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103种药食两用植物化学成分分析及功能活性评价

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中国食品学报 2024年第8期24卷 385-402页

作者：刘晓海茹月蓉张雪春周旭红何霞红王振兴西南林业大学生物与食品工程学院昆明650224 云南中医药大学、云南中医药大学科技处科研实验中心昆明650500 西南林业大学、西南山地森林资源保育与利用教育部重点实验室、云南省林下资源保护与利用重点实验室昆明650224

为比较分析我国传统药食同源植物,选取103种药食两用植物,根据外观将其分为果实、花叶、全草、种子、皮、根茎、真菌和其它类,测定其总酚和总黄酮含量,评价其体外抗氧化活性、α-葡萄糖苷酶和乙酰胆碱酯酶抑制能力,并采用高效液相色谱... 详细信息

为比较分析我国传统药食同源植物,选取103种药食两用植物,根据外观将其分为果实、花叶、全草、种子、皮、根茎、真菌和其它类,测定其总酚和总黄酮含量,评价其体外抗氧化活性、α-葡萄糖苷酶和乙酰胆碱酯酶抑制能力,并采用高效液相色谱分析其化学成分。结果表明:各药食两用植物的总酚和总黄酮含量差异较大,其中总酚含量以花叶类的丁香(309.59μg GAE/mg)、果实类的青果(229.64μg GAE/mg)最高,总黄酮含量以全草类的蒲公英(662.31μg RE/mg)、小蓟(505.33μg RE/mg)最高。相对而言,花叶、果实与全草类药食两用植物具有良好的的体外抗氧化活性。此外,果实类的覆盆子和青果、皮类的肉桂、花叶类的丁香显示出较好的α-葡萄糖苷酶抑制能力,而根茎类的姜黄、皮类的肉桂、全草类的香薷对乙酰胆碱酯酶的抑制能力较强,说明这些药食两用植物具有较好地预防糖尿病与阿尔茨海默病的潜力。高效液相色谱分析表明:从花叶类、果实类与全草类药食两用植物中检出的化合物种类较多,其中儿茶素、绿原酸与表儿茶素等是主要化合物,与抗氧化活性呈显著正相关关系,它们可能是这些药食两用植物抗氧化的主要活性物质。本文首次比较分析103种传统药食两用植物的化学成分和功能活性,对这些植物在居民膳食指导和临床治疗中的应用具有一定的参考价值。

关键词：药食两用植物活性成分抗氧化活性 α-葡萄糖苷酶乙酰胆碱酯酶

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Ferro-vanadium Slag in Improving Inner Chloride Solidification Rate of Cement Materials

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1065-1076页

作者： CHEN Pian MA Baoguo TAN Hongbo liu xiaohai State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450052China

We investigated the effects of ferro-vanadium slag(FVS)as a supplemental cementing material which can dissolve a large amount of active aluminum phases without excessive pretreatment or excitation to enhance the inner chloride solidified rate(CSR)of cement-based ***-FVS pastes with 0-30%content of FVS was designed,and the CSR was *** at different curing ages were studied by X-ray diffraction(XRD)and thermo-gravimetric analysis(TGA);hydration heat and^(29)Si nuclear magnetic resonance(^(29)Si-NMR)were tested to analyze the hydration degree of the system;mechanical properties in cement-FVS system were evaluated by compressive strength test,pore structure and the fractal *** revealed that the incorporation of FVS could greatly promote the CSR of cement-FVS *** with the control groups,30%dosage of FVS could increase the CSR by 69%at 3 d,47%at 7d,36%at 28 d and 34%at 60 *** was demonstrated that the incorporation of FVS could enhance the chemical solidifying ability of chloride,and the main reason was the promoted generation of Kuzel’s salt and the Friedel’s salt in hydrate products,and the enhanced chloride migration resistance capacity by increasing the volume of gel pores in the cement-FVS *** the influence of FVS on strength performance,this paper suggested that the suitable dosage of FVS as a supplemental cementing material was around 10%.The study in this paper might provide one efficient path to promote the chloride solidifying capacity of cement-based material and meanwhile the comprehensive utilization of FVS.

关键词： ferro-vanadium slag chloride solidified rate cement-FvS system Friedel's salt Kuzel's salt

Effect of Hydrated Calcium Aluminate Cement on the Chloride Immobilization of Portland Cement Paste

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Journal of Wuhan University of Technology(Materials Science) 2023年第6期38卷 1360-1371页

作者： LU Zhouling TAN Hongbo liu xiaohai CHEN Pian WANG Yifan LIANG Wenje State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

To improve the efficiency and stability of chloride immobilization of portland cement paste,hydrated calcium aluminate cement(HCAC)prepared by wet grinding of CAC was added into portland cement paste as an *** immobilized chloride ratio(ICR)was evaluated,and the mechanism of chloride immobilization was researched by XRD,DTG,NMR,and MIP *** analysis results demonstrated that HCAC could improve the chloride immobilization capacity of portland cement *** mechanism was attributed to the following aspects:chemical binding capacity was enhanced via producing more Kuzel’s salt;physical adsorption capacity was reduced by decreasing the C-S-H gel;migration resistance was enhanced through refining the pore structure.

关键词： hydrated calcium aluminate cement portland cement paste chloride immobilization kuzel's salt pore structure

钢纤维对粉煤灰-矿渣基地质聚合物工作性及力学性能的影响研究

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混凝土 2024年第6期 121-125,133页

作者：田崇霏王亚洲刘晓海弥杰张道令罗忠涛郑州大学材料科学与工程学院河南郑州450052 河南人邦科技股份有限公司河南洛阳471700

采用控制变量法,研究了钢纤维长度与掺量对粉煤灰-矿渣基地质聚合物工作性及力学性能的影响。试验结果表明:钢纤维长度与掺量对地质聚合物的凝结时间影响不大,钢纤维长度及掺量增加,地质聚合物初始流动度下降;钢纤维对地质聚合物的抗压... 详细信息

采用控制变量法,研究了钢纤维长度与掺量对粉煤灰-矿渣基地质聚合物工作性及力学性能的影响。试验结果表明:钢纤维长度与掺量对地质聚合物的凝结时间影响不大,钢纤维长度及掺量增加,地质聚合物初始流动度下降;钢纤维对地质聚合物的抗压强度、抗折强度、折压比、等效弯曲强度、等效弯曲韧性具有明显的增强作用,且长钢纤维优于短钢纤维。

关键词：钢纤维长度掺量地质聚合物工作性力学性能

Effects of Reducing River Flow on Pulse Residence Time in Little Manatee River,USA

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Transactions of Tianjin University 2009年第2期15卷 95-100页

作者： HUANG Wenrui,liu xiaohai(Department of Civil Engineering,Florida State University,Tallahassee,Florida 32310-6046,USA) Department of Civil Engineering Florida State University Tallahassee USA

Residence time is an important indicator for river environmental *** this paper,a 3D hydrodynamic model has been successfully applied to Little Manatee River to characterize the mixing and transport process and residence *** model employs horizontal curvilinear orthogonal grids to represent the complex river system that consists of branches and *** model has been satisfactorily calibrated and verified by using two continuous data *** data sets consist of hourly observations of all forcing boundaries,including freshwater inputs,tides,winds,salinity and temperatures at bay boundary,and air temperatures for model *** data sets also consist of hourly observations of water levels,salinity,and temperature at several river *** calibrated and verified hydrodynamic model was used to predict residence time in the Little Manatee *** the minimum flow of 0.312 m3/s,the pulse residence time(PRT) is 108 *** simulations were also conducted for 17 flow *** regression equations have been satisfactorily derived to correlate PRT to freshwater *** coefficient R2 is 0.982 for PRT.

关键词： hydrodynamic modeling estuary residence time tidal river

Effect of Nano Silica on Hydration and Microstructure Characteristics of Cement High Volume Fly Ash System Under Steam Curing

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Journal of Wuhan University of Technology(Materials Science) 2019年第3期34卷 604-613页

作者： MA Baoguo MEI Junpeng State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan430070China Department of Construction Cost Wuhan University of TextileWuhan430200China

The influences of nano silica (NS) on the hydration and microstructure development of steam cured cement high volume fly ash (40 wt%, CHVFA) system were investigated. The compressive strength of mortars was tested with different NS dosage from 0 to 4%. Results show that the compressive strength is dramatically improved with the increase of NS content up to 3%, and decreases with further increase of NS content (e g, at 4%). Then X?ray diffraction (XRD), differential scanning calorimetry-thermogravimetry (DSCTG), scanning electron microscope (SEM), energy disperse spectroscopy (EDS), mercury intrusion porosimeter (MIP) and nuclear magnetic resonance (NMR) were used to analyze the mechanism. The results reveal that the addition of NS accelerates the hydration of cement and fly ash, decreases the porosity and the content of calcium hydroxide (CH) and increases the polymerization degree of C-S-H thus enhancing the compressive strength of mortars. The interfacial transition zone (ITZ) of CHVFA mortars is also significantly improved by the addition ofNS, embodying in the decrease of Ca/Si ratio and CH enrichment of ITZ.

关键词： nano silica cement high volume fly ash hydration pozzolanic reaction pore structure interfacial transition zone

Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy

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Science China Chemistry 2024年第7期67卷 2412-2422页

作者： Yu Chen Yu Guo Jiaoli Wang Ruiting liu xiaohai Yang Kemin Wang Ying Pu Hui Shi Jin Huang Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China National Clinical Research Center for Geriatric Disorders Department of GeriatricsXiangya HospitalCentral South UniversityChangsha 410008China

DNAzyme-based gene therapy faces some challenges including cell penetration,activity limitation,and co-delivery ***-assembled DNA nanomedicine has attracted widespread attention due to its many *** is urgent to develop a universal DNA degradation strategy for precise programmable drug ***,we reported a self-catabolic DNAzyme nanospheres(SCNS),which could simultaneously achieve cell penetration,activity enhancement,and co-delivery *** SCNS were assembled through Y-DNA stepwise hybridization with each other,which were then loaded with aptamer(Apt),doxorubicin(Dox),and zinc oxide nanoparticles(ZnO NPs).The acid-triggered dissociation of ZnO NPs leads to the generation of Zn^(2+)ions cofactors for immediately self-catabolic DNAzyme *** the disassembly of the SCNS,three types of anticancer treatments would be activated,which include Zn^(2+)involved reactive oxygen species(ROS),Dox-induced chemotherapy,and DNAzyme-based gene *** experimental results show that the nanoplatform(Apt-SCNS-Dox-ZnO)has a good tumor-killing effect and minimal side *** a smart self-driven drug delivery nanoplatform,it is anticipated to displace extraordinary potential in biomedicine and bioengineering.

关键词： DNAzyme nanosphere ZnO NPs ROS Dox anticancer therapy

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关于国际中文智慧教育的几点思考

语言教学与研究 2022年第5期 1-9页

作者：刘利刘晓海北京语言大学语言资源高精尖创新中心 100083

本文基于北京语言大学国际中文智慧教育工程的理论和实践探索,首次提出了“国际中文智慧教育”这一概念并阐释其内涵、样态和特征,对开展国际中文智慧教育的必要性、发展方向和实现路径等进行了讨论。

关键词：国际中文智慧教育教育信息化教学模式创新教育生态

Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas

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Science China(Life Sciences) 2013年第2期56卷 163-173页

作者： DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu liu xiaohai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Chemistry Tsing Hua University China Zhongyuan Engineering Corporation China National Nuclear Corporation China Nuclear Industry Beijing 410 Hospital of China Institute of Atomic Energy

Invasive nonfunctional pituitary adenomas （NFPAs） are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control of NFPA. Although radiation therapy and radiosurgery are useful to prevent tumor regrowth, they are frequently withheld because of severe complications. Boron neutron capture therapy （BNCT） is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue. Folate receptor （FR）-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis. In this study, FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas. After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons, the cell viability of NFPAs was significantly decreased, while apoptotic cells were simultaneously increased. However, cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells. The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT. In conclusion, FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs ceils for BNCT. Furthermore, our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy, while exploring these new applications of BNCT for tumors, especially benign tumors.

关键词： nonfunctional pituitary adenomas folate receptor nanoparticles boron neutron capture therapy