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An example of toxic medicine used in Traditional Chinese Medicine for cancer treatment

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Journal of Traditional Chinese Medicine 2023年第2期43卷 209-210页

作者： liu hengrui Tianjin Yinuo Biomedical Co. Ltd.Tianjin 061102China

An interesting paper “Toxicmedicine used in Traditional Chinese Medicine for cancer treatment:are ion channels involved?”1 was published in the Journal of Traditional Chinese Medicine on August 17 this year.This paper proposed a unique view of the potential role of ion channels in the pharmacological effects of toxic Traditional Chinese Medicine(TCM) for cancer.

关键词： treatment Traditional Medicine

Research Progress on Distribution,Sources and Ecological Effects of Phthalate in Soil

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Agricultural Biotechnology 2024年第1期13卷 28-30页

作者： hengrui ZHANG Shasha liu Guangdong Key Laboratory of Environmental Health and Land Resource School of Environmental and Chemical EngineeringZhaoqing UniversityZhaoqing 526061China

Phthalate esters(PAEs)are widely used as main plasticizers in plastic products,agricultural regulators,toys,and other fields.This paper reviewed the research progress on the distribution,sources,and ecological effects of PAEs.The effects of PAEs on soil microorganisms,animals,plants and soil properties were explored in sequence,providing effective theoretical basis for future research on PAEs.

关键词： Phthalate ester Distribution Source Ecological effect

FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2260-2274页

作者： Hao Meng Zhiying Liao Yanting Ji Dong Wang Yang Han Chaolin Huang Xujuan Hu Jingyi Chen hengrui Zhang Zonghong Li Changliang Wang Hui Sun Jiaqi Sun Lihua Chen Jiaxiang Yin Jincun Zhao Tao Xu Huisheng liu School of Biomedical Engineering Guangzhou Medical UniversityGuangzhou 511495 GuangdongChina Guangzhou National Laboratory Guangzhou 510320 GuangdongChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Center for Translational Medicine Wuhan Jinyintan HospitalWuhan 430023 HubeiChina School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou 510006 GuangdongChina

The angiotensin-converting enzyme 2(ACE2)is a primary cell surface viral binding receptor for SARS-CoV-2,so finding new regulatory molecules to modulate ACE2 expression levels is a promising strategy against COVID-19.In the current study,we utilized islet organoids derived from human embryonic stem cells(hESCs),animal models and COVID-19 patients to discover that fibroblast growth factor 7(FGF7)enhances ACE2 expression within the islets,facilitating SARS-CoV-2 infection and resulting in impaired insulin secretion.Using hESC-derived islet organoids,we demonstrated that FGF7 interacts with FGF receptor 2(FGFR2)and FGFR1 to upregulate ACE2 expression predominantly inβcells.This upregulation increases both insulin secretion and susceptibility ofβcells to SARS-CoV-2 infection.Inhibiting FGFR counteracts the FGF7-induced ACE2 upregulation,subsequently reducing viral infection and replication in the islets.Furthermore,retrospective clinical data revealed that diabetic patients with severe COVID-19 symptoms exhibited elevated serum FGF7 levels compared to those with mild symptoms.Finally,animal experiments indicated that SARS-CoV-2 infection increased pancreatic FGF7 levels,resulting in a reduction of insulin concentrations in situ.Taken together,our research offers a potential regulatory strategy for ACE2 by controlling FGF7,thereby protecting islets from SARS-CoV-2 infection and preventing the progression of diabetes in the context of COVID-19.

关键词： ACE2 FGF7 islet

The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions:insights from a single-arm,phase II trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2202-2214页

作者： Bo Cheng Caichen Li Jianfu Li Longlong Gong Peng Liang Ying Chen Shuting Zhan Shan Xiong Ran Zhong hengrui Liang Yi Feng Runchen Wang Haixuan Wang Hongbo Zheng Jun liu Chengzhi Zhou Wenlong Shao Yuan Qiu Jiancong Sun Zhanhong Xie Zhu Liang Chenglin Yang Xiuyu Cai Chunxia Su Wei Wang Jianxing He Wenhua Liang Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Medical Department Genecast Biotechnology Co.LtdWuxiChina Department of Radiation Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Respiratory Medicine the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Department of Cardiothoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiangChina Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenChina Department of VIP Inpatient Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaSun Yat-sen UniversityGuangzhouChina Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Immune checkpoint inhibitors targeting the programmed cell death-1(PD-1)protein significantly improve survival in patients with advanced non-small-cell lung cancer(NSCLC),but its impact on early-stage ground-glass opacity(GGO)lesions remains unclear.This is a single-arm,phase II trial(NCT04026841)using Simon’s optimal two-stage design,of which 4 doses of sintilimab(200 mg per 3 weeks)were administrated in 36 enrolled multiple primary lung cancer(MPLC)patients with persistent high-risk(Lung-RADS category 4 or had progressed within 6 months)GGOs.The primary endpoint was objective response rate(ORR).T/B/NK-cell subpopulations,TCR-seq,cytokines,exosomal RNA,and multiplexed immunohistochemistry(mIHC)were monitored and compared between responders and non-responders.Finally,two intent-to-treat(ITT)lesions(pure-GGO or GGO-predominant)showed responses(ORR:5.6%,2/36),and no patients had progressive disease(PD).No grade 3-5 TRAEs occurred.The total response rate considering two ITT lesions and three non-intent-to-treat(NITT)lesions(pure-solid or solid-predominant)was 13.9%(5/36).The proportion of CD8^(+)T cells,the ratio of CD8^(+)/CD4^(+),and the TCR clonality value were significantly higher in the peripheral blood of responders before treatment and decreased over time.Correspondingly,the mIHC analysis showed more CD8^(+)T cells infiltrated in responders.Besides,responders’cytokine concentrations of EGF and CTLA-4 increased during treatment.The exosomal expression of fatty acid metabolism and oxidative phosphorylation gene signatures were down-regulated among responders.Collectively,PD-1 inhibitor showed certain activity on high-risk pulmonary GGO lesions without safety concerns.Such effects were associated with specific T-cell re-distribution,EGF/CTLA-4 cytokine compensation,and regulation of metabolism pathways.

关键词： lesions metabolism doses

基于区块链及IPFS的农产品多链追溯系统研究

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中国农机化学报 2024年第7期45卷 127-134页

作者：张净唐恒睿刘晓梅江苏大学电气信息工程学院江苏镇江212013 江苏科茂信息技术有限公司江苏镇江212001

面对农产品供应市场日益庞大以及现存追溯系统中心化结构严重、溯源信息模糊简陋、数据安全难以得到有效保障等问题,通过分析供应链的业务流程及相关特点,融合区块链及IPFS技术设计灵活的多链分布式追溯系统以应对错综复杂多变的市场情... 详细信息

面对农产品供应市场日益庞大以及现存追溯系统中心化结构严重、溯源信息模糊简陋、数据安全难以得到有效保障等问题,通过分析供应链的业务流程及相关特点,融合区块链及IPFS技术设计灵活的多链分布式追溯系统以应对错综复杂多变的市场情况中的精准溯源及监管的需求。充分利用星际文件系统IPFS的去重存储以及分布式存储特性提高存储资源的利用率,解决以往溯源数据存储中心化严重、数据类型单一、负载过大等问题;区块链多链与IPFS私有网络的结合以及CBC、ECC两个加密算法的采用可以支持全面的市场监管,并可以满足企业隐私数据的加密保护需求。为验证模型有效性,以水培蔬菜溯源项目作为应用案例进行分析测试,其中区块链多链系统吞吐量达到上链500 TPS、查询400 TPS;CBC加密算法的相关性、扩展性分析中密文改变率分别达到96.727%、97.136%。测试结果表明:本追溯系统在实现溯源数据高效记录存储和精准监管溯源的基础上,也能够给予供应链内各方合法权益及隐私数据有效的安全保护,亦可以面对业务交错复杂的市场供应链,为完整可靠的农产品区块链追溯监管系统研究发展与落地实现提供借鉴与参考。

关键词：农产品追溯区块链数据加密数据安全 IPFS

城市综合能源系统协同调控与互动交易研究综述

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高电压技术 2024年第4期50卷 1357-1375,I0001页

作者：马恒瑞王波王蔚董旭柱刘书福丁书伟交直流智能配电网湖北省工程中心武汉430072 武汉大学电气与自动化学院武汉430072 新能源电力系统智慧运行教育部重点实验室(青海大学能源与电气工程学院) 西宁810016

城市是工业、服务业的聚集地,是经济增长的主引擎,未来城市综合能源系统的发展目标将不仅仅局限于满足社会能源需求,还需要将视角提升到支撑城市全局发展层面。因此,城市综合能源系统协同调控与互动交易相关研究不仅是近年来研究的热点... 详细信息

城市是工业、服务业的聚集地,是经济增长的主引擎,未来城市综合能源系统的发展目标将不仅仅局限于满足社会能源需求,还需要将视角提升到支撑城市全局发展层面。因此,城市综合能源系统协同调控与互动交易相关研究不仅是近年来研究的热点问题,也是促进人类和城市可持续发展的必要解决问题。该文首先分析了相关研究的发展趋势和发文热度。然后在模型层面,分别讨论了城市综合能源系统的基本协同调控模型以及满足零碳需求、韧性提升需求、互动交易场景下的协同调控模型;在决策框架和算法层面,就目前常用的双层优化、鲁棒优化、人工智能优化方法分别进行概括分析;对城市综合能源系统仿真软件的特点进行了归纳总结。最后,对城市综合能源系统中多能源协同运行灵活性潜力挖掘、全设备模型建模方法与信息交换技术、多元用户互动特性分析、信息-物理-社会深度融合的需求和挑战进行了展望。

关键词：城市综合能源系统协同调控互动交易模型决策框架求解方法

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大断面偏压隧道超浅埋洞口施工关键技术

重庆建筑 2024年第6期23卷 44-47页

作者：赵金洪陈绍清刘恒瑞重庆高新技术产业开发区城市建设事务中心重庆401329 重庆科技大学安全工程学院重庆401331

隧道暗挖施工的安全影响因素较多,特别是在隧道洞口地质环境条件较差时,生产安全事故控制难度更大。该文以文峰山1#隧道急倾斜地层四车道大断面洞口超浅埋段为例,通过采取地面注浆加固,施作洞门套拱和打超长管棚作为进洞条件;洞身开挖... 详细信息

隧道暗挖施工的安全影响因素较多,特别是在隧道洞口地质环境条件较差时,生产安全事故控制难度更大。该文以文峰山1#隧道急倾斜地层四车道大断面洞口超浅埋段为例,通过采取地面注浆加固,施作洞门套拱和打超长管棚作为进洞条件;洞身开挖采用双侧壁导坑七步工法,首先完成超前小导管施工,后采用大型配套机械挖掘,减少扰动,控制台阶间作业面距离及左右导坑先后行的长度,以确保大倾角超浅埋段掌子面岩石的稳定性,实现小台阶快速成环,有效解决隧道进洞难的问题,达到早进洞的目标,对该隧道安全顺利完工提供了有力保障,对类似隧道项目的施工有重要的借鉴作用。

关键词：大断面隧道偏压超浅埋施工技术

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Effectiveness associated with different therapies for senile osteoporosis: a network Meta-analysis

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Journal of Traditional Chinese Medicine 2020年第1期40卷 17-27页

作者： Wang Haixia Mo Shu Yang Li Wang Panpan Sun Kehuan Xiong Yingquan liu hengrui liu Xiaoguang Wu Zhidi Ou Ling Li Xiaoyun Peng Xunqian Peng Bojia He Haibin Tian Ya Zhang Ronghua Zhu Xiaofeng School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China Cancer Research Institute and School of Pharmacy Jinan UniversityGuangzhou 510632China Department of Traditional Chinese Medicine the First Affiliated Hospital of Jinan UniversityGuangzhou 510632China

OBJECTIVE:The aim of this study was to evaluate the effectiveness of Chinese herbal medicines for invigorating the kidney(CHMIK)on senile osteoporosis.METHODS:We searched for studies in English-language databases(Pub Med,the Cochrane Library,and Web of Science)and Chinese-language databases(China National Knowledge Infrastructure,Wan Fang Data,VIP Chinese periodical service platform),and China Biology Medicine disc from their inception to September 2017.Randomized controlled trials comparing the effectiveness of Traditional Chinese Medicine therapies(alone or in combination)and conventional clinical medicine therapies among older adult patients with osteoporosis were identified.We conducted a network Meta-analysis with a Bayesian hierarchical random-effects model using RStudio software,Version 3.4.1.RESULTS:Forty-three randomized controlled trials assessing the differences between Traditional Chinese Medicine and conventional clinical medicine were identified,including 15 treatments and involving 3316 patients.The results of the network Meta-analysis indicated that alendronate(odds ratio[OR]=0.20,95%confidence interval[CI]:0.047-0.73)and calcium(OR=0.18,95%CI:0.11-0.30)are significantly more effective if combined with oral CHMIK.CHMIK alone is significantly more effective than both alendronate(OR=0.34,95%CI:0.10-1.0)and calcium(OR=0.13,95%CI:0.056-0.28).Moreover,CHMIK+tuina+calcium is more effective than CHMIK+calcium+vitamin D+alendronate(OR=18.0,95%CI:1.1-2.7 e+02).CONCLUSION:The present network Meta-analysis found that alendronate and calcium are more effective if combined with oral CHMIK and that oral CHMIK alone may be more effective than alendronate or calcium.Tuina may have an advantage over oral medicines.Oral CHMIK and calcitonin show the most potential for treating senile osteoporosis.

关键词： Osteoporosis Aged Reinforcing kidney Traditional Chinese drugs Alendronate Calcium Calcitonin Network Meta-analysis

基于近红外光谱法和FPGA的纺织物成分检测系统

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电子器件 2024年第1期47卷 255-264页

作者：张恒瑞姚丞韬刘向南京信息工程大学电子与信息工程学院江苏南京210044 南京信息工程大学计算机学院(网络空间安全学院) 江苏南京210044

在纺织品检测中,纤维成分定量检测是一项重要的检测项目,其要求拥有准确、快速、环保的检测手段和检测仪器,以满足市场对纺织物纤维成分检测的需求。提出了一种基于近红外光谱法和FPGA的纺织物成分检测系统,通过滨松光子MEMS-FPI传感器... 详细信息

在纺织品检测中,纤维成分定量检测是一项重要的检测项目,其要求拥有准确、快速、环保的检测手段和检测仪器,以满足市场对纺织物纤维成分检测的需求。提出了一种基于近红外光谱法和FPGA的纺织物成分检测系统,通过滨松光子MEMS-FPI传感器采集近红外光谱数据,利用一维卷积神经网络建模,使用知识蒸馏缩减网络规模,最终部署在FPGA上。实验结果表明,该方案的检测效果较好(R^(2)>0.82),可以以较低的功耗及延时(<1 ms)实现良好的表现。

关键词：纺织物成分检测卷积神经网络近红外光谱法 FPGA 知识蒸馏