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Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms

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Chinese Chemical Letters 2024年第3期35卷 66-75页

作者： Ya-Nan Tang Dingding Jiang Xuejun Wang yunqi liu Dacheng Wei State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Institute of Molecular Materials and Devices Fudan UniversityShanghai 200433China

The outbreak of COVID-19 has drawn great attention around the ***-CoV-2 is a highly infectious virus with occult transmission by many mutations and a long incubation *** particular,the emergence of asymptomatic infections has made the epidemic even more ***,early diagnosis and timely management of suspected cases are essential measures to control the spread of the *** simple,portable,and accurate diagnostic techniques for SARS-CoV-2 is the key to epidemic *** advantages of point-of-care testing technology make it play an increasingly important role in viral detection and *** review summarizes the point-of-care testing platforms developed by nucleic acid detection,immunological detection,and nanomaterial-based biosensors ***,this paper provides a prospect for designing future highly accurate,cheap,and convenient SARS-CoV-2 diagnostic technology.

关键词： COVID-19 Point-of-care testing platforms Nucleic acid detection Asymptomatic infection Biosensors

Clean air captures attention whereas pollution distracts:evidence from brain activities

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 5-15页

作者： Jianxun Yang yunqi liu Berry van den Berg Susie Wang Lele Chen Miaomiao liu Jun Bi State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science&TechnologyNanjing 210044China Nanjing Foreign Language School Nanjing 210008China Department of Experimental Psychology University of GroningenGrote Kruisstraat 2/19712 TSGroningenThe Netherlands Department of Social Psychology University of GroningenGrote Kruisstraat 2/19712 TSGroningenThe Netherlands School of Education Science Nantong UniversityNantong 226019China

Awareness of the adverse impact of air pollution on attention-related performance such as learning and driving is rapidly ***,there is still little known about the underlying neurocognitive *** an adapted dot-probe task paradigm and event-related potential(ERP)technique,we investigated how visual stimuli of air pollution influence the attentional allocation *** were required to make responses to the onset of a target presented at the left or right visual *** probable location of the target was forewarned by a cue(pollution or clean air images),appearing at either the target location(attention-holding trials)or the opposite location(attention-shifting trials).Behavioral measures showed that when cued by pollution images,subjects had higher response accuracy in attention-shifting *** analysis results revealed that after the cue onset,pollution images evoked lower N300 amplitudes,indicating less attentioncapturing effects of dirty *** the target onset,pollution cues were correlated with the higher P300 amplitudes in attention-holding trials but lower amplitudes in attention-shifting *** indicates that after visual exposure to air pollution,people need more neurocognitive resources to maintain attention but less effort to shift attention *** findings provide the first neuroscientific evidence for the distracting effect of air *** conclude with several practical implications and suggest the ERP technique as a promising tool to understand human responses to environmental stressors.

关键词： Air pollution Attention Disengagement Performance Event-related potential

Direct synthesis of unnatural amino acids and modifications of peptides via LADA strategy

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Chinese Chemical Letters 2024年第1期35卷 237-242页

作者： yunqi liu Junliang Zhou Zhankui Sun Shanghai Frontiers Science Center for Drug Target Identification and Drug Delivery School of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Pharm-X CenterSchool of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240China AI Pharma Center Zhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai 201203China Shanghai Artificial Intelligence Laboratory Shanghai 200232China

Unnatural amino acids(UAAs)have broad applications in pharmaceutical sciences and biological *** synthetic methods for UAAs mainly rely on asymmetric catalysis and often require several *** is a lack of direct and simple *** address this challenge,we designed the LADA(labeling-activation-desulfurization-addition)strategy:selective labeling and activation of cysteine residues,the photocatalytic desulfurization and the subsequent radical addition to *** composed of two steps,it is one-pot synthesis and has advantages such as high functional group tolerance,biocompatible reaction condition,and retained *** highly efficient strategy was successfully applied in the direct synthesis of unnatural amino acids and modifications of peptides with more than 50 examples.

关键词： Unnatural amino acids Peptide modifications Desulfurization Cysteine Radical addition

Electric-Induced Cycloelimination for Simulating Structural Plasticity in Organic Nociceptors

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CCS Chemistry 2024年第6期6卷 1466-1476页

作者： Zhiheng Zhu Kai liu Haojie Huang Yangshuang Bian Mingcong Qin Chengyu Wang Wei Wen Mingliang Zhu Wenkang Shi Yanwei liu Zhiyuan Zhao Huijuan Yan Hanlin Wang yunqi liu Yunlong Guo Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100190

Continuous lifelong acquisition,updating,and finetuning of knowledge and skills is of crucial significance for the survival of ***,current neuromorphic devices exhibit obvious catastrophic forgetting when restimulated by new *** remains a challenge for neuromorphic devices and artificial intelligence to achieve continuous ***,we propose an electric-induced cycloelimination strategy to realize an organic transistor nociceptor that can simulate synaptic and structural *** system benefits from the ring-opening characteristics of cross-linked poly(vinyl cinnamate)under a strong pulse voltage,during which new energy-level trap states are *** prepared organic transistor nociceptors exhibit both structural and synaptic *** simulate the characteristics of human nociceptors,including threshold,relaxation,sensitization,and maladaptation *** the first time,we have simulated and explored the structural plasticity behavior in organisms based on electronic *** remarkably,the transistor nociceptors realize the reinput of information without forgetting the initial informa *** strategy developed for the preparation of organic transistor nociceptors provides insights for addressing the catastrophic forgetting in the lifelong learning of intelligent neuromorphic devices.

关键词： electric-induced cycloelimination structural plasticity organic nociceptors organic transistors metaplasticity

TypeⅠcritical dynamical scalarization and descalarization in Einstein-Maxwell-scalar theory

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 40-58页

作者： Jia-Yan Jiang Qian Chen yunqi liu Yu Tian Wei Xiong Cheng-Yong Zhang Bin Wang Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

We investigated the critical dynamical scalarization and descalarization of black holes within the framework of the EinsteinMaxwell-scalar theory featuring higher-order coupling *** the critical scalarization and descalarization displayed first-order phase *** examining the nonlinear dynamics near the threshold,we always observed critical solutions that are linearly unstable static scalarized black *** critical dynamical scalarization and descalarization share certain similarities with the typeⅠcritical gravitational ***,their initial configurations,critical solutions,and final outcomes differ *** provide further insights into the dynamical results,we conducted a comparative analysis involving static solutions and perturbative analysis.

关键词： black hole(de)scalarization dynamical critical behavior attractor

Non-invasive estimation of pulmonary hypertension and clinical deterioration risk in pediatric congenital heart disease:Development and validation of predictive tools

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Chinese Medical Journal 2024年第11期137卷 1384-1386页

作者： Ting Wang Dansha Zhou Yuqin Chen Suhua Kuang Yue Xing Qijian Yi Zhengxia Pan Weibin Xu Jiao Rao yunqi liu Guoliang Lu Ziying Lin Xiang Li Yi Xie Yulong Wu Peng An Xiaoxiao Deng Jiayue He Jiayi Xie Chenxi Li Gang Geng Daiyin Tian Enmei liu Jingsi Huang Zhou Fu Jian Wang Department of Respiratory Chongqing Higher Institution Engineering Research Center of Children’s Medical Big Data Intelligent ApplicationNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China State Key Laboratory of Respiratory Diseases National Center for Respiratory MedicineGuangdong Key Laboratory of Vascular DiseasesNational Clinical Research Center for Respiratory DiseasesGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Cardiac Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Cardiovascular Medicine Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Thoracic and Cardiac Surgery Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Cardiac Center of Guangdong Women and Children Hospital Guangzhou GuangzhouGuangdong 511400China Department of Guangzhou Laboratory Guangzhou International Bio IslandGuangzhouGuangdong 510005China

To the Editor:Owing to the heterogeneity of congenital heart disease-associated pulmonary hypertension(CHDPH)disease and the development of the pulmonary vascular system in pediatric patients,the management of CHD-PH in children is signicantly different from that in adults.[1]Early identication and intervention of CHD-PH are of great signicance for disease management in children with CHD,and non-invasive,accurate clinical tools are urgently needed to predict PH risk in children with ***,the applicability of the current risk-scoring system to pediatric CHD-PH remains ***,there are presently no user-friendly,non-invasive online tools available for predicting CHD-PH,and there is a scarcity of related studies in Asian *** study aimed to develop and validate the prediction tools for estimating the risk of pulmonary hypertension and clinical deterioration in children with congenital heart disease.

关键词： pediatric congenital hypertension

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本征柔性有机电子器件的研究进展

科学通报 2024年第10期69卷 1279-1297页

作者：史文康赵志远郭云龙刘云圻中国科学院化学研究所有机固体重点实验室北京分子科学国家研究中心北京100190 中国科学院大学化学科学学院北京100049

本征柔性有机电子学是近年来涌现的一项变革性的前沿交叉学科,它赋予电子材料可印刷、可折叠和可拉伸等特性,使其应用于健康医疗、柔性显示、传感探测、人工智能和脑机接口等前沿领域.为了进一步拓展本征柔性有机电子器件的应用场景,设... 详细信息

本征柔性有机电子学是近年来涌现的一项变革性的前沿交叉学科,它赋予电子材料可印刷、可折叠和可拉伸等特性,使其应用于健康医疗、柔性显示、传感探测、人工智能和脑机接口等前沿领域.为了进一步拓展本征柔性有机电子器件的应用场景,设计开发高性能、高显示度、高稳定性的本征柔性材料和有机电子器件是当前的研究重点.本文主要介绍了近年来本征柔性有机电子学相关领域的前沿研究进展,重点讨论了本征柔性材料与有机电子器件的设计和制备策略、本征柔性材料图案化工艺和集成电路,分析了本征柔性有机电子学领域的技术瓶颈和前沿问题,总结和展望了本征柔性有机电子器件的应用前景与未来发展趋势.

关键词：柔性电子本征柔性材料本征柔性有机器件图案化工艺本征柔性有机电路

12 mm厚TC4钛合金激光-MIG复合焊接头组织与性能研究

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精密成形工程 2024年第5期16卷 21-29页

作者：刘鸿铭朱宗涛刘云祺刘瑞琳西南交通大学材料科学与工程学院成都610031

目的探究TC4激光-MIG复合焊接头显微组织与基本力学性能之间的联系,分析接头不同区域的断裂行为。方法利用激光-MIG复合焊制备TC4钛合金对接接头,采用光学显微镜和扫描电镜观察接头焊缝区、热影响区及母材的显微组织,在室温下进行了显... 详细信息

目的探究TC4激光-MIG复合焊接头显微组织与基本力学性能之间的联系,分析接头不同区域的断裂行为。方法利用激光-MIG复合焊制备TC4钛合金对接接头,采用光学显微镜和扫描电镜观察接头焊缝区、热影响区及母材的显微组织,在室温下进行了显微硬度测试、拉伸性能测试与断裂韧性测试,并对试样断口进行了观察分析。结果接头的焊缝区组织为粗大的β相柱状晶,晶内纵横分布着αʹ针状马氏体和针状α相,靠近焊缝一侧的热影响区则由针状αʹ相、α集束与少量细小的块状α相构成。随着远离焊缝中心,母材侧热影响区组织转变为块状的α相、少量α集束及初生β相,并最终趋于与母材组织相似。热影响区的显微硬度值达到最大,这是因为该区域存在比焊缝区更为细小的针状αʹ相。接头的平均抗拉强度和断后伸长率分别为1020.22 MPa和7.38%。接头在拉伸时主要在焊缝区发生断裂。焊缝区展现出比母材区和热影响区更优异的断裂韧性,平均值为87.14 MPa·m1/2,焊缝区内纵横交错的网篮组织与集束是其断裂韧性较高的主要原因。结论在TC4钛合金的激光-MIG复合焊过程中,针状α相和αʹ马氏体的存在会提高焊缝的显微硬度和断裂韧性,但相较于母材塑性没有提升,通过调控焊缝区显微组织结构,可以获得所需性能的接头。

关键词：钛合金激光-MIG复合焊接微观组织断裂韧性断口

焊接位置对激光-电弧复合焊接底部驼峰的影响

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精密成形工程 2024年第5期16卷 174-181页

作者：张君豪朱宗涛刘瑞琳刘云祺西南交通大学材料科学与工程学院成都610031

目的通过改变焊接位置来抑制底部驼峰的形成进而降低生产成本。方法使用高速摄像机观察平向焊接和横向焊接2种不同焊接位置下熔池的匙孔和底部驼峰的形成过程,并对底部凸起受到的金属蒸气反冲压力、熔融金属重力以及表面张力进行受力分... 详细信息

目的通过改变焊接位置来抑制底部驼峰的形成进而降低生产成本。方法使用高速摄像机观察平向焊接和横向焊接2种不同焊接位置下熔池的匙孔和底部驼峰的形成过程,并对底部凸起受到的金属蒸气反冲压力、熔融金属重力以及表面张力进行受力分析。结果在S355J2W耐候钢的激光-电弧复合焊接平焊过程中,受金属蒸气反冲作用力的影响,熔融金属迅速从匙孔底部排出,流入匙孔底部凸起区域,底部凸起的增长速度极快,仅需7.5 ms即可形成大尺寸的驼峰。而在横向焊接中,匙孔前壁凸起数量减少,导致金属蒸气反冲压力减小,匙孔排出的熔融金属量减少,底部凸起的增速减缓,在13.6 ms时才达到最大高度,使驼峰在底部熔池凝固之前难以形成。结论采用横向焊接的方式可以有效避免驼峰的产生,降低生产成本。同时,该方式在焊缝背部成形效果方面也表现良好,为优化焊接工艺提供了重要参考。

关键词：激光-电弧复合焊接高速摄像焊接位置底部驼峰受力平衡