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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui Chen LI Yan ZHANG Jun feng liu Sheng hui hu Dan He XU Chong Xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong nie Kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao feng WANG huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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基于增强型多尺度残差生成对抗网络的图像压缩

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计算机工程与设计 2024年第8期45卷 2415-2422页

作者：马婷刘友鑫胡峰聂伟吴建芳西南石油大学电气信息学院四川成都610500 江苏势通生物科技有限公司研发中心江苏南通226000 重庆邮电大学通信与信息工程学院重庆400065

为解决低码率下更符合人类视觉感知的图像压缩,提出一种基于增强型多尺度残差生成对抗网络的有损压缩方法。在网络框架的自动编码器中,使用一种结构上改进的增强型多尺度残差块,其可以扩大感受野,更容易获得图像的全局信息。引入简易注... 详细信息

为解决低码率下更符合人类视觉感知的图像压缩,提出一种基于增强型多尺度残差生成对抗网络的有损压缩方法。在网络框架的自动编码器中,使用一种结构上改进的增强型多尺度残差块,其可以扩大感受野,更容易获得图像的全局信息。引入简易注意力模块,帮助网络更加关注图像复杂的部分,减少简单部分的比特。判别器部分采用全新的相对平均判别器,在网络框架中使用LPIPS(learned perceptual image patch similarity)感知损失减轻图像伪影问题。采用两阶段训练的方式解决引入生成对抗网络导致训练不稳定的问题。实验结果表明了在低码率下所提模型的有效性,与之前的工作相比,所提方法在感知失真指标上表现更优,性能提升了65%左右,重建图像更符合人类视觉感知。

关键词：低码率图像压缩生成对抗网络多尺度残差块注意力模块相对平均判别器感知损失

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播量和行距对箭筈豌豆农艺结实性状及产量的影响

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中国土壤与肥料 2024年第6期 215-221页

作者：郑春风刘春增张济世吕玉虎史鹏飞聂良鹏曹卫东河南省农业科学院植物营养与资源环境研究所河南郑州450002 信阳市农业科学院河南信阳464000 中国农业科学院农业资源与农业区划研究所北京100081

为了探讨豫南本地箭筈豌豆条播种植适宜播量和行距,采用双因素试验设计,分别设3个播量水平和4个行距水平,研究不同播量和行距配置对箭筈豌豆生长发育、鲜草、秸秆及种子产量结实的影响,为完善箭筈豌豆实际生产中的高产栽培技术提供科学... 详细信息

为了探讨豫南本地箭筈豌豆条播种植适宜播量和行距,采用双因素试验设计,分别设3个播量水平和4个行距水平,研究不同播量和行距配置对箭筈豌豆生长发育、鲜草、秸秆及种子产量结实的影响,为完善箭筈豌豆实际生产中的高产栽培技术提供科学理论指导。结果显示,播量一定时,株高、单株鲜干重随行距的增加呈现先增加后减少趋势,且在行距30、40 cm时获得最大值;茎粗和分枝数随行距的增加呈逐渐减少趋势,均在行距20 cm时获得最大值。行距一定时,株高、SPAD值随播量的增加呈逐渐增加趋势;茎粗、分枝数随播量的增加呈逐渐减少趋势。筛选出结实性播量行距最佳配置为:播量18.75 kg/hm^(2)、行距30 cm,播量26.25 kg/hm^(2)、行距30 cm和播量33.75 kg/hm^(2)、行距40 cm。不同播量和行距处理下箭筈豌豆种子、鲜草和秸秆产量差异显著(P<0.05)。种子产量以播量26.25 kg/hm^(2)、行距30 cm最高,达3753 kg/hm^(2);播量33.75 kg/hm^(2)、行距40 cm和播量33.75 kg/hm^(2)、行距30 cm次之,产量分别达3468和3436 kg/hm^(2)。鲜草和秸秆产量均以播量33.75 kg/hm^(2)、行距20 cm最高,达35910和16878 kg/hm^(2);播量33.75 kg/hm^(2)、行距30 cm和播量33.75 kg/hm^(2)、行距40 cm次之,产量分别达26761和13052、23662和12127 kg/hm^(2)。综上,以收获鲜草和秸秆产量为目的,优选播量33.75 kg/hm^(2)和行距20 cm组合配置;收获种子产量优选播量26.25 kg/hm^(2)和行距30 cm组合配置。

关键词：箭筈豌豆播量行距农艺性状结实性状产量

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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao Yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-Ming He Jin-Wei hu Han-Xiong huang Tu-Chen huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-Yun Li Ren-Ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan liu Shu-Kui liu Yan-Dong liu Yu liu Yuan-Yuan liu Zhong-Zhi liu Hao Ma Yu-Cai Mao Qi-Yuan nie Jin-hua Ning hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-Yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-feng Yue Ming Zeng Zhi Zeng feng-Shou Zhang Lei Zhang Zhen-hua Zhang Zhen-Yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Apolipoprotein E Gene Polymorphisms Are Risk Factors for Spontaneous Intracerebral Hemorrhage:A Systematic Review and Meta-analysis

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Current Medical Science 2019年第1期39卷 111-117页

作者： Hao nie Yang hu Na liu Ping ZHANG Gai-gai LI Yan-yan LI Chao PAN Hai-han YU Qian WU Guo-feng WU Zhou-ping TANG Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Affiliated Hospital of Guizhou Medical University Guiyang 550004China

Intracerebral hemorrhage(ICH)is a serious clinical disease with high morbidity,whose pathogenesis might be related to apolipoprotein E(APOE)gene *** comprehensively evaluate the risk factors for ICH occurrence,we performed a *** searched online databases to identify eligible studies based on the relationship between APOE genetic polymorphisms and ICH occurrence *** and pooled odds ratios(ORs)were calculated and by assessing small study bias,we drew the relationship between APOE polymorphisms and ICH *** included 15 eligible studies in our study containing a total of 1642 ICH samples and 5545 normal *** comparison of e4 andε3 APOE genotypes revealed that specific and pooled ORs showed a significantly increased odds ratio in ICH patients with theε4 genotype,indicating thatε4 gene is a risk factor for ICH occurrence,and the heterogeneity is ***,it was found that theε2 genotype also contributed to the incidence rate of ***,after the subgroup analysis by ethnicity,this APOE genetic polymorphism acted as a harmful factor only in white populations,but did not show an effect in Asian *** was suggested that both 82 andε4 APOE alleles were risk factors for ICH in *** were risk factors in white populations only,neither had a detectable effect in Asian populations after subgroup analysing by ethnicity.

关键词： intracerebral hemorrhage apolipoprotein E allele genetic polymorphism metaanalysis

长沙市某县退出小反刍兽疫强制免疫暴发的定性风险评估

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畜牧兽医杂志 2024年第1期43卷 94-100页

作者：奉佳周元中欧建伟胡长青张韬杨辉刘增再颜克旭聂迅峄王辉刘华长沙市动植物疫病预防控制中心湖南长沙410000 宁乡市动植物疫病预防控制中心长沙市农业农村局安徽省动物疫病预防与控制中心

小反刍兽疫(PPR)是一种由小反刍兽疫病毒引起的疾病,主要感染山羊和绵羊。2021年为加快推进小反刍兽疫无疫区建设,实现小反刍兽疫非免疫无疫区建设标准,长沙市某县拟在本地开展小反刍兽疫退出强制免疫风险评估。通过对小反刍兽疫监测流... 详细信息

小反刍兽疫(PPR)是一种由小反刍兽疫病毒引起的疾病,主要感染山羊和绵羊。2021年为加快推进小反刍兽疫无疫区建设,实现小反刍兽疫非免疫无疫区建设标准,长沙市某县拟在本地开展小反刍兽疫退出强制免疫风险评估。通过对小反刍兽疫监测流调、危害识别、风险路径的确定和风险因素层级评估等方法进行的定性风险评估初步显示,在该地取消小反刍兽疫强制免疫后可能会发生小反刍兽疫的风险等级为中。在风险管理措施上,提出该地退出强制免疫应推迟一年,重点完善政策支持、加强监测排查、加强检疫监管、强化培训宣传等建议。

关键词：小反刍兽疫强制免疫暴发风险评估

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Improvement of high-temperature strength of 6061 Al matrix composite reinforced by dual-phased nano-AlN and submicron-Al_(2)O_(3)particles

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Transactions of Nonferrous Metals Society of China 2022年第10期32卷 3197-3211页

作者： Ke-wei XIE Jin-feng nie Kai-qi hu Xia MA Xiang-fa liu Key Laboratory for Liquid-Solid Structural Evolution&Processing of Materials Ministry of EducationShandong UniversityJinan 250061China Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Mechanical Engineering Shandong University of TechnologyZibo 255000China

Nano-AlN and submicron-Al_(2)O_(3) particles were simultaneously utilized in a 6061 Al matrix composite to improve the high-temperature *** to the SEM and TEM characterization,nano-AlN and submicron-Al_(2)O_(3) particles are uniformly distributed in the Al *** hardness results indicate that different from the traditional 6061 Al matrix alloy,the aging kinetics of the composite is obviously accelerated by the reinforcement *** T6-treated composite exhibits excellent tensile properties at both room temperature and elevated *** at 350℃,the T6-treated composite not only has a high yield strength of 121 MPa and ultimate tensile strength of 128 MPa,but also exhibits a large elongation of 11.6%.Different strengthening mechanisms of nano-AlN and submicron-Al_(2)O_(3) particles were also discussed in detail.

关键词： 6061 Al matrix composite nano-AlN particles submicron-Al_(2)O_(3)particles high-temperature strength

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Discovery of carbon-based strongest and hardest amorphous material

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National Science Review 2022年第1期9卷 25-35页

作者： Shuangshuang Zhang Zihe Li Kun Luo Julong He Yufei Gao Alexander V.Soldatov Vicente Benavides Kaiyuan Shi Anmin nie Bin Zhang Wentao hu Mengdong Ma Yong liu Bin Wen Guoying Gao Bing liu Yang Zhang Yu Shu Dongli Yu Xiang-feng Zhou Zhisheng Zhao Bo Xu Lei Su Guoqiang Yang Olga P.Chernogorova Yongjun Tian Center for High Pressure Science (CHiPS) State Key Laboratory of Metastable Materials Science and Technology Yanshan University Key Laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University Department of Engineering Sciences and Mathematics Lule a University of Technology Department of Physics Harvard University Center for High Pressure Science and Technology Advanced Research Department of Materials Science Saarland University Key Laboratory of Photochemistry Institute of Chemistry University of Chinese Academy of Sciences Baikov Institute of Metallurgy and Materials Science Russian Academy of Sciences

Carbon is one of the most fascinating elements due to its structurally diverse allo tropic forms stemming from its bonding varieties(sp,sp~2 and sp~3).Exploring new forms of carbon has been the eternal theme of scientific ***,we report on amorphous(AM) carbon materials with a high fraction of sp~3 bonding recovered from compression of fullerene C60 under high pressure and high temperature,previously *** of photoluminescence and absorption spectra demonstrates that they are semiconducting with a bandgap range of 1.5-2.2 eV,comparable to that of widely used AM *** mechanical tests demonstrate that synthesized AM-Ⅲ carbon is the hardest and strongest AM material known to date,and can scratch diamond crystal and approach its *** produced AM carbon materials combine outstanding mechanical and electronic properties,and may potentially be used in photovoltaic applications that require ultrahigh strength and wear resistance.

关键词： amorphous carbon ultrahard ultrastrong semiconductor phase transition