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Research advances in the function and anti-aging effects of nicotinamide mononucleotide

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第9期25卷 723-735页

作者： Min wang Yuan CAO Yun LI Lu wang Yuyan liu zihui DENG Lianrong ZHU Hongjun KANG Chinese PLA Medical School Beijing100853China department of Critical Care Medicine the First Medical CentreChinese PLA General HospitalBeijing100853China department of Emergency The Second Hospital of Hebei Medical UniversityShijiazhuang050004China department of Biochemistry Chinese PLA Medical SchoolBeijing100853China department of Clinical Nutrition the First Medical CentreChinese PLA General HospitalBeijing100853China Nephrology institute of the Chinese People’s Liberation Army State Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchDepartment of Nephrologythe First Medical CenterChinese PLA General HospitalBeijing100853China

Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary *** these concerns is an imperative task,with the aims of postponing the aging process and finding effective treatments for age-related degenerative *** investigations have highlighted the significant roles of nicotinamide adenine dinucleotide(NAD+)in the realm of *** has been empirically evidenced that supplementation with nicotinamide mononucleotide(NMN)can elevate NAD+levels in the body,thereby ameliorating certain age-related degenerative *** principal anti-aging mechanisms of NMN essentially lie in its impact on cellular energy metabolism,inhibition of cell apoptosis,modulation of immune function,and preservation of genomic stability,which collectively contribute to the deferral of the aging *** paper critically reviews and evaluates existing research on the anti-aging mechanisms of NMN,elucidates the inherent limitations of current research,and proposes novel avenues for anti-aging investigations.

关键词： Nicotinamide mononucleotide(NMN) Anti-aging Energy metabolism Apoptosis DNA repair

Synthesis and thermodynamic analysis of nano-La2O3

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Progress in Natural Science:Materials International 2007年第7期17卷 838-844页

作者： liu Lili~(1,2) Tang jie~2 Li Yuxiang~1 Zhang Mei~(1**) wang Xidong~(1,3) (1.department of Physical Chemistry,University of Science and technology beijing,beijing 100083,china 2.National institute for Materials Science,Segen 1-2-1,Tsukuba 305-0047,Japan 3.College of Engineering,beijing University,beijing 100871,china) [a]department of Physical Chemistry University of Science and Technology Beijing Beijing China [b]National institute Materials Science Tsukuba Jpan [c]College of Engineering Beijing University Beijing China

The thermodynamic parameters of La（NO3）3and La（OH）3are evaluated and the thermodynamics of nano-La2O3syn- thetic process is *** the base of thermodynamic analysis,La2O3nano-powders are prepared by the sol-gel method and the experi- ment scheme is designed by an orthogonal *** dry-gelatin is analyzed with differential thermal analysis/thermo-gravimetric analy- sis（TGA-DTA）and X-ray diffraction *** microstructure of nano-La2O3powders is observed by transmission dectron micro- *** synthetic parameters affecting the average grain size and dispersivity of nano-La2O3particles are experimentally examined and *** the results indicate that nano-La2O3particles well-dispersed are obtained and the average grain size is in the range of 20—50 nm.

关键词： nano-La2O3 sol-gel thermodynamic analysis

Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma

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Frontiers of Medicine 2024年第4期18卷 690-707页

作者： Zhe Nian Dan wang Hao wang Wenxu liu Zhenyi Ma jie Yan Yanna Cao jie Li Qiang Zhao Zhe liu department of Immunology School of Basic Medical SciencesTianjin Medical UniversityTianjin300070China Zhejiang Key Laboratory of Medical Epigenetics Department of Cell BiologySchool of Basic Medical SciencesHangzhou Normal UniversityHangzhou311121China department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin300060China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing211166China

Neuroblastoma(NB)is one of the most common childhood *** percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor ***,the molecular mechanisms triggering NB metastasis remain largely *** this study,we generated a transcriptomic atlas of 15447 NB cells from eight NB samples,including paired samples of primary tumors and bone marrow *** used time-resolved analysis to chart the evolutionary trajectory of NB cells from the primary tumor to the metastases in the same patient and identified a common‘starter’subpopulation that initiates tumor development and ***‘starter’population exhibited high expression levels of multiple cell cycle-related genes,indicating the important role of cell cycle upregulation in NB tumor *** addition,our evolutionary trajectory analysis demonstrated the involvement of partial epithelial-to-mesenchymal transition(p-EMT)along the metastatic route from the primary site to the bone *** study provides insights into the program driving NB metastasis and presents a signature of metastasis-initiating cells as an independent prognostic indicator and potential therapeutic target to inhibit the initiation of NB metastasis.

关键词： single-cell RNA sequencing metastasis neuroblastoma epithelial-to-mesenchymal transition

Hyperbranched polymer hollow-fiber-composite membranes for pervaporation separation of aromatic/aliphatic hydrocarbon mixtures

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Chinese Journal of Chemical Engineering 2024年第5期69卷 13-22页

作者： Tong liu Hao Sun Xiangqiong wang jie Li Zhanquan Zhang Pei Wu Naixin wang Quanfu An beijing Key Laboratory for Green Catalysis and Separation Department of Chemical EngineeringCollege of Materials Science and EngineeringBeijing University of TechnologyBeijing 100124China Petrochemical Research institute CNPCBeijing 102206China

The separation of aromatic/aliphatic hydrocarbon mixtures is crucial in the petrochemical *** is regarded as a promising approach for the separation of aromatic compounds from alkanes. Developing membrane materials with efficient separation performance is still the main task since the membrane should provide chemical stability, high permeation flux, and selectivity. In this study, the hyperbranched polymer(HBP) was deposited on the outer surface of a polyvinylidene fluoride(PVDF)hollow-fiber ultrafiltration membrane by a facile dip-coating method. The dip-coating rate, HBP concentration, and thermal cross-linking temperature were regulated to optimize the membrane *** obtained HBP/PVDF hollow-fiber-composite membrane had a good separation performance for aromatic/aliphatic hydrocarbon mixtures. For the 50%/50%(mass) toluene/n-heptane mixture, the permeation flux of optimized composite membranes could reach 1766 g·m^(-2)·h^(-1), with a separation factor of 4.1 at 60℃. Therefore, the HBP/PVDF hollow-fiber-composite membrane has great application prospects in the pervaporation separation of aromatic/aliphatic hydrocarbon mixtures.

关键词： Aromatic/aliphatic hydrocarbons Hyperbranched polymer Pervaporation Hollow fiber membrane Dip-coating

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Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme

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Nano Research 2024年第3期17卷 1827-1836页

作者： Daji wang jie wang Dan liu Jiuyang He Meiying wang Haibing Huang Guohui Nie Hui Ding Xiyun Yan Nanozyme Synthesis Center Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China Shenzhen Key Laboratory of nanozymes and Translational Cancer Research Department of Otolaryngologyand Shenzhen Institute of Translational MedicineShenzhen Second People’s Hospital/the First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen 518035China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China department of Rheumatology and Immunology Shenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen 518055China

The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively *** continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its early *** this study,we successfully synthesized a single-atom nanozyme(SANzyme)through the application of iron-porphyrin based metal organic framework(MOF-FeP).The MOF-FeP possesses precisely-defined electronic and geometric structures that accurately mimic highly-evolved catalytic site of natural *** peroxidase-like activity of MOF-FeP enables it to catalyze the chemiluminescence of luminol *** integrating MOF-FeP into a traditional strip,we created a rapid and highly-sensitive evaluation tool for detecting ***,the MOF-FeP strip enables the simultaneous detection of three EBV-IgAs,greatly improving the accuracy of EBV-associated NPC *** sensitivities of the MOF-FeP strip(75.56%–93.30%)surpass those of current enzyme-linked immunosorbent assay(ELISA)methods(64.44%–82.22%).This test takes only 16 min to perform as opposed to the customary 1–2 h required for standard ***,the MOF-FeP strip is suitable for whole blood samples,thereby significantly simplifying the sample preparation and detection *** conclusion,the MOF-FeP strip combines the simplicity of traditional strip with the high catalytic activity of *** innovative MOF-FeP strip offers a new point-of-care strategy for EBV-IgAs detection,which is expected to markedly facilitate early screening for EBV-associated diseases.

关键词： iron-porphyrin single-atom nanozyme(SANzyme) chemiluminescence strips Epstein-Barr virus(EBV) nasopharyngeal carcinoma(NPC) antibody detection

Spatially distributed cytokinins:Metabolism,signaling,and transport

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Plant Communications 2024年第7期5卷 52-67页

作者： Jiangzhe Zhao Jingqi wang jie liu Penghong Zhang Guzel Kudoyarova Chang-Jun liu Kewei Zhang Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants College of Life SciencesZhejiang Normal UniversityJinhuaZhejiang 321004P.R.China Ufa institute of Biology Ufa Federal Research CenterRASProspekt Oktyabrya 69Ufa 450054Russia Biology department Brookhaven National LaboratoryUptonNY 11973USA

Cytokinins are mobile phytohormones that regulate plant growth,development,and environmental *** major cytokinin species include isopentenyl adenine(iP),trans-zeatin(tZ),cis-zeatin(cZ),and dihydrozeatin(DZ).The spatial distributions of different cytokinin species in different organelles,cells,tissues,and organs are primarily shaped by biosynthesis via isopentenyltransferases(IPT),cytochrome P450 monooxygenase,and 50-ribonucleotide phosphohydrolase and by conjugation or catabolism via glycosyltransferase or cytokinin oxidase/*** bind to histidine receptor kinases in the endoplasmic reticulum or plasma membrane and relay signals to response regulators in the nucleus via shuttle proteins known as histidine phosphotransfer *** movements of cytokinins from sites of biosynthesis to sites of signal perception usually require long-distance,intercellular,and intracellular *** the past decade,ATP-binding cassette(ABC)transporters,purine permeases(PUP),AZA-GUANINE RESISTANT(AZG)transporters,equilibrative nucleoside transporters(ENT),and Sugars Will Eventually Be Exported transporters(SWEET)have been characterized as involved in cytokinin transport *** review begins by introducing the spatial distributions of various cytokinins and the subcellular localizations of the proteins involved in their metabolism and *** focus on an inventory of the characterized transporters involved in cytokinin compartmentalization,including long-distance,intercellular,and intracellular transport,and the regulation of the spatial distributions of cytokinins by environmental *** directions for cytokinin research are also discussed.

关键词： cytokinin biosynthesis transporter signal transduction environmental changes

Current Immunotherapy Strategies for Rheumatoid Arthritis:The Immunoengineering and Delivery Systems

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Research 2024年第3期2023卷 169-189页

作者： Chenyu Zhang Peixiang Ma An Qin Liao wang Kerong Dai Yuanyuan liu jie Zhao Zuyan Lu School of Medicine Shanghai UniversityShanghaiChina Clinical and Translational Research Center for 3D Printing technology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System ShanghaiChina.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease accompanied by persistent multiarticular synovitis and cartilage degradation. The present clinical treatments are limited to disease-modifying anti-rheumatic drugs (DMARDs) and aims to relieve pain and control the inflammation of RA. Despite considerable advances in the research of RA, the employment of current clinical procedure is enormous, hindered by systemic side effect, frequent administration, tolerance from long-lasting administration, and high costs. Emerging immunoengineering-based strategies, such as multiple immune-active nanotechnologies via mechanism-based immunology approaches, have been developed to improve specific targeting and to reduce adverse reactions for RA treatments. Here, we review recent studies in immunoengineering for the treatment of RA. The prospect of future immunoengineering treatment for RA has also been discussed.

关键词： drugs Rheumatoid treatment

Unlocking iron-based mixed-phosphate cathode for sodium-ion batteries through off-stoichiometry

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Nano Research 2024年第9期17卷 8119-8125页

作者： Zhaolu liu Yongjie Cao Ning wang Hui Yang Hao Zhang Xinyue Xu Nan wang jie Xu Yao liu Junxi Zhang Yongyao Xia Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power Shanghai University of Electric PowerShanghai 200090China department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200433China School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243002China Key Laboratory of Interfacial Physics and technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China

The off-stoichiometric iron-based phosphate(Na_(3.12)Fe_(2.44)(P_(2)O_(7))_(2),denoted as Na3.12)as a low cost and high structure stability cathode material has been widely studied for sodium-ion batteries(SIBs).However,the lower theoretical specific capacity(117 mAh·g^(-1))has seriously limited its practical *** this work,we incorporate varying proportion of sodium-iron phosphate(NaFePO_(4))into the Na3.12 to form a series of new high specific capacity mixed-phosphates Na_(3.12+x)Fe_(2.44+x)(P_(2)O_(7))_(2)(PO_(4))x cathode materials for *** optimizing the introduction amount of NaFePO_(4)into Na_(3.12),the practical reversible of Na_(3.12+x)Fe_(2.44+x)(P_(2)O_(7))_(2)(PO_(4))_(x) increased from 92 to 125.2 mAh·g^(-1).The nano-size Na5.12Fe4.44(P_(2)O_(7))_(2)(PO_(4))_(2) cathode material shows a reversible specific capacity of 125.2 mAh·g^(-1)at 0.1 C in *** at 60 C,it still exhibits a reversible specific capacity of 93.3 mAh·g^(-1)and keeps a capacity retention ratio of 87%after 3000 cycles at 20 ***,we present a novel approach to design a series of off-stoichiometric mixed-phosphates cathode materials for SIBs.

关键词： sodium-ion batteries cathode material iron-based mixed-phosphates off-stoichiometric

Review on Lithium-ion Battery PHM from the Perspective of Key PHM Steps

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 1-22页

作者： Jinzhen Kong jie liu Jingzhe Zhu Xi Zhang Kwok-Leung Tsui Zhike Peng Dong wang School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Grado department of Industrial and Systems Engineering Virginia Polytechnic Institute and State UniversityBlacksburg 24061USA School of Mechanical Engineering Ningxia UniversityNingxia 750021China

Prognostics and health management(PHM)has gotten considerable attention in the background of Industry *** PHM contributes to the reliable and safe operation of electric ***,relevant reviews are still continuously updated over *** this paper,we browsed extensive literature related to battery PHM from 2018to 2023 and summarized advances in battery PHM field,including battery testing and public datasets,fault diagnosis and prediction methods,health status estimation and health management *** last topic includes state of health estimation methods,remaining useful life prediction methods and predictive maintenance *** of these categories is introduced and discussed in *** on this survey,we accordingly discuss challenges left to battery PHM,and provide future research *** research systematically reviews recent research about battery PHM from the perspective of key PHM steps and provide some valuable prospects for researchers and practitioners.

关键词： Lithium-ion batteries Prognostics and health management Remaining useful life State of health Predictive maintenance

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