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The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review

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Chinese Journal of Natural Medicines 2024年第08期 676-698页

作者： QI Jianzhao WU Jing KANG Shijie GAO Jingming Hirokazu Kawagishi liu hongwei liu Chengwei Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang College of Life Science Northeast Forestry University Shaanxi Key Laboratory of Natural Products & Chemical Biology College of Chemistry & Pharmacy Northwest A&F University Faculty of Agriculture Shizuoka University State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences

Fungal phytochemicals derived from higher fungi, particularly those from the culinary-medicinal genus Hericium, have gained significant attention in drug discovery and healthcare. This review aims to provide a comprehensive analysis of the chemical structures, biosynthetic pathways, biological activities, and pharmacological properties of monomeric compounds isolated from Hericium species. Over the past 34 years, 253 metabolites have been identified from various Hericium species, including cyathane diterpenes,alkaloids, benzofurans, chromenes, phenols, pyrones, steroids, and other miscellaneous compounds. Detailed investigations into the biosynthesis of erinacines, a type of cyathane diterpene, have led to the discovery of novel cyathane diterpenes. Extensive research has highlighted the biological activities and pharmacological properties of Hericium-derived compounds, with particular emphasis on their neuroprotective and neurotrophic effects, immunomodulatory capabilities, anti-cancer activity, antioxidant properties, and antimicrobial actions. Erinacine A, in particular, has been extensively studied. Genomic, transcriptomic, and proteomic analyses of Hericium species have facilitated the discovery of new compounds and provided insights into enzymatic reactions through genome mining. The diverse chemical structures and biological activities of Hericium compounds underpin their potential applications in medicine and as dietary supplements. This review not only advances our understanding of Hericium compounds but also encourages further research into Hericium species within the realms of medicine, health, functional foods, and agricultural microbiology. The broad spectrum of compound types and their diverse biological activities present promising opportunities for the development of new pharmaceuticals and edible products.

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Daily consumption of Siraitia grosvenorii alleviated lipid accumulation and colon barrier injury via modulation of gut microbiota in high-fat diet C57BL/6 mice

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Food Science and Human Wellness 2024年

作者： Jingru Song Yulu Wei Xiaohua Jiang hongwei liu Xiaojie Yan Dianpeng Li Fenglai Lu Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization， Guangxi Institute of Botany， Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences State Key Laboratory of Mycology， Institute of Microbiology， Chinese Academy of Sciences， No.1 Beichenxi Road Engineering Research Center of Innovative Traditional Chinese， Zhuang and Yao Materia Medica， Ministry of Education， Guangxi University of Chinese Medicine

Siraitia grosvenorii (SG)， a traditional edible medicine in China， has shown potential application in health foods due to multiple bioactivities. However， few comparative studies have investigated the effect of daily intake of SG products by traditional drinking way on alleviating metabolic disorders caused by long-term high fat and high sugar diet (HF-HSD). This study investigated the effects of two commercial SG products (SG juice containing comprehensive compositions and mogrosides extract containing high content mogroside V) supplement on fat content， lipid accumulation， colon barrier and gut microbiota in a 38-week HF-HSD mice trial. Results showed that the SG intervention could decrease the weight gain and body fat content， alleviated lipid accumulation， low-grade inflammation and colon barrier injury. SG juice intake was found to increase the antioxidant enzyme activities of serum glutathione peroxidase (GSH-Px) and liver superoxide dismutase (SOD). 16S rDNA analysis found that SG could restore the gut microbiota with downregulation of harmful bacteria increased by HF-HSD and enhancement of the abundances of beneficial genus. In particular， SG juice significantly enriched taxonomic family Prevotellaceae and genus Alloprevotella. These results indicated that SG might be a functional additive to prevent disease risk caused by excess fat and sugar diet， and active ingredients resulting to the discrepancy of performance especially on gut microbiota are worthy of in-depth investigation.

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Integration of communications,sensing and computing

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Journal of Information and Intelligence 2024年第4期2卷 287-288页

作者： Zhi-Quan Luo hongwei liu Zhi Tian Nan Zhao The Chinese Academy of Engineering China The Chinese University of Hong Kong ShenzhenChina Xidian University China George Mason University USA

With the increasing demand for wireless services and advancements in science and technology,the integration of communications,sensing and computing(I-CSC)has emerged as a research hotspot in the field of information and communication technology.I-CSC is a new information processing paradigm that tightly integrates communications,sensing,and computing to create a cohesive system where these components are designed to work synergistically,enhancing the overall efficiency and reliability of information transmission and processing.

关键词： computing technology. services

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毛泽东对中华民族现代文明的探索与贡献

湖南科技大学学报(社会科学版) 2024年第2期27卷 1-7页

作者：段治文刘宏伟浙江大学马克思主义学院

毛泽东是探索建设中华民族现代文明的伟大先驱。在民族复兴的历史进程中，毛泽东把握文明发展的规律和要求，沿着“民众大联合——建设中华民族的新国家——建设现代化的社会主义国家”的思想进程，为创造中华民族现代文明的基本形态做... 详细信息

毛泽东是探索建设中华民族现代文明的伟大先驱。在民族复兴的历史进程中，毛泽东把握文明发展的规律和要求，沿着“民众大联合——建设中华民族的新国家——建设现代化的社会主义国家”的思想进程，为创造中华民族现代文明的基本形态做出了不懈努力。在“第二个结合”的理论逻辑中，毛泽东积极探寻中华传统文明的现代转型道路，既主张以实事求是的科学态度对待历史文化遗产，又强调以坚定的历史自信、文化自信巩固中华文化主体性。在世界文明的发展脉络中，毛泽东以文明互鉴的理性观念观照世界文明，并基于民族本位汲取世界文明成果，有力地推进了中华文明与世界文明的有机融合。

关键词：毛泽东中华民族现代文明历史贡献

Ganoboninketal C from Ganoderma boninense improves the efficacy of CDDP-based chemotherapy through inhibiting translesion DNA synthesis

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Food Science and Human Wellness 2024年第5期13卷 2982-2992页

作者： Xiaolu Ma Fei Yang Ke Ma Hongyan Shen Junjie Han Kai Wang Yeran Yang Jiawei Zhu Ruiyuan An Qilin Wang Tie-Shan Tang Bo Zhou hongwei liu Caixia Guo College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China CAS Key Laboratory of Genomics and Precision Medicine Beijing Institute of Genomics/China National Center for BioinformationUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Institute of Microbiology University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100101China

Translesion DNA synthesis(TLS)can bypass DNA lesions caused by chemotherapeutic drugs,which usually result in drug *** its key role in mutagenesis and cell survival after DNA damage,inhibition of the TLS pathway has emerged as a potential target for improving the efficacy of DNA-damaging agents such as cisplatin(CDDP),a widely used anticancer ***,few suitable natural TLS inhibitors have been ***,we found that a triterpenoid compound Ganoboninketal C(26-3)from Ganoderma boninense,a traditional Chinese medicine,can impair CDDP-induced TLS polymerase eta(Polη)focus formation,PCNA monoubiquitination as well as ***,26-3 can significantly sensitize tumor cells to CDDP killing and reduce the proportion of cancer stem cells in AGS and promote apoptosis after CDDP ***,26-3 can also sensitize tumor cells to Gefitinib ***,through RNA-seq analysis,we found that 26-3 could abrogate the CDDP-induced upregulation of Polηand PIDD(p53-induced protein with a death domain),2 known factors promoting TLS ***,we found that activating transcription factor 3 is a potential novel TLS *** together,we have identified a natural TLS inhibitor 26-3,which can be potentially used as an adjuvant to improve clinical efficacy.

关键词： Ganoderma boninense Ganoboninketal C Cisplatin chemotherapy Translesion DNA synthesis

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一种原位测量非饱和土的气体扩散系数和渗透系数的方法与装置

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岩土工程学报 2024年第5期46卷 948-958页

作者：刘红位王孟奇詹良通冯嵩吴涛福州大学紫金地质与矿业学院福建福州350108 浙江大学岩土工程研究所浙江杭州310058 浙江大学软弱土与环境土工教育部重点实验室浙江杭州310058 福州大学土木工程学院福建福州350108 江苏科技大学土木工程与建筑学院江苏镇江212000

气体扩散系数Dg和渗透系数Kg是研究非饱和土中气体运移的两个重要参数。推导了稳态条件下,非饱和土中气体运移参数的计算理论。该理论基于示踪气体浓度C与气体流量q1之间及压力梯度P与气体流量q2之间的变化规律,分别确定非饱和土的Dg,K... 详细信息

气体扩散系数Dg和渗透系数Kg是研究非饱和土中气体运移的两个重要参数。推导了稳态条件下,非饱和土中气体运移参数的计算理论。该理论基于示踪气体浓度C与气体流量q1之间及压力梯度P与气体流量q2之间的变化规律,分别确定非饱和土的Dg,Kg。依据推导的理论公式,设计并研制了一种原位测量非饱和土的Dg,Kg的装置。开展土柱试验,利用新装置测量非饱和土的Dg,Kg,并采用单元试验和数值模拟验证新方法和装置的有效性。研究表明新方法测量的非饱和土的Dg,Kg与单元试验及数值模拟结果吻合良好。基于数值模拟开展的敏感性分析结果揭示:Dg测量准确度随土体的质量含水率w减少而降低,而Kg的测量准确度受含水量的影响不显著;非饱和土的Dg,Kg的测量准确度均随着注气球半径增加而降低,但是注气球半径对Kg的测量准确度的影响更为显著,当注气球半径增加到0.05 m时,其准确度约为55%;土体各向异性降低测量准确度,当竖向与水平向的气体运移参数的比值Dgv/Dgh和Kgv/Kgh均为0.1时,Dg,Kg的测量准确度仍可达到40%以上。

关键词：非饱和土气体扩散系数气体渗透系数原位测量装置数值模拟

中国社会治理现代化水平的统计测度与时空特征

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统计与决策 2024年第7期40卷 63-68页

作者：龚宇润刘宏伟大连理工大学马克思主义学院辽宁大连116023

文章基于2012—2021年中国31个省份的面板数据,从社会稳定、社会参与、社会公正、社会成长和公共服务5个维度构建中国社会治理现代化评价指标体系,用熵权-TOPSIS法、Dagum基尼系数、莫兰指数和核密度估计法考察其地区差异和时空演变特... 详细信息

文章基于2012—2021年中国31个省份的面板数据,从社会稳定、社会参与、社会公正、社会成长和公共服务5个维度构建中国社会治理现代化评价指标体系,用熵权-TOPSIS法、Dagum基尼系数、莫兰指数和核密度估计法考察其地区差异和时空演变特征。研究发现:总体上社会治理现代化水平呈稳步上升趋势,但区域不平衡的问题仍然存在,省份间呈现“东优西劣”的发展趋势;区域差异呈现先扩大后缩小的“倒U”型趋势,地区间差异在整体差异中占主导地位,地区内差异对总体差异的贡献也不容忽视;不同区域的社会治理现代化水平并非随机分布的,而是存在一定的空间集聚现象;全国社会治理现代化水平的绝对差异表现出一定幅度的扩大趋势,中西部地区存在一定程度的极化现象。

关键词：社会治理中国式现代化区域差异时空演化

党的初心使命与马克思主义中国化的逻辑进路——基于新民主主义革命时期的考察

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思想政治教育研究 2024年第1期40卷 115-122页

作者：段治文刘宏伟浙江大学马克思主义学院浙江杭州310058

中国共产党百年来践行初心、担当使命的历史,就是持之以恒推进马克思主义中国化的历史。初心使命不仅是中国共产党坚守马克思主义的逻辑起点,而且是马克思主义中国化道路探索的内在指引,彰显出中国共产党人理想信念与使命担当有机结合... 详细信息

中国共产党百年来践行初心、担当使命的历史,就是持之以恒推进马克思主义中国化的历史。初心使命不仅是中国共产党坚守马克思主义的逻辑起点,而且是马克思主义中国化道路探索的内在指引,彰显出中国共产党人理想信念与使命担当有机结合的精神内涵。就理论逻辑而言,中国共产党的初心使命内蕴于马克思主义中国化的理论成果之中,不仅表征出人民至上、民族本位及理论创新的价值意蕴与思想特质,并通过基于中国共产党实践活动而形成的“革命话语”得以科学阐释。初心使命乃是中国共产党历史活动的根本遵循,决定了马克思主义与中国实际相结合的逻辑进路,并成为通往民族复兴、人民幸福的必由之路。

关键词：中国共产党初心使命马克思主义中国化

非自然的内容、非自然的形式——电影叙事的非自然性

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外国语文 2024年第2期40卷 53-64页

作者：刘宏伟马美天津外国语大学英语学院天津300204

后经典叙事学强调理论流派的融合发展,将电影叙事学与非自然叙事学相融合的电影非自然叙事研究成为后经典叙事学领域的一个必要支派。电影叙事中非自然的内容与非自然的形式是电影非自然叙事研究的核心问题。电影叙事内容的非自然性通... 详细信息

后经典叙事学强调理论流派的融合发展,将电影叙事学与非自然叙事学相融合的电影非自然叙事研究成为后经典叙事学领域的一个必要支派。电影叙事中非自然的内容与非自然的形式是电影非自然叙事研究的核心问题。电影叙事内容的非自然性通过世界图式呈现为“不可能”的故事世界,电影叙事形式的非自然性与语篇图式和语言图式中出现的图式干扰相关。语篇图式的非自然性往往源于影片采用的伪线性和反线性的反常规叙事结构,语言图式的非自然性常常表现为视听并行与视听对立的反常规视听互动模式。

关键词：电影非自然叙事不可能的故事世界反常规叙事结构反常规视听互动

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