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Journal of Genetics and Genomics 2009年第3期36卷 173-183页

作者： Junzhou Li Yan Xie Anyong Dai Lifeng liu zichao Li Key Laboratory of Crop Genomics and Genetic Improvement of Ministry of Agriculture and Beijing Key Laboratory of Crop Genetic Improvement China Agricultural University Beijing 100193 China

Phosphorous （P） deficiency is a major restraint factor for crop production and plants have developed several mechanisms to adapt to low P stress. In this study, a set of 271 introgression lines （ILs） were used to characterize the responses of seedlings to low P availability and to identify QTLs for root traits, biomass, and plant height under P-deficiency and P-sufficiency conditions. Plant height, total dry weight, shoot dry weight, and root number were inhibited under P-deficiency, whereas maximum root length （MRL） and root-shoot ratio （RS） were induced by P-deficiency stress. Relative MRL （RMRL, the ratio of MRL under P-deficiency to MRL under P-sufficiency con- dition） and relative RS （RRS） were used to evaluate P-deficiency tolerance at the seedling stage. A total of 24 additive QTLs and 29 pairs of epistatic QTLs were detected, but only qRN4 was detected in both conditions. This suggested that different mechanisms may exist in both P supply levels. QTLs for adaptive traits （RMRL, RRS, RRV, and RRDW） and qRN4 consistently expressed to increase trait stability may contribute to P-deficiency tolerance. Twelve intervals were cluster regions of QTLs for P-deficiency tolerance, and one QTL （qRRSS） showed pleiotropic effects on P-deficiency tolerance and drought tolerance. These interesting QTLs can be used in marker-assisted breeding through the target ILs.

关键词： introgression lines phosphorous deficiency tolerance QTL mapping rice root traits

Structural Evolution of Chepaizi Uplift and its Control on Stratigraphic Deposition in the Western Junggar Basin, China

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Acta Geologica Sinica(English Edition) 2019年第4期93卷 1060-1075页

作者： NI Minjie CHEN Shi liu zichao SHANG Fengkai QI Jiafu WANG Lishuang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China College of Geosciences China University of PetroleumBeijing 102249China Exploration and Development Research Institute Shengli Oilfield CompanySINOPECDongying 257015ShandongChina

Geological mapping,interpreted cross sections,structural analyses and residual thickness maps were used to characterize the evolution of stress setting,structure and stratigraphic distribution of the Chepaizi Uplift,which is a NW-SE trending structure located in the Western Junggar *** NS-trending faults show an important transpressional phase during the Late Permian,as demonstrated by tectonic stress field and stratigraphic thickness variations.A major compressional thrusting and strike-slip phase during the Late Jurassic created a series of NW-SE faults that originated by the large-scale uplift event in the Northern *** were reactivated as thrust and dextral strike-slip *** addition,the angular unconformity observed between Jurassic and Cretaceous provide evidence of this tectonic *** of normal faults indicate that the area records southward tilting and regional derived extensional stress that took place during the *** that,thick Early Cenozoic strata are widely *** balanced cross-section highlights the evolution of stress setting and stratigraphic distribution of the Chepaizi Uplift.

关键词： structural evolution seismic section Junggar Basin Chepaizi Uplift Northern Tianshan

Identification of Hirudo Species from Different Sources

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Medicinal Plant 2023年第4期14卷 18-23页

作者： Shuang PAN Jinhua liu Ying ZHANG zichao liu Qingkang YAN Jining Institute for Food and Drug Control Jining 272073China Kunming University Kunming 650214China Shandong Kangyuantang Pharmaceutical Co. Ltd.Weishan 277660China

[Objectives] To identify the species of Hirudo from different sources. [Methods] In accordance with morphological, anatomical and molecular taxonomic characteristics, the identification conclusion was drawn. [Results] The living samples of Hirudo belong to 1 order, 2 families, 3 genera and 5 species, and the dry samples of medicinal leeches belong to 4 species. [Conclusions] The sources of medicinal leeches are complex, and there is a problem that Hirudo from different basic sources are mixed for medication.

关键词： Medicinal leeches Species Identification

除虫菊酯和迷迭香对大鼠大脑突触体ATP酶的活性影响

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应用与环境生物学报 2008年第3期14卷 399-402页

作者：刘子超梁醒财中国科学院昆明动物研究所昆明650223 中国科学院研究生院北京100049

除虫菊酯越来越广泛地被应用于农业和家庭昆虫防治，主要通过作用于膜结合蛋白而对动物起神经毒性。迷迭香因其抗氧化功能而被应用于很多商业化的除虫菊酯产品中。本实验以大鼠大脑突触体ATP酶为研究对象，对除虫菊酯和迷迭香的药理学... 详细信息

除虫菊酯越来越广泛地被应用于农业和家庭昆虫防治，主要通过作用于膜结合蛋白而对动物起神经毒性。迷迭香因其抗氧化功能而被应用于很多商业化的除虫菊酯产品中。本实验以大鼠大脑突触体ATP酶为研究对象，对除虫菊酯和迷迭香的药理学进行了研究．用Percoll梯度离心法分离突触体，通过检测无机磷的量来测定总ATP酶和Mg2＋-ATP酶活性．结果表明，除虫菊酯在浓度为10μmol／L时总ATP酶和Mg2＋-ATP酶分别降低到对照的80．3％和46．9％．迷迭香在浓度为0．3～30μmol／L时几乎不影响ATP酶活性，当浓度上升到3000μmol／L时，总ATP酶活性降低到66．8％，而Mg2＋-ATP酶活性降低到54．5％．10μmol／L除虫菊酯和30μmol／L迷迭香混合物引起总ATP酶和Mg2＋-ATP酶分别降低到72．9％和33．4％．结论：1）除虫菊酯能抑制大鼠大脑ATP酶活性；2）迷迭香只在高浓度下才对ATP酶有抑制作用；3）迷迭香能增强除虫菊酯对ATP酶的抑制作用．

关键词：除虫菊酯迷迭香总ATP酶 Mg2+-ATP酶大鼠大脑突触体

乳酸化修饰参与调控DNA损伤修复和癌细胞化疗敏感性

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Science Bulletin 2024年第9期69卷 1185-1187页

作者：刘子超黄奕乐刘兴国 CAS Key Laboratory of Regenerative Biology Joint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong 999077China Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative MedicineChina-New Zealand Joint Laboratory on Biomedicine and HealthCUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative MedicineGIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research CentreInstitute for Stem Cell and RegenerationGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China

The phenomenon in which cells prefer glycolysis to oxidative phosphorylation with increased lactate production is known as the Warburg effect and is found prevalent in cancer cells and pluripotent stem cells [1]. In addition to being an intermediate metabolite of glycolysis, lactate has been reported as a signal involved in multiple important biological processes, such as innate immunity [2], the cell cycle [3], hippocampal neurogenesis [4].

关键词：化疗敏感性 immunity DNA损伤修复

Heart Failure-Like Reaction Is Likely Involved in the Feeding Behaviour of Blood-Sucking Leeches

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Advances in Bioscience and Biotechnology 2024年第1期15卷 52-69页

作者： Li Yang Jiao Shu Xiao Wang Wei Yu Debin Wang zichao liu Bin Wang College of Pharmacy Dali University Dali China ERC of Novel Livestock & Poultry Vaccine & Crucial Industrial Tech of Yunnan DOE Kunming University Kunming China Department of Pharmacy 920th Hospital of Joint Logistics Support Force PLA Kunming China

Medicinal leeches have been utilized in therapy for thousands of years. However, the adaptation physiology between leeches and hosts is not fully understand. To disclose the molecular mechanisms of adaptation between leech and host, the body transcriptomes of hunger and fed blood-sucking Poecilobdella javanica, Haemadipsa cavatuses, and Hirudo nipponia leeches were obtained by RNA sequencing, after comparison, a stratified unigenes group was obtained, which closely correlated to body distension. In the group, Rfamide receptor decreased significantly (P < 0.05) while serotonin receptor increased significantly (P < 0.05). Moreover, four KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, including cardiac muscle contraction, complement and coagulation cascades, renin-angiotensin system, and hypertrophic cardiomyopathy were significantly enriched. The unigenes annotation, neuroregulators correlation analysis and induced function of the KEGG pathways, were consistently supported the same result as: vasoconstriction and systole reaction enhance in hunger leeches and vice versa vasodilation and diastole increase in fed leeches, meanwhile, Interspecific comparison and correlative analyses of physiological function showed that the strongest reaction of induced heart failure from four KEGG occur in strongest reaction of systole in hungry P. javanica and in strongest reaction of diastole in fed H. nipponia. Overall, heart failure is likely a physiological function involved in feeding behaviour.

关键词： Blood-Sucking Leeches Transcriptomic Analysis Heart Failure Feeding Behaviour

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基于预测校正的落角约束计算制导方法

航空学报 2022年第8期43卷 515-530页

作者：刘子超王江何绍溟李宇飞北京理工大学宇航学院北京100081 北京理工大学无人机自主控制技术北京市重点实验室北京100081 北京理工大学信息与电子学院北京100081

针对带有落角约束的导弹制导问题,提出一种基于预测校正思想的计算制导方法。根据导弹飞行状态与落角之间的映射关系设计了深度监督学习网络,在导弹飞行过程中基于观测信息实时预测落角;根据落角误差与控制指令之间的映射关系设计了深... 详细信息

针对带有落角约束的导弹制导问题,提出一种基于预测校正思想的计算制导方法。根据导弹飞行状态与落角之间的映射关系设计了深度监督学习网络,在导弹飞行过程中基于观测信息实时预测落角;根据落角误差与控制指令之间的映射关系设计了深度强化学习模型,在比例导引律的基础上增加偏置项,基于预测落角误差实时输出偏置项,校正落角误差。引入深度监督学习网络解决了传统强化学习方法中的稀疏奖励问题。设计了仿真飞行实验训练深度监督学习网络与深度强化学习模型,然后测试了提出的计算制导方法的性能。仿真结果表明所设计的计算制导方法准确地实现了落角控制,在嵌入式计算机的计算精度高,实时性好,具备工程实用价值。

关键词：落角约束计算制导预测校正制导偏置比例导引律深度学习

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基于迁移学习的角度约束时间最短制导算法

航空学报 2023年第19期44卷 237-251页

作者：罗皓文何绍溟金天宇刘子超北京理工大学宇航学院北京100081 北京理工大学无人机自主控制技术北京市重点实验室北京100081

由于导弹所处的气动环境等外界条件复杂多变,因此在特定气动环境中表现优异的深度监督学习制导算法将无法直接作用于新环境,这给制导指令的精准预测带来了很大挑战。针对上述问题,本文以落角约束下优化飞行时间的制导问题为背景,提出了... 详细信息

由于导弹所处的气动环境等外界条件复杂多变,因此在特定气动环境中表现优异的深度监督学习制导算法将无法直接作用于新环境,这给制导指令的精准预测带来了很大挑战。针对上述问题,本文以落角约束下优化飞行时间的制导问题为背景,提出了一种基于迁移学习的角度约束时间最短制导算法,该算法只需极少量的新数据,便能使制导律迅速适应不同的气动环境。在本文中,我们首先通过域对抗地训练特征提取器和域判别器,从不同气动环境的弹道数据中提取出对气动变化不敏感的关键特征;其次设计了适应于不同气动环境的偏置加速度预测器,进而实现了对导弹的精准制导;最后,大量数值仿真结果表明,在新气动环境下,基于迁移学习的角度约束时间最短制导算法仍能实现制导指令的精准预测。

关键词：计算制导深度学习迁移学习落角约束偏置比例导引律

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基于深度学习的时间角度控制制导律

系统工程与电子技术 2023年第11期45卷 3579-3587页

作者：刘子超王江何绍溟北京理工大学宇航学院北京100081 北京理工大学中国-阿联酋智能无人系统“一带一路”联合实验室北京100081 北京理工大学长三角研究院(嘉兴) 浙江嘉兴314019

针对考虑导弹气动力的时间角度控制制导问题,设计了一种基于深度学习的时间角度控制制导律;设计预测模块对考虑气动力的飞行器剩余飞行时间进行预测,预测模块引入前馈环节融合深度学习方法与理论模型,使用理论模型估计剩余飞行时间,使... 详细信息

针对考虑导弹气动力的时间角度控制制导问题,设计了一种基于深度学习的时间角度控制制导律;设计预测模块对考虑气动力的飞行器剩余飞行时间进行预测,预测模块引入前馈环节融合深度学习方法与理论模型,使用理论模型估计剩余飞行时间,使用深度神经网络估计理论模型的预测误差,提高剩余飞行时间预测精度;将精确剩余飞行时间引入时间角度控制制导律,使飞行时间误差收敛至零附近,最终实现飞行时间和攻击角度的共同控制。通过仿真试验验证了所设计的制导方法能够实现时间角度控制,相对于基于常值速度假设提出的制导律具有更好的制导性能。

关键词：导弹制导飞行时间控制攻击角度控制深度学习

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西藏美术馆建设记

西藏人文地理 2022年第1期 6-21页

作者：刘子超不详

红色工业遗迹如今,洛桑多吉已过耳顺之年,对自己的一生仍不无感慨。1975年,十八岁的他离开山南曲松县,通过招工进入拉萨水泥厂,一干就是三十八年。坐落在根培乌孜山麓西侧、东嘎山山脚下的拉萨水泥厂,是西藏第一家水泥制造企业。在青藏... 详细信息

红色工业遗迹如今,洛桑多吉已过耳顺之年,对自己的一生仍不无感慨。1975年,十八岁的他离开山南曲松县,通过招工进入拉萨水泥厂,一干就是三十八年。坐落在根培乌孜山麓西侧、东嘎山山脚下的拉萨水泥厂,是西藏第一家水泥制造企业。在青藏铁路通车之前,西藏长期交通不便,运送水泥困难,运输成本极高。

关键词：运输成本工业遗迹水泥厂曲松县青藏铁路通车西藏