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Littlewood–Paley Operators on Spaces with Variable Exponent on Homogeneous Groups

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Acta Mathematica Sinica,English Series 2020年第5期36卷 535-558页

作者： Dong Li liu Ji man ZHAO Key Laboratory of Mathematics and Complex Systems Ministry of Education Institution of Mathematics and Mathematical Education School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

In this paper,on homogeneous groups,we study the Littlewood–Paley operators in variable exponent ***,we prove that the weighted Littlewood–Paley operators are controlled by the weighted Hardy–Littlewood maximal function,and obtain the vector-valued inequalities of the Littlewood–Paley operators,including the Lusin function,Littlewood–Paley g function and gλ* ***,we prove the boundedness of multilinear Littlewood–Paley gψ,λ* function.

关键词： Littlewood–Paley operators variable Lebesgue spaces homogeneous groups

High mass-loading and binder-free flexible vanadium-based oxide cathode for zinc-ion battery via a bridge of MXene

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Journal of Materials Science & Technology 2023年第12期143卷 84-92页

作者： Kan Fang Fei Li Gui-Gen Wang Yi-Lin liu man-Lin Tan Da-qiang Zhao Hua-Yu Zhang Jie-Cai Han Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen 518055China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150080China Research Institute of Tsinghua University in Shenzhen Shenzhen 518055China

Flexible zinc-ion batteries(ZIBs)are promising power sources for portable devices due to their high safety and low production ***,the low mass-loading and limited areal capacity of cathode materials are the major problems blocking the practicability of ***,a high mass-loading and binder-free flexible vanadium oxide(MCV@CC)cathode with a large areal capacity was fabricated via the bridge effect of *** functional MXene bridge induces the growth of the vanadium oxide active layer on the carbon cloth(CC)flexible *** binder-free cathode can reduce the electrochemically inactive weight of the whole electrode,which enhances the energy density of ***,the MCV@CC cathode(mass-loading of∼7 mg cm^(−2))delivers a desirable areal capacity(2.36 mAh cm^(−2))and good cycling stability(capacity retention of 86.1%after 1200 cycles at 10 mA cm^(−2)).Moreover,several ex-situ characterization results indicate that the reaction mechanism upon battery cycling is based on the reversible Zn^(2+)/H^(+)(de)intercalation in the vanadium oxide ***,the assembled quasi-solid-state MCV@CC//Zn flexible battery exhibits decent performance at different bending *** a bridge effect strategy sheds light on the construction of high mass-loading flexible electrodes for ZIBs applications.

关键词： Zinc-ion batteries Vanadium oxide MXene bridge High mass-loading Flexible electrode

Exploring the molecular mechanism of Suoquan pill in the treatment of diabetic kidney disease based on network pharmacology,molecular docking,in vitro experiment

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Traditional Medicine Research 2024年第11期9卷 27-37页

作者： Zi-Jie Yan Yu Kang Shu-man liu Fang-Yu Wang man Xiao Yi-qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Graduate School Heilongjiang Academy of Traditional Chinese MedicineHarbin 150001China Department of Pharmacology College of PharmacyHainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:Diabetic kidney disease(DKD)is a microvascular complication of diabetes mellitus and is the main cause of end-stage renal *** pills(SQP)has a variety of pharmacological activities and multiple therapeutic effects,and it is used clinically as a basic formula for the treatment of ***:Public databases were used to identify SQP compounds and the potential targets of SQP and DKD.A drug-component-therapeutic target network was ***-protein interaction network analysis,Gene Ontology functional analysis,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were used to analyse the potential molecular mechanisms of SQP based on common targets of drugs and *** docking simulations were conducted to confirm the binding abity of the core compounds to key *** efficacy and predicted molecular mechanisms of SQP were validated using cell counting kit-8 assay,flow cytometry,and western blotting with HK-2 cells as a ***:Network pharmacology analysis showed that 26 compounds and 207 potential targets of SQP were involved in the treatment of DKD;boldine,denudatin B,pinocembrin,kaempferoid,and quercetin were considered core compounds,and epidermal growth factor receptor(EGFR)and proto-oncogene,non-receptor tyrosine kinase(SRC)were considered key *** Ontology enrichment analysis indicated that protein phosphorylation and negative regulation of apoptotic processes are important biological processes in the treatment of DKD by *** docking confirmed the excellent binding abilities of boldine,denudatin B,kaempferide,and quercetin to EGFR and *** results of in vitro experiments showed that treatment with an ethanolic extract of SQP significantly protected HK-2 cells from high glucose-induced cell *** addition,the SQP ethanol extract inhibited the phosphorylation of EGFR and SRC,suppressed the apoptosis rate,and regulated apoptosis-related proteins in HK-2 cells under hig

关键词： traditional Chinese medicine diabetic kidney disease Suoquan pill network analysis molecular docking

Ectopic pregnancy implanted under the diaphragm: A rare case report

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World Journal of Clinical Cases 2021年第36期9卷 11437-11442页

作者： qiang-Le Wu Xiao-man Wang Dong Tang Department of Radiology The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina Department of Ultrasound The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

BACKGROUND Abdominal pregnancy is a rare type of ectopic *** describe here a case of ectopic pregnancy implanted under the surface of the diaphragm,presenting the particular features of imaging findings from ultrasound,computed tomography(CT)and magnetic resonance imaging(MRI).CASE SUMMARY A 30-year-old woman presented with complaint of intermittent abdominal pain,that had begun 5 d *** had no current or abnormal vaginal bleeding,and her serum human chorionic gonadotropin level(13372.08 IU/L)indicated *** ultrasound showed a mixed echogenic mass in the right ***(plain)scan showed a curved high density mass beneath the subhepatic *** scan showed a curved mixed signal,with restricted diffusion beneath the subhepatic *** ultrasound demonstrated a mixed echogenic mass in the right lobe of the liver near the apex of the diaphragm,with a visible yolk sac and germ cell region with a *** laparoscopy visualized a dark red mass under the right diaphragm,which was resected *** examination of the resected mass confirmed an ectopic *** recovery was swift and uneventful,and the patient was discharged to *** Ectopic pregnancy should be in the differential diagnostic workup(via multiple imaging modalities)of childbearing woman with unexplained abdominal pain.

关键词： Ectopic pregnancy Diaphragmatic Ultrasonography Computed tomography Magnetic resonance Case report

Cholesterol metabolism and homeostasis in the brain

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Protein & Cell 2015年第4期6卷 254-264页

作者： Juan Zhang qiang liu Chinese Academy of Sciences Key Laboratory of Brain Function and Disease and School of Life Sciences University ofScience and Technoloqv of China. Hefei 230026. China

Cholesterol is an essential component for neuronal physiology not only during development stage but also in the adult life. Cholesterol metabolism in brain is in- dependent from that in peripheral tissues due to blood- brain barrier. The content of cholesterol in brain must be accurately maintained in order to keep brain function well. Defects in brain cholesterol metabolism has been shown to be implicated in neurodegenerative diseases, such as Alzheimer＇s disease （AD）, Huntington＇s disease （HD）, Parkinson＇s disease （PD）, and some cognitive deficits typical of the old age. The brain contains large amount of cholesterol, but the cholesterol metabolism and its complex homeostasis regulation are currently poorly understood. This review will seek to integrate current knowledge about the brain cholesterol metabo- lism with molecular mechanisms.

关键词： cholesterol metabolism homeostasis,apoE

White Matter“Matters”in Alzheimer’s Disease

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Neuroscience Bulletin 2022年第3期38卷 323-326页

作者： man-Yu Xu Zhi-qiang Xu Yan-Jiang Wang Department of Neurology and Center for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China The Institute of Brain and Intelligence Third Military Medical UniversityChongqing400042China

Alzheimer's disease(AD)is a neurodegenerative disease that increasingly burdens many families *** AD is generally thought to be closely associated with gray matter,many studies have identified significant changes in white matter as well,including demyelination and function alterations in oligodendrocytes in the AD *** addition,Ap plaques,the most important pathological characteristic in AD,are deposited in late-myelinating regions such as the prefrontal and temporal lobes,where myelin is prone to damage[1].All the evidence hints that the changes in myelin are closely associated with the onset and progression of AD,prompting scientists to outline the process of changing myelin in AD and develop novel strategies for the treatment of AD.

关键词： Alzheimer alterations damage

Understanding the Global Cancer Statistics 2018:implications for cancer control

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Science China(Life Sciences) 2021年第6期64卷 1017-1020页

作者： Zijie Cai qiang liu Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Cancer incidence and mortality increase rapidly worldwide,making cancer the major cause of death in most *** the current cancer burden in different regions is necessary to find out potential risk factors and generate ... 详细信息

关键词： Cancer cancer mortality

Lipid metabolism in Alzheimer's disease

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Neuroscience Bulletin 2014年第2期30卷 331-345页

作者： qiang liu Juan Zhang CAS Key Laboratory of Brain Function and Disease and School of Life Sciences University of Science and Technology of China Department of Genetics Washington University School of Medicine

Lipids play crucial roles in cell signaling and various physiological processes, especially in the brain. Impaired lipid metabolism in the brain has been implicated in neurodegenerative diseases, such as Alzheimer＇s disease （AD）, and other central nervous system insults. The brain contains thousands of lipid species, but the complex lipid compositional diversity and the function of each of lipid species are currently poorly understood. This review integrates current knowledge about major lipid changes with the molecular mechanisms that underlie AD pathogenesis.

关键词： brain aging lipid metabolism Alzheimer's disease

Herbal Medicines Prevent the Development of Atopic Dermatitis by Multiple Mechanisms

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Chinese Journal of Integrative Medicine 2019年第2期25卷 151-160页

作者： man Mao-qiang HU Li-zhi Peter M.Elias Dermatology Service Veterans Affairs Medical Center Department of Dermatology University of California San Francisco School of Basic Medical Sciences Tianjin Medical University

Atopic dermatitis(AD) is among the most common skin disorders in humans. Although a variety of regimens are available for the treatment of AD, preventive approaches are limited. Recent studies have demonstrated that certain naturally-occurring herbal medicines are effective in preventing the development of AD via divergent mechanisms, such as inhibiting cytokine and chemokine expression, IgE production, inflammatory cell infiltration, histamine release, and/or enhancement of epidermal permeability barrier function. Yet, they exhibit few adverse effects. Since herbal medicines are widely available, inexpensive and generally safe, they could represent an ideal approach for preventing the development of AD, in both highly developed and developing countries.

关键词： herbal medicines T cells cytokines permeability barrier dermatitis