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Relationship of plasma creatinine and lactic acid in type 2 diabetic patients without renal dysfunction

Chinese Medical Journal 2009年第21期122卷 2547-2553页

作者： liu fang lu jun-xi tang jun-ling li li lu hui-juan hou xu-hong jia wei-ping xiang kun-san Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Institute for Diabetes Shanghai Clinical Center of Diabetes Shanghai 200233 China

Background As one of most widely-used biguanides, metformin can induce the lactic acidosis in patients with renal failure though its incidence is very low. However, lactic acidemia induced by metformin was reported in patients without renal dysfunction. It is unclear that whether lactatemia exists in diabetic patients with normal renal function in Chinese or not and its influencing factors. This study aimed to clarify the influencing factors of lactic acid, and identify a practiced clinical marker to predict the hyperlactacidemia in diabetics with normal renal function. Methods The clinical data and venous blood samples of 1024 type 2 diabetic patients treated with （n=426） or without metformin （n=599） were collected. The lactic acid was assayed by enzyme-electrode method. The biochemical indexes included creatinine （Cr） and hepatase were measured with enzymatic procedures. The lactic acid concentrations of different Cr subgroups were compared, and the correlation and receiver operating characteristic curve analysis were used. Results The mean lactic acid level and the proportion of hyperlactatemia of metformin group were significantly higher than that of non-metformin group （P 〈0.01）, but no lactic acidosis was found in all patients. The correlation and multiple stepwise regression analysis indicated that the correlative factors of lactic acid in turn were Cr, metformin, alanine transferase （ALT）, body mass index （BMI）, Urine albumin （Ualb）, and blood urea nitrogen （BUN） in total patients; and Cr, ALT, BMI and BUN in non-metformin treated patients; Cr and ALT in metformin-group. The lactate concentration increased with the increment of Cr levels, and reached its peak at Cr 111-130 μmol/L, and the optimal cutoff of Cr in predicting hyperlactacidemia was 96.5 μmol/L. Conclusions Metformin can increase the incidence of lactatemia in type 2 diabetic patients without renal dysfunction. Cr, ALT, and BMI are independent associated factors of blood lactic acid levels. There

关键词： diabetes mellitus lactic acid creatinine metformin cutoff

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun Zhao Shao-lin xiong xiang-Yang Wen xin-Qiao li Ce Cai Shuo xiao Qi luo Wen-xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-Qiu Zhang Yue Huang lu li xing Wen Fei Zhang Jing Duan Chen-wei Wang Dong-li Shi Peng Zhang Qi-Bin Yi Chao-Yang li Yan-Bing xu xiao-Hua liang Ya-Qing liu Da-li Zhang xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng Yang xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou Wang xing Zhou Yi Zhao Wang-Chen xue Chao Zheng jia-Cong liu xing-Bo Han Jin-ling Qi jia Huang Ke-Ke Zhang Can Chen xiong-Tao Yang Dong-Jie hou Yu-Sa Wang Rui Qiao xiang Ma xiao-Bo li ping Wang xin-Ying Song li-Ming Song Shi-Jie Zheng Bing li hong-Mei Zhang Yue Zhu wei Chen jian-jian He Zhen Zhang Jin hou hong-jun Wang Yan-Chao Hao xiang-Yu Wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao xiao-Fei Lan Yan-Guo li Gang li xu-fang li fang-jun lu hong lu Bin Meng Feng Shi hui Wang hui-Zhen Wang Yu-Peng xu jia-wei Yang xue-juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li luo Yong-Heng Zhao Gang Zhao li-Cai Deng xiao-wei liu Yi-Peng Jing Gang Wang Hao-Tong Zhang jian-Rong Shi xiang-Qun Cui Yao-Quan Chu Guo-ping li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-jun Chen kun-xin Chen li Chen xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng jian-Ning Fu Peng Gao xue-Fei Gong Bo-Zhong Gu Yan-xin Guo Zhan-Wen Han Bo-liang He Jin-liang hou Yong-hui hou Wen hou hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei jia fang-Hua jiang xiang jiang Zhi-Bo jiang Ge Jin xiao Kong xu Kong Ya-juan Lei Ai-Hua li Chang-Hua li Guang-wei li Hai-Ning li jian li Qi li Shuang li Sha-Sha li xin-Nan li Yan li Yin-Bi li Ye-ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi lu Yu luo Yin-Dun Mao Heidi Newberg Ji-jun Ni Zhao-xiang Qi Yong-jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su hong-jun Su Zheng-hong tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang hong-Chi Wang jian Wang jia-Ning Wang jian-ling Wang jian-ping Wang jun-xian Wang Lei Wang Meng-xin Wang Shou-Guan Wang Shu-Qing Wang xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng wei Ming-Zhi wei hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu xiao-Zheng xing ling-Zhe xu xin-Qi xu Yan xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu hui Yuan Hai-Bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng Zhang Hua-wei Zhang jian-Nan Zhang li-Pin Zhang wei Zhang Yong Zhang Yan-xia Zhang Zheng-Chao Zhang Ming Zhao fang Zhou xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究

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Science Bulletin 2023年第18期68卷 2106-2114,M0004页

作者： Zhuo-Yu An Ye-jun Wu Yu hou Heng Mei wei-xia Nong Wen-Qian li Hu Zhou Ru Feng jian-ping Shen jun Peng Hai Zhou Yi liu Yong-ping Song lin-Hua Yang Mei-Yun fang jian-Yong li Yun-Feng Cheng Peng liu Ya-Jing xu Zhao Wang Yi luo Zhen Cai hui liu Jing-Wen Wang juan li xi Zhang Zi-Min Sun xiao-Yu Zhu xin Wang Rong Fu liang Huang Shao-Yuan Wang Tong-Hua Yang li-ping Su liang-Ming Ma xie-Qun Chen Dai-hong liu hong-xia Yao jia Feng hong-Yu Zhang Ming jiang Ze-ping Zhou Wen-Sheng Wang xu-liang Shen Yangjin Baima Yue-Ying li Qian-Fei Wang Qiu-Sha Huang Hai-xia Fu xiao-lu Zhu Yun He Qian jiang Hao jiang Jin lu xiang-Yu Zhao Ying-jun Chang Tao Wu Yao-Zhu Pan lin Qiu Da Gao A-Rong Jin wei li Su-jun Gao Lei Zhang Ming hou xiao-jun Huang xiao-hui Zhang on behalf of the National Cooperative ITP Working Group Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250014China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Department of Hematology First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi 832002China Department of Hematology Qinghai Provincial People’s HospitalXining 810007China Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityHenan Institute of HematologyZhengzhou 450008China Department of Hematology Beijing HospitalBeijing 100044China Department of Hematology Zhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310006China Department of Hematology Senior Department of Hematologythe Fifth Medical Center of PLA General HospitalBeijing 100044China Department of Hematology the Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Hematology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Department of Hematology The First Affiliated Hospital with Nanjing Medical University(Jiangsu Province Hospital)Nanjing 210029China Department of Hematology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Hematology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Hematology Beijing Friendship HospitalCapital Medical UniversityBeijing 100044China Institute of Hematology the First Affiliated HospitalZhejiang UniversityHangzhou 310058China Department of Hematology Beijing Tongren HospitalBeijing 100005China Department of Hematology The First Affiliated HospitalSun Yat-sen UniversityGuang

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者... 详细信息

原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。

关键词： Critical bleeding Severe bleeding Immune thrombocytopenia Machine learning Prediction model

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肾功能正常的2型糖尿病患者血肌酐与乳酸水平相关

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中华内分泌代谢杂志 2009年第1期25卷 42-45页

作者：刘芳陆俊茜唐峻岭陆汉魁王静李诀侯旭宏陆惠娟贾伟平项坤三上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病临床医学中心上海市糖尿病研究所200233 上海交通大学附属第六人民医院核医学科 200233

目的探讨肾功能正常的2型糖尿病患者的血肌酐与血乳酸水平的关系以及应用二甲双胍后对血乳酸的影响。方法选择肾功能正常的住院2型糖尿病患者723例，其中应用二甲双胍者（用药组）275例，未用双胍类者（对照组）448例。用酶电极法测定... 详细信息

目的探讨肾功能正常的2型糖尿病患者的血肌酐与血乳酸水平的关系以及应用二甲双胍后对血乳酸的影响。方法选择肾功能正常的住院2型糖尿病患者723例，其中应用二甲双胍者（用药组）275例，未用双胍类者（对照组）448例。用酶电极法测定血乳酸水平，同时检测空腹血糖、胰岛素、HbA1C、尿素氮、肌酐和丙氨酸转氨酶（ALT）等水平。结果（1）用药组的平均血乳酸水平高于对照组[（1．33±0．57vs1．17±0．47）mmol／L，P〈0．01]；高乳酸血症的发生率显著高于对照组（9．45％vs4．91％，P〈0．01），但均未达到酸中毒的水平。（2）相关性分析结果显示，血乳酸水平与血肌酐、尿素氮、ALT、体重指数（BMI）呈明显正相关。在校正ALT和BMI后，肌酐仍与血乳酸呈正相关（r=0．345，P〈0．01）。（3）按肌酐水平进行分层后，血乳酸水平随着血肌酐水平升高而增加，肌酐〉90μmol／L后显著增高；受试者工作特征（ROC）曲线分析表明预测血乳酸水平增高的肌酐截点是95．35μmol／L。结论肾功能正常的2型糖尿病患者应用二甲双胍虽具有较好的安全性，但仍有极少数患者可出现乳酸水平的轻度升高。血肌酐〉95．35μmol／L者发生高乳酸血症的风险增加。

关键词：糖尿病乳酸肌酐二甲双胍

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2型糖尿病患者血乳酸水平的性别差异及二甲双胍对其的影响

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中华内分泌代谢杂志 2010年第5期26卷 372-376页

作者：李青刘芳唐峻岭郑泰山陆俊茜陆惠娟贾伟平上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病临床医学中心上海市糖尿病研究所上海市糖尿病重点实验室200233

目的探讨肝肾功能正常的2型糖尿病患者血乳酸水平的性别差异，以及二甲双胍对此性别差异的影响。方法选择肝肾功能正常的2型糖尿病住院患者1021例，分为二甲双胍用药组（男213例，女210例）和二甲双胍未用药组（男299例，女299例）。用... 详细信息

目的探讨肝肾功能正常的2型糖尿病患者血乳酸水平的性别差异，以及二甲双胍对此性别差异的影响。方法选择肝肾功能正常的2型糖尿病住院患者1021例，分为二甲双胍用药组（男213例，女210例）和二甲双胍未用药组（男299例，女299例）。用酶电极法测定空腹血乳酸水平，同时测定血糖、肝肾功能等指标。分析血乳酸的相关因素，并比较用药组、非用药组和总组以及各肌酐、谷丙转氨酶（ALT）亚组和年龄亚组（〈45岁、45～55岁、〉55岁）的不同性别的血乳酸水平。结果二甲双胍用药组的血乳酸水平明显高于未用药组[（1．32±0．53对1．14±0．49）mmol／L，P〈0．01]，其中共61例患者存在高乳酸血症，但未出现乳酸酸中毒。Spearman相关分析显示，除肌酐、ALT外，血乳酸水平还与性别、二甲双胍及体重指数（BMI）呈显著正相关（P〈0．01）。多因素logistic回归分析进一步表明，性别、肌酐、ALT及二甲双胍是发生高乳酸血症的独立相关因素。在总组、用药组及未用药组中女性的血乳酸水平均显著高于男性（均P〈0．05）。与男性相比，在不同的肌酐和ALT亚组，女性的血乳酸水平较高；在各年龄亚组女性的血乳酸水平均高于男性，以〈45岁亚组为著（P=0．021）。结论2型糖尿病患者血乳酸水平具有性别差异，二甲双胍对不同性别的2型糖尿病患者血乳酸水平影响不同，女性，尤其是绝经期前女性的血乳酸更容易升高。

关键词：糖尿病 2型二甲双胍血乳酸性别肌酐谷丙转氨酶

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The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： xiao Chen Bin lu hui-xian li xue-Ying li Yu-wei Wang Francisco Xavier Castellanos li-ping Cao Ning-xuan Chen wei Chen Yu-Qi Cheng Shi-xian Cui Zhao-Yu Deng Yi-Ru fang Qi-Yong Gong Wen-Bin Guo Zheng-jia-Yi Hu li Kuang Bao-juan li Le li Tao li Tao lian Yi-Fan liao Yan-Song liu Zhe-Ning liu jian-ping lu Qing-Hua luo Hua-Qing Meng Dai-hui Peng jiang Qiu Yue-Di Shen Tian-Mei Si Yan-Qing tang Chuan-Yue Wang Fei Wang Hua-Ning Wang Kai Wang xiang Wang Ying Wang Zi-Han Wang xiao-ping Wu Chun-Ming xie Guang-Rong xie Peng xie xiu-Feng xu hong Yang jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang wei Zhang Zhi-jun Zhang jun-juan Zhu xi-Nian Zuo Jing-ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao jianshe Cao Antoine Chance xuejun Chang Yue Chang Zhe Chang xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen xiang Chen xiaoyu Chen xin Chen xun Chen xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at junO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang pingping Chen Po-An Chen Shaomin Chen Shenjian Chen xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri lukas Fajt Donghua Fan Lei Fan Can fang jian fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia Universitélibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina xi’an jiaotong University Xi’anChina xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The jiangmen Underground Neutrino Observatory(junO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of junO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of junO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),junO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,junO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino junO

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注射用丹参多酚酸盐的临床应用综合评价

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中国药学杂志 2021年第6期56卷 507-514页

作者：韩晟赵熙子史录文林丽开李大魁陈凯先宣利江马传江马海英方唯一王丽霞文爱东付秀娟左燕刘小玲刘向红刘国强朱珠陈万生陈维红吴方建吴玉波吴晖张伟张毕奎林慧周国华欧阳荣胡元会姜明燕赵春景贾乐川晋月萍唐洪梅曹俊岭梁春商洪才董占军董吁钢翟所迪北京大学医药管理国际研究中心北京100191 武汉大学中南医院武汉大学医院管理研究所武汉430071 北京协和医院北京100730 中国科学院上海药物研究所上海201203 山东中医药大学附属医院济南250014 中国医科大学附属第四医院沈阳110000 复旦大学附属华东医院上海200030 中国中医科学院广安门医院北京100053 中国人民解放军空军军医大学第一附属医院西安710032 吉林大学第二医院长春130041 陕西省人民医院西安710068 内蒙古自治区人民医院呼和浩特010017 山东大学齐鲁医院济南250012 河北医科大学第三医院石家庄050051 海军军医大学第二附属医院上海200003 山西白求恩医院(山西医学科学院) 太原030032 长江航运总医院武汉430015 哈尔滨医科大学附属第四医院哈尔滨150001 昆明医科大学第一附属医院昆明650032 河南省人民医院郑州450003 中南大学湘雅二医院长沙410011 海南省药学会海口570102 南京大学医学院附属金陵医院南京210000 湖南中医药大学第一附属医院长沙410007 中国医科大学附属第一医院沈阳110001 重庆医科大学附属第二医院重庆400010 宁夏医科大学总医院银川750004 山西医科大学第一医院太原030001 广州中医药大学第一附属医院广州510405 北京中医药大学东方医院北京100078 北京中医药大学东直门医院北京100007 河北省人民医院石家庄050051 中山大学附属第一医院广州510080 北京大学第三医院北京100191

目的以注射用丹参多酚酸盐为例,探索中药注射剂临床应用的综合评价方法,为今后相关工作的开展和完善提供参考。方法通过文献检索和获取相关文献资料,从有效性、安全性、经济性、顺应性和标签信息等方面对注射用丹参多酚酸盐进行系统综... 详细信息

目的以注射用丹参多酚酸盐为例,探索中药注射剂临床应用的综合评价方法,为今后相关工作的开展和完善提供参考。方法通过文献检索和获取相关文献资料,从有效性、安全性、经济性、顺应性和标签信息等方面对注射用丹参多酚酸盐进行系统综合评价。结果除说明书适应证外,丹参多酚酸盐在心血管疾病、脑血管疾病等多种超说明书适应证中都存在具有一定质量的临床研究证据;在安全性、经济性方面的文献证据较为丰富。结论注射用丹参多酚酸盐在有效性、安全性及经济性等方面的临床研究证据较多,且具有一定的体系。但作为一个临床应用大品种,该药依然需要在一些方面做出更多的研究努力。

关键词：丹参酚酸B镁药品综合评价中药注射剂有效性安全性

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