Effectiveness associated with different therapies for senile osteoporosis: a network Meta-analysis

作     者：Wang Haixia Mo Shu Yang Li Wang Panpan Sun Kehuan Xiong Yingquan Liu Hengrui Liu Xiaoguang Wu Zhidi Ou Ling Li Xiaoyun Peng Xunqian Peng Bojia He Haibin Tian Ya Zhang Ronghua Zhu Xiaofeng Wang Haixia;Mo Shu;Yang Li;Wang Panpan;Sun Kehuan;Xiong Yingquan;Liu Hengrui;Liu Xiaoguang;Wu Zhidi;Ou Ling;Li Xiaoyun;Peng Xunqian;Peng Bojia;He Haibin;Tian Ya;Zhang Ronghua;Zhu Xiaofeng

作者机构：School of Traditional Chinese MedicineJinan UniversityGuangzhou 510632China College of PharmacyJinan UniversityGuangzhou 510632China Cancer Research Institute and School of PharmacyJinan UniversityGuangzhou 510632China Department of Traditional Chinese Medicinethe First Affiliated Hospital of Jinan UniversityGuangzhou 510632China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2020年第40卷第1期

页      面：17-27页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China"Kidney Health Bone,Marrow Link Brain",a Study of Chinese Nourishing Kidney Herbs’Mechanism of Treatment of Osteoporosis Based on Neuropeptide Network "Too Salty to Hurt the Bone",A Study on the Molecular Mechanism of High Salt Affecting Bone Metabolism Based on Related Ion Channels and Intervention of A Compound Chinese Medicine for Reinforcing Kidney(No.81473509,81673837) 

主　　题：Osteoporosis Aged Reinforcing kidney Traditional Chinese drugs Alendronate Calcium Calcitonin Network Meta-analysis 

摘      要：OBJECTIVE:The aim of this study was to evaluate the effectiveness of Chinese herbal medicines for invigorating the kidney(CHMIK)on senile ***:We searched for studies in English-language databases(Pub Med,the Cochrane Library,and Web of Science)and Chinese-language databases(China National Knowledge Infrastructure,Wan Fang Data,VIP Chinese periodical service platform),and China Biology Medicine disc from their inception to September *** controlled trials comparing the effectiveness of Traditional Chinese Medicine therapies(alone or in combination)and conventional clinical medicine therapies among older adult patients with osteoporosis were *** conducted a network Meta-analysis with a Bayesian hierarchical random-effects model using RStudio software,Version ***:Forty-three randomized controlled trials assessing the differences between Traditional Chinese Medicine and conventional clinical medicine were identified,including 15 treatments and involving 3316 *** results of the network Meta-analysis indicated that alendronate(odds ratio[OR]=0.20,95%confidence interval[CI]:0.047-0.73)and calcium(OR=0.18,95%CI:0.11-0.30)are significantly more effective if combined with oral *** alone is significantly more effective than both alendronate(OR=0.34,95%CI:0.10-1.0)and calcium(OR=0.13,95%CI:0.056-0.28).Moreover,CHMIK+tuina+calcium is more effective than CHMIK+calcium+vitamin D+alendronate(OR=18.0,95%CI:1.1-2.7 e+02).CONCLUSION:The present network Meta-analysis found that alendronate and calcium are more effective if combined with oral CHMIK and that oral CHMIK alone may be more effective than alendronate or *** may have an advantage over oral *** CHMIK and calcitonin show the most potential for treating senile osteoporosis.