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Characteristics and main control factors of Ordovician shoal dolomite gas reservoir in Gucheng area,Tarim Basin,NW China

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Petroleum Exploration and Development 2022年第1期49卷 52-63页

作者： FENG Jun ZHANG Yajin ZHANG Zhenwei FU Xiaofei WANG Haixue WANG Yachun liu Yang ZHANG junlong LI Qiang FENG Zihui College of Earth Science Northeast Petroleum UniversityDaqing 163318China Ministry of Education Key Laboratory of Continental Shale Hydrocarbon Accumulation and Efficient Development Northeast Petroleum UniversityDaqing 163318China Exploration and Development Research Institute Daqing Oilfield Company Ltd.Daqing 163712China Heilongjiang Institute of Technology Ha’erbin 150050China

Based on seismic, drilling data and experimental analysis, the characteristics and main controlling factors of shoal dolomite gas reservoir in the third member of Ordovician Yingshan Formation of Gucheng area, Tarim basin were examined.The study shows that the dolomite gas reservoir in Gucheng area is lithologic gas reservoir controlled by shoal and fault jointly,and its formation is mainly attributed to the following factors:(1) The continuously developing paleotectonic structure has been in the direction of gas migration and accumulation;(2) The large area of medium-high energy grain bank deposited in gentle slope environment is the material basis for the formation of dolomite reservoir;(3) Atmospheric water leaching and dolomitization and fluid dissolution in fault zone are the key factors for the formation of high-quality dolomite reservoir;(4)The natural gas comes from cracking of the ancient oil reservoir and hydrocarbon generation of dispersed organic matter in source rocks, and the NNE-trending strike-slip fault is the dominant channel for vertical migration of natural gas;(5) Limestone cap rocks in the first and second members of Yingshan Formation provide direct sealing for the formation of gas reservoir there. On the basis of comprehensive analysis, it is pointed out that the Gucheng area has three grain shoal zones in the third member of Yingshan Formation in nearly S-N direction, which together with seven strike-slip fault zones in NNE direction control the development of shoal dolomite gas reservoir.

关键词： Tarim Basin Gucheng area Ordovician Yingshan Formation dolomite gas reservoir grain shoal facies strike-slip fault dissolution

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薄皮甜瓜新品种菊城622的选育

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中国瓜菜 2024年第6期37卷 167-170页

作者：吴占清郭岩范君龙刘冰魏春华胡建斌李琼王盼乔程志强开封市农林科学研究院河南开封475000 西北农林科技大学园艺学院陕西杨凌712100 河南农业大学园艺学院郑州450046

菊城622是以自育多代自交系纯合材料KT128为母本、KT150为父本杂交选育而成的薄皮甜瓜新品种。该品种在河南省春季塑料大棚栽培全生育期90 d,果实发育期28 d。植株长势强,直立性好,节间短,连续坐果能力强,每株可留瓜3~5个。果实棒状,果... 详细信息

菊城622是以自育多代自交系纯合材料KT128为母本、KT150为父本杂交选育而成的薄皮甜瓜新品种。该品种在河南省春季塑料大棚栽培全生育期90 d,果实发育期28 d。植株长势强,直立性好,节间短,连续坐果能力强,每株可留瓜3~5个。果实棒状,果皮灰白色,果肉绿色,口感酥脆爽口,清香味,果实整齐一致。平均单瓜质量0.5 kg,平均果肉厚度2.1 cm,中心可溶性固形物含量(w,后同)14.7%,边部12.3%,667 m^(2)产量约3200 kg。适合在黄淮生态区河南省及周边地区栽培。该品种于2022年6月通过农业农村部非主要农作物品种登记。

关键词：薄皮甜瓜新品种菊城622 杂交1代

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Oxygen-vacancy-containing cerium oxide nanoparticle-decorated nanonetwork-structured carbon toward high-performance lithium–sulfur batteries

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SusMat 2023年第1期3卷 137-144页

作者： Chuanfa Li Pengwei Ma Shenghao Lin Zongheng Cen junlong Huang Yin Cui Shimei Li Shaohong liu Ruowen Fu Dingcai Wu PCFM Lab School of ChemistrySun Yat-sen UniversityGuangzhouP.R.China Research Center of Medical Sciences Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouP.R.China

Lithium-sulfur(Li-S)batteries have been regarded as promising next-generation energy-storage devices owing to their inherently high theoretical energy density.Unfortunately,the poor capacity and cycling life caused by severe polysulfide shuttle effect and sluggish redox kinetics in sulfur cathodes greatly impede the practical application of Li-S batteries.Herein,a new class of nanonetworkstructured carbon decorated with oxygen-vacancy-containing cerium oxide nanoparticles(NSC-CeO_(2−x)),in which carbon skeleton is composed of highly conductive carbon nanotube core welded by hybrid carbon shell,has been developed via one-step heating treatment of hybrid molecular brush and further employed as functional interlayer to modify separator of Li-S battery.Owing to the synergistic effect of the highly active CeO_(2−x)nanoparticles and the threedimensional carbon nanonetwork in enhancing the preservation of the soluble polysulfides and boosting the redox kinetics of sulfur species,the NSC-CeO_(2−x)significantly promotes the electrochemical performance of sulfur cathode.As a result,the as-constructed Li-S batteries exhibit an ultrahigh initial sulfur utilization of 92.9%and an extremely large capacity of 751mA h g^(−1) at a high rate of 5 C.Remarkably,a stable capacity of 728 mA h g^(−1)over 300 cycles at 1 C is also achieved.

关键词： lithium-sulfur batteries nanonetwork-structured carbon oxygen vacancies

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血液制品临床研究现状及要点浅析

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世界临床药物 2024年第4期45卷 358-363页

作者：倪娜姜山冯静仪刘嘉欣王俊龙陈桂良中国医药工业研究总院药物临床研究中心上海200437 上海益临思医药开发有限公司上海200437 上海药品审评核查中心上海201203

血液制品作为一类特殊的生物制品,在开展临床研究时,除要符合临床研究的相关法律法规外,在方案设计、项目管理、数据管理及统计分析等各方面也有需要进行特殊考虑之处。该文主要从血液制品临床研究的角度出发,对临床研究的现状、方案设... 详细信息

血液制品作为一类特殊的生物制品,在开展临床研究时,除要符合临床研究的相关法律法规外,在方案设计、项目管理、数据管理及统计分析等各方面也有需要进行特殊考虑之处。该文主要从血液制品临床研究的角度出发,对临床研究的现状、方案设计要点及项目管理要点进行浅析,为血液制品的临床研究提供一些研究思路,拓展产品应用,提升产品临床研究效率和质量。

关键词：血液制品临床研究方案设计项目管理

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3D-bioprinted cholangiocarcinoma-on-a-chip model for evaluating drug responses

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Bio-Design and Manufacturing 2023年第4期6卷 373-389页

作者： Qiong liu Luis SMille Cesar Villalobos Ingrid Anaya Matthias Vostatek Sili Yi Wanlu Li junlong Liao Huanghui Wu Yongteng Song Lize Xiong Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Shanghai 200434China Department of Bioengineering Stanford UniversityPalo AltoCA 94305USA Biotechnological Engineering Program Monterrey Institute of Technology and Higher Education64849 MonterreyNuevo LeónMexico Molecular Biotechnology University of Applied Sciences Campus Vienna1100 ViennaAustria Rapid Manufacturing Engineering Center School of Mechatronical Engineering and AutomationShanghai UniversityShanghai 200444China

Cholangiocarcinoma(CCA)is characterized by heterogeneous mutations and a refractory nature.Thus,the development of a model for effective drug screening is urgently needed.As the established therapeutic testing models for CCA are often ineffective,we fabricated an enabling three-dimensional(3D)-bioprinted CCA-on-a-chip model that to a good extent resembled the multicellular microenvironment and the anatomical microstructure of the hepato-vascular-biliary system to perform high-content antitumor drug screening.Specifically,cholangiocytes,hepatocytes,and vascular endotheliocytes were employed for 3D bioprinting of the models,allowing for a high degree of spatial and tube-like microstructural control.Interestingly,it was possible to observe CCA cells attached to the surfaces of the gelatin methacryloyl(GelMA)hydrogelembedded microchannels and overgrown in a thickening manner,generating bile duct stenosis,which was expected to be analogous to the in vivo configuration.Over 4000 differentially expressed genes were detected in the CCA cells in our 3D coculture model compared to the traditional two-dimensional(2D)monoculture.Further screening revealed that the CCA cells grown in the 3D traditional model were more sensitive to the antitumoral prodrug than those in the 2D monoculture due to drug biotransformation by the neighboring functional hepatocytes.This study provides proof-of-concept validation of our bioprinted CCA-on-a-chip as a promising drug screening model for CCA treatment and paves the way for potential personalized medicine strategies for CCA patients in the future.

关键词： Tumor-on-a-chip Biliary tumor 3D bioprinting Tumor microenvironment Drug screening

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聚乙烯醇颗粒栓塞治疗种植牙后口底假性动脉瘤1例

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中国介入影像与治疗学 2024年第5期21卷 313-313页

作者：徐通洁朱俊龙何虎强孙晓磊刘勇西南医科大学附属医院血管外科四川泸州646000

患者男,69岁,接受种植牙操作后右面颊部及口底肿胀、疼痛3天,经抗感染及其他消肿等治疗后效果不佳;否认相关病史及家族史。查体:右面颊部稍肿胀,皮下见瘀斑,右侧口腔底部舌下见1.2 cm×1.0 cm结节(图1A),边界清楚,质软,有搏动感。颈部增... 详细信息

患者男,69岁,接受种植牙操作后右面颊部及口底肿胀、疼痛3天,经抗感染及其他消肿等治疗后效果不佳;否认相关病史及家族史。查体:右面颊部稍肿胀,皮下见瘀斑,右侧口腔底部舌下见1.2 cm×1.0 cm结节(图1A),边界清楚,质软,有搏动感。颈部增强CT:口底肌肉广泛肿胀,口底右侧(牙槽内侧旁)见1.7 cm×1.2 cm不规则高密度结节,动脉期明显强化(图1B),与邻近小动脉关系密切,考虑假性动脉瘤可能。数字减影血管造影(digital subtraction angiography,DSA)显示口底右侧结节为假性动脉瘤,由右侧下牙槽动脉及其分支供血(图1C)。影像学诊断:右侧下牙槽动脉假性动脉瘤。穿刺右侧股动脉,以泥鳅导丝配合Vertebra单弯导管超选右侧颈外动脉至右侧下牙槽动脉,明确假性动脉瘤破口后,超选至破口附近,于透视下以脉冲式缓慢推注150~250μm聚乙烯醇(polyvinyl alcohol,PVA)颗粒予以栓塞;之后复查造影显示右侧口底假性动脉瘤消失且无对比剂外溢(图1D)。治疗后随访显示面颊部肿胀及瘀斑消退、口底结节消失。临床综合诊断:种植牙后右侧下牙槽动脉假性动脉瘤。本例报道通过医院伦理会批准(KY2024170)。

关键词：动脉瘤,假性栓塞,治疗性聚乙烯乙醇

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Performance of overlapped shield tunneling through an integrated physical model tests,numerical simulations and real-time field monitoring

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Underground Space 2017年第1期2卷 45-59页

作者： junlong Yang Chen liu Qiushi Chen Xiongyao Xie Key Laboratory of Geotechnical and Underground of Ministry of Education Tongji UniversityShanghai 200092China Department of Geotechnical Engineering Tongji UniversityShanghai 200092China Glenn Department of Civil Engineering Clemson UniversityClemsonSC 29634USA

In this work,deformations and internal forces of an existing tunnel subjected to a closely overlapped shield tunneling are monitored and analyzed using a series of physical model experiments and numerical simulations.Effects of different excavation sequences and speeds are explicitly considered in the analysis.The results of the physical model experiments show that the bottom-up tunneling procedure is better than the top-down tunneling procedure.The incurred deformations and internal forces of the existing tunnel increase with the excavation speed and the range of influence areas also increase accordingly.For construction process control,real-time monitoring of the power tunnel is used.The monitoring processes feature full automation,adjustable frequency,real-time monitor and dynamic feedback,which are used to guide the construction to achieve micro-disturbance control.In accordance with the situation of crossing construction,a numerical study on the performance of power tunnel is carried out.Construction control measures are given for the undercrossing construction,which helps to accomplish the desired result and meet protection requirements of the existing tunnel structure.Finally,monitoring data and numerical results are compared,and the displacement and joint fracture change models in the power tunnel subject to the overlapped shield tunnel construction are analyzed.

关键词： Overlapped tunnel Automatic monitoring Micro-disturbance control

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石灰茶籽壳灰改良红黏土试验对比研究

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实验与分析 2024年第1期2卷 17-21页

作者：朵延部杨子泉周玉豪刘凯帆王志文武俊龙信阳学院土木工程学院河南信阳464000

以信阳红黏土为研究对象,分别掺入3%、6%、9%、12%的石灰、茶籽壳灰对其改良,通过界限含水量试验、直接剪切试验、无侧限抗压试验、压缩试验与电镜微观扫描对比分析两种材料改良红黏土效果,试验结果表明:(1)掺入石灰、茶籽壳灰能够影响... 详细信息

以信阳红黏土为研究对象,分别掺入3%、6%、9%、12%的石灰、茶籽壳灰对其改良,通过界限含水量试验、直接剪切试验、无侧限抗压试验、压缩试验与电镜微观扫描对比分析两种材料改良红黏土效果,试验结果表明:(1)掺入石灰、茶籽壳灰能够影响塑限、液限、塑性指数,塑性指数、塑限、液限影响程度依次降低;(2)石灰掺入量9%能够较好地改良红黏土工程特性;(3)石灰改良红黏土机理是CaO与土体中活性物质生成Ca(OH)_(2)、水化硅酸钙(C-S-H)、水化铝酸钙(C-A-H)等凝胶物质,凝胶物质包裹土颗粒,使得土体微观结构致密,致使土体强度提升;(4)茶籽壳灰其化学成分与红黏土中活性物质没有发生化学反应,生成凝胶物质,其改良效果弱于石灰。

关键词：石灰茶籽壳灰红黏土改良土工试验电镜扫描

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联合盆底彩超数据和临床资料探讨压力性尿失禁的危险因素

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中华腔镜泌尿外科杂志(电子版) 2024年第4期18卷 323-330页

作者：黄俊龙刘柏隆罗瑞翔李晓阳李文双柳政陈嘉良周祥福中山大学附属第三医院泌尿外科

目的结合盆底彩超测量数据及相关的临床资料，构建压力性尿失禁的多因素Logistic回归模型，探讨压力性尿失禁发病的危险因素。方法选取2022年10月至2023年10月所有就诊于中山大学附属第三医院泌尿外科门诊需要完善盆底彩超检查的女性... 详细信息

目的结合盆底彩超测量数据及相关的临床资料，构建压力性尿失禁的多因素Logistic回归模型，探讨压力性尿失禁发病的危险因素。方法选取2022年10月至2023年10月所有就诊于中山大学附属第三医院泌尿外科门诊需要完善盆底彩超检查的女性患者238例，其中压力性尿失禁组123例，无压力性尿失禁组115例。收集所有患者的临床资料以及盆底彩超测量数据。采用t检验或卡方检验进行差异性分析筛选压力性尿失禁的危险因素，运用多因素Logistic回归进一步筛选压力性尿失禁的独立危险因素，根据独立危险因素构建压力性尿失禁的预测模型并绘制该模型的受试者工作特征曲线加以验证。此外，根据尿失禁咨询委员会国际评分标准（ICI-Q-SF）将压力性尿失禁患者分为轻、中、重度三组，利用卡方检验对三组患者的盆底独立危险因素进行差异性分析。结果多因素Logistic回归显示，患者BMI≥24 kg/m2、有阴道分娩史、分娩胎儿体质量大、膀胱颈移动度增大、尿道内口漏斗形成、肛提肌裂孔扩张、膀胱膨出及会阴体运动过度与压力性尿失禁的发生密切相关，差异具有统计学意义（P<0.05）。基于多因素分析结果，构建出压力性尿失禁的预测模型，ROC曲线下面积为0.928(95%CI:0.890～10.966,P<0.001)，模型的最佳截断值为0.382，灵敏度为92.0%，特异度为84.3%。并且，与轻度压力性尿失禁相比，中、重度压力性尿失禁患者膀胱颈移动度增大率、尿道内口漏斗的形成率、肛提肌裂孔扩张率、膀胱膨出率及会阴体过度运动率更高，差异有统计学意义（P<0.05）。结论临床资料结合盆底彩超构建的压力性尿失禁预测模型，可以为临床筛查女性压力性尿失禁高危人群提供简便、科学的工具。盆底彩超数据有望成为压力性尿失禁分度的客观依据。

关键词：压力性尿失禁盆底彩超危险因素

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Small Sample Gear Fault Diagnosis Method Based on Transfer Learning

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Open Journal of Applied Sciences 2023年第12期13卷 2461-2479页

作者： Han Zhang Shihao liu Xiyang Wang junlong Zhang School of Aircraft Engineering Nanchang Hangkong University Nanchang China

Aiming at the problems of lack of fault diagnosis samples and low model generalization ability of cross-working gear based on deep transfer learning, a fault diagnosis method based on improved deep residual network and transfer learning was proposed. Firstly, one-dimensional signal is transformed into two-dimensional time-frequency image by continuous wavelet transform. Then, a deep learning model based on ResNet50 is constructed. Attention mechanism is introduced into the model to make the model pay more attention to the useful features for the current task. The network parameters trained by ResNet50 network on ImageNet dataset were used to initialize the model and applied to the fault diagnosis field. Finally, to solve the problem of gear fault diagnosis under different working conditions, a small sample training set is proposed for fault diagnosis. The method is applied to gearbox fault diagnosis, and the results show that: The proposed deep model achieves 99.7% accuracy of gear fault diagnosis, which is better than the four models such as VGG19 and MobileNetV2. In the cross-working condition fault diagnosis, only 20% target dataset is used as the training set, and the proposed method achieves 93.5% accuracy.

关键词： Gear Fault Diagnosis Transfer Learning CWT Deep Residual Network Deep Learning

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