的数据采集与应用研究

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天津理工大学学报 2025年第1期41卷 145-152页

作者：郝如毅刘娟天津理工大学环境科学与安全工程学院

呼包鄂榆城市群是我国西北地区重要的城市群中心。基于能值理论的分析方法，对2020年呼包鄂榆城市群发展的各项数据进行采集、整理、计算后进行综合分析。结果显示：2020年呼包鄂榆城市群总能值中可更新资源能值的占比为0.24%、不可更... 详细信息

呼包鄂榆城市群是我国西北地区重要的城市群中心。基于能值理论的分析方法，对2020年呼包鄂榆城市群发展的各项数据进行采集、整理、计算后进行综合分析。结果显示：2020年呼包鄂榆城市群总能值中可更新资源能值的占比为0.24%、不可更新资源能值的占比较高，达95.67%;能值自给率为96%;区域环境负载率较高；能值产出率为24.46%;城市群能值密度和人均能值量超全国平均水平。可持续指标显示城市群为高度发达的“消费者”导向型经济体；健康能值指数表明呼包鄂榆城市群在城市健康评分分级标准中判定为“很健康”。最后根据数据结论，对呼包鄂榆城市群健康发展提出针对性对策和建议。

关键词：呼包鄂榆城市群能值理论可持续发展健康指数

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Kinetic study on desulfurization and denitrification using microwave irradiation over activated carbon

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Science China(Technological Sciences) 2011年第9期54卷 2321-2326页

作者： MA ShuangChen YAO juan juan jin Xin ZHANG Bo School of Environment North China Electric Power University Baoding 071003 China

Sulfur dioxide （SO2） and nitrogen oxide （NOx） in flue gas can be removed by combining microwave induced catalysis and adsorption on activated carbon. The reaction mechanisms of desulfurization and denitrification by microwave irradiation were analyzed based on the measurement of reaction products. Thermodynamic parameters for desulfurization and denitrification by thermal-carbon reduction were predicted according to the principles of thermodynamics. The experimental results indicated that the desulfurization and denitrification reaction processes include three reaction stages： slow reaction zone, transitional zone and rapid reaction zone. In high temperature zone, activation energies for the reduction of SO2 and nitrogen monoxide （NO） are 30.69 and 24.06 kJ mo1-1, respectively. This study shows that microwave can effectively enhance the removal of pollutants through its heating effect and the induced catalysis.

关键词： microwave desulfurization denitrification kinetics

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Review of computer-generated hologram algorithms for color dynamic holographic three-dimensional display

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Light(Science & Applications) 2022年第9期11卷 1962-1978页

作者： Dapu Pi juan liu Yongtian Wang Beijing Engineering Research Center for Mixed Reality and Advanced Display School of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China

Holographic three-dimensional display is an important display technique because it can provide all depth information of a real or virtual scene without any special *** recent years,with the development of computer and optoelectronic technology,computer-generated holograms have attracted extensive attention and developed as the most promising method to realize holographic ***,some bottlenecks still restrict the development of computer-generated holograms,such as heavy computation burden,low image quality,and the complicated system of color holographic *** overcome these problems,numerous algorithms have been investigated with the aim of color dynamic holographic three-dimensional *** this review,we will explain the essence of various computer-generated hologram algorithms and provide some insights for future research.

关键词： holographic dynamic overcome

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Direct solution for fixed source location using well-posed TDOA and FDOA measurements

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Journal of Systems Engineering and Electronics 2020年第4期31卷 666-673页

作者： liu Congfeng YUN jinwei SU juan Research Institute of Electronic Countermeasure Xidian UniversityXi’an 710071China

Based on the time differences of arrival(TDOA) and frequency differences of arrival(FDOA) measurements of the given planar stationary radiation source, the joint TDOA/FDOA location algorithm which solves the location of the target directly is proposed. Compared with weighted least squares(WLS) methods,the proposed algorithm is also suitable for well-posed conditions,and gets rid of the dependence on the constraints of Earth's surface. First of all, the solution formulas are expressed by the radial range. Then substitute it into the equation of the radial range to figure out the radial range between the target and the reference station. Finally use the solution expression of the target location to estimate the location of the target accurately. The proposed algorithm solves the problem that WLS methods have a large positioning error when the number of observation stations is not over-determined. Simulation results show the effectiveness of the proposed algorithm, including effectively increasing the positioning accuracy and reducing the number of observatories.

关键词： passive location joint time differences of arrival/frequency differences of arrival(TDOA/FDOA)location direct solution stationary emitter well-posed equations

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“双来源”病理生理学教师对医学生实践能力的影响

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教育教学论坛 2017年第35期 242-243页

作者：于海荣刘金霞赵娟董雅洁李瑞香承德医学院基础医学部河北承德067000

病理生理学是沟通基础医学和临床医学的重要桥梁学科。本文着重研究病理生理学师资培养,并分析了"双来源"病理生理学教师对提高医学生实践能力的培养,为病理生理学师资培养乃至医学本科师资培养提供了一定的参考。

关键词：病理生理学 “双来源”教师医学生实践能力

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Multidisciplinary approaches in the management of advanced hepatocellular carcinoma:Exploring future directions

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4052-4054页

作者： Xin-jin liu Yi-Xiu Lin liu-Xiang Chen Wen-juan Yang Bing Hu Department of Gastroenterology and Hepatology/Medical Engineering Integration Laboratory of Digestive Endoscopy West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Recently,we read the article“Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of the literature”published in the World Journal of Gastrointestinal *** prognosis of advanced hepatocellular carcinoma(HCC)is poor,and multidisciplinary comprehensive treatment is currently the main research *** case report demonstrated the efficacy of the combination therapy of transcatheter arterial chemoembolization,hepatic arterial infusion chemotherapy,epclusa,lenvatinib and sintilimab for a patient with advanced HCC,and the report can serve as a reference for clinical *** would also like to share some of our views.

关键词： Hepatocellular carcinoma Multidisciplinary conversion therapy Pathological complete response Comment

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