乳酸化修饰参与调控DNA损伤修复和癌细胞化疗敏感性

作     者：刘子超 黄奕乐 刘兴国 Zichao Liu;Yile Huang;Xingguo Liu

作者机构：CAS Key Laboratory of Regenerative BiologyJoint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Centre for Regenerative Medicine and HealthHong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong 999077China Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative MedicineChina-New Zealand Joint Laboratory on Biomedicine and HealthCUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative MedicineGIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research CentreInstitute for Stem Cell and RegenerationGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2024年第69卷第9期

页      面：1185-1187页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China (2023YFE0210100, 2022YFE0210100, 2019YFA0904500, 2022YFA1103800) the National Natural Science Foundation of China (32025010, 92157202, 32241002, 92254301, 92357302, 32261160376,31970709, 32070729, 32100619, 32170747, 32322022, 32370782, 32371007, 32300608, 32300620) NSFC/RGC Joint Grant Scheme 2022/2023 (N_CUHK 428/22) the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB0480000) the Key Research Program, CAS (ZDBSZRKJZ-TLC003) International Cooperation Program, CAS (154144KYSB20200006) CAS Project for Young Scientists in Basic Research (YSBR-075) Guangdong Province Science and Technology Program (2023B0303000023, 2023B1111050005, 2023A1515030231, 2022A1515110493, 2023B1212060050, 2021A1515012513, 2021B1515020096, 2022A1515012616, 2022A1515110951, 2023B1212120009) Guangzhou Science and Technology Program (202102021037, 202102020827, 202102080066, 202206060002, 2023A04J0414) Health@Inno HK funding support from the Innovation Technology Commission of the Hong Kong SAR, Basic Research Project of Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and CAS Youth Innovation Promotion Association 

主　　题：化疗敏感性 immunity DNA损伤修复 

摘      要：The phenomenon in which cells prefer glycolysis to oxidative phosphorylation with increased lactate production is known as the Warburg effect and is found prevalent in cancer cells and pluripotent stem cells [1]. In addition to being an intermediate metabolite of glycolysis, lactate has been reported as a signal involved in multiple important biological processes, such as innate immunity [2], the cell cycle [3], hippocampal neurogenesis [4].