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“Omics” in pharmaceutical research: overview, applications, challenges, and future perspectives

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Chinese Journal of Natural Medicines 2015年第1期13卷 3-21页

作者： YAN Shi-Kai liu run-Hui JIN Hui-Zi liu xin-ru YE Ji SHAN Lei ZHANG Wei-Dong School of Pharmacy Shanghai Jiao Tong University School of Pharmacy Second Military Medical University Shanghai Institute of Pharmaceutical Industry

In the post-genomic era, biological studies are characterized by the rapid development and wide application of a series of "omics" technologies, including genomics, proteomics, metabolomics, transcriptomics, lipidomics, cytomics, metallomics, ionomics, interactomics, and phenomics. These "omics" are often based on global analyses of biological samples using high through-put analytical approaches and bioinformatics and may provide new insights into biological phenomena. In this paper, the development and advances in these omics made in the past decades are reviewed, especially genomics, transcriptomics, proteomics and metabolomics; the applications of omics technologies in pharmaceutical research are then summarized in the fields of drug target discovery, toxicity evaluation, personalized medicine, and traditional Chinese medicine; and finally, the limitations of omics are discussed, along with the future challenges associated with the multi-omics data processing, dynamics omics analysis, and analytical approaches, as well as amenable solutions and future prospects.

关键词： Omics Genomics Transcriptomics Proteomics Metabolomics Target Discovery Toxicity Assessment PersonalizedMedicine Traditional Chinese Medicine

Qualitative and Quantitative Analysis of Alkaloids in Cortex Phellodendri by HPLC-ESI-MS/MS and HPLC-DAD

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Chemical Research in Chinese Universities 2011年第1期27卷 38-44页

作者： ZHU Shuang-lai DOU Sheng-shan liu xin-ru liu run-hui ZHANG Wei-dong HUANG Hong-lin ZHANG Yi HU Yao-hua WANG Shu-ping School of Pharmacy Second Military Medical University Shanghai 200433 P. R. China School of Pharmacy Jiangxi University of Traditional Chinese Medicine Nanchang 330004 P. R. China School of Pharmacy Shanghai Jiaotong University Shanghai 200240 P. R. China School of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou 350108 P. R. China School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 610075 P. R. China

A combined method of high performance liquid chromatograph-elecrtrospray-ionization mass spectrometer（HPLC-ESI-MS/MS） coupled with a photodiode array detector（HPLC-DAD） and principal component analysis（PCA） was applied to the qualitative and quantitative analyses of alkaloids in Cortex Phellodendri（CP） samples, and to the differentiation of two species of CP, Cortex Phellodendri Chinensis（CPC） and Cortex Phellodendri Amurensis（CPA）. Twenty-two peaks appeared in the HPLC-MS base peak chromatogram of CP detected by the HPLC-ESI-MS/MS analysis, and the alkaloids were identified according to the MSn data, the known MS fragmentation rules and the literature data. Five alkaloids including berberine, palmatine, jatrorrhizine, phellodendrine and magnoflorine were simultaneously determinated by the HPLC-DAD. Berberine was the primary component in all CP samples, and the contents of berberine and palmatine were exploited to be two critical parameters for effective discrimination between the two species of CP. The average content of berberine in CPC（58.75 mg/g） was higher than that in CPA（9.16 mg/g）, while the content of palmatine was less, only 0.25 mg/g in CPC and 4.19 mg/g in CPA. With the use of PCA, samples datasets were separated successfully into two different clusters corresponding to the two species, and berberine, pahnatine, phellodendrine and magnoflorine contribute most to the above mentioned calssifying . The proposed method oroved to be a useful tool in the aualitv control of Chinese herbal medicines.

关键词： Cortex Phellodendri Alkaloid HPLC-ESI-MS/MS Quantitative analysis Qualitative analysis Principal component analysis

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忆阻器单阻态下的记忆电容行为及多态特性

物理学报 2019年第6期68卷 238-244页

作者：刘汝新董瑞新闫循领肖夏聊城大学物理科学与信息工程学院山东省光通信科学与技术重点实验室聊城252059

采用供体-受体类型的共聚物构建了Al/共聚物/ITO结构的有机记忆器件,并对其电流-电压(I-V)和电容-电压(C-V)特性进行了研究.结果表明:器件不仅表现出明显的记忆电阻特征,而且在单个电阻状态下还存在记忆电容行为,使器件呈现出两种电阻... 详细信息

采用供体-受体类型的共聚物构建了Al/共聚物/ITO结构的有机记忆器件,并对其电流-电压(I-V)和电容-电压(C-V)特性进行了研究.结果表明:器件不仅表现出明显的记忆电阻特征,而且在单个电阻状态下还存在记忆电容行为,使器件呈现出两种电阻状态和与之对应的四种电容状态,具有电阻和电容的双参量记忆能力.在此基础上对器件的电容开关行为进行了电压幅值的调制,使器件出现了更多的电容状态,为多级存储的实现提供了一条有效途径.最后通过引入分子内部极化算符,建立了记忆电阻和记忆电容的关联性,给出了描述器件双参量多状态特征的矩阵模型.

关键词：记忆电阻记忆电容多态特征

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成长琐事

快乐青春（经典阅读）（中学生必读） 2011年第1期 13-14页

作者： liu xin ru

莫顿·亨特在父亲的引导下，走一步再走一步，懂得了面对困难应化整为零，最终成长为一个勇毅睿智的男子汉。在我们成长的道路上．也总有一些人一些事。让我们变得更加坚强，更加勇敢．更加懂得感恩，更加懂得珍惜生命中所有美好的过往... 详细信息

莫顿·亨特在父亲的引导下，走一步再走一步，懂得了面对困难应化整为零，最终成长为一个勇毅睿智的男子汉。在我们成长的道路上．也总有一些人一些事。让我们变得更加坚强，更加勇敢．更加懂得感恩，更加懂得珍惜生命中所有美好的过往……这些都可以成为我们成长的桥梁，成为我们心灵和岁月的典藏。

关键词：成长化整为零男子汉

Annual Frequency of Tropical Cyclones Directly Affecting Guangdong Province:Prediction Based on LSTM-FC

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Journal of Tropical Meteorology 2022年第1期28卷 45-56页

作者： HU Ya-min CHEN Yun-zhu HE Jian liu Sheng-jun YAN Wen-jie ZHAO Liang WANG Ming-sheng LI Zhi-hui WANG Juan-huai DONG Shao-rou liu xin-ru Guangdong Climate Center Guangzhou 510641 China School of Mathematics and Statistics Central South UniversityChangsha 410083 China State Key Laboratory of Numerical Modeling for Atmosphere Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 China

Tropical cyclone(TC)annual frequency forecasting is significant for disaster prevention and mitigation in Guangdong *** on the NCEP-NCAR reanalysis and NOAA Extended Reconstructed global sea surface temperature(SST)V5 data in winter,the TC frequency climatic features and prediction models have been *** 1951-2019,353 TCs directly affected Guangdong with an annual average of about *** have experienced an abrupt change from abundance to deficiency in the mid to late 1980 with a slightly decreasing trend and a normal distribution.338 primary precursors are obtained from statistically significant correlation regions of SST,sea level pressure,1000hPa air temperature,850hPa specific humidity,500hPa geopotential height and zonal wind shear in *** those 338 primary factors are reduced into 19 independent predictors by principal component analysis(PCA).Furthermore,the Multiple Linear Regression(MLR),the Gaussian Process Regression(GPR)and the Long Short-term Memory Networks and Fully Connected Layers(LSTM-FC)models are constructed relying on the above 19 *** three different kinds of test sets from 2010 to 2019,2011 to 2019 and 2010 to 2019,the root mean square errors(RMSEs)of MLR,GPR and LSTM-FC between prediction and observations fluctuate within the range of 1.05-2.45,1.00-1.93 and 0.71-0.95 as well as the average absolute errors(AAEs)0.88-1.0,0.75-1.36 and 0.50-0.70,*** for the 2010-2019 experiment,the mean deviations of the three model outputs from the observation are 0.89,0.78 and 0.56,together with the average evaluation scores 82.22,84.44 and 88.89,*** prediction skill comparisons unveil that LSTM-FC model has a better performance than MLR and *** conclusion,the deep learning model of LSTM-FC may shed light on improving the accuracy of short-term climate prediction about TC *** current research can provide experience on the development of deep learning in this field and help to achieve furthe

关键词： tropical cyclone frequency long short-term memory network fully connected layers Gaussian process regression multiple linear regression

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三维模型匹配的谱图小波描述符

浙江大学学报（工学版） 2019年第4期53卷 761-769页

作者：胡玲李钦松刘圣军刘新儒中南大学数学与统计学院湖南长沙410000 湖南第一师范学院数学与计算科学学院湖南长沙410000

为了实现三维模型的点-点匹配,基于谱图小波变换(SGWT)构建点的描述符.对三维模型各顶点处的脉冲函数进行多尺度谱图小波变换,因为这些小波系数能够充分反映模型各顶点处的多尺度几何信息,将它们依次作为元素形成多维向量.该向量即为模... 详细信息

为了实现三维模型的点-点匹配,基于谱图小波变换(SGWT)构建点的描述符.对三维模型各顶点处的脉冲函数进行多尺度谱图小波变换,因为这些小波系数能够充分反映模型各顶点处的多尺度几何信息,将它们依次作为元素形成多维向量.该向量即为模型各点的谱图小波描述符,点描述符的欧式距离可以度量点与点之间的几何差异性.由于谱图小波(SGW)同时使用低通和带通滤波器分析信号且能够稳定地重构信号,这使得提出的描述符具有很好的形状分辨能力、紧凑性和鲁棒性.实验结果显示,谱图小波描述符具有比同类方法更卓越的性能.

关键词：拉普拉斯-贝尔特米算子模型匹配谱图小波(SGW) 点描述符滤波器

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随机增长网络模型的稳定性分析

河北工业大学学报 2010年第5期39卷 17-19,40页

作者：谭利刘新儒中南大学数学科学与计算技术学院湖南长沙410075

研究了一类同时具有择优和随机选择的混合性网络模型的度序列.利用Stolz定理给出了求解网络模型度序列的严格而简易的方法.发现模型的度序列服从幂律分布,度指数可以在3到之间变化.此外,还将模型推广到每步增加边数为随机变量的情况,得... 详细信息

研究了一类同时具有择优和随机选择的混合性网络模型的度序列.利用Stolz定理给出了求解网络模型度序列的严格而简易的方法.发现模型的度序列服从幂律分布,度指数可以在3到之间变化.此外,还将模型推广到每步增加边数为随机变量的情况,得到类似的结论.

关键词：随机图度序列幂律

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论《觉醒年代》中的动物意象

南阳理工学院学报 2024年第5期16卷 48-53页

作者：刘欣如西南大学文学院重庆400715

《觉醒年代》的成功破圈为中国电视剧“精品化”战略实践提供了有益的经验。该剧以一种有温度的方式,讲述了从新文化运动到中国共产党成立之间的历史故事,颇具革命浪漫主义色彩。本文借用洛特曼的影像语言观,对《觉醒年代》中反复出现... 详细信息

《觉醒年代》的成功破圈为中国电视剧“精品化”战略实践提供了有益的经验。该剧以一种有温度的方式,讲述了从新文化运动到中国共产党成立之间的历史故事,颇具革命浪漫主义色彩。本文借用洛特曼的影像语言观,对《觉醒年代》中反复出现的动物意象进行阐释,认为“骆驼”呈现了人与社会的双重压抑,“白鸽”传递出革命者的悲悯情怀,“蚂蚁”成为先驱生死之义的见证,“鸡”的出现是对封建糟粕的批判,“猴”完成了对民族病灶的反思。这种创作方式突破了传统叙事语态的限制,丰富了主旋律影视剧的艺术表达。

关键词：觉醒年代动物意象表意系统艺术表达

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低磷血症的临床诊断与治疗

中国实用内科杂志 2024年第5期44卷 380-384页

作者：韩文霞刘心如山东第一医科大学附属省立医院内分泌代谢病科山东济南250021 山东中医药大学第一临床医学院山东济南250014

低磷血症是临床上常见的电解质紊乱之一,常伴有钙的代谢紊乱。临床上引起低磷血症的原因很多,且临床症状表现不一,缺乏特异性,容易被误诊。文章主要综述了低磷血症的原因、临床表现、实验室检查、诊断以及低磷血症的治疗,为临床医师提... 详细信息

低磷血症是临床上常见的电解质紊乱之一,常伴有钙的代谢紊乱。临床上引起低磷血症的原因很多,且临床症状表现不一,缺乏特异性,容易被误诊。文章主要综述了低磷血症的原因、临床表现、实验室检查、诊断以及低磷血症的治疗,为临床医师提供诊疗思路。

关键词：低磷血症成纤维生长因子23 诊断治疗